Ki-67 labeling index as a prognostic marker in advanced stomach cancer

Sang Hyuk Seo,Kwang Hee Kim,Sang Hoon Oh,Yunseon Choi,Ki Jung Ahn,Ji Young Lee,Sang Min Lee,박지선,Woo Gyeong Kim 대한외과학회 2019 Annals of Surgical Treatment and Research(ASRT) Vol.96 No.1

Purpose: Proliferation marker Ki-67 is widely used in cancer prognosis prediction. We tried to investigate the role of Ki-67 as a prognostic factor in stomach cancer after surgery in this study. Methods: We retrospectively evaluated 251 patients who underwent curative resection for gastric cancer from 2010 to 2015. In pathologic examination, Ki-67 labeling index was defined as the percentage of Ki-67 antigen positive cells. Prognostic significance of Ki-67 for gastric cancer was evaluated. Disease-free survival (DFS) was assessed as a primary end-point. Results: The median follow-up period was 28.0 months. Thirty-one patients (12.4%) showed Ki-67 labeling index (LI) lower than 25%. Sixty-eight patients (26.6%) showed recurrence during follow-up period. Recurrence was associated with Ki- 67 LI level (≤25%, P = 0.016), and lymph node metastasis status (P = 0.002). High Ki-67 LI level (>25%) was also related to p53 positivity (P < 0.001) and poorly cohesive type (P = 0.002). The 3-year DFS was 69.4%. Low Ki-67 LI level (≤25%) was related with low DFS (47.6% vs. 72.6%, P = 0.016). T stage (P < 0.001), N stage (P = 0.006), lymphovascular invasion (P = 0.010), and neuronal invasion (P = 0.001) also affected the DFS. In addition, T stage (P = 0.03) and Ki-67 LI (P = 0.035) were independent prognostic factors for DFS. In patients treated with adjuvant chemotherapy (n = 239, 93.4%), low Ki-67 (≤25%) was a poor prognostic factor for DFS (P = 0.013). Conclusion: Low Ki-67 LI predicts high rate of progression and low DFS of stomach cancer. Ki-67 LI can be a predictive marker in resected stomach cancer treated with surgery and adjuvant chemotherapy.

Comparison of Proliferative Activity in Each Histological Subtypes of Benign and Atypical Intracranial Meningiomas by PCNA and Ki-67 Immunolabeling

최승진,장은덕,권성오,계대곤,박춘근,이상원,강준기,Choi, Seung Jin,Chang, Eun Deok,Kwon, Seung Oh,Kye, Dae Kon,Park, Choon Keun,Lee, Sang Won,Kang, Joon Ki The Korean Neurosurgical Society 2000 Journal of Korean neurosurgical society Vol.29 No.9

