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나춘기,이무성,홍순강 木浦大學校 工業技術硏究所 1997 工業技術硏究誌 Vol.7 No.-
The purpose of this study is to examine the reusability of fly ashs produced by coal-fired power plants as an raw material in the manufacturing process of building resources such as brick, by investigating, in first, the mineralogical and chemical properties of raw materials including fly ashs of the Honam and the Samcheonpo thermal power plants and clay of the Hwangdeung area, and then examining the quility of pilot productions of fly ash-clay brick having various mixing proportions of fly ash. In general, the coal fly ashs separated in grain size under 200mesh and of Honam power plant have higher alkali contents but lower unburned carbon residues than those over 200mesh and of Samcheonpo power plant. This higher contents of alkali components such as CaO and Na2O and lower contents of unburned carbon have contributed to make dense structure in fly ahs-clay brick manufactured. Therefore, the clay brick manufactured by mixture of the Honam fly ash have more dence structure and much higher compressional strength than that of the Samcheonpo, and shows the trend of increasing the compressional strength from 1100-1300kg/㎠ to 170kg/㎠ with increasing the proportion of fly ash part from 10% to 50%. In contrast to Honam fly ash, the compressional strength of clay brick produced by the Samcheonpo fly ash decrease from 600-720kg/㎠ to 270-300kg/㎠ with increasing the mixing ratio of fly ash from 10% to 50%, due to high unburned carbon contents and low alkali contents of Samcheonpo fly ash.
침전반응법으로 합성한 수산아파타이트 분말의 중금속 흡착 특성 및 폐수중의 유해 금속 제거제로서의 유용성
이무성,나춘기,이미숙,김옥배,김문영,Lee, Mu Seong,Na, Choon Ki,Lee, Mi Suk,Kim, Oak Bae,Kim, Moon Young 대한자원환경지질학회 1995 자원환경지질 Vol.28 No.3
It is well known that hydroxyapatite [$Ca_{10}(PO_4)_6(OH)_2$] have an exchangeability for various heavy metal ions in aqueous solution. To evalute the feasibility of employing the synthetic hydroxyapatites as an eliminatable exchanger for environmentally noxious caions in waste water, the adsorption properties, the removal capacities and the selectivity of the apatites for various cations were investigated in more detailed. The heavy metal cations have been exchanged in calcium part of hydroxyapatite. The order of the degree of amount exchanged of the investigated cations is $Pb^{2+}>Cd^{2+}>Zn^{2+}>Ba^{2+}$. The molar ratios between released $Cd^{2+}$ ions and remeved divalent metal cations in the reacted solution with hydroxyapatite are roughly close to an integer 1.0, suggesting that an ion-exchange reaction could have played a major role in the removal of heavy metals rather then an adsorption effect. The exchangeability of the hydroxyapatite powder of Ca/P molar ratio 1.67, which have specipic surface area of $104.5m^2g^{-1}$, appeared to be better then $237.6{\mu}g$ per g for $Pb^{2+}$ ions. The removal capacity of the heavy metal ions varies directly as particle size of hydroxyapatites. All evidences obtained indicate that the synthesized hydroxyapatite powders by precipitation reaction method can be employed as an effective cation exchanger for eliminating noxious ions in waste water even in some improvemental.
