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Stress related activities of Sun-ginseng in SD Rats and ICR Mice
( Geum Seon Lee ),( Blendyl Saguan Tan Lee ),( Mi Kang Kim ),( Kyung Uoo Dong ),( Joo Yun Kim ),( Gu Young Yu ),( Jeong Sup Han ),( Hong Sook Ko ),( Il Ho Park ),( Jae Hoon Cheong ) 한국응용약물학회 2004 Biomolecules & Therapeutics(구 응용약물학회지) Vol.12 No.4
Geum Seon Lee,Tae Jin Kang 대한약학회 2021 약학회지 Vol.65 No.1
Our previous study reported that cuttlebone (CB) extract shows wound healing activity and enhances cell migration. In the present study, we examined the anti-inflammatory effect of CB in RAW 264.7 cells activated with lipopolysaccharide (LPS) for induction of inflammation. The expression of inflammatory mediators, including proinflammatory cytokines, was measured using enzyme-linked immunosorbent assay (ELISA) and reverse transcription polymerase chain reaction (RT-PCR) tests. The results showed that CB suppressed nitric oxide (NO) production in macrophages stimulated with LPS. Production of pro-inflammatory cytokines, such as tumor necrosis factor alpha (TNFα), interleukin (IL)-1β, and IL-6, decreased in LPS-induced RAW 264.7 cells after treatment with CB in a dose-dependent manner. Additionally, gene expression was inhibited by CB in a dose-dependent manner in LPS-stimulated macrophages. Furthermore, CB inhibited nuclear factor kappa B (NF-KB) p65 activation in macrophages activated with LPS. Therefore, these results suggest that CB exerts its anti-inflammatory effects via regulation of the NF-KB signaling pathway.
Success and Failure of Surgical Endodontic Treatment in Molar Teeth
Geum, Yun-Seon,Lee, Jang-Ryeol,Kim, Hyeon-Cheol,Lee, Sang-Cheol,Kim, Yeong-Uk Korean Academy of Dental Science 2010 Journal of korean dental science Vol.3 No.2
Despite the latest advancement made in its techniques and devices/apparatuses and the resulting rising expectation in the field of dental surgery, apicoectomy performed in the molar teeth remains a technical challenge and lacks evidence substantiated by long-term follow-up studies. This study sought to investigate the treatment outcomes and post-operative success rate in the root-end resected molar teeth accompanied by a high level of surgical risks due to their close proximity to the mandibular canal and maxillary sinus. A total of 68 patients who received treatment at Livingwell Dental Hospital between 2004 and 2010 and underwent apical surgery in the maxillary or mandibular molar area were enrolled in this study. A total of 160 roots collected from 75 molar teeth were subjected to surgical endodontic treatment and subsequently evaluated clinically as well as radiographically. Based on the results of the study, the clinical success rate was found to be 78.8% in cases involving radiological healing. Likewise, 90.7% of the roots recorded a robust clinical survival rate, but with incomplete healing as shown by radiography. The results indicate that the apical procedure involving molar teeth is a prognosis-friendly method that promises positive outcomes and higher success rate based on long-term follow-up observations.
Lee, Geum Seon,Yim, Dongsool,Cheong, Jae Hoon,Kang, Tae Jin Informa Healthcare 2012 IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY Vol.34 No.6
<P>Our previous report showed that Hydnocarpi Semen (HS) extract has wound repair activity at ulcer lesion in diabetic mice. In this study, fractions of <I>n</I>-Hexane, ethylacetate (EtOAc), and butanol (BuOH) from HS crude extract were evaluated for their wound healing activity by using <I>in vivo</I> diabetic ulcer models and <I>in vitro</I> acute inflammation model. Although <I>n</I>-Hexane and EtOAc fractions promote wound healing in mice with ulcer, the BuOH fraction exhibited the most potent wound healing activity and the wound area score significantly decreased after treatment of BuOH fraction even at dose of 2 mg/kg. BuOH fraction stimulated macrophages to increase the production of nitric oxide (NO) and TNF-α. The BuOH fraction also enhanced the production of TGF-β and VEGF, which were involved in fibroblast activation and angiogenesis. The mRNA expression and activation of MMP-9 were increased by three fractions and the activity was higher in BuOH fraction-treated group compared to the other groups. The mechanism that the HS helps to promote healing of diabetic ulcer is possibly associated with the production of TNF-α, a proinflammatory cytokine, as well as the secretion of VEGF, TGF-β, and MMP-9, which were involved in proliferation of capillaries and fibroblasts. These results suggest that HS can be a new candidate material for the treatment of wound in skin ulcer.</P>
The Role of the Ethylacetate Fraction from Hydnocarpi Semen in Acute Inflammation In Vitro Model
Lee, Geum Seon,Shim, Hong,Lee, Ki-Man,Kim, Seung Hyun,Yim, Dongsool,Cheong, Jae Hoon,Kang, Tae Jin The Korean Association of Immunobiologists 2012 Immune Network Vol.12 No.6
We previously reported that Hydnocarpi Semen (HS) has a wound healing effect on diabetic foot ulcer lesion in mice. In this study, ethylacetate (EtOAc) fraction from HS extract were evaluated for their wound healing activity by using in vitro acute inflammation model. GC and GC/MS analysis shows that the main constituents in EtOAc fraction are chaulmoogric acid, hydnocarpic acid, and gorlic acid. EtOAc fraction activated macrophages to increase the production of TNF-${\alpha}$. The fraction also increased the production of TGF-${\beta}$ and VEGF, which induced fibroblast activation and angiogenesis. These results suggest that the mechanism that the fraction helps to enhance healing of skin wound is possibly associated with the production of TNF-${\alpha}$, as well as secretion of VEGF, TGF-${\beta}$ and HS may have a new bioactive material for the treatment of skin wound.