목 적 : 양성 뇌수막종에 비하여 이형성 및 악성 뇌수막종이 나쁜 임상적인 예후 및 양상을 보이는 것은 잘 알려져 있으나, 양성 뇌수막종에 있어서 각각의 병리조직학적 아형에 따른 생물학적 양상의 차이에 대해서는 잘 알려지지 않거나 일부 논란이 되고있다. 본 연구에서는 이형성 뇌수막종 및 양성 뇌수막종의 각각의 병리조직학적 아형에 따른 증식능의 차이여부를 알아보고자 PCNA와 Ki-67표지지수를 분석하였다. 방 법 : 본원에서 뇌수막종으로 수술을 시행하여 얻은, 재발을 보여 재수술을 시행한 2례를 포함하여, 파라핀에 포매시킨 27개의 조직을 대상으로 병리학적인 증식능을 분석하기 위해, PCNA에 대한 단일항체 및 MIB-1 단일항체를 이용한 면역조직화학적 염색을 시행하였다. 조직학적 분류상 meningothelial type이 8례, transitional type이 9례, fibroblastic type이 5례였으며, 이형성 수막종이 5례였다. 결 과 : PCNA표지지수의 평균값은 양성 수막종에서 meningothelial type이 $4.82{\pm}5.10%$, transitional type이 $9.01{\pm}4.25%$, fibroblastic type이 $5.66{\pm}5.32%$를 보였으나 이형성 수막종에서는 $27.62{\pm}19.67%$의 높은 지수를 나타냈고, Ki-67 표지지수의 평균값은 양성 수막종의 아형에서 각각 $0.43{\pm}0.85%$, $0.44{\pm}1.08%$, $0.24{\pm}0.18%$를 보이고, 역시 이형성 수막종에서는 $0.84{\pm}0.59%$의 높은 지수를 보였다. 즉, 양성 수막종에서 각각의 아형에 따른 PCNA 및 Ki-67 표지지수는 통계학적으로 의미있는 차이는 없었으나(p>0.05), 이형성 수막종에서는 의미있는 높은 표지지수를 보여(p<0.05) 양성 수막종에서 보다 높은 증식능을 보임을 알 수 있었다. 결 론 : PCNA 및 Ki-67 표지지수를 이용한 증식능의 비교결과, 양성 뇌수막종에서는 각각의 아형에 따른 생물학적 양상이나 예후는 차이가 없을것으로 생각되나, 이형성 수막종에서는 높은 증식능을 보여 이에 대한 예후를 예상할 수 있을것으로 생각되며, 또한 이러한 표지지수가 병리조직학적으로 양성과 이형성의 감별에 많은 도움이 될것으로 사료된다. Objective : The clinical prognosis and biological behavior of atypical and especially malignant meningiomas are well known to be worse than benign meningioma, but the degree of biological aggressiveness in each classical subtypes of benign meningioma is controversy. This study was performed to see whether there is a difference in the proliferative activity between each different histological subtypes of benign meningioma as well as atypical meningioma. Methods : Paraffin-embedded surgical specimens of 27 meningiomas, including two recurrent tumors, were studied to evaluate proliferative activity by immunohistochemical method with monoclonal antibodies to proliferating cell nuclear antigen(PCNA) and MIB-1. The specimens consisted of 8 cases of meningothelial, 9 cases of transitional, 5 cases of fibroblastic subtypes and 5 cases of atypical meningiomas. Results : Mean PCNA labeling indices of meningothelial, transitional and fibroblastic meningiomas were $4.82{\pm}5.10%$, $9.01{\pm}4.25%$ and $5.66{\pm}5.32%$, but that of atypical meningiomas was $27.62{\pm}19.67%$, noting a higher value compared to all three subtypes of benign meningiomas. Mean Ki-67 labeling indices of the above 3 subtypes were $0.43{\pm}0.85%$, $0.44{\pm}1.08%$ and $0.24{\pm}0.18%$, and that of atypical meningiomas was also revealed to be of higher value ($0.84{\pm}0.59%$). PCNA and Ki-67 labeling indices were not statistically different between histological subtypes of benign meningioma(p>0.05), but the differences of both immunolabeling between benign and atypical meningiomas were statistically significant(p<0.05). Conclusion : Immunolabeling of PCNA and Ki-67 in intracranial meningiomas reveals no prognostic difference between meningothelial, transitional and fibroblastic subtypes in classical benign meningiomas by measuring expression of PCNA and Ki-67, but it seems to be helpful in differentiating benign and atypical meningioma, later showing more proliferative activity and biological aggressiveness.

