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      • Construction and Implementation Path of Tripartite Linkage School Sports Insurance Pattern

        Lian Xiao-gang,Cao Jing-chuan 아시아건강운동학회 2021 Journal of Asian Society for Health & Exercise Vol.3 No.2

        The construction of appropriate pattern is an important measure to promote the development of school sports insurance. The expert interview method and case study method and other research methods are adopted to explore the construction and implementation path of the tripartite linkage school sports insurance pattern. Research believes that tripartite linkage school sports insurance pattern is based on the modernization of national governance and the establishment of the concept of the assumption risk. Collaborative governance theory and welfare pluralism theory is the theoretical basis. The tripartite linkage pattern is an operation style of government-led, school-supported and family-based. It advocates the government, school and families jointly contribute in proportion to provide school sports insurance for students. The implementation of the tripartite linkage school sports insurance pattern can be promoted from government guidance, legal construction, pilot exploration and other ways.

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        The Blood Oxygenation T2* Values of Resectable Esophageal Squamous Cell Carcinomas as Measured by 3T Magnetic Resonance Imaging: Association with Tumor Stage

        Yu-lian Tang,Xiao-ming Zhang,Zhi-gang Yang,Yu-cheng Huang,Tian-wu Chen,Yan-li Chen,Fan Chen,Nan-lin Zeng,Rui Li,Jiani Hu 대한영상의학회 2017 Korean Journal of Radiology Vol.18 No.4

        Objective: To explore the association between the blood oxygenation T2* values of resectable esophageal squamous cell carcinomas (ESCCs) and tumor stages. Materials and Methods: This study included 48 ESCC patients and 20 healthy participants who had undergone esophageal T2*-weighted imaging to obtain T2* values of the tumors and normal esophagi. ESCC patients underwent surgical resections less than one week after imaging. Statistical analyses were performed to identify the association between T2* values of ESCCs and tumor stages. Results: One-way ANOVA and Student-Newman-Keuls tests revealed that the T2* value could differentiate stage T1 ESCCs (17.7 ± 3.3 ms) from stage T2 and T3 tumors (24.6 ± 2.7 ms and 27.8 ± 5.6 ms, respectively; all ps < 0.001). Receiver operating curve (ROC) analysis showed the suitable cutoff T2* value of 21.3 ms for either differentiation. The former statistical tests demonstrated that the T2* value could not differentiate between stages T2 and T3 (24.6 ± 2.7 ms vs. 27.8 ± 5.6 ms, respectively, p > 0.05) or between N stages (N1 vs. N2 vs. N3: 24.7 ± 6.9 ms vs. 25.4 ± 4.5 ms vs. 26.8 ± 3.9 ms, respectively; all ps > 0.05). The former tests illustrated that the T2* value could differentiate anatomic stages I and II (18.8 ± 4.8 ms and 26.9 ± 5.9 ms, respectively) or stages I and III (27.3 ± 3.6 ms). ROC analysis depicted the same cutoff T2* value of 21.3 ms for either differentiation. In addition, the Student’s t test revealed that the T2* value could determine grouped T stages (T0 vs. T1–3: 17.0 ± 2.9 ms vs. 25.2 ± 6.2 ms; T0–1 vs. T2–3: 17.3 ± 3.0 ms vs. 27.1 ± 5.3 ms; and T0–2 vs. T3: 18.8 ± 4.2 ms vs. 27.8 ± 5.6 ms, all ps < 0.001). ROC analysis indicated that the T2* value could detect ESCCs (cutoff, 20 ms), and discriminate between stages T0–1 and T2–3 (cutoff, 21.3 ms) and between T0–2 and T3 (cutoff, 20.4 ms). Conclusion: The T2* value can be an additional quantitative indicator for detecting ESCC except for stage T1 cancer, and can preoperatively discriminate between some T stages and between anatomic stages of this tumor.

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        Analysis on Robust Passivity of Uncertain Neural Networks with Time-Varying Delays via Free-Matrix-Based Integral Inequality

        Shen-Ping Xiao,Hong-Hai Lian,Hong-Bing Zeng,Gang Chen,Wei-Hua Zheng 제어·로봇·시스템학회 2017 International Journal of Control, Automation, and Vol.15 No.5

        This paper investigates the robust delay-dependent passivity problem of neural networks (NNs) with time-varying delays and parameter uncertainties. A suitable augmented Lyapunov-Krasovskii functional (LKF) with triple integral term, which takes full use of the neuron activation function conditions and the information of time-delay in integral term, is constructed. Furthermore, by utilizing integral inequality proposed recently and the combining reciprocally convex method to estimate the derivative of the LKF, some less conservative robust passivity conditions are derived in terms of LMI. The superiority of presented approaches are demonstrated via two classic numerical examples.

      • KCI등재

        Effectiveness and Safety of Dabrafenib in the Treatment of 20 Chinese Children with BRAFV600E-Mutated Langerhans Cell Histiocytosis

        Ying Yang,Dong Wang,Lei Cui,Hong-Hao Ma,Li Zhang,Hong-Yun Lian,Qing Zhang,Xiao-Xi Zhao,Li-Ping Zhang,Yun-Ze Zhao,Na Li,Tian-You Wang,Zhi-Gang Li,Rui Zhang 대한암학회 2021 Cancer Research and Treatment Vol.53 No.1

        Purpose We sought to investigate the effectiveness and safety of dabrafenib in children with BRAFV600E-mutated Langerhans cell histiocytosis (LCH). Materials and Methods A retrospective analysis was performed on 20 children with BRAFV600E-mutated LCH who were treated with dabrafenib. Results The median age at which the patients started taking dabrafenib was 2.3 years old (range, 0.6 to 6.5 years). The ratio of boys to girls was 2.3:1. The median follow-up time was 30.8 months (range, 18.9 to 43.6 months). There were 14 patients (70%) in the risk organ (RO)+ group and six patients (30%) in the RO– group. All patients were initially treated with traditional chemotherapy and then shifted to targeted therapy due to poor control of LCH or intolerance to chemotherapy. The overall objective response rate and the overall disease control rate were 65% and 75%, respectively. During treatment, circulating levels of cell-free BRAFV600E (cfBRAFV600E) became negative in 60% of the patients within a median period of 3.0 months (range, 1.0 to 9.0 months). Grade 2 or 3 adverse effects occurred in five patients. Conclusion Some children with BRAFV600E-mutated LCH may benefit from monotherapy with dabrafenib, especially high-risk patients with concomitant hemophagocytic lymphohistiocytosis and intolerance to chemotherapy. The safety of dabrafenib is notable. A prospective study with a larger sample size is required to determine the optimal dosage and treatment duration.

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