암환자의 삶의 질 도구개발

태영숙,강은실,이명화,박금자 성인간호학회 2000 성인간호학회지 Vol.12 No.4

This study was undertaken to develop an instrument to be used for measuring the concept of duality of life of Korean patients with cancer multidimensionary and correctly. It can contribute in holistic nursing care for Korean cancer patients and also provide and validate basic data to help oncology nurses measure the outcome of nursing intervention correctly. To develop this instrument, the researchers first estabilished a conceptual framework based on the results of qualitative data analysis and indepth interview method Development of the scale was conducted using a method in which 31 items were assessed by subjects' self report using linear analogue scales. The subjects were 79 D.M. Patients. 103 patients with acute illness, and 91 cancer Patients residing in Busan, Korea. Data were collected during the period from July, 24 to August 14. 2000. This instrument consisted of 31 items with a self report stale. This instrument covered 4 dimensions of cancer patients : 1) Physical wellbeing 2) psychological wellbeing 3) social wellbeing and 4)spiritual wellbeing. Each item had a possible score of 10. The reliability of the scale was tested with Cronbach's alpha. Validity was evaluated by examining the relationships of this scale. Youn's Quality of Life Questionnare scores and the Simple Quality of Life scale. Two separate runs of multiple regression were used to predict scores on the Simple Quality of Life measuremend. Further validation was obtained by examining the correlation between the instrument subscores and Youn's Quality of Life measurement subscore for convergence of this scale. Examination of the discriminant. power of the instrument was done using ANOVA test. The results are summarized as follows : 1.The reliability of the instrument for the quality of life was 0.8321 (Cronbach's alpha.), physical wellbeing dimension 0.6343. Psychological wellbeing dimension 0.6501, spiritual wellbeing dimension 0.5883. 2.This instrument had a high correlation with Youn's Quality of Life measurement(r= 0.636) in cancer Patients, whereas it had a low correlation with Simple Quality of Life measurement(r= 0.455) in cancel patients. In the D.M. patients, the instrument correlated with both the Youn's Quality of Llfe measurement and Simple Quality of life measurement(r=0.313. r= 0.407) and in the acute stage patients. the instrument had no correlation. 3.Multiple regression of individual Items on the Simple Quality of Life scores accounted for 56.8% of the variance in the Simple Quality of Life measurement, whereas, Youn's Quality of Life measurement scores accounts for 31.7%. The correlations collected from the three group had the same patterns of variations but especially the instrument developed in this study had higher disciminant power than that of Youn's Quality of Life Measurement.

Imperforate Hymen Causing Hematocolpos and Acute Urinary Retention in a 14-Year-Old Adolescent

Lee, Geum Hwa,Lee, Mi-Jung,Choi, Young Sik,Shin, Jae Il Korean Society of Pediatric Nephrology 2015 Childhood kidney diseases Vol.19 No.2

We report the case of a 14-year-old girl who visited the emergency room because of suprapubic discomfort and sudden acute urinary retention. She did not have any significant medical and surgical history, and her neurological examinations were all normal. Urinary catheterization led to the passage of 500 mL urine. Abdominal ultrasonography showed a hematocolpos that was compressing the urinary bladder. Gynecologic history taking revealed that the patient has not had menarche yet. Therefore, a cruciate incision was performed and her urination became normal. As the surgical outcome after adequate hymenotomy for imperforate hymen is usually good, the diagnosis of imperforate hymen is important. However, this condition is easily missed in the clinic because the first physician visited by the patient rarely takes a detailed gynecologic history or performs appropriate physical examinations. Although rare, imperforate hymen should be considered as a cause of acute urinary retention in the adolescence period. If an adolescent girl presents with abdominal pain and voiding dysfunction, a detailed gynecologic history and appropriate physical examinations of the genital introitus should be performed.

Imperforate Hymen Causing Hematocolpos and Acute Urinary Retention in a 14-Year-Old Adolescent

Geum Hwa Lee,이미정,최영식,신재일 대한소아신장학회 2015 Childhood kidney diseases Vol.19 No.2

We report the case of a 14-year-old girl who visited the emergency room because of suprapubic discomfort and sudden acute urinary retention. She did not have any significant medical and surgical history, and her neurological examinations were all normal. Urinary catheterization led to the passage of 500 mL urine. Abdominal ultrasonography showed a hematocolpos that was compressing the urinary bladder. Gynecologic history taking revealed that the patient has not had menarche yet. Therefore, a cruciate incision was performed and her urination became normal. As the surgical outcome after adequate hymenotomy for imperforate hymen is usually good, the diagnosis of imperforate hymen is important. However, this condition is easily missed in the clinic because the first physician visited by the patient rarely takes a detailed gynecologic history or performs appropriate physical examinations. Although rare, imperforate hymen should be considered as a cause of acute urinary retention in the adolescence period. If an adolescent girl presents with abdominal pain and voiding dysfunction, a detailed gynecologic history and appropriate physical examinations of the genital introitus should be performed.

