혈액암환자에서 조혈모세포 이식 후 따르는 헤르페스 바이러스 감영 양상

이호섭,탁희상,신성훈,김양수,남성진,김혜수,박진희,정수현,김성빈,김예나 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.1

배경 : 헤르페스바이러스과에는 단순포진 바이러스(HERPES SIMPLEX VIRUS, HSV), 수두대상포진 바이러스 (VARICELLA-ZOSTER VIRUS, VZV), 엡스타인-바 바이러스 (EPSTEIN-BARR VIRUS, EBV), 그리고 거대세포 바이러스 (CYTOMEGALOVIRUS, CMV) 등이 있다. 헤르페스바이러스 감염은 혈액암환자에서 조혈모세포 이식 환자에서 전파 (dissemination), 이차감염, 세균 중복 감염의 심각한 합병증을 일으킬 수 있다. 하지만 항암약물치료를 받는 림파종 환자에서 항 바이러스 약제의 사용 용량과 기간에 대한 concensus는 없다. 헤르페스바이러스 감염에 대한 발생율과 위험인자를 후향성으로 분석하였다. 방법 : 고신대학교 복음 병원에서 1995년 6월부터 2009 년 2월 사이에 새롭게 진단되어 조혈모세포 이식을 받은 전체 58명의 환자들이 후향적으로 현 연구에 등록했다. 헤르페스 바이러스 감염은 임상적 진단, 혈청학적 검사 또는 병리학적 진단에 기초하여 확진한다. 환자들의 특성은 다음과 같다: 평균 연령은 44세 (범위 19-62세)였고 남녀비는 30:28이었다. 등록된 질환은 백혈병 (n=9, 15.5%), 림프종 (n=30, 51.7%), 다발성 골수종 (n=12, 20.7%), 재생불량성 빈혈 (n=6, 10.3%) 그리고 골수이형성증후군 (n=1, 1.7%)이 포함되었다. 결과는 chi-squre test나 independent samples T test를 사용하여 분석되었다. Multivariate analysises에 대해 logistic regression test를 사용하였다. 결과 : 15명의 환자들 (25.9%)에서 조혈모세포 이식후 헤르페스 바이러스 감염이 발생하였다. 조혈모세포 이식 5년간 누적 발생율은 53.9%였다. Univariate analyses에서 헤르페스 바이러스 감염에 대한 유의한 위험 인자는 없었다. 하지만 조혈모세포 이식후 생존 기간(40.18 ± 30.14 months vs 20.06 ± 26.67 months, p=0.018)은 헤르페스 바이러스 감염의 낮은 발병율과 유의한 관련성이 있었다. 이식 편대 숙주질환 (GVHD)의 존재 (37.5% in developed GVHD vs 0% in no GVHD, p=0.200), 동종조혈 모세포 이식에서 면역억제요법의 기간 (15.98 ± 14.02 months vs 6.78 ± 3.67 months, p = 0.374)은 헤르페스 바이러스 감염에 대한 위험인자가 아니었다. 결론 : 조혈모세포 이식 후 생존 기간은 어사이클로비어 예방을 받은 혈액암 환자에서 헤르페스 바이러스 감염의 낮은 발병율과 연관성이 있는 것으로 보인다. 저용량의 어사이클로비어 예방은 헤르페스 바이러스 감염의 고위험군인 조혈모세포 이식을 받은 혈액암 환자에 필요하리라 생각된다. Background : Herpesviridae family includes herpes simplex virus, varicella zoster virus, Epstein-Barr virus, and cytomegalovirus, etc. Herpesviridae viral infection (HVI) can lead to serious complications including dissemination, secondary infection, bacterial superinfection in patients with hematologic malignancy following hematopoietic stem cell transplantation (HSCT). But there was no consensus on the dose and duration of antiviral agents prophylaxis in patients undergoing chemotherapy. We retrospectively analyzed the incidence and the risk factors for HVI. Method : A total of 58 patients who newly diagnosed and received HSCT with prophylaxis of acyclovir at the Kosin University Gospel Hospital, Busan, Korea between June 1995 and February 2009 were enrolled retrospectively in the current study. HVI was confirmed based on clinical diagnosis, serologic test or pathologic diagnosis. The characteristics of the patients were as follows: the median age was 44 years (range 19-62 years) with a female-to-male ratio of 30:28. The enrolled diseases included leukemia (n=9, 15.5%), lymphoma (n=30, 51.7%), multiple myeloma (n=12, 20.7%), aplastic anemia (n=6, 10.3%) and myelodysplastic syndrome (n=1, 1.7%). The results were analyzed using a chi-square test and independent samples T test. For the multivariate analysis, we used logistic regression test. Results : Fifteen patients (25.9%) developed HVI after HSCT. The cumulative incidence of HVI was 53.8% at 5 years after HSCT. In univariate analysis, there was no significant risk factor for HVI. The presence of graft-versus-host disease (GVHD) (37.5% in developed GVHD vs. 0% in no GVHD, p=0.200), duration of immunosuppressive therapy (IST) in allo-SCT (15.98 ± 14.02 months vs. 6.78 ± 3.67 months, p = 0.374) were not risk factors for HVI. Conclusion : The incidence of HVI was similar to that in historical other studies. There was no risk factor associated with development of HVI. Most of the HVI occurred within the first 24 months after transplantation. So long term use of antiviral prophylaxis may be needed to prevention of HVI after HSCT.