Beneficial Effects of Cynaroside on Cisplatin-Induced Kidney Injury In Vitro and In Vivo
Nho, Jong-Hyun,Jung, Ho-Kyung,Lee, Mu-Jin,Jang, Ji-Hun,Sim, Mi-Ok,Jeong, Da-Eun,Cho, Hyun-Woo,Kim, Jong-Choon Korean Society of ToxicologyKorea Environmental Mu 2018 Toxicological Research Vol.34 No.2
Anti-cancer drugs such as cisplatin and doxorubicin are effectively used more than radiotherapy. Cisplatin is a chemotherapeutic drug, used for treatment of various forms of cancer. However, it has side effects such as ototoxicity and nephrotoxicity. Cisplatin-induced nephrotoxicity increases tubular damage and renal dysfunction. Consequently, we investigated the beneficial effect of cynaroside on cisplatin-induced kidney injury using HK-2 cell (human proximal tubule cell line) and an animal model. Results indicated that $10{\mu}M$ cynaroside diminished cisplatin-induced apoptosis, mitochondrial dysfunction and caspase-3 activation, cisplatin-induced upregulation of caspase-3/MST-1 pathway decreased by treatment of cynaroside in HK-2 cells. To confirm the effect of cynaroside on cisplatin-induced kidney injury in vivo, we used cisplatin exposure animal model (20 mg/kg, balb/c mice, i.p., once a day for 3 days). Renal dysfunction, tubular damage and neutrophilia induced by cisplatin injection were decreased by cynaroside (10 mg/kg, i.p., once a day for 3 days). Results indicated that cynaroside decreased cisplatin-induced kidney injury in vitro and in vivo, and it could be used for improving cisplatin-induced side effects. However, further experiments are required regarding toxicity by high dose cynaroside and caspase-3/MST-1-linked signal transduction in the animal model.
Biliary atresia: color doppler US findings in neonates and infants.
Lee, Mu Sook,Kim, Myung-Joon,Lee, Mi-Jung,Yoon, Choon Sik,Han, Seok Joo,Oh, Jung-Tak,Park, Young Nyun Radiological Society of North America 2009 Radiology Vol.252 No.1
<P>PURPOSE: To describe color Doppler ultrasonographic (US) findings in livers of neonates with biliary atresia (BA) and to compare them with US findings in livers of neonates with non-BA and control subjects. MATERIALS AND METHODS: Institutional review board approval was obtained; acquisition of informed consent was exempted. US and color Doppler US findings were retrospectively reviewed in 64 patients with neonatal cholestasis and 19 control subjects. BA and non-BA were confirmed in 29 and 35 patients, respectively. Three pediatric radiologists assessed US and color Doppler US images, independently documented their findings, and resolved discrepancies by consensus. Triangular cord (TC) sign, gallbladder length, and hepatic artery and portal vein diameters were evaluated on US images. The presence of hepatic subcapsular flow was evaluated on color Doppler US images. Diagnostic value of TC sign and hepatic subcapsular flow in the diagnosis of BA were evaluated. Significance of hepatic artery and portal vein diameters in each group was assessed. RESULTS: In the diagnosis of BA, sensitivity and specificity of the TC sign on US images were 62% and 100%, respectively. On color Doppler US images, hepatic subcapsular flow was detected in all patients with BA and in five patients with non-BA. At the first review, there was a discrepancy between radiologists in interpretation of hepatic subcapsular flow in patients with non-BA. However, consensus was reached at the second review. There was no hepatic subcapsular flow in control subjects. Sensitivity and specificity of hepatic subcapsular flow on color Doppler US images were 100% and 80%-86%, respectively, on the basis of individual interpretations of reviewers. Sensitivity and specificity of hepatic subcapsular flow on color Doppler US images were 100% and 86%, respectively, on the basis of consensus reading. Mean diameter of the hepatic artery in patients with BA (2.1 mm +/- 0.7 [standard deviation]) was significantly larger than that in patients with non-BA (1.5 mm +/- 0.4, P < .001) and control subjects (1.5 mm +/- 0.4, P = .001). CONCLUSION: The presence of hepatic subcapsular flow is useful for differentiating between BA and other causes of neonatal jaundice.</P>
Subchronic toxicity evaluation of ethanol extract of <i>Cassia tora</i> L. seeds in rats
Lee, Mu-Jin,Nho, Jong-Hyun,Yang, Beo-Deul,Park, Ho,Lee, Hyun-Joo,Lee, Ki-Ho,Jang, Ji-Hun,Jung, Ho-Kyung,Kim, Sun-Ra,Cho, Hyun-Woo,Park, Hae-Sung,Lim, Je-Oh,Kim, Jong-Choon Elsevier 2019 Regulatory toxicology and pharmacology Vol.109 No.-