Protective effect of Curcuma longa L. extract on CCl4-induced acute hepatic stress

Geum-Hwa Lee,Hwa-Young Lee,Min-Kyung Choi,Hyung-Ryong Kim,Han-Jung Chae 한국식품영양과학회 2016 한국식품영양과학회 학술대회발표집 Vol.2016 No.10

4-phenylbutyric Acid Regulates Collagen Synthesis and Secretion Induced by High Concentrations of Glucose in Human Gingival Fibroblasts

Lee, Geum-Hwa,Oh, Hyo-Won,Lim, Hyun-Dae,Lee, Wan,Chae, Han-Jung,Kim, Hyung-Ryong The Korean Society of Pharmacology 2011 The Korean Journal of Physiology & Pharmacology Vol.15 No.6

High glucose leads to physio/pathological alterations in diabetes patients. We investigated collagen production in human gingival cells that were cultured in high concentrations of glucose. Collagen synthesis and secretion were increased when the cells were exposed to high concentrations of glucose. We examined endoplasmic reticulum (ER) stress response because glucose metabolism is related to ER functional status. An ER stress response including the expression of glucose regulated protein 78 (GRP78), C/EBP homologous protein (CHOP), inositol requiring enzyme alpha (IRE-$1{\alpha}$) and phosphoreukaryotic initiation factor alpha (p-eIF-$2{\alpha}$) was activated in the presence of high glucose. Activating transcription factor 4 (ATF-4), a downstream protein of p-eIF-$2{\alpha}$ as well as a transcription factor for collagen, was also phosphorylated and translocalized into the nucleus. The chemical chaperone 4-PBA inhibited the ER stress response and ATF-4 phosphorylation as well as nuclear translocation. Our results suggest that high concentrations of glucose-induced collagen are linked to ER stress and the associated phosphorylation and nuclear translocation of ATF-4.

Antimelanogenic Effects of Picrionoside A Isolated from the Leaves of Korean Ginseng

Lee, Dae-Young,Jeong, Sang Chul,Jeong, Yong Tae,Lee, Mi-Kyoung,Seo, Kyeong-Hwa,Lee, Jae-Won,Kim, Geum-Soog,Lee, Seung-Eun,Baek, Nam-In,Kim, Jin Hee Pharmaceutical Society of Japan 2015 Biological & pharmaceutical bulletin Vol.38 No.10

<P>This study was initiated to isolate active metabolites from the leaves of Panax ginseng. Among them, picrionoside A, a megastigmane glucoside, was isolated from the leaves of P. ginseng C. A. MAYER and its chemical structure was determined based on spectroscopic methods, including FAB-MS, one-dimensional (1D)-NMR, 2D-NMR, and IR spectroscopy. Picrionoside A from P. ginseng has not been investigated previously, and its biological or pharmaceutical activities have not been reported elsewhere. The IC50 value of mushroom tyrosinase-inhibitory activity of picrionoside A was 9.8???µM, and the rate of inhibition of synthesized melanin content in melan-a cells was 17.1% at a concentration of 80???µM without cytotoxicity. Furthermore, picrionoside A dramatically reduced body pigmentation in the zebrafish model. Taken together, the results suggest that picrionoside A isolated from the leaves of P. ginseng may be an effective skin-whitening agent that could be a potent candidate material in the cosmetic industry.</P>

Turmeric extract and its active compound, curcumin, protect against chronic CCl4-induced liver damage by enhancing antioxidation

Hwa-Young Lee,Seung-Wook Kim,Geum-Hwa Lee,Min-Kyung Choi,Han-Wool Jung,Young-Jun Kim,Ho-Jeong Kwon,Hyung-Ryong Kim,Han-Jung Chae 한국식품영양과학회 2016 한국식품영양과학회 학술대회발표집 Vol.2016 No.10

<i>Eucommia ulmoides</i> leaf (EUL) extract enhances NO production in ox-LDL-treated human endothelial cells

Lee, Geum-Hwa,Lee, Hwa-Young,Choi, Min-Kyung,Choi, An-Hong,Shin, Tai-Sun,Chae, Han-Jung Elsevier 2018 Biomedicine & pharmacotherapy Vol.97 No.-

