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      • KCI등재

        A Level Set Method to Image Segmentation Based on Local Direction Gradient

        ( Yanjun Peng ),( Yingran Ma ) 한국인터넷정보학회 2018 KSII Transactions on Internet and Information Syst Vol.12 No.4

        For image segmentation with intensity inhomogeneity, many region-based level set methods have been proposed. Some of them however can’t get the relatively ideal segmentation results under the severe intensity inhomogeneity and weak edges, and without use of the image gradient information. To improve that, we propose a new level set method combined with local direction gradient in this paper. Firstly, based on two assumptions on intensity inhomogeneity to images, the relationships between segmentation objects and image gradients to local minimum and maximum around a pixel are presented, from which a new pixel classification method based on weight of Euclidian distance is introduced. Secondly, to implement the model, variational level set method combined with image spatial neighborhood information is used, which enhances the anti-noise capacity of the proposed gradient information based model. Thirdly, a new diffusion process with an edge indicator function is incorporated into the level set function to classify the pixels in homogeneous regions of the same segmentation object, and also to make the proposed method more insensitive to initial contours and stable numerical implementation. To verify our proposed method, different testing images including synthetic images, magnetic resonance imaging (MRI) and real-world images are introduced. The image segmentation results demonstrate that our method can deal with the relatively severe intensity inhomogeneity and obtain the comparatively ideal segmentation results efficiently.

      • KCI등재

        Effects of resveratrol on the inflammatory response and renal injury in hyperuricemic rats

        Xiao Benxi,Ma Wenjun,Zheng Ying,Li Zhen,Li Dan,Zhang Yanjun,Li Yuanhong,Wang Duan 한국영양학회 2021 Nutrition Research and Practice Vol.15 No.1

        BACKGROUND/OBJECTIVES: Hyperuricemic nephropathy is a common cause of acute kidney injury. Resveratrol can ameliorate kidney injury, but the explicit mechanism remains unclear. We investigated the effects of resveratrol on the inflammatory response and renal injury in hyperuricemic rats. MATERIALS/METHODS: A rat model of hyperuricemic nephropathy was established by the oral administration of a mixture of adenine and potassium oxinate. Biochemical analysis and hematoxylin and eosin staining were performed to assess the rat kidney function. Enzyme-linked immunosorbent assays were performed to evaluate the immune and oxidative responses. RESULTS: The expression levels of urine albumin and β2-microglobulin were significantly decreased after resveratrol treatment. In addition, the levels of serum creatinine and uric acid were significantly decreased in the resveratrol groups, compared with the control group. The levels of proinflammatory factors, such as interleukin-1β and tumor necrosis factor-α, in kidney tissue and serum were also increased in the hyperuricemic rats, and resveratrol treatment inhibited their expression. Moreover, the total antioxidant capacity in kidney tissue as well as the superoxide dismutase and xanthine oxidase levels in serum were all decreased by resveratrol treatment. CONCLUSIONS: Resveratrol may protect against hyperuricemic nephropathy through regulating the inflammatory response.

      • KCI등재

        Paridis Saponins Inhibiting Carcinoma Growth and Metastasis In Vitro and In Vivo

        Shuli Man,Wenyuan Gao,Yanjun Zhang,Chaoyi Ma,Liu Yang,Yiwen Li 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.1

        Paris polyphylla Smith var. yunnanensis extracts, Rhizoma Paridis saponins (RPS) have been found to show strong antitumor activity. However, few studies have yet investigated pulmonary metastasis treatment with this herb. To detail the effective components in RPS and discuss the preliminary mechanism of antitumor effects in vivo and in vitro, a mixture isolated from RPS was investigated. The main constituents were identified as polyphyllin D, formosanin C, dioscin, Paris H, Paris VII and pennogennin 3-O-α-L-rhamnopyranosyl (1→4)-[β-L-rhamnopyranosyl (1→2)]-β-D-glucopyranoside. In our experiments, LA795 cells were exposed to the mixed compounds. Migration inhibition was evaluated by wound healing assay and migration assay in non-cytotoxic dose which was determined by MTT assay. The results demonstrated that the constituent in varying degrees inhibited the migration of the tumor cells in vitro. The mixture also showed antitumor effects on carcinoma in vivo. In conclusion, the mixture is a potent anticancer agent that elicits programmed cell death and inhibits the migration in murine lung adenocarcinoma, both in vitro and in vivo.