<P><B>Abstract</B></P> <P> <I>Cassia tora</I> Linn. is an annual or perennial plant of the Fabaceae/Leguminosae family. It is used in traditional medicine for various biological activities including anti-constipation, anti-inflammatory, visual acuity, and hepato-protective activities. The present study was carried out to investigate the potential toxicity of <I>C. tora</I> L. seed ethanol extract (CTSEE) following a 13-week repeated oral administration to Sprague-Dawley rats. CTSEE was administered orally to male and female rats for 13 weeks at 0 (control), 500, 1000, and 2000 mg/kg/day (<I>n</I> = 10, for male and female rats for each dose). Additional recovery groups from the control group and high dose group were observed for a 4-week recovery period. At the end of the treatment and recovery periods, animals were sacrificed, and their organs were weighed and blood samples collected. There were no treatment-related adverse effects in clinical signs, body weight, food consumption, estrous cycle, sperm parameters, urinalysis, hematology, serum biochemistry, necropsy findings, organ weight, and histopathology at any doses tested. Under the present experimental conditions, the no-observed-adverse-effect level of the CTSEE was >2000 mg/kg/day in both genders, and no target organs were identified.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Subchronic toxicity of <I>Cassia tora</I> L. seed ethanol extract (CTSEE) were investigated. </LI> <LI> No significant adverse effects were observed in the repeated dose toxicity study. </LI> <LI> The oral NOAEL of CTSEE was >2000 mg/kg/day in rats of both genders. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
이무춘(Mu Choon Lee),손승민(Seung Min Son),강민지(Min Ji Kang) 한국환경정책학회 2010 한국환경정책학회 학술대회논문집 Vol.2010 No.2
As climate change is emerging as an international issue and the importance of local government`s role for climate change countermeasure is growing, domestic municipal organizations are setting up counterplans for climate changes. While local municipalities are a specific space experiencing the effects and damages of climate changes, municipal governments are desired to take administrative measures closely related to citizens life as an important entity of executing mitigation and adaptation of climate changes, In particular, adaptation is a process through which societies help themselves to cope with an uncertain future, Adapting to climate changes entails taking the right measures to reduce the negative effects of climate changes (or exploit the positive ones) by making appropriate adjustments and changes. Methods of vulnerability assessment have been developed over the past several years in climate exposure, sensitivity and adaptive capacity, However, current local or community level vulnerability assessment studies are not done well. Therefore, local and community level vulnerability assessments were conducted for an adaptation planning of the local government Wonju.
폐기물 처리시설 입지선정의 효율화 방안에 관한 연구 - 여주군 폐기물 매립지 입지선정 사례를 중심으로 -
이무춘(Mu Choon Lee),구자건(Ja Kon Koo),김기철(Ki Cheol Kim),권연정(Yeon Jeong Kwon) 한국환경영향평가학회 1999 환경영향평가 Vol.8 No.1
The comparative evaluation is the most effective method for site selection because the selection of waste treatment facility is to determine the optimum site out of limited candidate sites. This study adopted the ordinal scale evaluation, one of methods of comparative evaluation. The ordinal scale evaluation aims to determine the investigating items referring to the character of sites, to determine the importance factors for investigating items, and to determine the optimum site according to the quantitative evaluation. As a result of this study, the defects of the former reports on the environmental characteristics, such as obscurity of meaning and subjective statement, were reduced by the ordinal scale evaluation which is one of the quantitative evaluation methods. This ordinal scale evaluation method has some valuable advantages, such as, to be able to consider the cost-effect efficiency, to consider the objectiveness and the clearness of the reports on the environmental characteristics. Therefore the reducement of social complications about site selection of the indisposed facilities could be expected by this study.