Antigastritis effects of <i>Armillariella tabescens</i> (Scop.) Sing. and the identification of its anti-inflammatory metabolites

Lee, Seulah,Lee, Dahae,Park, Jun Yeon,Seok, Soonja,Jang, Tae Su,Park, Hyun Bong,Shim, Sang Hee,Kang, Ki Sung,Kim, Ki Hyun Pharmaceutical Society of Great Britain 2018 Journal of pharmacy and pharmacology Vol.70 No.3

Korean Dictionaries and Some Model Dictionaries of the World : Critical Essays toward the Plan for a New Korean Dictionary

Lee, Sang Sup,Nam, Ki Shim,Ahn, Sam Huan,Choi, Young Ai,Hong, Chai Song 연세대학교 언어정보개발원 1988 사전편찬학 연구 Vol.1 No.1

After briefly reviewing the history of lexcoigraphy in modem Korea, Nam Kishim tackles many problems created by the general deficiency of current Korean monolingual dictionaries in phonological morphological and semantic points. For example, most Korean dictionaries do not treat such phonological changes as the shortening of the stem vowel ㅓ in 더운, the prenominal form of the adjective 덥다, whose stem vowel ㅓ is pronounced long. He also takes issue with the practice of Korean dictionaries of including all kinds of proper names on little reliable principles : a typical dictionary enters a 600m-high hill while excluding better-known mountains higher than that. Hong Chai-song concentrates on the often misguiding information on transitive / intransitive verbs in current dictionaries. For example, a representative dictionary designates the verb 뛰다 simply as intransitive. But it is quite often used as an transitive also. In the sentence, 철수는 운동장을 뛰었다, 운동장 is the object of the transitive verb 뛰다. How could the compilers miss such an obvious fact? Hong suggests that they may have not been interested in being grammatically informative. A historical survey of the Oxford English Dictionary(OED) is given by Lee Sang-sup, with special emphasis on the vast amount of quotations from real sources contributed by thousands of volunteer readers through several decades and on its unwavering historical principle. A comparison between the OED's definition of Kimchi and a Korean dictionary's 김치 is given, showing the difference of principle in treating the same lexical item. Ahn Sam-huan presents a detailed account of Grimm's Deutsches Wo¨rterbuch which took generations of German lexicographers 133 years from its inception to its completion in 1971. On the basis of his study, Ahn suggests that future dictionary makers should cooperate as a group on a long-range comprehensive project. A moltivolume dictionary is an all-important cultural event for the whole nation, not to be influenced by private commercial interests. Choi Young-ai's survey of Chinese lexicography highlights the now on-going publication of 漢語字典 and 漢語詞典, admirable results of the cooperative effort of hundreds of Chinese scholars, a modus operandi for the Yonsei University graze to adopt in planning a new dictionary of the Korean language.

THE VARIATIONS OF JAPANESE APRICOT (PRUNUS MUME) CULTIVATED AROUND IN MTS. JIRI.

Lee,Jun-Ki,Hyun,Sang-Ki,Lee,Sang-Sun,Chai,Jung-Ki 한국자원식물학회 2002 Plant Resources Vol.5 No.1

Twenty-three plants of Japanese apricot (Prunus mume) were collected from several sites around Mountains JIRI in Korea. Japanese apricots having the different morphological features were evenly distributed in the groups made from the cluster analysis, indicating no geographic distributions but artificial vegetations in Korea. Japanese apricots were, as based on the PCR-RAPD techniques, clustered into the three groups; a group (prototype) having the five white petals with the five red sepals, a group (green type) having the five white petals with the five green sepals, and a group (hybrid type) having the more than five red petals with various colored sepals. The prototype apricots showed higher toxicities than other type apricot against bacteria and production of less compounds in TLC plates. The polypetal types of Japanes apricot were related to those of p. armebiaca in the characteristics of seed (the ruggedness), but also to be closed to those of p. armebiaca in PCR-RAPD analysis. The cluster analysis of the twenty three apricots and its related species calculated from the two primers were shown to distinguish relationships of cultivars within species, or of individual plants within cultivars, but also to display the two overlapping bands resulted from PCR-RAPD technique.