<P><B>Abstract</B></P> <P> <I>Eucommia ulmoides</I> leaves (EULs), referred to as Du-zhong, are utilized to lower blood pressure and improve liver and kidney tone, and also have been applied to cardiovascular disease in Korea, China, and Japan. Endothelial dysfunction, which is caused by endothelial nitric oxide synthase (eNOS) uncoupling, is an initial step in atherosclerosis. In this study, we investigated the protective effects of EUL aqueous extract against ox-LDL-induced eNOS uncoupling and its possible mechanisms in human umbilical vein endothelial cells (HUVECs). A EUL component, aucubin, was also applied to ox-LDL-exposed HUVECs. Whereas ox-LDL significantly decreased nitric oxide (NO) levels in HUVECs, EUL extract and aucubin led to significant recovery of NO levels. When treated with ox-LDL in the presence of EUL extracts or aucubin, O<SUB>2</SUB> <SUP>-</SUP> production was markedly reduced in HUVECs compared to treatment with ox-LDL alone. EUL extract and aucubin also led to recovery of phospho-eNOS Thr495 expression, a critical signaling component in eNOS uncoupling, suggesting that EUL has regulatory effects against eNOS uncoupling and might play preventive/regulatory roles against vascular endothelial dysfunction.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

4-phenylbutyric Acid Regulates Collagen Synthesis and Secretion Induced by High Concentrations of Glucose in Human Gingival Fibroblasts

Geum-Hwa Lee,Hyo-Won Oh,Hyun-Dae Lim,Wan Lee,Han-Jung Chae,Hyung-Ryong Kim 대한생리학회-대한약리학회 2011 The Korean Journal of Physiology & Pharmacology Vol.15 No.6

High glucose leads to physio/pathological alterations in diabetes patients. We investigated collagen production in human gingival cells that were cultured in high concentrations of glucose. Collagen synthesis and secretion were increased when the cells were exposed to high concentrations of glucose. We examined endoplasmic reticulum (ER) stress response because glucose metabolism is related to ER functional status. An ER stress response including the expression of glucose regulated protein 78 (GRP78), C/EBP homologous protein (CHOP), inositol requiring enzyme alpha (IRE-1Ձ) and phosphor- eukaryotic initiation factor alpha (p-eIF-2Ձ) was activated in the presence of high glucose. Activating transcription factor 4 (ATF-4), a downstream protein of p-eIF-2Ձ as well as a transcription factor for collagen, was also phosphorylated and translocalized into the nucleus. The chemical chaperone 4-PBA inhibited the ER stress response and ATF-4 phosphorylation as well as nuclear translocation. Our results suggest that high concentrations of glucose-induced collagen are linked to ER stress and the associated phosphorylation and nuclear translocation of ATF-4.

Platycodi Radix and its active compounds ameliorate against house dust mite-induced allergic airway inflammation and ER stress and ROS by enhancing anti-oxidation

Lee, Hwa-Young,Lee, Geum-Hwa,Kim, Hye-Kyung,Chae, Han-Jung Elsevier 2019 Food and chemical toxicology Vol.123 No.-

<P><B>Abstract</B></P> <P>Allergic airway inflammation is an increasing global health problem, and novel strategies to prevent or ameliorate the condition are needed. The endoplasmic reticulum (ER) is involved in protein synthesis and maturation, and is a susceptible to sub-organelle stress including inflammation and ROS-amplifying signaling. Here, the effects of Platycodi Radix extracts (PRE) on house dust mite (HDM) extract (<I>Dematophagoides pteronyssius</I>)-induced asthma were investigated. Following 50, 100, or 200 mg/kg-PRE-treatment, the infiltration of inflammatory cells, ER stress, and NF-κB signaling were controlled. The expression of inflammatory cytokines and mucin5AC was also inhibited in the presence of PRE. Consistently, in the HDM-exposed human bronchial epithelial cells, ER stress and its associated ROS were significantly increased along with NF-κB signaling, which was also attenuated by PRE and its components. This study suggests that PRE might be useful as a therapeutic/preventive agent in HDM-associated allergic airway inflammation. ER stress and its associated ROS signaling involved in inflammation provide additional mechanistic insight into the underlying molecular mechanism.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Platycodi Radix inhibits HDM-induced allergic airway inflammation response in mice. </LI> <LI> Platycodi Radix protects HDM-induced nuclear translocation of NF-κB p65 and cytokine expression in mice. </LI> <LI> Platycodi Radix regulates HDM-induced ER stress, lipid peroxidation and ROS accumulation in mice. </LI> <LI> Platycoside E, platycodin D<SUB>3</SUB> and Platycodi Radix inhibits HDM-induced allergic airway inflammation response in mice. </LI> </UL> </P>