이금선(Geum-Seon Lee),윤미은(Mi-Eun Yun) 한국콘텐츠학회 2021 한국콘텐츠학회논문지 Vol.21 No.2
본 연구의 목적은 다회차 음주에 따른 장소별 음주량과 알코올의존을 분석하는 것이다. 국제 알코올 통제연구의 일환으로 2012년에 수집된 단면 데이터를 사용하였으며, 만19-64세 음주자 1,789명 중 855명을 대상으로 하였다. 다회차 음주자 비율은 남성(χ²=37.607, p<.001), 학생(χ²=52.466, p<.001), 미혼자(χ²=34.205, p<.001), 흡연경험이 있거나 스트레스가 있는 군(χ²=40,09, p<.001, χ²=21.66, p<.001)에서 유의적으로 높았다. 특히, 미혼자, 흡연자, 스트레스군의 알코올 섭취량이 기혼자, 비흡연자, 비스트레스군보다 유의적으로 더 높았다. 다회차에 걸쳐 알코올 섭취량이 가장 높은 장소는 주류 판매 업종인 술집으로 나타났다(F=67.8g, p<0.001). 음주자의 음주차수가 증가할수록 총 알코올 섭취량이 증가하였으며(F=209.993, p<0.001) 알코올의존도 검사인 RAPS4와 DSM-IV에서 양성 반응을 나타낸 음주자의 수(%)가 각각 (F=129.836, p<0.001; F=94.669, p<0.001) 증가하였다. 음주자 중 알코올의존 교차비는 남성이 여성보다 2.3(95% CI: 1.745-3.057)배, 무직자는 직장인보다 3차에서 3.2(95% CI: 1.053-9.838)배, 흡연자는 비흡연자보다 3차에서 3.9(95% CI: 1.230-12.292)배, 그리고 스트레스군도 비스트레스군보다 2.1(95% CI:1.561-2.768)배 높았다. 결론적으로 음주차수가 증가할수록 흡연여부나 스트레스와의 관련성과 알코올 의존도가 높아져 알코올에 더 취약할 수 있음을 시사한다. The purpose of this study was to analyze the alcohol volume consumed and alcohol dependancy according to multiple rounds of drinking. Sectional data collected in 2012 as part of an International Alcohol Control Study were used, and 855 of 1,789 drinker aged 19 to 64 were conducted. The proportion of multiple rounds drinking were significantly higher in males(χ²=37.607, p<.001), students(χ²=52.466, p<.001), single(χ²=34.205, p<.001), smoking experience and stressed(χ²=40,09, p<.001; χ² =21.66, p<.001) among drinkers. In particular, the alcohol volume consumed of unmarried people, smokers, and stress groups were significantly higher than married people, non-smokers and no-stress group. The highest alcohol intake in the first, 2nd and third rounds was found in bars in the liquor trade (F=67.8g, p<0.001). The total alcohol intake increased as the number of rounds increased (F=209.993, p=0.001) and the number of drinkers who tested positive for alcohol dependency increased, using the tests RAPS4 and DSM-IV(F=129.836, p<0.001; F=94.669, p<0.001). The OR of alcohol dependancy in males was 2.3(95% CI: 1.745-3.057), unemployed was 3.2(95% CI: 1.053-9.838), smokers was 3.9(95% CI: 1.230-12.292), and stress group was 2.1(95% CI: 1.561-2.768) compared to females, employed, non-smokers, and no-stress group respectively. In conclusion, it suggests that those consuming multiple rounds drinking can become more vulnerable to alcohol harms due to its relation to smoking, stress and increased dependence on alcohol.