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      • KCI등재

        Efficacy and Safety of Radiofrequency Ablation Performed by an Endocrinologist for Benign Thyroid Nodules

        Tae Hyun Kim,Se Mi Kim, M.D.,Ah Lon Jung, M.D.,Seung Ki Moon, M.D.,Dong Hoon Yang,Cheol Min Park,Shin Hyoung Jo, M.D.,Dae Won Park, M.D.,Seok Ho Seo, M.D.,Seung Hyun Lee, M.D.,Jong Taek Kim, M.D.,Soon 대한갑상선학회 2015 International Journal of Thyroidology Vol.8 No.2

        Background and Objectives: Radiofrequency ablation has recently been used for the treatment of benign thyroid nodules, with outstanding results. However, in most studies, the procedure was usually performed by a radiologist or surgeon. This study aimed to evaluate the efficacy and safety of radiofrequency ablation for nodules >2 cm performed by an endocrinologist with several years of experience performing fine-needle aspiration cytology. Materials and Methods: This study was a cross-sectional analysis of 111 patients who received radiofrequency ablation between April 2010 and July 2013. A total of 73 patients with 75 nodules >2 cm in diameter with at least 6 months of follow-up examinations were included. Results: The mean follow-up period was 11.5 months. The mean nodule volume decreased from 17.0±15.3 mL preoperatively to 6.0±8.5 mL postoperatively, with a mean volume reduction of 69.7%. There were no major complications, and only 1 patient (1.3%) presented with a minor complication (hemorrhaging of the thyroid parenchyma). Conclusion: Radiofrequency ablation is a safe method for reducing benign thyroid nodules, and is not associated with any major complications.

      • KCI등재후보

        갑상선 수질암 환자에서 칼시토닌 정상화와 관련된 예후인자

        김정한,김상욱,남석진,서정민,양정현,Jeong-Han Kim,M.D.,Sang-wook Kim,M.D.,Seok-Jin Nam,M.D.,Jeong-meen Seo,M.D. and Jung-Hyun Yang,M.D. 대한갑상선-내분비외과학회 2003 The Koreran journal of Endocrine Surgery Vol.3 No.2

        Purpose: Medullary thyroid carcinoma (MTC) is an uncommon thyroid tumor. Calcitonin (CT) is a very specific marker of this cancer and has a major place in the postoperative follow-up. The aim of this study was to evaluate the outcome of surgical treatment for MTC and to identify the prognostic factors for the normalization of CT after surgery. Methods: Retrospective analysis of 29 patients with MTC from 1994 to 2002 in Samsung Medical Center was carried out. Results: 22 female and 7 male were identified and their mean age was 46.9 years. Mean follow-up was 42.7 months. 5 patients had MEN2a; all had pheochromocytoma and 2 among them had hyperplasia of parathyroid gland. The majority of patients (86.2%) presented with a palpable neck mass and 23 patients were diagnosed with MTC preoperatively. Total thyroidectomy with or without neck dissection was performed in all patients. Cervical lymph node involvement was detected in 34.5% of these patients. Basal CT levels were found to be normal in 15 patients (51.7%) postoperatively. 1 distant metastasis, 6 loco-regional metastases and 1 death were observed during follow-up period. Overall survival rate was 94.7% and disease-free survival rate was 62.9% at 5 years. Univariate analysis showed that extra-thyroidal invasion and involvement of lymph node were significant prognostic factors for normalization of CT after surgery. Conclusion: Considering the high recurrence rate in the thyroid bed and cervical lymph node, more extensive and thorough neck dissection is needed for the treatment of MTC. (Korean J Endocrine Surg 2003;3:121-126)

      • KCI등재

        Analysis of the Effect of Imbalanced Flow on the KSTAR’s Superconducting Magnet

        Hyun-Jung Lee,Y. M. Park,D. S. Park,Y. J. Lee,S. W. Kwag,N. H. Song,Y. B. Chang,J. J. Joo,K. M. Moon,N. W. Kim,H. L. Yang 한국물리학회 2014 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.65 No.8

        The KSTAR superconducting (SC) magnets are cable-in-conduit-conductor (CICC) type magnets,which have a hundred parallel and twisted SC strands in a square conduit with a porosityof 0.36. They are cooled by the forced flow of supercritical helium with a 2bar pressure drop. Aflow imbalance test of the magnet cooling channels, one of the quality assurance processes, wasconducted using Ar gas at room temperature during the magnet’s manufacture, and was carriedout again after assembly. In those tests, the flow imbalance was measured to be within at most±10% for the all cooling channels, which satisfied the criterion (±20%). During individual testsof the magnets, the tendency of the flow imbalance showed that the mass flow rate of the upper(U) magnets PF1, PF2, PF5, PF6, and PF7 was higher than that of the lower (L) magnets. Onthe other hand, the mass flow rate of the upper magnets PF3 and PF4 was lower than that of thelower magnets. After assembly, this imbalance became more serious, and the measured mass flowrate of the upper magnets was higher than that of lower magnet at the PF2, PF3 PF4, and PF5magnets. This imbalance can influence the temperature and the pressure of supercritical helium, aswell as accelerate reversal flow and limit operating performance. In this paper, the helium behavioris analyzed and is explained to be due to the flow imbalance in the PF magnet.

      • SCOPUSKCI등재

        Characterization and preparation of bioinspired resorbable conduits for vascular reconstruction

        Yang, S. k.,Shafiq, M.,Kim, D.,Park, C.,Jung, Y.,Hyun, S. THE POLYMER SOCIETY OF KOREA 2016 Macromolecular Research Vol.24 No.4

        <P>Soft tissues such as blood vessels possess mechanical behavior characterized by a 'J-shaped' stress-strain curve with a low-stiffness and a highly elastic zone. These biomechanical characteristics result in rapid endothelialization, smooth muscle cell regeneration, and aneurysm inhibition. The objective of this study was to fabricate biodegradable vascular grafts mimicking the mechanical properties of native arteries. Vascular grafts (inner diameter = 5.0 mm, length = 2.0 cm) were fabricated by dip coating poly(L-lactide-co-epsilon-caprolactone) (PLCL) copolymers on polydioxanone (PDO) fibers. We used PDO fibers of different diameters to yield vascular grafts with a range of mechanical properties. Biomechanical properties, microstructure, and biocompatibility of the grafts were assessed using circumferential tensile testing, burst pressure measurement, scanning electron microscopy, and subcutaneous implantation, respectively. Vascular grafts possessed circumferential tensile strength and strain in the range of 4.07 to 5.98 MPa and 2.83 to 3.47 MPa, respectively, and were circumferentially stronger than expanded polytetrafluoroethylene (ePTFE) grafts. Burst pressure was physiologically relevant in the range of 1323.0 to 1736 kPa and water entry pressure was between 102.66 to 257.33 kPa. Mechanical properties of the grafts were also assessed in vivo after subcutaneous implantation in Sprague-Dawley rats for up to 8 weeks. Examination of the retrieved grafts indicated that the 'J-shaped' strain/stress curve was maintained for up to 3 week in PDO/PLCL vascular grafts. In contrast, ePTFE grafts did not maintain 'J-shaped' stress-strain behavior after in vivo implantation. Histological analysis demonstrated cellularization within PDO/PLCL grafts, whereas, PTFE grafts showed cellularization and neotissues mainly at the outer side. Our results suggest a new methodology for the fabrication of biodegradable vascular grafts with mechanical behaviour comparable to the native arteries that might avoid failure due to mechanical mismatch between the graft and native arteries.</P>

      • SCISCIESCOPUSKCI등재

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