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- 저자 : Shanmugapriya, T. (검색결과 19 건)
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Engineering pharmaceutical nanocarriers for photodynamic therapy on wound healing: Review
Shanmugapriya, Karuppusamy,Kang, Hyun Wook Elsevier S.A. 2019 Materials Science and Engineering C Vol. No.
<P><B>Abstract</B></P> <P>In the present scenario, promising efforts have been improved by the researchers towards the development of nanocarriers that can be challenge fundamental tasks in photodynamic therapy (PDT) for wound management. In the past few years, nanotechnology-based therapy has attracted good attention with the advancement of nanotechnology such as PDT, chemotherapy, photothermal therapy. PDT has emerged as a promising clinical treatment method for wound healing. In this respect, great effort has been made towards the development of nanocarriers for targeted PDT in wound management. Nowadays, attention is concentrated on the advancement of nanomaterials using innovative methods in wound care for treating wounds with the faster healing effect. In this review, we present and discuss how nanocarriers have arisen as an interesting delivery nanoplatform for effective and consistent PDT. They can be easily delivered photodynamically and can demonstrate healing mechanisms for achieving target wound tissue/cells; therefore, PDT can be used in wound treatment to target cells specifically through release on demand, target-specific delivery, and in vivo labelling imaging. In addition, we also highlighted that the future goal for researchers is the development of biocompatible and biodegradable nanomaterials for all the phases of wound healing.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Development of nanocarriers for PDT in wound healing process is of quite challenge. </LI> <LI> PDT is promising alternative approach for improved wound healing treatment method. </LI> <LI> Biocompatible biomaterials become a dynamic role in each wound healing stages. </LI> <LI> Pharmaceutical nanocarriers can significantly improve the wound healing efficacy. </LI> <LI> Nanocarrier systems may improve in vitro and in vivo applications of wound related. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Shanmugapriya, Karuppusamy,Kim, Hyejin,Saravana, Periaswamy Sivagnanam,Chun, Byung-Soo,Kang, Hyun Wook Elsevier 2018 Colloids and surfaces Biointerfaces Vol.172 No.-
<P><B>Abstract</B></P> <P>Emulsion-based delivery systems have been fabricated and developed to increase the bioavailability of astaxanthin and alpha-tocopherol as active compounds for various biomedical applications. Astaxanthin-alpha tocopherol nanoemulsion (ATNE) is well known for its potential 6.–6.30 effect. The current study investigated ATNE by spontaneous (SENE) and ultrasonication emulsification (USNE) methods to optimally fabricate oil/water nanoemulsion characterized for biomedical applications. The two methods were compared by using a response surface method of 3-level Box-Behnken design (BBD) with significant factors. Transmission electron microscopy (TEM) confirmed spherical-shaped nanoemulsion from SENE and USNE methods and dynamic light scattering (DLS) proved the good stability of the fabricated nanoemulsion. Cytotoxicity studies on three different cancer cells confirmed that the nanoemulsion at higher concentrations was more toxic than one at lower concentrations by accompanying a significant decrease in the cellular viability after 24 and 48 h of exposure. The wound-healing potential using scratch assay evidenced faster healing effect of the nanoemulsion. Both minimal inhibitory concentration (MIC) and minimum bactericidal concentrations (MBC) methods confirmed significant antibacterial activity to disrupt the integrity of the bacterial cell membrane. The current results suggested that ATNE act as effectively targeted drug delivery vehicles in the future for cancer treatment applications due to its significant results of anticancer, wound healing, and antimicrobial effects.</P> <P><B>Highlights</B></P> <P> <UL> <LI> ATNE nanoemulsion showed small droplet size. </LI> <LI> It has maintained a kinetically high stability for three months. </LI> <LI> ATNEs at lower concentrations reduced cancer cell viability and induced apoptosis. </LI> <LI> It also increased fibroblast cell migration and disrupted bacterial cell membrane. </LI> <LI> The remarkable findings are good wound healing and antibacterial activities. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Shanmugapriya, Karuppusamy,Kim, Hyejin,Lee, Yong Wook,Kang, Hyun Wook Elsevier 2020 CERAMICS INTERNATIONAL Vol.46 No.6
