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- 저자 : Lee Wonjae (검색결과 301 건)
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Investigation of Enantiomer Separation Using Chiral Crown Ethers as Chiral Selectors
Lee, Wonjae The Basic Science Institute Chosun University 2016 조선자연과학논문집 Vol.9 No.1
A number of chiral selectors have been developed and applied for enantiomer separation of a variety of chiral compounds. Among these chiral selectors are chiral crown ethers, a class of synthetic host polyether molecules that bind protonated chiral primary amines with high selectivity and affinity. In this paper, two important chiral crown ethers as chiral selectors of bis-(1,1'-binaphthyl)-22-crown-6 and (18-crown-6)-2,3,11,12-tetracarboxylic acid (18-C-6-TA) are focused. They have been widely used to resolve the enantiomers of chiral compounds containing a primary amino moiety using chiral stationary phases (CSPs) or chiral selectors by high-performance liquid chromatography (HPLC), capillary electrophoresis (CE) and so on in chirotechnology. Also, it was described that the commercially available covalent type HPLC CSPs derived from (+)- and (-)-18-C-6-TA have been developed and successfully applied for the resolution of various primary amino compounds including amino acids.
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Long-term Prognosis of Mild to Moderate Aortic Stenosis and Coronary Artery Disease
Lee Wonjae,Choi Wonsuk,강시혁,Hwang In-Chang,Choi Hong-Mi,Yoon Yeonyee E.,Cho Goo-Yeong 대한의학회 2021 Journal of Korean medical science Vol.36 No.6
Background: There is an incomplete understanding of the natural course of mild to moderate aortic stenosis (AS). We aimed to evaluate the natural course of patients with mild to moderate AS and its association with coronary artery disease (CAD). Methods: We retrospectively analyzed 787 patients diagnosed with mild to moderate AS using echocardiography between 2004 and 2010. Cardiac death and aortic valve replacement (AVR) for AS were assessed. Results: A median follow-up period was 92 months. Compared to the general population, patients with mild to moderate AS had a higher risk of cardiac death (hazard ratio [HR], 17.16; 95% confidence interval [CI], 13.65–21.59; P < 0.001). Established CAD was detected in 22.4% and associated with a significantly higher risk of cardiac mortality (adjusted HR, 1.62; 95% CI, 1.04–2.53; P = 0.033). The risk of cardiac death was lower when patients were taking statin (adjusted HR, 0.64; 95% CI, 0.41–0.98; P = 0.041), which was clear only after 7 years. Both patients with CAD and on statin tended to undergo more AVR, but the difference was not statistically significant (the presence of established CAD; adjusted HR, 1.63; 95% CI, 0.51–3.51; P = 0.214 and the use of statin; adjusted HR, 1.86; 95% CI, 0.76–4.58; P = 0.177). Conclusion: Mild to moderate AS does not have a benign course. The presence of CAD and statin use may affect the long-term prognosis of patients with mild to moderate AS.
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Wonjae Lee,Yeonyee E. Yoon,Ohkyung Kwon,이희선,Hyo Eun Park,Eun Ju Chun,Su-Yeon Choi,Goo-Yeong Cho,Hyuk-Jae Chang 대한심장학회 2019 Korean Circulation Journal Vol.49 No.5
Background and Objectives: Coronary artery calcium (CAC) scoring in the asymptomatic population can improve cardiovascular risk prediction. We aimed to assess CAC progression and the impact of coronary risk factors on the CAC progression rate in asymptomatic Korean individuals with a baseline CAC score of zero. Methods: The study population was derived from the Korea Initiatives on Coronary Artery Calcification (KOICA) registry: a retrospective, single ethnicity, multicenter registry of asymptomatic individuals who underwent CAC scoring as a part of a health checkup. Individuals with at least two CAC scores and an initial score of zero were included. CAC progression was defined as [√CAC score (follow-up) − √CAC score (baseline)] ≥2.5. The 10-year atherosclerotic cardiovascular disease (ASCVD) risk was calculated. Results: Among 6,268 participants (mean age, 48.0±7.1 years; male, 80.5%), 719 (11.5%) experienced CAC progression during follow-up (median, 109 months; interquartile range, 78–208 months). The CAC progression rate was 0.3%, 1.9%, 4.3%, 8.6%, and 16.7% in years 1–5, respectively. The chance of CAC progression at 5 years was 13.1%, 22.0%, and 27.9% for individuals with a 10-year ASCVD risk of <5%, ≥5% but <7.5%, and ≥7.5%, respectively. A multivariable analysis revealed age, male sex, waist circumference, diabetes, and low-density lipoprotein cholesterol level as independently associated with annualized CAC progression (p<0.001, p=0.017, p=0.025, p=0.032, and p=0.003, respectively). Conclusions: The probability of CAC progression is very low in Korean individuals with a CAC score of zero. However, the risk of CAC progression increases nonlinearly over time, and increases as the 10-year ASCVD risk increases.
