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Lee, Seonae,Kim, Ka Young,Lim, Na Young,Jung, Jin Hwan,Lee, Ji Ha,Choi, Myong Yong,Jung, Jong Hwa Elsevier 2019 Journal of hazardous materials Vol.378 No.-
<P><B>Abstract</B></P> <P>Uranyl is a radioactive, toxic pollutant commonly found in the waste remaining after nuclear fuel reprocessing, and it poses several types of risks to human health; therefore, developing absorbents and chemical probes for this compound is crucial to overcoming these issues. This study examined the sensing abilities of terpyridine-appended benzenetricarboxyamide (T-BTA) as a chromogenic probe for detecting uranyl ions (UO<SUB>2</SUB> <SUP>2+</SUP>). The complex with Eu<SUP>3+</SUP> (<B>1–Eu</B>) spontaneously formed nanostructured fibers in H<SUB>2</SUB>O owing to the triamide groups of T-BTA, which induced intermolecular hydrogen-bonding interactions. The strong blue emission of these nanofibers in H<SUB>2</SUB>O was quenched upon adding UO<SUB>2</SUB> <SUP>2+</SUP> but not upon adding any other metal ion. This high selectivity was probably because of the interactions between the nitrigen atoms of the terpyridine moieties of <B>1</B> and UO<SUB>2</SUB> <SUP>2+</SUP>. Furthermore, the <B>1–Eu</B> nanofibers assumed spherical morphologies when UO<SUB>2</SUB> <SUP>2+</SUP> was added. To develop a convenient UO<SUB>2</SUB> <SUP>2+</SUP> sensor, an electrospun film incorporating <B>1–Eu</B> (<B>ESF–1–Eu</B>) was manufactured, and it exhibited high selectivity for UO<SUB>2</SUB> <SUP>2+</SUP> over a variety of rival metal ions. The plot for luminescence change of <B>ESF–1–Eu</B> vs UO<SUB>2</SUB> <SUP>2+</SUP> concentrations in seawater samples showed a good linearty. Thus, the <B>ESF–1–Eu</B> shows potential as a useful sensor for detecting and removing UO<SUB>2</SUB> <SUP>2+</SUP> in H<SUB>2</SUB>O.</P> <P><B>Highlights</B></P> <P> <UL> <LI> T-BTA complex with Eu<SUP>3+</SUP> formed nanostructured fibers by the intermolecular H-bonding. </LI> <LI> The strong blue emission of <B>1-Eu</B> was selectively quenched upon adding UO<SUB>2</SUB> <SUP>2+</SUP>. </LI> <LI> An electrospun film incorporating <B>1–Eu</B> recognized high selectivity for UO<SUB>2</SUB> <SUP>2+</SUP>. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
김다홍,Seona Jo,Dongjin Lee,Seok‑Min Kim,Ji Min Seok,여선주,이준희,JaeJong Lee,Kangwon Lee,Tae‑Don Kim,박수아 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Background Patients face a serious threat if a solid tumor leaves behind partial residuals or cannot be completely removed after surgical resection. Immunotherapy has attracted attention as a method to prevent this condition. However, the conventional immunotherapy method targeting solid tumors, that is, intravenous injection, has limitations in homing in on the tumor and in vivo expansion and has not shown effective clinical results. Method To overcome these limitations, NK cells (Natural killer cells) were encapsulated in micro/macroporeforming hydrogels using 3D bioprinting to target solid tumors. Sodium alginate and gelatin were used to prepare micro-macroporous hydrogels. The gelatin contained in the alginate hydrogel was removed because of the thermal sensitivity of the gelatin, which can generate interconnected micropores where the gelatin was released. Therefore, macropores can be formed through bioprinting and micropores can be formed using thermally sensitive gelatin to make macroporous hydrogels. Results It was confirmed that intentionally formed micropores could help NK cells to aggregate easily, which enhances cell viability, lysis activity, and cytokine release. Macropores can be formed using 3D bioprinting, which enables NK cells to receive the essential elements. We also characterized the functionality of NK 92 and zEGFR-CAR-NK cells in the pore-forming hydrogel. The antitumor effects on leukemia and solid tumors were investigated using an in vitro model. Conclusion We demonstrated that the hydrogel encapsulating NK cells created an appropriate micro–macro environment for clinical applications of NK cell therapy for both leukemia and solid tumors via 3D bioprinting. 3D bioprinting makes macro-scale clinical applications possible, and the automatic process shows potential for development as an off-the-shelf immunotherapy product. This immunotherapy system could provide a clinical option for preventing tumor relapse and metastasis after tumor resection.