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Dynamic Coalition Formation Based on Multi-sided Negotiation
Lin Xiang,Haijun Tao 보안공학연구지원센터 2015 International Journal of Database Theory and Appli Vol.8 No.1
The coalition formation is an important aspect of multi-agent negotiation and cooperation. Based on the Bilateral Shapley-Value, a multi-sided eigenvalue is presented by using the reference of n-person stochastic cooperative game. It is obvious when multi-sided eigenvalue have superadditivity, rational agents will combine to one coalition. A dynamic coalition formation algorithm is constructed based on the eigenvalue. Procedures of multi-sided negotiation, agent’s negotiation and coalition condensing are introduced in detail. In the end, the complexity, validity, coalition stability and parameter’s function of the algorithm is given. According to these, the correctness of the algorithm is proven.
Susceptibility Genes for Multiple Sclerosis Identifed in a Gene-Based Genome-Wide Association Study
Xiang Lin,Fei-Yan Deng,Xin Lu,Shu-Feng Lei 대한신경과학회 2015 Journal of Clinical Neurology Vol.11 No.4
Background and Purpose Multiple sclerosis (MS) is a demyelinating and infammatory disease of the central nervous system. Te aim of this study was to identify more genes associated with MS. Methods Based on the publicly available data of the single-nucleotide polymorphism-based genome-wide association study (GWAS) from the database of Genotypes and Phenotypes, we conducted a powerful gene-based GWAS in an initial sample with 931 family trios, and a replication study sample with 978 cases and 883 controls. For interesting genes, gene expression in MS-related cells between MS cases and controls was examined by using publicly available datasets. Results A total of 58 genes was identifed, including 20 “novel” genes signifcantly associated with MS (p<1.40×10-4). In the replication study, 44 of the 58 identifed genes had been genotyped and 35 replicated the association. In the gene-expression study, 21 of the 58 identifed genes exhibited diferential expressions in MS-related cells. Tus, 15 novel genes were supported by replicated association and/or diferential expression. In particular, four of the novel genes, those encoding myelin oligodendrocyte glycoprotein (MOG), coiled-coil alpha-helical rod protein 1 (CCHCR1), human leukocyte antigen complex group 22 (HCG22), and major histocompatibility complex, class II, DM alpha (HLA-DMA), were supported by the evidence of both. Conclusion zTe results of this study emphasize the high power of gene-based GWAS in detecting the susceptibility genes of MS. Te novel genes identifed herein may provide new insights into the molecular genetic mechanisms underlying MS.
Comparison of Two Feather-Degrading Bacillus Licheniformis Strains
Lin, Xiang,Lee, Soo-Won,Bae, Hee Dong,Shelford, Jim A.,Cheng, Kuo-Joan Asian Australasian Association of Animal Productio 2001 Animal Bioscience Vol.14 No.12
Bacillus licheniformis strains L-25 and PWD-1 are two thermophilic feather-degrading bacteria. Despite isolated from different environmental conditions, they were both capable of breaking down chicken feathers and growing in a medium in which feather was the only source of carbon and nitrogen. A 1.46-kb keratinase gene (ker B) was isolated from strain L-25 by a polymerase chain reaction (PCR) using L-25 genomic DNA as templates. Sequencing results reveal that ker B shares great sequence identity with a previously published keratinase gene of B. licheniformis PWD-1 (ker A). Only two amino acids differences were found in the deduced amino acid sequence between the keratinases from L-25 and PWD-1. However several nucleotide changes were found upstream of the putative promoter region. Protease inhibition studies indicated that neutral protease activity accounted for approximate 25 to 30% of total extracellular proteolytic activity produced by strain L-25 in the feather medium. In contrast, no measurable neutral protease activity was produced by strain PWD-1 in the feather medium. When glucose (1%), a common catabolic repressor, was added into the feather medium, L-25 was still able to grow and produce keratinase. Strain PWD-1 produced no neutral protease activity and its growth was severely inhibited in the feather medium containing glucose. L-25 produced an enhanced level of keratinase in the feather medium in comparison with PWD-1.
Xiang Nan Lin,Jae Eun Lee,Dong Kyun Yim 위기관리 이론과 실천 2021 Journal of Safety and Crisis Management Vol.11 No.2
The purpose of this article is to promote the participation of non-governmental organizations in the management of major infectious diseases in China. We intend to analyze and evaluate the management methods, functions, behaviors, and funding methods of NGOs involved in the prevention and control of infectious diseases in China through various levels of theory and empirical analysis: evaluation and formal judgment of various methods and backgrounds. Government agencies are involved in evaluating the effectiveness of major infectious disease prevention and control in China. It is worth paying full attention to social forces facing sudden public crises, especially non-governmental organizations. The strong momentum of the epidemic has encouraged all actors in society to cooperate and work efficiently and orderly in the prevention and control of infectious diseases.
Resolution of Racemic Ketoprofen in Organic Solvents by Lipase from Burkholderia cepacia G63
Xiang-lin Zhang,Tao Liu,Li Xu,Xiaohua Gui,Feng Su,Yunjun Yan 한국생물공학회 2012 Biotechnology and Bioprocess Engineering Vol.17 No.6
A lipase from the Burkholderia cepacia strain G63 immobilized on resin was used for the resolution of ketoprofen. To study its catalytic properties in enantioselective esterication, different alcohols and solvents were tested to select the most suitable acyl acceptor and reaction medium. Compared with the low activity of the free lipase, the enzyme activity and E value of the immobilized lipase were significantly enhanced. The enantioselectivity of the immobilized lipase could also be markedly improved by adding a small amount of 18-crown-6. RSM was employed to optimize the reaction parameters. The optimal reaction conditions were: reaction time 22.50 h, additives dosage 0.4322 g (0.33 mmol/mL), and substrate molar ratio 54.11:1. Under optimal conditions, the maximal E value was up to 10.01, which exhibited a better enantioselectivity than some commercial lipases, such as Novozym 435,Lipozyme RM IM and LipozymeTL IM.
An Improved Energy Balance Routing Protocol based on LEACH Protocol
Xiang Lin Qin 보안공학연구지원센터 2016 International Journal of Future Generation Communi Vol.9 No.12
LEACH algorithm is a classical hierarchical routing algorithm; it uses the cluster head rotation mechanism to allocate the energy consumption to the whole network. But because of the randomness of the cluster head selection, the optimal number of cluster heads can not be obtained, at the same time, its position cannot do the best, some regions of the cluster head may be more concentrated, some areas may not cluster head, lead to the distance of non-cluster head node and cluster head node is too large, the energy consumption is too large. Soan improved routing algorithm based on LEACH algorithm is proposed, the basic idea is to determine the optimal number of cluster heads, non-uniform clustering, at the same time, the threshold is added in the LEACH algorithm, the nodes with high residual energy become cluster heads, in the process of transmission, multi hop transmission mechanism is adopted among cluster heads. Simulation results show that, this algorithm further reduces the energy consumption in the network, effectively extending the life cycle of the network.