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- 검색키워드
- 저자 : Linlin Tian (검색결과 7 건)
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Linlin Li,Xing Geng,Lili Tian,Dabo Wang,Qin Wang 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.10
Grape seed proanthocyanidins (GSP) are knownas condensed tannins and have been used as an anti-oxidantin various neurodegenerative diseases. In our study, GSPwas used as a daily dietary supplement and the neuroprotectiveeffects were evaluated on the retinal ganglion cells(RGCs) in the retinal tissues in glaucomatous DBA/2D (D2)mice. D2 mice and age-matched non-glaucomatous DBA/2JGpnmb+(D2-Gpnmb+) mice were fed with GSP or a controldiet for up to 6 months. The intraocular pressure (IOP), RGCsurvival, glial fibrillary acidic protein (GFAP), the levels ofapoptotic proteins, and the expression of oxidative stressmarkers in retinal tissues were determined. In our study, theneuroprotective effects of GSP on retinal tissues were confirmed,as evidenced by (a) GSP inhibited the IOP elevationin D2 mice; (b) GSP enhanced RGC survival and mediatedthe apoptotic protein expression; (c) GSP suppressed GFAPexpression; and (d) the oxidative stress and the levels ofmitochondrial reactive oxygen species were regulated byGSP. Our findings indicate that GSP has promising potentialto preserve retinal tissue functions via regulating oxidativestress and mitochondrial functions.
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Yuan Linlin,Tian Xiufen,Zhang Yanfei,Huang Xinhui,Li Qing,Li Wencai,Li Shenglei 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
Laryngeal squamous cell carcinoma (LSCC) is one of the most common subtypes of head and neck malignancies worldwide. Long intervening/intergenic noncoding RNAs (LINCRNAs) have been recently implicated in various biological processes that take place in the setting of laryngeal cancer, but the regulatory role of LINC00319 in LSCC remains largely unknown. The current study aimed to elucidate the regulatory effect of LINC00319 on the development and progression of LSCC via high-mobility group box 3 (HMGB3). Microarray-based analysis was initially conducted to identify differentially expressed long noncoding RNAs, after which the expression of LINC00319 and HMGB3 in LSCC tissues and cells was determined accordingly. CD133 + CD144 + TU177 cells were subsequently isolated and transfected with LINC00319 overexpression vector (oe-LINC00319), short hairpin RNA (sh)-LINC00319, sh-HMGB3, sh-E2F transcription factor 1 (E2F1), and oe-E2F1, as well as their corresponding controls. The proliferative, invasion, self-renewal, and tumorigenic abilities of CD133 + CD144 + TU177 cells were then evaluated. Our in vitro findings were further confirmed following subcutaneous injection of cells expressing the corresponding plasmids into nude mice. LINC00319 and HMGB3 expressions were elevated in LSCC cells and tissues. LINC00319 increased HMGB3 expression by recruiting E2F1. Furthermore, the stimulatory role of LINC00319 on the proliferation, invasion, self-renewal ability, and tumorigenicity of CD133 + CD144 + TU177 cells was achieved by upregulating HMGB3 via recruitment of E2F1. The in vitro findings were also confirmed by in vivo experiments. Taken together, these data show that downregulating LINC00319 in CD133 + CD144 + TU177 cells may serve as a potential anticancer regimen by inhibiting the proliferation and invasion of cancer stem cells in LSCC.
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Zhai, Cong,Chou, Xiujian,He, Jian,Song, Linlin,Zhang, Zengxing,Wen, Tao,Tian, Zhumei,Chen, Xi,Zhang, Wendong,Niu, Zhichuan,Xue, Chenyang Elsevier 2018 APPLIED ENERGY Vol.231 No.-
<P><B>Abstract</B></P> <P>There is plenty of exploitable energy in the ambient environments. Triboelectric nanogenerator is an innovative electricity generation technology to convert the wasted mechanical energy into electrical energy. However, the output of conventional triboelectric nanogenerators cannot be employed efficiently because their tremendous internal resistance limits the current of electrons. Inspired by the principle of lightning rods, for the first time we propose the utilization of electrostatic discharge to improve the performance of triboelectric nanogenerators, which is realized by an opposite needles structure enclosed in an inert atmosphere. When this structure is connected in series with a vertical contact-separation triboelectric nanogenerator, the strong electric field near tips of two needles ionizes the gas around them, forming a conductive plasma channel between the tips, and releasing a mass of free charges. As a result, some exciting performances are obtained in triboelectric nanogenerator. The output peak-to-peak voltage is increased from 300 V to 1300 V, and the equivalent impedance of energy harvesting circuit is reduced from 100 MΩ to 10 kΩ. Especially in the optimal conditions, the maximum continuous power can even be significantly improved by 330.76%. Therefore, this work provides a new strategy for the energy conversion technology, which is significant for the advancement and application of triboelectric nanogenerators.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A strategy is proposed to improve the performance of triboelectric nanogenerators. </LI> <LI> The maximum continuous power can be boosted dramatically by electrostatic discharge. </LI> <LI> This design reduces the optimal impedance that is important for circuit matching. </LI> <LI> With this design triboelectric nanogenerators can directly drive low-power devices. </LI> <LI> This work is also significant for macro-energy conversion, such as ocean energy. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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miR-29 family inhibited the proliferation and migration of lung cancer cells by targeting SREBP-1
Lin Lin,Bao Yongxia,Tian Miao,Ren Qiu,Zhang Wei 대한독성 유전단백체 학회 2022 Molecular & cellular toxicology Vol.18 No.2
Backgrounds Lipid metabolism dysregulation is an important characteristic of tumor cells. Increased lipid metabolism provides a vital material and energy source for tumor growth, thereby promoting tumor invasion and metastasis. Objectives In the current work, we carried out a series of in vivo and in vitro studies to explore the relationship between miR-29 and lung cancer. Results The results showed that miR-29 was down-regulated in lung cancer, and overexpression of miR-29 inhibited the proliferation and migration of lung cancer cells (in vitro). Anti-lung cancer effect of miR-29 in vivo was evaluated, and results indicated that transfection of miR-29b/c markedly inhibited lung tumor growth (in vivo). We further explored the potential mechanism by which miR-29 could inhibit the cell proliferation of lung cancer. It is well known that lipid metabolism dysregulation is an important characteristic of tumor cells. Increased lipid metabolism provides a vital material and energy source for tumor growth, thereby promoting tumor invasion and metastasis, and sterol regulatory element-binding protein 1 (SREBP) is involved in liposome metabolism. Therefore, we analyzed the interaction between miR-29C and SREBP-1 in lung cancer cells. Bioinformatics analysis showed that the miR-29 has the potential binding site on SCAP and SREBP mRNA, and Luciferase reporter gene assays revealed the interaction between 3′UTR of SREBP-1 mRNA and miR-29c. Further study showed that miR-29 suppressed (SREBP-1) expression by interacting with 3′UTR of SREBP-1. Further work indicated that miR-29 transfection strongly inhibited lung cancer cell proliferation, which was rescued by the overexpression of SREBP-1. Conclusion These fi ndings demonstrate that transfection of miR-29 suppressed lung cancer proliferation via inhibiting SREBP-1 expression. The current study provides a basis for exploring the targeted agents against lung cancer.
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