http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Lingxiang Chen (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
Chen Wenjia,Ma Zhaochen,Yu Lingxiang,MAO Xia,Ma Nan,Guo Xiaodong,Yin Xiaoli,Jiang Funeng,Wang Qian,Wang Jigang,Fang Mingliang,Lin Na,Zhang Yanqiong 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Artesunate (ART) has been indicated as a candidate drug for hepatocellular carcinoma (HCC). Glucosylceramidase (GBA) is required for autophagic degradation. Whether ART regulates autophagic flux by targeting GBA in HCC remains to be defined. Herein, our data demonstrated that the dramatic overexpression of GBA was significantly associated with aggressive progression and short overall survival times in HCC. Subsequent experiments revealed an association between autophagic activity and GBA expression in clinical HCC samples, tumor tissues from a rat model of inflammation-induced HCC and an orthotopic mouse model, and human HCC cell lines. Interestingly, probe labeling identified GBA as an ART target, which was further verified by both a glutathione-S-transferase pulldown assay and surface plasmon resonance analysis. The elevated protein expression of LC3B, the increased numbers of GFP-LC3B puncta and double-membrane vacuoles, and the enhanced expression of SQSTM1/p62 indicated that the degradation of autophagosomes in HCC cells was inhibited by ART treatment. Both the in vitro and in vivo data revealed that autophagosome accumulation through targeting of GBA was responsible for the anti-HCC effects of ART. In summary, this preclinical study identified GBA as one of the direct targets of ART, which may have promising potential to inhibit lysosomal autophagy for HCC therapy.
-
Тhe use of aluminium and magnesium alloys in automotive lightweight technologies
Zhiyuan Hao,Yao Ju,Lingxiang Chen 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.9
This paper presents comparative characteristics of the aluminum and magnesium alloys in the context of their utilization in the metallurgical and automotive industry. The studies carried out in our work help to solve the problem of reducing the weight of automotive devices to reduce fuel consumption through the use of aluminum-magnesium alloys. The originality of our article lies in a comprehensive study of the stated problem: development of a research methodology, testing of the alloys under study for uniaxial tension, quantitative analysis of the Portevin-Le Chatelier effect, development of a mathematical model for optimizing parts, computer simulation of the viscoplastic properties of a model sample. Analysis of the obtained strength parameters demonstrates that the flow characteristics of the two-phase alloy of aluminum and magnesium exceed the ultimate tensile strength by 50 %. Rate of extension was inversely proportional to the intensity of the Portevin-Le Chatelier effect.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
