Relationship between the FRAX® score and falls in community-dwelling middle-aged and elderly people

Ling-Chun Ou,Yin-Fan Chang,Chin-Sung Chang,Ting-Hsing Chao,Ruey-Mo Lin,Zih-Jie Sun,Chih-Hsing Wu 대한골다공증학회 2016 Osteoporosis and Sarcopenia Vol.2 No.4

Objectives: Falls is a risk factor for fracture. The FRAX® predicts fractures. Whether the FRAX® is associated with fall in both gender is inconclusive. The aim of our study is to evaluate the association between FRAX scores and falls. Methods: The cross-sectional study set from 2009 to 2010 included 1200 community-dwelling people who were systematically sampled in central Taiwan. The 1200 participants (men: 524; women: 676; ?40 years old) completed questionnaires about socioeconomic status; lifestyle; medical and fall history were completed. FRAX scores with and without bone mineral density (BMD) were calculated by using the Taiwan calculator. Results: A total of 19.8% participants fell down. Binary regression models showed that diabetes mellitus history (OR: 1.61; 95% CI: 1.03e2.52), the FRAX without BMD in a continuous major score (OR: 1.06; 95% CI: 1.03e1.09), continuous hip score (OR: 1.11; 95% CI: 1.05e1.16), categorical major score ? 10% (OR: 1.81; 95% CI: 1.25e2.61), and categorical hip score ? 3% (OR: 1.80; 95% CI: 1.30e2.50) were independent risk factors for falls. FRAX with BMD in a continuous major score (OR: 1.04; 95% CI: 1.02e1.06), continuous hip score (OR: 1.06; 95% CI: 1.02e1.09), categorical major score ? 10% (OR: 1.52; 95% CI: 1.09e2.12), and categorical hip score ? 3% (OR: 1.53; 95% CI: 1.13e2.09) were also independent risk factors. Conclusions: We concluded that FRAX® scores with and without BMD were unanimously correlated with falls in community-dwelling middleaged and elderly males and females.

Enhanced Electrochemical Activity and Chromium Tolerance of the Nucleation‑Agent‑Free La2Ni0.9Fe0.1O4+δ Cathode by Gd0.1Ce0.9O1.95 Incorporation

Yihan Ling,Huixin Xie,Zijing Liu,Xiaoni Du,Hui Chen,Xuemei Ou,Ling Zhao,Riyan Achmad Budiman 대한금속·재료학회 2018 ELECTRONIC MATERIALS LETTERS Vol.14 No.4

For the sake of improving the electrochemical activity and chromium tolerance of the K2NiF4- type oxide, La2NiO4+ δ (LNO), with nonnucleation agents like Mn and Sr elements, the electrochemical performance and degradation were comparatively studied at two cathodes La2Ni0.9Fe0.1O4+ δ (LNF) and LNF-40wt%Gd0.1Ce0.9O1.95 (LNF-GDC) on the GDC electrolyte,where 5wt%Cr2O3 incorporation provides Cr-containing atmosphere. Compared with non-doped LNO, LNF shows a higherinterstitial oxygen concentration (δ = 0.298) and a lower electrical conductivity, where bivalent Ni ion, Ni×Ni , and trivalentNi ion, Ni⋅Ni , and trivalent Fe ion on Ni-site, Fe⋅Ni , were observed from the XPS measurements. LNF-GDC shows greatlyreduced interfacial polarization resistances (Rp), which are only half of those of LNF, indicating a better electrochemicalperformance. More importantly, no significant degradation of LNF-GDC in performance has been observed under exposureof Cr-containing atmosphere at 700 °C for 350 h, while Rp of LNF increased by nearly 20%, suggesting LNF by GDCincorporation can enhance the electrochemical performance as well as chromium tolerance for intermediate temperaturesolid oxide fuel cells (IT-SOFCs).