Ki-67 Expression Gives Additional Prognostic Information on St. Gallen 2007 and Adjuvant! Online Risk Categories in Early Breast Cancer

Jung, So-Youn,Han, Wonshik,Lee, Jong Won,Ko, Eunyoung,Kim, Eunkyu,Yu, Jong-Han,Moon, Hyeong-Gon,Park, In Ae,Oh, Do-Youn,Im, Seock-Ah,Kim, Tae-You,Hwang, Ki-Tae,Kim, Sung-Won,Noh, Dong-Young Springer - Society of Surgical Oncology 2009 Annals of Surgical Oncology Vol.16 No.5

Adult Patients with Congenital Muscular Torticollis Treated with Bipolar Release : Report of 31 Cases

Lee, Gun Sang,Lee, Myung Ki,Kim, Woo Jae,Kim, Ho Sang,Kim, Jeong Ho,Kim, Yun-Suk The Korean Neurosurgical Society 2017 Journal of Korean neurosurgical society Vol.60 No.1

Objective : We assessed the surgical results of bipolar release in 31 adult patients with uncorrected congenital muscular torticollis (CMT) and more than 12 months of follow-up. Methods : Thirty-one patients underwent a bipolar release of the sternocleidomastoid muscle (SCM) and were retrospectively analyzed. The mean follow-up period was 14.9 months (range, 12-30). The mean age at time of surgery was 30.3 years (range, 20-54). Patients were evaluated with a modified Lee's scoring system, cervicomandibular angle (CMA) measurement, and a global satisfaction rating scale using patient self-reporting. Results : The modified Lee's scoring system indicated excellent results in 4 (12.9%) patients, good in 18 (58.1%), and fair in 9 (29.0%) at the last follow-up after surgery. The improvements in neck movement and head tilt were statistically significant (p<0.05). The preoperative mean CMA was $15.4^{\circ}$ (range, 5.4-29.0), which was reduced to a mean of CMA of $6.3^{\circ}$ (range, 0-25) after surgery (p<0.05). The global satisfaction rating scale was 93.7% (range, 90-100). A transient sensory deficit on the ipsilateral lower ear lobe was noted in three cases. No significant permanent complications occurred. Conclusion : Bipolar release of the SCM is a safe and reliable technique for the treatment of CMT in adults.

초음파 영상 데이터를 활용한 내장기 추나요법 시술 부위 탐색 연구

이상진 ( Sang-jin Lee ),기성훈 ( Sung-hoon Ki ),고동균 ( Dong-kyun Koh ),이상훈 ( Sang-hun Lee ),임형호 ( Hyoung-ho Lim ),송윤경 ( Yun-kyung Song ) 한방재활의학과학회 2022 한방재활의학과학회지 Vol.32 No.2

Objectives This study was conducted to confirm anatomical information near the treatment areas of visceral chuna manual therapy and to secure stability and effectiveness during the treatment. Methods For 50 healthy adult men and women, a total of 13 ultrasound images were taken of the 7 treatment areas which are the representative treatment areas of visceral Chuna manual therapy. Results The treatment area of the bottom of the liver can be palpated around the right side ST19 and CV14. The treatment area of the gallbladder and the common bile duct can be palpated around the right side SP16 and ST20. The treatment area of the cardia and the pylorus can be palpated around the left side KI21, right side ST20, ST21, KI19, KI20, CV12, and CV13. The origin point of the mesentery root can be moved to the left and lower left from CV12 and can be palpated. The treatment area of the ileocecal valve and the cecum can be palpated around the right side SP14. The treatment area for the colic flexure can be palpated around the both side LR13. The treatment support point for the kidneys can be palpated around both side BL51. Conclusions It is thought that if the ultrasound image data from the meridians around the treatment site is used as an auxiliary, it will be more effective in terms of safety and effectiveness during the treatment of visceral Chuna manual therapy. (J Korean Med Rehabil 2022;32(2):139-154)