건치아동의 연조직 측모에 관한 두부방사선계측학적 연구

선예경,손동수,이상훈 大韓小兒齒科學會 1993 大韓小兒齒科學會誌 Vol.20 No.1

The purpose of this study was to obtain standard measurements of the soft tissue profile of the children who had excellent mixed dentition. Cephalometric roentgenograms of 35 children(17 boys and 18 girls, Hellman dental age ⅢB) among the contestants in 1992 Healthy Dintition Contest in Seoul were studied for the soft tissue profile and following results were obtained; 1.Means and standard deviations of the children were obtained. 2.Maxillary sulcus thickness was thicker in male(p<0.05). 3.Lower lip lingth and lower facial height were longer in male(p<0.01). 4.No significant differences were noted between male and female in the facial convexity,lip protrusion,nose protrusion and inclination measurements(p>0.05). 5.Upper and lower lips were more protrusive and longer,soft tissue chins were thicker,profiles were straighter and sulcuses were more shallow in the Korean Healthy Dintition Contestants than in those of the Caucasian children.

여수국가산업단지 인근 지역 대기오염물질 농도에 영향을 미치는 요인분석

김민영,변정훈,이영훈,이건영,한지은,이예림,임지현,장봉기 순천향대학교 기초과학연구소 2022 순천향자연과학연구 논문집 Vol.28 No.1,2

Eight monitoring stations in the Yeosu National Industrial Complex will determine the concentration of air pollutants measured every hour in 2019, analyze what factors affect them, and how they correlate with the air pollutant measurements. Six air pollutants (SO2, NO2, O3, CO, PM-10 and PM-2.5) measured at eight monitoring stations around Yeosu National Industrial Complex (Seogang-dong, Wolnae-dong, Munsu-dong, Yeocheon-dong, Deokchung-dong, Hwayang-myeon, Yulchon-myeon, Samil-dong) the measurement data for each hour of the year were downloaded to analyze the concentration by weather condition, time zone, season, separation distance from Yeosu Industrial Complex, and separation distance from Gwangyang Industrial Complex. SO2, NO2, and CO concentrations were significantly higher in winter, significantly lower in summer, and O3, PM-10, and PM-2.5 concentrations were significantly higher in spring. SO2, CO, PM-10, and PM-2.5 concentrations were significantly higher between 10 a.m. and 12 p.m., NO2 concentrations were significantly higher between 7 a.m. and 9 a.m., and O3 concentrations were significantly higher between 13 p.m. and 15 p.m.(p<0.001). The concentration of air pollutants (SO2, NO2, CO, PM-10, PM-2.5) excluding O3 was found to have a negative (-) correlation with weather condition, and in the case of O3, it was found to have a positive (+) correlation with PM-10, PM-2.5, temperature and wind speed. It was confirmed that the concentration of air pollutants emitted from the Yeosu National Industrial Complex differs depending on the season, time and distance to the industrial complex. This study aims to establish measures to minimize health damage to residents living relatively close to the industrial complex and contribute to the establishment of management and response measures according to the properties of substances to reduce the concentration of air pollutants in the future.

