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Effect of Anti-glaucoma Agents on Myopic Retinoschisis
Kyuhwan Jang,Junghwa Lee,Kyungmin Lee,Mi Jeung Kim,Joonhong Sohn 대한안과학회 2020 Korean Journal of Ophthalmology Vol.34 No.6
Purpose: To evaluate the effect of intraocular pressure (IOP)-lowering medications on myopic retinoschisis. Methods: The medical records of 33 patients (36 eyes) with myopic retinoschisis associated with pathologic myopia werereviewed retrospectively. The patients were divided into two groups: the study group comprising patients undergoing treatmentwith anti-glaucoma medications for suspected glaucoma; the control group comprising patients who did not use anyIOP lowering medications. The changes in retinoschisis in the two groups were compared using the Spectralis domain opticalcoherence tomography thickness map protocol. Results: The study group included 18 eyes (17 patients), and the control group included 18 eyes (16 patients). There were nosignificant differences between the 6-month and 12-month improvement or aggravation rates of the two groups (p = 0.513and 0.137, respectively). However, after 18 months, the aggravation rate of retinoschisis was significantly lower in the studygroup (p = 0.003). The improvement / aggravation rate was 58.33% / 16.67% in the study group and 0% / 57.14% in the controlgroup. Conclusions: The use of IOP-lowering medications for more than a year may be useful for the management of retinoschisisassociated with pathologic myopia.
Virus-mimetic polymer nanoparticles displaying hemagglutinin as an adjuvant-free influenza vaccine
Lee, Chaeyeon,Jeong, Jonghwa,Lee, Taeheon,Zhang, Wei,Xu, Li,Choi, Ji Eun,Park, Ji Hyun,Song, Jae Kwang,Jang, Sinae,Eom, Chi-Yong,Shim, KyuHwan,Seong Soo, A.An,Kang, Young-Sun,Kwak, Minseok,Jeon, Hyeon Elsevier 2018 Biomaterials Vol.183 No.-
<P><B>Abstract</B></P> <P>The generation of virus-mimetic nanoparticles has received much attention in developing a new vaccine for overcoming the limitations of current vaccines. Thus, a method, encompassing most viral features for their size, hydrophobic domain and antigen display, would represent a meaningful direction for the vaccine development. In the present study, a polymer-templated protein nanoball with direction oriented hemagglutinin1 on its surface (H1-NB) was prepared as a new influenza vaccine, exhibiting most of the viral features. Moreover, the concentrations of antigen on the particle surface were controlled, and its effect on immunogenicity was estimated by <I>in vivo</I> studies. Finally, H1-NB efficiently promoted H1-specific immune activation and cross-protective activities, which consequently prevented H1N1 infections in mice.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
MATLAB의 Auto code generation과 Verification 기능을 이용한 자동차 실내램프 시스템 검증에 관한 연구
이규환(Kyuhwan Lee),정이화(Leehwa Jeong),경태호(Taeho Kyung),홍인표(Inpyo Hong),구자용(Jaryong Ku) 한국자동차공학회 2010 한국자동차공학회 학술대회 및 전시회 Vol.2010 No.11
Recently, Software design is developed by regular procedures. But these regular procedures are difficult to fulfill in the field. The field can be changed the project in coding or test step by the change of requirements or the occurrence of a problem. Model-Based Design is proposed this problem solution. Model-Based Design is recycled in various stages of design information. So, the design method can be modeling and simulation before to the real hardware. This Model-Based Design’s typical program is the MATLAB. The interior lamp of automotive is developed very much. Recent interior lamp is not simple. The interior lamp functions are only lamp ON or OFF function but also CAN communication, Data processing, Input processing, analysis and results output function. This function is working used MCU(microcontroller unit). Also center fascia is have very many function. So, this place can’t add function. For that reason, interior lamp is including something of user indirect control like bluetooth module. Reliability is important in interior lamp because of this complicated function. And this reliability of products raises the commercial value. So this paper is suggested development method of interior lamp system using MATLAB.
이규환(Lee Kyuhwan),전제성(Jeon Jesung),김기영(Kim Kiyoung),정대석(Jung Daeesuk) 한국지반환경공학회 2007 한국지반환경공학회논문집 Vol.8 No.6
압밀현상을 예측하는데 있어, 압밀특성이 상이한 이질층의 존재 및 투수성에 대한 비선형 물질함수 특성을 고려하는 것은 기존 고전 압밀론에서의 많은 가정사항들을 극복하여 실제 현상에 더욱 부합하는 예측결과를 얻는데 있어 중요한 요소라 할 수있다. 본 연구에서는 이질층에 대한 경계면 방정식을 유도하고, 이를 기존 유한차분해석기법에 포함시켜 이질층에 대한 압밀해석을 실시하였다. 또한 이질층을 단일토층으로 환산하여 압밀예측에 이용하는 기존방법과 본 연구에 의한 압밀해석 결과를 비교, 분석하였다. 한편, 유효응력단계별 투수성의 비선형성을 고려하기 위하여 기존 선형 압밀이론을 이용하되, 각 유효응력 단계별 압밀계수에 관한 함수식을 적용하는 근사 비선형 해석기법을 개발하여 본 압밀해석에 적용하였다. The interface layer having different consolidation properties and nonlinear material function with permeability needs to be considered to predict consolidation behavior. In this study, interface equation between different layers has been derived and then applied to existing finite difference scheme for conducting consolidation analysis. These results have been compared with those by conventional method in which different layers are converted to single layer having conversion value of properties. Also, although the conventional consoilidation analysis is used to consider non-linearity of the permeability with effective stress, an approximated nonlinear method as a function of consoilidation coefficient with effective stress have been developed and applied to the consoilidation analysis for various cases.
가상 시험운전을 위한 다양한 용도의 스티어링 테스트 벤치 개발
이규환(Kyuhwan Lee),알리 고쉐인(Ali Ghosein),스테판 하쿨리(Stephan Hakuli) 한국자동차공학회 2014 한국자동차공학회 학술대회 및 전시회 Vol.2014 No.11
The steering system with its challenging functions has to be successfully integrated and interlinked in the whole vehicle, with implementation and validation preferably occurring as early as possible. It is important to evaluate subjective criteria and translate them into objective criteria. The used X-in-the-Loop method stands for the seamless inclusion of all relevant components and systems - model, software and hardware - in the whole vehicle. As important functions have to be tested and validated, e. g. ADAS, the whole vehicle has to be examined in realistic driving situations.