<P><B>Abstract</B></P> <P>The present study evaluated the effect of fucoidan/alginate-polyethylene glycol-gellan gum (Fu/AL-PEG@GGH) hydrogel using low-level laser therapy (LLLT) on facilitating wound healing for wound care management. The hydrogel was fabricated and characterized to evaluate the wound healing potential. Cytotoxicity and apoptotic effects were evaluated with L929 and NIH3T3 cells. Uniform spherical sheets were observed with high thermal stability caused by porous matrixes with the increased cell viability and fast cell migration. Scar tissue was reduced by larger wound contraction with faster healing effects from the hydrogel + LLLT-treated group at day 14. The polysaccharides may promote wound healing due to the strong bonds by the physical cross-linking in hydrogel preparation. The results from hydrogel + LLLT-treated group confirmed an effective wound healing potential from the presence of high fibroblast and collagen deposition. Therefore, the combined practice of the hydrogel with LLLT may enhance a wound healing process for effective wound care applications.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Fu/AL-PEG@GG H was fabricated for wound healing applications. </LI> <LI> Fu/AL-PEG@GG hydrogel is non-toxic with faster cell migration. </LI> <LI> Polysaccharides evoked strong bonds by physical cross-linking in hydrogels. </LI> <LI> Hydrogel could promote collagen deposition and decrease the inflammation process. </LI> <LI> Fu/AL-PEG@GG hydrogel combined with LLLT resulted in the enhanced wound healing in an animal model. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Shanmugapriya, Karuppusamy,Kim, Hyejin,Saravana, Periaswamy Sivagnanam,Chun, Byung-Soo,Kang, Hyun Wook Elsevier 2018 INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES Vol.118 No.2
<P><B>Abstract</B></P> <P>A nanocomposite film, chitosan (CS)-polyvinylpyrrolidone (PVP)-bentonite (BN) was fabricated to enhance wound healing processes as a new nanoplatform for wound dressing. Both physical properties and antibacterial activity of the proposed film were examined to validate its applicability and inhibitory effect for wound management. <I>In vitro</I> cytotoxicity was evaluated by using MTT assay on L929 and NIH3T3 cells to identify the toxicity level of the film. <I>In vivo</I> wound healing test assessed the wound healing performance in animal models. The results confirmed a strong interaction between surface functional groups among CS, PVP and BN with suitable surface morphology and high thermal stability. The CS-PVP-BN film improved various material features such as including mechanical property, tensile strength, pH and porosity, inhibitory activity on bacterial organisms, and collagen deposition. The animal study confirmed that the fabricated film yielded a rapid healing rate of 97%, less scarring, thick granulation at the 11th day, regeneration of epidermis at the 16th day, and abundant deposition of collagen and fibroblast, compared with control. The non-toxic nanocomposite film can be a promising antibacterial wound dressing with rapid wound healing effects in wound care management.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Greater surface interaction between new nanocomposite films with high thermal stability. </LI> <LI> Nanocomposite films have good antibacterial effect. </LI> <LI> Non-toxic films act as biocompatible antibacterial wound dressings. </LI> <LI> CS-PVP-BN2 films have the fastest healing rate (97%) with high collagen deposition and less scarring. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>Schematic illustration of wound healing by using nanocomposite films as wound dressing.</P> <P>[DISPLAY OMISSION]</P>
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Recent research trends in perfluoropolyether for energy device applications: a mini review
Shanmugapriya Sathyanarayanan,Kim Myeong Gon,Im Sejin,Jeong Yujin,Surendran Subramani,박태언,윤영훈,이현정,Kim Tae-Hoon,심욱 한국세라믹학회 2024 한국세라믹학회지 Vol.61 No.1
Fluorinated polymers are a significant class of functional materials in the field of polymer chemistry. Endowed with remarkable properties, such as high chemical and solvent resistance, enhanced electrical properties, high thermal and electrochemical stability, and low surface energy, they find potential applications in various fields such as chemical processing, electrical/electronic industries, automotive/aircraft industries, medical instrumentations, consumer products, and energy storage or conversion devices. Among a wide variety of commercially significant fluorinated polymers, perfluoropolyether (PFPE) plays a substantial role in energy applications because of its super-hydrophobicity, non-crystallinity, non-flammability, low toxicity, and gas-permeability features. This review briefly confers the properties, production, and significant studies of perfluoropolyether as electrolytes in batteries, followed by a detailed discussion on their role as solid electrolyte interphase (SEI) in metal-ion batteries, oxygen selective membrane (OSM) in metal–air batteries, and as a hydrophobic coating for gas diffusion electrodes in fuel cell applications. Besides, other energy-related applications of PFPE that open up the future scopes of perfluoropolyether in the field of energy storage and conversion devices are also presented.