The Impact of Imperfect Channel Estimation on Adaptive Power and Rate DS/CDMA Communications

Ye Hoon Lee,Dong Ho Kim 보안공학연구지원센터 2013 International Journal of Control and Automation Vol.6 No.5

Short- and Long-Term Outcomes of Acute Severe Ulcerative Colitis in Korea : The 1999-2005 Cohort

Lee, Ho-Su,Yang, Suk-Kyun,Soh, Jae Seung,Lee, Seohyun,Bae, Jung Ho,Lee, Hyo Jeong,Park, Sang Hyoung,Yang, Dong-Hoon,Kim, Kyung-Jo,Ye, Byong Duk,Byeon, Jeong-Sik,Myung, Seung-Jae,Yoon, Yong Sik,Yu, Cha Oxford University Press 2015 Inflammatory bowel diseases Vol.21 No.8

<P>No previous studies have evaluated the long-term outcomes of acute severe ulcerative colitis (ASUC) in non-Caucasian populations. The purposes of this study were to evaluate the short- and long-term outcomes of Korean patients with ASUC.</P>

Risk Factors and Clinical Outcomes Associated with Cytomegalovirus Colitis in Patients with Acute Severe Ulcerative Colitis :

Lee, Ho-Su,Park, Sang Hyoung,Kim, Sung-Han,Kim, Jihun,Choi, Jene,Lee, Hyo Jeong,Kim, Wan Soo,Lee, Jeong-Mi,Kwak, Min Seob,Hwang, Sung Wook,Yang, Dong-Hoon,Kim, Kyung-Jo,Ye, Byong Duk,Byeon, Jeong-Sik Oxford University Press 2016 Inflammatory bowel diseases Vol.22 No.4

<P>Background: Cytomegalovirus (CMV) colitis can contribute to an unfavorable outcome of acute severe ulcerative colitis (ASUC). The purpose of this study was to evaluate the clinical outcomes of ASUC according to the CMV status and identify risk factors for CMV colitis in patients with ASUC. Methods: We retrospectively analyzed patients with ASUC from 2011 to 2014 according to the criteria of Truelove and Witts. CMV colitis was diagnosed by histopathological and/or immunohistochemical analysis of tissue samples. The risk factors for CMV colitis were investigated and clinical outcomes were assessed using the rate of rescue therapy and colectomy. Results: Of 149 patients with ASUC, 50 (33.6%) were diagnosed with CMV colitis. During admission, 16 of 149 patients (10.7%) underwent colectomy: 7 of 50 (14.0%) in the ASUC-CMV group versus 9 of 99 (9.1%) in the ASUC-only group (P = 0.364). The need for rescue therapy was 2.28-fold higher in the ASUC-CMV group than in the ASUC-only group in multivariate analysis (95% confidence interval, 1.10-4.72). Multivariate analysis also revealed that recent use of high-dose steroids (odds ratio, 3.30; 95% confidence interval, 1.33-8.19) and a higher Mayo score (odds ratio, 1.58; 95% confidence interval, 1.05-2.38) were risk factors for CMV colitis. Conclusions: CMV colitis often occurs in ASUC, particularly in patients who have recently been treated with high-dose steroids and have a higher Mayo score on admission. Patients with ASUC and CMV colitis seem to have a poorer prognosis, as indicated by the greater need for rescue therapy.</P>

Investigation of Microstructure in Friction Stir Welded Al-Cu-Li Alloy

Lee, Ye Rim,No, Kookil,Yoon, Jong Hoon,Yoo, Joon Tae,Lee, Ho Sung Trans Tech Publications, Ltd. 2016 Key Engineering Materials Vol.705 No.-

<P>It is well known that the addition of Li to aluminum alloys offers an attractive combination of low density and high modulus, which are useful for lightweight structures of aerospace vehicles. However, microstructure of Al-Li alloys are complex, which consist of a number of equilibrium and metastable phases. In addition, Al-Li alloys are weldable but the weldability is not as good as that of other aerospace alloys. This is due to the reactive property of element Li during melting and causes porosity, cracking and low joint efficiency. In friction stir welding (FSW), rotating welding tool generates frictional heat and by keeping the tool rotating and moving speed, the heat from friction causes the plate to soften without melting. Therefore, this solid state welding is adequate to Al-Li alloys. The friction stir welded joint was divided into 9 regions and each microstructure was investigated in detail to present the microstructure evolution and material flows during friction stir welding process. The recrystallized structure is observed in nugget zone and the evidence of initiation of dynamic recrystallization is found around the boundary between thermo-mechanically affected zone (TMAZ) and nugget region. This paper describes the results of a study to investigate the microstructure change of Al-Cu-Li alloy during the friction stir welding process.</P>

Effects of ginsenosides and their metabolites on voltage-dependent Ca(2+) channel subtypes.

