http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Kim, Sujin,Cho, Yoon Hee,Lee, Inae,Kim, Wonji,Won, Sungho,Ku, Ja-Lok,Moon, Hyo-Bang,Park, Jeongim,Kim, Sungkyoon,Choi, Gyuyeon,Choi, Kyungho Elsevier 2018 Environment international Vol.119 No.-
<P><B>Abstract</B></P> <P>Prenatal exposure to persistent organic pollutants (POPs) has been linked to numerous adverse birth outcomes among newborn infants in many epidemiological studies. Although epigenetic modifications have been suggested as possible explanations for those associations, studies have rarely reported a relationship between POP exposure during pregnancy and DNA methylation in the placenta.</P> <P>In the present study, we investigated the association between prenatal exposure to several POPs, including organochlorine pesticides (OCPs), polybrominated diphenyl ethers (PBDEs), and polychlorinated biphenyls (PCBs), and methylation levels of long interspersed element 1 (LINE-1), as well as imprinted genes in placental DNAs among Korean mother-child pairs (N = 109). We assessed the association of DNA methylation not only with each target POP (single-POP models) but also with multiple POPs applying principal component analysis (multiple-POP models). Potential associations between placental DNA methylation and birth outcomes of newborn infants were also estimated.</P> <P>In single-POP models, significant associations were detected between OCP measurements and placental DNA methylation. Elevated concentrations of β-hexachlorhexane (β-HCH) in maternal serum collected during delivery were significantly associated with a decrease in methylation of LINE-1 in the placenta. Higher levels of <I>p</I>,<I>p</I>′-dichlorodiphenyltrichloroethane (<I>p</I>,<I>p</I>′-DDT) in maternal serum were associated with hypermethylation of <I>insulin-like growth factor 2</I> (<I>IGF2</I>). In multiple-POP models, a significant and positive association between DDTs and <I>IGF2</I> methylation was also observed. Placental LINE-1 methylation was inversely associated with birth length. Our observations indicate that prenatal exposure to several POPs including DDTs is associated with the changes in methylation of genes, including major imprinted genes in the placenta. The consequences of these epigenetic alterations in placenta during development deserve further investigation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Associations between POP exposure and placental DNA methylation were evaluated. </LI> <LI> A multi-pollutant exposure was added in the models with principal component analysis. </LI> <LI> Exposure to DDTs, including <I>p</I>,<I>p</I>′-DDT, was related to methylation of <I>IGF2</I> in the placenta. </LI> <LI> Several POPs might affect epigenetic regulation of key placental DNAs. </LI> </UL> </P>
Kim, Soon-Chan,Hong, Chang-Won,Jang, Sang-Geun,Kim, Ye-Ah,Yoo, Byong-Chul,Shin, Young-Kyoung,Jeong, Seung-Yong,Ku, Ja-Lok,Park, Jae-Gahb Neoplasia Press 2018 Translational oncology Vol.11 No.5
<P>Peritoneal metastasis is one of the major patterns of unresectability in colorectal cancer (CRC) and a cause of death in advanced CRC. Identification of distinct gene expressions between primary CRC and peritoneal seeding metastasis is to predict the metastatic potential of primary human CRC. Three pairs of primary CRC (SNU-2335A, SNU-2404A, and SNU-2414A) and corresponding peritoneal seeding (SNU-2335D, SNU-2404B, and SNU-2414B) cell lines were established to determine the different gene expressions and resulting aberrated signaling pathways in peritoneal metastasis tumor using whole exome sequencing and microarray. Whole exome sequencing detected that mutation in <I>CYP2A7</I> was exclusively shared in peritoneal seeding cell lines. Microarray identified that there were five upregulated genes (<I>CNN3</I>, <I>SORBS1</I>, <I>BST2</I>, <I>EPSTI1</I>, and <I>KLHL5</I>) and two downregulated genes (<I>TRY6</I> and <I>STYL5</I>) in the peritoneal metastatic cell lines. <I>CNN3</I> expression was highly augmented in both mRNA and protein levels in peritoneal metastasis cells. Knockdown of Calponin 3 resulted in augmented level of E-cadherin in peritoneal metastasis cells, and migration and invasiveness decreased accordingly. We suggest that <I>CNN3</I> takes part in cell projection and movement, and the detection and distribution of <I>CNN3</I> may render prognostic information for predicting peritoneal seeding metastasis from primary colorectal cancer.</P>