      • SCISCIESCOPUS

        Sharpened VO<sub>2</sub> Phase Transition via Controlled Release of Epitaxial Strain

        Lee, Daesu,Lee, Jaeseong,Song, Kyung,Xue, Fei,Choi, Si-Young,Ma, Yanjun,Podkaminer, Jacob,Liu, Dong,Liu, Shih-Chia,Chung, Bongwook,Fan, Wenjuan,Cho, Sang June,Zhou, Weidong,Lee, Jaichan,Chen, Long-Qin American Chemical Society 2017 NANO LETTERS Vol.17 No.9

        <P>Phase transitions in correlated materials can be manipulated at the nanoscale to yield emergent functional properties, promising new paradigms for nanoelectronics and nanophotonics. Vanadium dioxide (VO2), an archetypal correlated material, exhibits a metal insulator transition (MIT) above room temperature. At the thicknesses required for heterostructure applications, such as an optical modulator discussed here, the strain state of VO2 largely determines the MIT dynamics critical to the device performance. We develop an approach to control the MIT dynamics in epitaxial VO2 films by employing an intermediate template layer with large lattice mismatch to relieve the interfacial lattice constraints, contrary to conventional thin film epitaxy that favors lattice match between the substrate and the growing film. A combination of phase-field simulation, in situ real-time nanoscale imaging, and electrical measurements reveals robust undisturbed MIT dynamics even at preexisting structural domain boundaries and significantly sharpened MIT in the templated VO2 films. Utilizing the sharp MIT, we demonstrate a fast, electrically switchable optical waveguide. This study offers unconventional design principles for heteroepitaxial correlated materials, as well as novel insight into their nanoscale phase transitions.</P>

      • KCI등재

        Integration of wastewater treatment units and optimization of waste residue pyrolysis conditions in the brominated phenol flame retardant industry

        Shiqi Liu,Xiangting Hou,Chengze Yu,Xiangrui Pan,Junhao Ma,Guocheng Liu,Chengzhi Zhou,Yanjun Xin,Qinghua Yan 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.115 No.-

        Among the bromine flame retardants, tetrabromobisphenol A (TBBPA) is a highly effective flame retardantthat can be used as both reactive and additive. However, the synthesis reaction of TBBPA has alow conversion rate and many brominated phenolic organics. Therefore, there is an urgent need toremove brominated organic pollutants produced in the process of producing flame retardants to reducethe harm to the environment and human beings and to reduce production costs. In this study, an efficientprocess was developed to treat the wastewater and waste residue generated in TBBPA production process,realizing its harmless and resource utilization. In the resource utilization system, through the ingeniousdesign of solution mixing, precipitation separation, three-effect evaporation and concentration,valuable substances were extracted to realize the recovery and reuse of wastewater. In the harmless utilizationprocess of hazardous waste residue, through high-temperature pyrolysis at 500 C for 2 h afteroptimization with hypoxia-hyperoxia atmosphere modulation, it can avoid the production of dioxinsand carbon black, effectively remove the organic impurities, realize the harmlessness and obtain highqualitysodium sulfate. This paper aims to propose a simple, efficient and feasible utilization system,including the three major technological processes of TBBPA production, integrated wastewater treatmentand optimized the harmless treatment of waste residue to obtain sodium sulfate, so as to realize TBBPAgreen production. Compared with the traditional TBBPA synthesis system, wastewater and waste residuetreatment processes, the TBBPA quality is increased by 2 % and the economic cost is reduced by 10 %,which is of great significance to the development of the industry.

      • Resequencing 302 wild and cultivated accessions identifies genes related to domestication and improvement in soybean

        Zhou, Zhengkui,Jiang, Yu,Wang, Zheng,Gou, Zhiheng,Lyu, Jun,Li, Weiyu,Yu, Yanjun,Shu, Liping,Zhao, Yingjun,Ma, Yanming,Fang, Chao,Shen, Yanting,Liu, Tengfei,Li, Congcong,Li, Qing,Wu, Mian,Wang, Min,Wu, Nature Publishing Group, a division of Macmillan P 2015 Nature biotechnology Vol.33 No.4

        Understanding soybean (Glycine max) domestication and improvement at a genetic level is important to inform future efforts to further improve a crop that provides the world's main source of oilseed. We detect 230 selective sweeps and 162 selected copy number variants by analysis of 302 resequenced wild, landrace and improved soybean accessions at >11× depth. A genome-wide association study using these new sequences reveals associations between 10 selected regions and 9 domestication or improvement traits, and identifies 13 previously uncharacterized loci for agronomic traits including oil content, plant height and pubescence form. Combined with previous quantitative trait loci (QTL) information, we find that, of the 230 selected regions, 96 correlate with reported oil QTLs and 21 contain fatty acid biosynthesis genes. Moreover, we observe that some traits and loci are associated with geographical regions, which shows that soybean populations are structured geographically. This study provides resources for genomics-enabled improvements in soybean breeding.

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