Soluble N-ethylmaleimide-sensitive Factor Attachment Receptor (SNARE) Protein Involved in the Remission of Depression by Acupuncture in Rats

Ling Fan,Zhao Chen,Wenbin Fu,Nenggui Xu,Jianhua Liu,Aiping Lu,Ziping Li,Shengyong Su,Taixiang Wu,Aihua Ou 사단법인약침학회 2016 Journal of Acupuncture & Meridian Studies Vol.9 No.5

This study aims to investigate the molecular mechanisms of acupuncture in the remission of depression. A depressive disorder model was induced by exposing Sprague–Dawley rats to chronic unpredictable stress. The rats were divided into five groups: healthy (blank group) and stressed rats (model group), and stressed rats treated with acupuncture (acupuncture group), riluzole (riluzole group), acupuncture combined with botulinum toxin A (BTX-A) injection (acupuncture+BTX-A group) or riluzole combined with BTX-A injection (riluzole+BTX-A group). Behavioral analysis showed significant differences in sucrose consumption, weight, and horizontal or vertical movements between the model and both the riluzole and acupuncture groups. No obvious differences between the riluzole+BTX-A and acupuncture+BTX-A groups were found. Moreover, no significance differences in glutamate content in the hippocampus were found among the riluzole+BTX-A, acupuncture+BTX-A and model groups (p>0.05). Western blots and reverse transcription polymerase chain reactions were employed to detect protein and mRNA expressions of VGLUT2, SNAP25, VAMP1, VAMP2, VAMP7, and syntaxin1; no obvious differences among the riluzole+BTX-A, acupuncture+BTX-A and model groups were found. These data suggest that soluble N-ethylmaleimide-sensitive factor attachment receptor proteins are involved in the remission of depression in rats treated with acupuncture.

Cocktail Formula and Application Prospects for Oral and Maxillofacial Organoids

Ou Mingyu,Li Qing,Ling Xiaofang,Yao Jinguang,Mo Xiaoqiang 한국조직공학과 재생의학회 2022 조직공학과 재생의학 Vol.19 No.5

Oral and maxillofacial organoids (OMOs), tiny tissues and organs derived from stem cells cultured through 3-d cell culture models, can fully summarize the cell tissue structure, physiological functions and biological characteristics of the source tissues in the body. OMOs are applied in areas such as disease modelling, developmental and regenerative medicine, drug screening, personalized treatment, etc. Although the construction of organoids in various parts of the oral and maxillofacial (OM) region has achieved considerable success, the existing cocktail formulae (construction strategies) are not widely applicable for tissues of various sources due to factors including the heterogeneity of the source tissues and the dependence on laboratory technology. Most of their formulae are based on growth factor niches containing expensive recombinant proteins with their efficiency remaining to be improved. In view of this, the cocktail formulae of various parts of the OM organs are reviewed with further discussion of the application and prospects for those OMOs to find some affordable cocktail formula with strong operability and high repeatability for various maxillofacial organs. The results may help improve the efficiency of organoid construction in the laboratory and accelerate the pace of the clinical use of organoid technology.

Study of the Effects of the Antisite Related Defects in Silicon Dioxide of Metal-Oxide-Semiconductor Structure on the Gate Leakage Current

Ling-Feng Mao,Zi-Ou Wang,Ming-Zhen Xu,Chang-Hua Tan 대한전자공학회 2008 Journal of semiconductor technology and science Vol.8 No.2

The effects of the antisite related defects on the electronic structure of silica and the gate leakage current have been investigated using first-principles calculations. Energy levels related to the antisite defects in silicon dioxide have been introduced into the bandgap, which are nearly 2.0 eV from the top of the valence band. Combining with the electronic structures calculated from first-principles simulations, tunneling currents through the silica layer with antisite defects have been calculated. The tunneling current calculations show that the hole tunneling currents assisted by the antisite defects will be dominant at low oxide field whereas the electron direct tunneling current will be dominant at high oxide field. With increased thickness of the defect layer, the threshold point where the hole tunneling current assisted by antisite defects in silica is equal to the electron direct tunneling current extends to higher oxide field.

Study of the Effects of the Antisite Related Defects in Silicon Dioxide of Metal-Oxide-Semiconductor Structure on the Gate Leakage Current

Mao, Ling-Feng,Wang, Zi-Ou,Xu, Ming-Zhen,Tan, Chang-Hua The Institute of Electronics and Information Engin 2008 Journal of semiconductor technology and science Vol.8 No.2

The effects of the antisite related defects on the electronic structure of silica and the gate leakage current have been investigated using first-principles calculations. Energy levels related to the antisite defects in silicon dioxide have been introduced into the bandgap, which are nearly 2.0 eV from the top of the valence band. Combining with the electronic structures calculated from first-principles simulations, tunneling currents through the silica layer with antisite defects have been calculated. The tunneling current calculations show that the hole tunneling currents assisted by the antisite defects will be dominant at low oxide field whereas the electron direct tunneling current will be dominant at high oxide field. With increased thickness of the defect layer, the threshold point where the hole tunneling current assisted by antisite defects in silica is equal to the electron direct tunneling current extends to higher oxide field.