Kim, Sujin,Cho, Yoon Hee,Won, Sungho,Ku, Ja-Lok,Moon, Hyo-Bang,Park, Jeongim,Choi, Gyuyeon,Kim, Sungkyoon,Choi, Kyungho Elsevier 2019 Environment international Vol.130 No.-
<P><B>Abstract</B></P> <P>Exposure to persistent organic pollutants (POPs) during pregnancy is associated with a disruption in thyroid hormone balance. The placenta serves as an important environment for fetal development and also regulates thyroid hormone supply to the fetus. However, epigenetic changes of thyroid regulating genes in placenta have rarely been studied. This study was conducted to evaluate the association between several POP concentrations in maternal serum and DNA methylation of thyroid hormone-related genes in the placenta. The placenta samples were collected from 106 Korean mother at delivery, and the promoter methylation of the placental genes was measured by a bisulfite pyrosequencing. The <I>deiodinase type 3</I> (<I>DIO3</I>), <I>monocarboxylate transporter 8</I> (<I>MCT8</I>), and <I>transthyretin</I> (<I>TTR</I>) genes were selected as the target genes as they play an important role in the regulation of fetal thyroid balance. Because people are exposed to multiple chemicals at the same time, a multiple-POP model using principal component analysis (PCA) was applied to evaluate the association between the multiple POPs exposure and the epigenetic change in placenta. In addition, a single-POP model which includes one chemical each in the statistical model for association was conducted.</P> <P>Based on the single-POP models, serum concentrations of <I>p,p</I>′-dichlorodiphenyldichloroethylene (<I>p,p</I>′-DDE) and brominated diphenyl ether-47 (BDE-47) were significantly associated with an increase in placental <I>DIO3</I> methylation, but only among female infants. Among male infants, a positive association between serum <I>p,p</I>′-DDT and <I>MCT8</I> methylation level was found. According to the multiple-POP models, serum DDTs were positively associated with <I>DIO3</I> methylation in the placenta of female infants, while a positive association with <I>MCT8</I> methylation was observed in those of the male infants. Our observation showed that in utero exposure to DDTs may influence the DNA methylation of <I>DIO3</I> and <I>MCT8</I> genes in the placenta, in a sexually dimorphic manner. These alterations in placental epigenetic regulation may in part explain the thyroid hormone disruption observed among the newborns or infants followed by in utero exposure to POPs.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Promoter DNA methylation of placental genes related to thyroid hormone was measured. </LI> <LI> Some maternal serum POPs were associated with methylation of these placental genes. </LI> <LI> DNA methylation of <I>DIO3</I> and <I>MCT8</I> genes by maternal POP was differed by infant sex. </LI> </UL> </P>
A Pediatric Case of Toxic Hepatitis Induced by Hovenia Dulcis
Kim, Yun Ji,Ryu, Seung Lok,Shim, Jae Won,Kim, Duk Soo,Shim, Jung Yeon,Park, Moon Soo,Jung, Hye Lim The Korean Society of Pediatric Gastroenterology 2012 Pediatric gastroenterology, hepatology & nutrition Vol.15 No.2
Toxic hepatitis is a rare but devastating disease in children. Herbs are widely used in oriental medicine to treat various symptoms in Korea, however, several herbs have been reported to induce liver injury. We report a case of toxic hepatitis induced by Hovenia dulcis in a 3-year-old boy. He complained of nausea, abdominal discomfort, and jaundice. The patient had consumed water boiled with hovenia dulcis for about 1 year prior to presentation. A diagnosis of toxic hepatitis was made based on his history, laboratory data, viral markers, ultrasonography, and biopsied liver tissue. We administered supportive management for acute fulminant hepatitis but his symptoms and liver function progressed. He was transferred to another hospital for further evaluation and consideration for liver transplantation. Because acute liver failure due to herbs or dietary supplement taken for a long time is often fetal, it is important to make early diagnosis and stop taking the drug as soon as drug induced liver injury is suspected.