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Shanmugapriya P.,Kumaran M. Senthil,Baskaran J.,Nayanatara C.,Sharmila P.,Eltamaly Ali M. 대한전기학회 2022 Journal of Electrical Engineering & Technology Vol.17 No.2
Demand response management (DRM) aims to curb the energy consumption by reducing the peak load and thereby improve the performance of distributed generation (DG). From the utility perspective, the cost of generation should be kept minimum, whereas from the customer’s view, the social welfare should be maximum. Therefore this research focuses on a new method based on intelligent algorithm to optimally operate the demand side management in the presence of DG units and demand response. Initially, the location, size and rating of DG units are selected to achieve the optimization of real, reactive power and voltage deviation Index. Finally comprehensive case studies are taken into consideration with DRM strategy to vindicate the technical and economical benefi ts. Reduction in congestion and power loss with maximized customer benefi t are taken as an objective function in this stage. Probability-Based Incremental Learning is implemented and it is tested in a standard IEEE 33bus system and a real-time Indian utility 23-bus system. Results reveal that the proposed optimization technique ensures better performance, reliability, and effi ciency even under parameter variations to prove the superiority of the proposed strategy
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S. Shanmugapriya,K. Subramanian 대한토목학회 2016 KSCE JOURNAL OF CIVIL ENGINEERING Vol.20 No.4
This paper focused on investigating the key factors for safety improvement in construction organizations and the causal relationship among the key factors using Partial Least Squares Structural Equation Modeling approach (PLS-SEM). A hypothetical conceptual model for improving safety performance was developed based on the European Foundation for Quality Management (EFQM) model, which provides the framework for organizational management systems in identifying the areas of performance improvement. The conceptual model is composed of five enablers namely Leadership, People, Partnership and Resources, Policy and Strategy and Process and one Result criteria which are achieving the goals of safety performance improvement. The study has adopted questionnaire survey as the methodology to test the conceptual model. The indicators for these enablers and result criteria were extracted from the past literature and by a pilot study. Then a questionnaire was framed as per the discussion with the experts in the construction industry and distributed to clients, contractors and consultants. The results of the model suggested that leadership construct strongly influences people (path coefficient = 0.52) and process construct strongly influences the goals of attaining safety performance improvement (path coefficient = 0.68 and R2 value = 0.457). The Global fit index of the model was found to be 0.42 which suggest that the model has good reliability and validity and fits the data very well. The findings from this study provide insight to construction professionals to focus on the implications from leadership factors and process factors to improve the safety performance within an organization.
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Selvaraj Shanmugapriya,Haldar Dipanwita,Srivastava Hari Shanker 대한공간정보학회 2021 Spatial Information Research Vol.29 No.5
The study was focused on assessing the condition of pearl millet crop in critical growth stages using both polarimetric Radarsat-2 and dual-polarized Sentinel-1 datasets. The results revealed that bajra having a close structured phenology like maize and Jowar, exhibited significant changes in RVI due to differences in the crop calendar dates. For bajra, polarimetric RVI generated from information rich Radarsat-2 was observed to have a higher level of saturation till 6 kgm-2 biomass with a R2 of 0.7. In all instances, RVI exhibited a significant relationship with VWC and plant volume with a R2 above 0.7 due to its higher sensitivity towards crop dielectric constant. Unlike NDVI, RVI increased with an increase in Leaf Area Index till 5.8 even during panicle initiation stage. Backscatter and truncated RVI almost follow a similar trend of RVI response for various crop growth parameters. Hence, in case of regional analysis and high cost of Radarsat-2 dataset, one can use freely available sentinel data for RVI analysis due to its wider swath coverage. The observed high correlation of crop age with RVI (R2 = 0.6) proved to be the best tool for predicting sowing dates in staggered sowing zones.
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