Lee, Jun-Ho,Jeong, Sang Min,Kim, Jong-Hoon,Lee, Byung-Hwan,Yoon, In-Soo,Lee, Joon-Hee,Choi, Sun-Hye,Lee, Sang-Mok,Park, Yong-Sun,Lee, Jung-Ha,Kim, Sung Soo,Kim, Hyoung-Chun,Lee, Boo-Yong,Nah, Seung-Ye Korean Society for Molecular Biology 2006 Molecules and cells Vol.21 No.1

<P>In previous reports we demonstrated that ginsenosides, active ingredients of Panax ginseng, affect some subsets of voltage-dependent Ca(2+) channels in neuronal cells expressed in Xenopus laevis oocytes. However, the major component(s) of ginseng that affect cloned Ca(2+) channel subtypes such as alpha(1C) (L)-, alpha(1B) (N)-, alpha(1A) (P/Q)-, a1E (R)- and a1G (T) have not been identified. Here, we used the two-microelectrode volt-age clamp technique to characterize the effects of ginsenosides and ginsenoside metabolites on Ba(2+) currents (IBa) in Xenopus oocytes expressing five different Ca(2+) channel subtypes. Exposure to ginseng total saponins (GTS) induced voltage-dependent, dose-dependent and reversible inhibition of the five channel subtypes, with particularly strong inhibition of the a1G-type. Of the various ginsenosides, Rb(1), Rc, Re, Rf, Rg(1), Rg(3), and Rh(2), ginsenoside Rg(3) also inhibited all five channel subtypes and ginsenoside Rh(2) had most effect on the a1C- and a1E-type Ca(2+) channels. Compound K (CK), a protopanaxadiol ginsenoside metabolite, strongly inhibited only the a(1G)-type of Ca(2+) channel, whereas M4, a protopanaxatriol ginsenoside metabolite, had almost no effect on any of the channels. Rg(3), Rh(2), and CK shifted the steady-state activation curves but not the inactivation curves in the depolarizing direction in the alpha(1B)- and alpha(1A)-types. These results reveal that Rg(3), Rh(2) and CK are the major inhibitors of Ca(2+) channels in Panax ginseng, and that they show some Ca(2+) channel selectivity.</P>

ADI Analysis of Toxicity Report on 141 Bactericides including Anilazine

Ye Ji Bae,Jong Su Byun,Ki Hoon Kim,Min Jeong Lee,Do Hoon Kim,Ji Soo Seo,Seung-Woo Lee,Sung-Hee Choi,Ok-Nam Bae,Jin Seok Kang,Beom Seok Han 한국농약과학회 2021 한국농약과학회 학술발표대회 논문집 Vol.2021 No.11

This study analyzed the Acceptable Daily Intake (ADI) level for the toxicity assessment report on 141 bactericides, including registered in domestic country. NOAEL and ADI of bactericides toxicity study evaluated at domestic and foreign institute, toxicity study type based ADI setting, grade of ADI level, major toxicity and target organ were analyzed. As a result, agencies the most reporting bactericides toxicity data is the Food Safety Commission in Japan (FSC, 36%). Other government agencies are EFSA, EPA, JMPR, INCHEM and other apparatuses in that order. When setting different ADI level to one substance, the cause of the ADI difference among institution was the type of the toxicity test, modification of significant figures and safety factor in that order. As for major toxicity study affecting ADI setting, the chronic toxicity was the highest (25%, 35/141). Other toxicities were chronic/carcinogenicity combined test, repeated dose toxicity test, carcinogenicity test, reproductive and developmental toxicity in that order. As for the classification of ADI grade, a number of ADI range was usually confirmed in the between 0.01 mg/kg bw/day and 0.1 mg/kg bw/day (59%, 83/141). The major target organ affecting ADI setting was the liver (hypertrophy, fatty change, etc.). After that, the kidney (pigmentation, etc.) and thyroid (hypertrophy, etc.) were listed in that order, and other organs were selected as target organs. Therefore, the toxicity report analysis of 141 bactericides will contribute to obtain reliable safety data and evaluate accurate risk assessment of pesticide.

Mentoring Relationship in Sports and Its Applicability to Positive Youth Development Context: A Literature Review and Recommendation

Ye Hoon Lee,Boyun Woo 상명대학교 글로벌문화예술교육연구소 2020 Research in Dance and Physical Education Vol.4 No.2