DeepX: Deep Learning Accelerator for Restricted Boltzmann Machine Artificial Neural Networks
IEEE 2018 IEEE transactions on neural networks and learning Vol.29 No.5
<P>Although there have been many decades of research and commercial presence on high performance general purpose processors, there are still many applications that require fully customized hardware architectures for further computational acceleration. Recently, deep learning has been successfully used to learn in a wide variety of applications, but their heavy computation demand has considerably limited their practical applications. This paper proposes a fully pipelined acceleration architecture to alleviate high computational demand of an artificial neural network (ANN) which is restricted Boltzmann machine (RBM) ANNs. The implemented RBM ANN accelerator (integrating <TEX>$1024\times 1024$</TEX> network size, using 128 input cases per batch, and running at a 303-MHz clock frequency) integrated in a state-of-the art field-programmable gate array (FPGA) (Xilinx Virtex 7 XC7V-2000T) provides a computational performance of 301-billion connection-updates-per-second and about 193 times higher performance than a software solution running on general purpose processors. Most importantly, the architecture enables over 4 times (12 times in batch learning) higher performance compared with a previous work when both are implemented in an FPGA device (XC2VP70).</P>
김원용(Won-yong Kim),김종원(Jong-won Kim),김현준(Hyun-jun Kim),김경동(Kyoung-dong Kim),김도현(Do-hyun Kim),최대식(Dae-sik Choi),오형록(Hyoung-lok Oh),이준영(Jun-young Lee) 전력전자학회 2011 전력전자학술대회 논문집 Vol.2011 No.7
최근 하이브리드 및 전기자동차의 집약적인 발전과 함께 충전기술이 대두 되고 있다. 본 논문은 충전기능만을 고려한 단방향 충전시스템에서 양방향 배터리 충/방전 시스템에 대하여 서술한다. 양방향 시스템은 주차 된 차량의 배터리를 저장 매체로 활용하여 V2G(Vehicle to Grid)기술로 활용할 수 있어 잉여전력에 대해서 계통으로 전력을 전송할 수 있다. 용량은 가정용으로써 3.3㎾ 탑재형 단상 양방향 충/방전기에 대한 시뮬레이션과 실험을 통해 결과를 도출했다.
Ryu, Seung Lok,Shim, Jae Won,Kim, Duk Soo,Jung, Hye Lim,Park, Moon Soo,Park, Soo-Hee,Lee, Jinmi,Lee, Won-Young,Shim, Jung Yeon The Korean Pediatric Society 2013 Clinical and Experimental Pediatrics (CEP) Vol.56 No.4
Purpose: We investigated the mRNA levels of peroxisome proliferator-activated receptor (PPAR)-${\alpha}$, PPAR-${\gamma}$, adipokines, and cytokines in the lung tissue of lean and obese mice with and without ovalbumin (OVA) challenge, and the effect of rosiglitazone, a PPAR-${\gamma}$ agonist. Methods: We developed 6 mice models: OVA-challenged lean mice with and without rosiglitazone; obese mice with and without rosiglitazone; and OVA-challenged obese mice with and without rosiglitazone. We performed real-time polymerase chain reaction for leptin, leptin receptor, adiponectin, vascular endothelial growth factor (VEGF), tumor necrosis factor (TNF)-${\alpha}$, transforming growth factor (TGF)-${\beta}$, PPAR-${\alpha}$ and PPAR-${\gamma}$ from the lung tissue and determined the cell counts and cytokine levels in the bronchoalveolar lavage fluid. Results: Mice with OVA challenge showed airway hyperresponsiveness. The lung mRNA levels of PPAR${\alpha}$ and PPAR-${\gamma}$ increased significantly in obese mice with OVA challenge compared to that in other types of mice and decreased after rosiglitazone administeration. Leptin and leptin receptor expression increased in obese mice with and without OVA challenge and decreased following rosiglitazone treatment. Adiponectin mRNA level increased in lean mice with OVA challenge. Lung VEGF, TNF-${\alpha}$, and TGF-${\beta}$ mRNA levels increased in obese mice with and without OVA challenge compared to that in the control mice. However, rosiglitazone reduced only TGF-${\beta}$ expression in obese mice, and even augmented VEGF expression in all types of mice. Rosiglitazone treatment did not reduce airway responsiveness, but increased neutrophils and macrophages in the bronchoalveolar lavage fluid. Conclusion: PPAR-${\alpha}$ and PPAR-${\gamma}$ expressions were upregulated in the lung tissue of OVA-challenged obese mice however, rosiglitazone treatment did not downregulate airway inflammation in these mice.