An Improved Evaluation Index System for the Host Information Security Evaluation System

Yuyi Ou,Jinbiao Xie,Jie Ling 보안공학연구지원센터 2015 International Journal of Security and Its Applicat Vol.9 No.3

This paper studies the principle of the host information security risk assessment and the method to determine the right of each index’s weight. Because Liao Hui and others proposed network terminal security assessment index system exists index weights unreasonable distribution problem, using Delphi method and AHP calculate each index weight and the weights of total ranking of lowest level indexes relative to the highest lever indexes, identified the indicators which have greatest impact to the assessment objectives and apply it to a host of information security evaluation system. Uses the fuzzy comprehensive evaluation method and combined with examples to prove the index system after improving its weight distribution can be more scientifically reflect the importance of the indexes in the evaluation system and the result of the host information security evaluation is reasonable and comprehensive.

Competitive Sorption of Bisphenol a and Phenol in Soils and the Contribution of Black Carbon

Yu-Heng Ou,Ying-Jie Chang,Feng-Yi Lin,Meei-Ling Chang,Yang-Hsin Shih 한국토양비료학회 2014 한국토양비료학회 학술발표회 초록집 Vol.2014 No.6

One-pot Process of 2'-Deoxyguanylic Acid Catalyzed by a Multi-enzyme System

Yanyu Li,Qingbao Ding,Ling Ou,Yahui Qian,Jiao Zhang 한국생물공학회 2015 Biotechnology and Bioprocess Engineering Vol.20 No.1

2'-Deoxyguanylic acid (deoxyguanosine-5'-monophosphate, dGMP) is a substance required by livingcells that is used extensively in reagents, fine chemicalsand other industrial fields. Traditionally, dGMP is separatedfrom DNA degradation products, which is low-yieldingand time-consuming. Herein, we investigated a novel, onepotmulti-enzymatic cascade reaction to produce dGMP. This reaction involved purine nucleoside phosphorylase(PNPase) and acetate kinase (ACKase) from Escherichiacoli, N-deoxyribosytransferase II (NDT-II) from Lactobacillusdelbrueckii and deoxyguanosine kinase (dGKase) fromBacillus subtilis. During the reaction, the initial guanosinesubstrate was cleaved into guanine and ribose-1-phosphateby PNPase. Then, deoxyguanosine (dGR) was subsequentlyproduced from a reaction between guanine and thymidinecatalysed by NDT-II. Finally, the intermediate dGR wasphosphorylated to dGMP by dGKase and a cytidinetriphosphate (CTP) regeneration system that utilised acetylphosphate via ACKase. A very small amount of CTP wasadded because CTP regeneration was efficient to transfer aphosphate group from acetyl phosphate to dGR. After 12 hof incubation, a maximal dGMP yield of up to 76% wasobtained based on the addition of 5 mM guanosine and 5mM thymidine.

Potential Mechanisms of Benzyl Isothiocyanate Suppression of Invasion and Angiogenesis by the U87MG Human Glioma Cell Line

Zhu, Yu,Zhang, Ling,Zhang, Guo-Dong,Wang, Hong-Ou,Liu, Ming-Yan,Jiang, Yuan,Qi, Li-Sha,Li, Qi,Yang, Ping Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.19

Glioma is one of the most common tumors in China and chemotherapy is critical for its treatment. Recent studies showed that benzyl isothiocyanate (BITC) could inhibit the growth of glioma cells, but the mechanisms are not fully understood. This study explored the inhibitory effect of BITC on invasion and angiogenesis of U87MG human glioma cells in vitro and in vivo, as well as potential mechanisms. It was found that BITC could inhibit invasion and angiogenesis of human glioma U87MG cells by inducing cell cycle arrest at phase G2/M. It also was demonstrated that BITC decreased expression of cyclin B1, p21, MMP-2/9, VE-cadherin, CD44, CXCR4 and MTH1, the activity of the telomerase and $PKC{\zeta}$ pathway. Microarray analysis was thus useful to explore the potential target genes related to tumorigenic processes. BITC may play important roles in the inhibition of invasion and angiogenesis of human glioma cells.