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Xu, Zhongwei,Wu, Chaoxing,Li, Fushan,Chen, Wei,Guo, Tailiang,Kim, Tae Whan Elsevier 2018 Nano energy Vol.49 No.-
<P><B>Abstract</B></P> <P>The development of electronic-skin (e-skin) with artificial tactile-perception is crucial for emerging artificial-intelligence systems. However, considering the relatively simple function of existing e-skins, their performances still have much room for improvement. Here, a cuttable, transparent, stretchable, and lightweight e-skin that functions on the basis of the triboelectric effect is demonstrated. Well-designed micro-gaps are introduced to make the e-skin respond sensitively to various mechanical stimulations, including pressing, stretching, folding, and twisting. Ag nanowires coated with graphene quantum dots are employed as the electrode, as well as the friction layer, to increase the sensitivity to external mechanical stimulations. Self-powered, smart, artificial fingers with tactile sensation to monitor the actions of the fingers were fabricated to demonstrate the potential application of our newly developed e-skin. The architecture and the material system of the device demonstrated in this work will promote the development of human-machine interfaces and intelligent machines.</P> <P><B>Highlights</B></P> <P> <UL> <LI> E-skins on the basis of the triboelectric effect are demonstrated. </LI> <LI> The e-skin responds sensitively to various mechanical stimulations. </LI> <LI> Graphene quantum dot-coated Ag nanowires are employed to increase the sensitivity to the mechanical stimulations. </LI> <LI> Self-powered, smart, artificial fingers based on the e-skins are demonstrated. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Veeramalai, Chandrasekar Perumal,Li, Fushan,Liu, Yang,Xu, Zhongwei,Guo, Tailiang,Kim, Tae Whan Elsevier 2016 APPLIED SURFACE SCIENCE - Vol.389 No.-
<P><B>Abstract</B></P> <P>In this work, we demonstrated the field emission properties of few layer molybdenum disulphide (MoS<SUB>2</SUB>) nanosheets synthesized by a hydrothermal method. Structural investigation indicates the as-synthesized MoS<SUB>2</SUB> layers were two dimensional few layer nanosheets with a sharp atomic edges. The field emission properties of the MoS<SUB>2</SUB> nanosheets were investigated and the results indicate that the MoS<SUB>2</SUB> nanosheets had an excellent field emission performance with turn on field of 1.0V/μm, threshold field of 2.1V/μm, and a field enhancement factor of 9880. Furthermore, the emission current shows the stability over 2h of continuous operation. The as-synthesized MoS<SUB>2</SUB> few layer nanosheets hold potential for application in next-generation field emission devices.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Monolayer or few layer Molepdenum disulphide nanosheets were synthesized via aqueous hydrothermal method using MoO<SUB>3</SUB> powder source. </LI> <LI> The synthesized nanosheets agglomerated while deposited on the substrates due to vanderwalls interaction between nanosheets. </LI> <LI> The superior field mission properties have been achieved for MoS<SUB>2</SUB> nanosheets attributed to the sharp edges of nanosheets. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Beyond Canonical PROTAC: Biological targeted protein degradation (bioTPD)
Huifang Wang,Runhua Zhou,Fushan Xu,Kongjun Yang,Liuhai Zheng,Pan Zhao,Guangwei Shi,Lingyun Dai,Chengchao Xu,Le Yu,Zhijie Li,Jianhong Wang,Jigang Wang 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Targeted protein degradation (TPD) is an emerging therapeutic strategy with the potential to modulate disease associated proteins that have previously been considered undruggable, by employing the host destructionmachinery. The exploration and discovery of cellular degradation pathways, including but not limited toproteasomes and lysosome pathways as well as their degraders, is an area of active research. Since the conceptof proteolysis-targeting chimeras (PROTACs) was introduced in 2001, the paradigm of TPD has been greatlyexpanded and moved from academia to industry for clinical translation, with small-molecule TPD being particularlyrepresented. As an indispensable part of TPD, biological TPD (bioTPD) technologies including peptide-, fusionprotein-, antibody-, nucleic acid-based bioTPD and others have also emerged and undergone significantadvancement in recent years, demonstrating unique and promising activities beyond those of conventional small molecule TPD. In this review, we provide an overview of recent advances in bioTPD technologies, summarize theircompositional features and potential applications, and briefly discuss their drawbacks. Moreover, we present somestrategies to improve the delivery efficacy of bioTPD, addressing their challenges in further clinical development.