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Lee, Wonjae,Yun, Subin,Choi, Geum Hee,Jung, Tae Woo S. Karger AG 2018 Pathobiology Vol.85 No.5
<P><B><I>Objective:</I></B> β-Aminoisobutyric acid (BAIBA), a myokine, is a thymine catabolite that is induced during exercise, leading to browning of white fat, hepatic fatty acid oxidation, and suppression of hepatic lipogenesis. However, the effects of BAIBA on the progression of atherosclerosis remain unclear. <B><I>Methods:</I></B> We performed a Western blot analyses to determine various protein expression. ELISAs (enzyme-linked immunosorbent assays), cell adhesion assays, and cell viability assays were also performed on human umbilical vascular endothelial cells (HUVECs) and human monocytes (THP-1 cells). <B><I>Results:</I></B> In the current study, we demonstrate that BAIBA suppresses atherosclerotic reactions caused by lipopolysaccharide (LPS) treatment via an AMPK-dependent pathway. Treatment of HUVECs and THP-1 cells with BAIBA inhibited the LPS-induced phosphorylation of nuclear factor-κB (NFκB) and the secretion of proinflammatory cytokines. In HUVECs, expression of adhesion molecules and LPS-stimulated adhesion of THP-1 cells to the endothelium were significantly decreased after BAIBA treatment. Furthermore, LPS-induced endoplasmic reticulum (ER) stress and cell toxicity were significantly decreased after BAIBA treatment of HUVECs. Notably, all of these proatherosclerotic effects were fully abrogated by treatment with small interfering RNA targeting AMPK. <B><I>Conclusion:</I></B> BAIBA ameliorates LPS-induced atherosclerotic reactions via AMPK-mediated suppression of inflammation and ER stress.</P>
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Lee Wonjae,Park Seungsoo,Park Jaikoo 한국자원공학회 2021 Geosystem engineering Vol.24 No.4
In this study, the grinding characteristics of waste printed circuit boards (PCBs) were evaluated using a population balance model (PBM). The grinding characteristics under various conditions (hammer rotational speeds of 1600, 2000, and 2400 rpm; screen aperture sizes of 0.71, 1.0, and 1.40 mm; and maximum feed sizes of 4, 6, and 8 mm) were identified. A PBM for a continuous hammer mill was used to quantitatively demonstrate the grinding characteristics. No significant difference was observed in the particle sizes of the products for various hammer rotational speeds. Nevertheless, the specific rate of breakage increased with the hammer rotational speed. As expected, a narrow screen aperture yielded a fine product. The mean residence time was increased in this case to comminute the particles to a finer size. Furthermore, a finer feed was predicted to yield a finer product; however, a coarser feed was observed to yield such a product instead. Each hammer milling condition should be controlled with respect to the hammer milling performance and target particle size of the product.
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Towards 6G Hyper-Connectivity: Vision, Challenges, and Key Enabling Technologies
Lee, Howon,Lee, Byungju,Yang, Heecheol,Kim, Junghyun,Kim, Seungnyun,Shin, Wonjae,Shim, Byonghyo,Poor, H. Vincent 한국통신학회 2023 Journal of communications and networks Vol.25 No.3
Technology forecasts anticipate a new era in whichmassive numbers of humans, machines, and things are connectedto wireless networks to sense, process, act, and communicatewith the surrounding environment in a real-time manner. Tomake the visions come true, the sixth generation (6G) wirelessnetworks should be hyper-connected, implying that there areno constraints on the data rate, coverage, and computing. Inthis article, we first identify the main challenges for 6G hyper-connectivity, including terabits-per-second (Tbps) data rates forimmersive user experiences, zero coverage-hole networks, andpervasive computing for connected intelligence. To overcomethese challenges, we highlight key enabling technologies for6G such as distributed and intelligence-aware cell-free mas-sive multi-input multi-output (MIMO) networks, boundless andfully integrated terrestrial and non-terrestrial networks, andcommunication-aware distributed computing for computation-intensive applications. We further illustrate and discuss thehyper-connected 6G network architecture along with open issuesand future research directions.
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What should be considered to redesign Netflix for Middle-aged South Korean People?
Wonjae Lee,Juwhan Han,Taeyoung Go,Makida Gebregiorgis Tesfaye 한국HCI학회 2022 한국HCI학회 학술대회 Vol.2022 No.2
As Netflix is getting increasingly popular in COVID-19 situation, this study aims to understand the needs and wishes of the middle-aged people in South Korea so that the service can deliver better user experience for the user group. A main research question was formulated, what designers can do to improve the current experience of Netflix users aged 40-60. To answer the question, user interviews, narration, and collage making were adopted as method. Those who were familiar with the existing broadcasting media services were recruited. By studying the middle-aged, it was discovered that the absence of various genres and the inconvenience of using buttons were problematic, and also that they wanted to feel experiences that could not be experienced in reality and various emotions that communicate with reality through Netflix. The implications and limitations of the study were discussed at the end.
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