법률서비스 조직의 내부품질이 직원 및 고객의 만족도와 충성도에 미치는 영향: 서비스-수익 체인(S-PC) 모델을 중심으로

이상기(Lee, Sang-Ki),구자원(Gu, Ja-Won) 한국경영교육학회 2020 경영교육연구 Vol.35 No.1

[연구목적] 본 연구는 법률서비스 조직의 내부품질이 직원 및 고객의 만족도와 충성도에 미치는 영향을 분석하고, 그에 따른 시사점을 찾기 위하여 실증분석을 수행하였다. [연구방법] 본 연구를 위하여 서비스-수익 체인 모델을 활용하였으며, 183명의 변호사, 변리사, 기타 전문가들을 대상으로 설문을 수행하였으며, 분석을 위하여 SPSS와 AMOS 버전 25를 사용하였다. [연구결과] 실증분석 결과 서비스제공 준비수준은 직원만족도, 직원층성도, 고객충성도에 정(+)의 영향을 보였고, 고객만족도에는 유의미한 영향을 보이지 않았다. 내부서비스 품질은 직원만족도, 직원충성도, 고객만족도, 고객충성도 모두 유의미한 영향을 갖지 않는 것으로 나타났다. 서비스 생산성 및 품질은 고객만족도와 고객충성도에 정(+)의 영향을 미치는 것으로 나타났고, 직원만족도 및 직원충성도에는 유의미한 영향을 보이지 않았다. 서비스가치 전달은 고객만족도에 정(+)의 영향을 갖는 것으로 분석되었지만, 직원만족도, 직원충성도, 고객충성도에는 유의미한 영향을 갖지 않는 것으로 나타났다. 직원만족도와 고객충성도는 경영성과에 정(+)의 영향을 보였고, 직원충성도와 고객만족도는 경영성과에 영향을 미치지 않는 것으로 나타났다. [연구의 시사점] 본 연구에서는 선행연구에서 제시되는 내용과는 일부 다른 결과가 도출되었다. 이것은 법률서비스 및 서비스 제공자의 특수성에 기인한 것으로 판단된다. S-PC 모델이 단일 모델로 모든 성과경로를 설명하는 데에는 한계가 있다고 지적한 선행연구의 내용과 부합한다. S-PC 모델의 장점과 한계를 같이 이해하고, 산업과 기업(조직)의 특수성을 고려한 추가적인 검토가 함께 전략에 반영되어야 한다고 제시한다. [Purpose] This study conducted empirical analysis to analyze the impact of internal quality of legal service organization on employee and customer satisfaction and loyalty, and to find any implications accordingly. [Methodology] The Service-Profit Chain model was used to carry out this empirical study. For this study, 183 responses from lawyers, patent attorneys, customs agents, para-legals, patent technology experts, and legal support staffs were analyzed. A total of 20 hypotheses were set up and tested to verify. [Findings] As a result of the empirical analysis, the level of readiness for service provision had a positive effect on employee satisfaction, employee loyalty, and customer loyalty, but not on customer satisfaction. In terms of internal service quality, it had no meaningful effect on employee satisfaction, employee loyalty, customer satisfaction, and customer loy2alty. Service productivity and quality were found to have a positive effect on customer satisfaction and customer loyalty, but not on employee satisfaction and employee loyalty. Service value delivery had a positive effect on customer satisfaction, but did not have a meaningful effect on employee satisfaction, employee loyalty, and customer loyalty. Employee satisfaction and customer loyalty had a positive effect on operational performance, however employee loyalty and customer satisfaction did not affect operational performance. [Implications] This study has shown some different results from those generally understood due to the characteristics of the service and the propensity of the service provider. The research results are consistent with the findings of previous studies, which point out that the S-PC model, as an integrated single model, has limitations in explaining all performance path. This study explains the limitations of the S-PC model and suggests that additional considerations should be taken into account in the service strategy, while taking advantage of the merits as an integrated model and at the same time taking into account the specificity of each industry or organization.

