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- 저자 : Lingyun Dai (검색결과 2 건)
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Crashworthiness design of bionic-shell thin-walled tube under axial impact
Lingyun Qin,Shuyi Yang,Hongzhou Li,Juchuan Dai,Guosheng Wang,Qihui Ling,Zhewu Chen 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.7
Bionic structures have been widely utilized in the crashworthiness design of thin-walled structures due to their superior energy absorption capabilities. This study constructed a bionic-shell thin-walled tube (BST) with excellent crashworthiness based on the structural bionic principle using the shell shape cross-section as the prototype. First, the theoretical model of the mean crushing force (MCF) for BST under axial compression was developed. An experiment was conducted and the reliability of the finite element model was verified. Then, the effects of structural parameters, such as the number of ribs, wall thickness, and inner tube diameter on the crashworthiness of the BST were investigated using the finite element method. Finally, to obtain the ideal configuration of structural parameters, the BST was optimized using the response surface method (RSM) with specific energy absorption (SEA) and crushing force efficiency (CFE) as the optimization objectives and peak crushing force (PCF) as the constraint condition. The results showed that the BST with six ribs exhibited the best crashworthiness under the same mass. The optimized BST-6 was found to have better energy absorption performance than the double circular tube (DCT) and the bionic-horsetail thin-walled tube (BHT). Compared with the DCT, the SEA and CFE increased by 35.15 % and 32.23 %, respectively.
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Beyond Canonical PROTAC: Biological targeted protein degradation (bioTPD)
Huifang Wang,Runhua Zhou,Fushan Xu,Kongjun Yang,Liuhai Zheng,Pan Zhao,Guangwei Shi,Lingyun Dai,Chengchao Xu,Le Yu,Zhijie Li,Jianhong Wang,Jigang Wang 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Targeted protein degradation (TPD) is an emerging therapeutic strategy with the potential to modulate disease associated proteins that have previously been considered undruggable, by employing the host destructionmachinery. The exploration and discovery of cellular degradation pathways, including but not limited toproteasomes and lysosome pathways as well as their degraders, is an area of active research. Since the conceptof proteolysis-targeting chimeras (PROTACs) was introduced in 2001, the paradigm of TPD has been greatlyexpanded and moved from academia to industry for clinical translation, with small-molecule TPD being particularlyrepresented. As an indispensable part of TPD, biological TPD (bioTPD) technologies including peptide-, fusionprotein-, antibody-, nucleic acid-based bioTPD and others have also emerged and undergone significantadvancement in recent years, demonstrating unique and promising activities beyond those of conventional small molecule TPD. In this review, we provide an overview of recent advances in bioTPD technologies, summarize theircompositional features and potential applications, and briefly discuss their drawbacks. Moreover, we present somestrategies to improve the delivery efficacy of bioTPD, addressing their challenges in further clinical development.
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