출판학 연구 동향 및 특성에 관한 논문 - 한국출판학연구(1982~2006)를 중심으로 : 출판학 연구 동향 및 특성에 관한 논문

이기성(Lee Ki-Sung) 한국출판학회 2006 한국출판학연구 Vol.0 No.51

‘출판학 연구 동향 및 특성에 관한 논문―한국출판학연구(1982~2006)를 중심으로’ 연구 논문은 1982년도부터 2006년 6월 통권 제50호까지 한국출판학연구에 실린 272건의 논문을 분석한 것이다. 본 논문은 서론, 선행 연구 검토, 최종 매체별 구분, 출판 분야 및 단계별 구분, 언어 문자별 구분, 필자별 논문 구분, 결론의 7개 내용으로 구성되었다. 출판에 관한 분류 방법에 대하여는 민병덕 교수, 이기성 교수, 남석순 교수, 이종국 교수, 팽건염 교수, 기륜성남 교수 등 여러 학자가 이미 연구한 바 있다. 필자는 매체별 분류, 분야별 분류, 단계별 분류, 언어 문자별 분류의 4가지를 하나의 같은 범주 내에서 구분하는 것이 아니라 각기 다른 위치(차원)에서 구분하는 것이므로 논문이나 출판물은 하나이지만, 이것을 각기 4가지씩으로 분류하는 방법을 2000년도에 제안한 바 있다. 첫 번째 : 최종 매체(media)에 의한 논문 구분(① 종이 매체, ② 전자 매체(비종이 매체), ③ 공용의 3가지), 두 번째 : 분야(field)에 의한 논문 구분(① 교과서류, ② 단행본류, ③ 잡지류, ④ 신문류, ⑤ 일반), 세 번째 : 단계(step)에 의한 논문 구분(① 기획, ② 편집, ③ 제작, ④ 마케팅, ⑤ 총괄), 네 번째 : 언어(language) 문자에 의한 논문 구분(① 한국어, ② 영어, ③ 중국어, ④ 일본어, ⑤ 기타 문자) 결론적으로 첫째, 출판학이나 출판 산업을 분석하려면 2차원 이상으로 분류하는 방법(멀티차원분석법)이 필요하다. 둘째, 제작 단계와 편집 단계의 논문이 매우 필요하다. 셋째, 출판 관련 논문을 작성하는 필자가 절대적으로 부족하다. This study is divided into 7 parts ; Introduction, Classification systems, Classification -based on output media, Classification -based on publication fields and steps, Classification -based on language and letters, Classification -based on authors, and Conclusion. Theses given in the collection of learned papers of Studies of Korean Publishing Science have been issued from 1982 to 2006 are two hundred and seventy two. Many scholars have suggested the way of analyzing the publications and publishing industry. Professor B.D. Min’s method : General remark, Selection, Production, Distribution, Managing, and History. Professor K.S. Lee’s method : Divided with final output Media, Divide with publication Field(contnents), Divided with publication production Step, and Divided with typeset Language and letters. Professor S.S. Nam’s method : Theory of publishing, Education, Production, Circulation, Reception, Environment, Industry, Electronic Publishing, Law, and International Publishing. Professor J.G. Lee’s method : Theory, Copyright/Morals, Editing/Production, Textbook, Book, Magazine, Electronic Publishing, Management/Industry, Circumstances, International Publishing, and Reading/Reader. In this study, I propose the analyzing publications and publishing industry is not only one dimension but also more than two dimensions according to the angles of vision. The first dimension is divided into 3 sections based on output media, such as Paper, Electron(non-paper), and altogether. The second dimension is divided into 5 sections based on publishing field, such as Textbook, Book, Magazine, Newspaper, and General(the others). The third dimension is divided into 5 sections based on production step, such as Planning, Editing, Production, Marketing, and General(basis). The fourth dimension is also divided into 5 sections based on language and letters, such as Korean character, English, Chinese, Japanese, and the others. Multi Dimension Analysis(MDA) which is using more than two dimensions is the most suitable way of analyzing the publications and the theses related to publishing.