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Ha Young‐Ran,Jeong Se‐Jin,Jang Chang‐Won,Chang Kyu‐Sik,Kim Hyun‐Woo,Cho Shin‐Hyoung,Lee Hee‐Il 한국곤충학회 2021 Entomological Research Vol.51 No.2
Mosquitoes have adapted to various environmental conditions. Symbionts with mosquitoes impact this adaptation in different environments. In the field, mosquitoes could get exposed to antibiotics during their developmental period, which could reduce or eliminate their symbiotic microbes. However, the side effects of the antibiotics on the ovary and reproductive physiology of the Asian tiger mosquito, Aedes albopictus remains unknown. In this study, we investigated the effects of tetracycline and combinations of rifampicin and tetracycline at environmentally acceptable levels on the reproductive physiology of ovaries in Ae. albopictus. Rifampicin and tetracycline in combination reduced the hatching rate and fertility of Ae. albopictus compared to the untreated control group. These antibiotics induced histopathological damage and reactive oxygen species production in the ovaries. The combination of antibiotics decreased the expression of surface protein of Wolbachia (WSP) in Ae. albopictus. Additionally, the expression of Toll like receptor 2 (TLR2) and Myd88 were triggered by the combinations. The findings demonstrate the detrimental effects of antibiotics, particularly combinations of rifampicin and tetracycline, on the reproductive capacity of Ae. albopictus females.
알레르기성 비염 환자에서 절지동물성 특이항원의 양성율 및 항원간 일치율
황규윤,남해선,박준수,권준택,백병준,김장묵,오천환,조성란 순천향의학연구소 2000 Journal of Soonchunhyang Medical Science Vol.6 No.2
The current study was designed to evaluate the positive rates of arthropod allergens by Korean inhalant panel of MAST-CLA in patients with allergic rhinitis. One hundred sixty patients, diagnosed to allergic rhinitis in an Out Patient Center of Soonchunhyang University Chunan Hopsital during Aug 1998 to July 2000, were studied. 1. The overall positive rate among 35 specific allergens was 59.4% (95 patients). 2. The arthropod related allergen accounted for 82.1% (78 patients) of the positive rate. 3. Each positive rate of Dermatophagoides farinae (Df), Dermatophagoides pteronyssinus (Dp), house dust (Hd), and cockroach mix (Cm) was 45.0% (72 patients), 43.1% (69 patients), 28.1% (45 patients), and 8.8% (14 patients), respectively. 4.Significant agreement between arthropod allergens was observer (P < 0.05). 5. The obseved agreement between Df and Dp was 95.6%, showing most significant Kappa index (Kappa = 0.911, P < 0.001). There results suggested that although MAST-CLA is a useful measure of identifying specific allergens, the specificity of two mite allergen relatively low, implying because of common allergen between mites in Korean panel of MAST-CLA. Our data also supported that arthropod is the major cause of allergen in patients with allergic rhinitis, however, the MAST-CLA should be modified in order to exclude common allergen of mite and to include more specific mite allergen.
남해선,황규윤,,백병준,정윤영,오천환,조성란,박준수 순천향의학연구소;Soonchunhyang Medical Research Institute 2000 Journal of Soonchunhyang Medical Science Vol.6 No.1
To evaluate usefulness of application of MAST-CLA to indetify allergens, authors conducted MAST-CLA allergen-specific IgE assay and collected allergy related symptoms in 118 allergic patients diagnosed at Soonchunhyang University Chunan Hospital during October 1998 through January 2000. The results were as followings; 1. The mean (SD) age was 23.1 (±12.17) years old and teenagers accounted for 33.1% of patients. 2. The frequent allergic symptoms were sneezing (59.3%), rhinorrhea (53.4%), nasal stiffness (44.1%), itching sensation (24.6%), cough or sputum (16.1%), and eye symptom (8.5%) in order. 3. Among these subjects, 62.7% of patients revealed at least more than one specific allergen and 70.3% showed elevated total IgE levels by MAST-CLA. The three most frequent specific allergens were Dermatophagoides farinae (47.5%), Dermatophagoides pteronyssinus (45.8%), and house dust (30.5%). 4. While age was not significantly related to positive of both specific allergens and total IgE (P>0.05), sneezing and nasal stiffness were significantly associated with positive of specific allergen and total IgE, respectively (both P<0.05). 5. Total IgE increased with the number of specific allergens, but both specific allergen and total IgE were not significantly related to increases of allergic symptoms (P>0.05). In conclusion, our data suggest that MAST-CLA allergen-specific IgE assay is useful measure for identification of causative allergens in allergic patients, however, it is recommended that more specific allergic antigens should be determined and replaced or added to Korean inhalent panel of MAST-CLA.
과학교과교육 : 친환경 주택을 소재로 한 STEAM 학습자료 개발 및 적용
조경란 ( Gyung Ran Cho ),조규성 ( Kyu Seong Cho ) 전북대학교 과학교육연구소 2014 과학과 과학교육 논문지 Vol.39 No.1
이 연구는 친환경 주택을 소재로 한 STEAM 프로그램을 개발하고 그 효과를 알아보기 위한 것이다. 이를 위하여 친환경 주택을 소재로 한 프로그램을 개발한 후 중학생 30명을 대상으로 3차시에 걸쳐 수업을 진행하였다. 그리고 프로그램의 효과를 알아보기 위하여 창의적 사고 활동에 대한 설문자에 대해 사전, 사후 검사한 후 수집된 자료를 검정을 통해 확인 하였으며. 그 결과는 다음과 같다, 첫째, ‘친환경주택을 만들어 보자’를 주제로 한 STEAM 프로그램을 개발하고 실제 수업상황에 적용하였다, 둘째, 장의적 사고 활동과 관련된 네가지 하위요소에 대해 평균값이 상승하였으며, 특히 정교적 사고는 통계적으로 유의미한 값을 보였다. 셋째, STEAM 프로그램에 대한 학생들의 인식 또한 대체로 긍정적인 반응을 보였다. This study aims to investigate a effecls of STEAM teaching -learning program based on eco house, The participants are 30 middle school students, The STEAM progeam was applied to an actual science class, conducted over three lessons, For the evaluation of creative thinking activities, the samequcstionnaire was given to students before and after the program and a t-tcst was conducted to test the findings for significance, The findings of this study are as follows, First, given that “Let`s Build a Eco House,” the STEAM program was developed specifically for application in a classroom environment using the STEAM model and leaming criterion Second, all four subcategories of creative thinking activies showed an increase on average, though the increase in elaborate thinking activities were showh to be significant, The perception and subjective evaluation of students regarding the STEAM program were generally positive.
Kyu hyun Yoon,Kyung duk Min,Hee ran Chun,Soong Nang Jang,Sung il Cho 한국역학회 2015 Epidemiology and Health Vol.37 No.-
OBJECTIVES: Obesity is a well-recognized risk factor for type 2 diabetes mellitus (DM) among young and middle-aged adults in South Korea. To elaborate on the association between obesity and Diabetes mellitus (DM), subjective data from self-reporting survey or objective data from health examination is generally used. This study was conducted to validate the change of association from using these different measurements. METHODS: Community Health Survey data and Korea National Health and Nutrition Examination Survey data, as subjective and objective data respectively, were used. Population, resident in Seoul and over 45 aged, were selected for the study and the association between obesity and DM were defined by using multivariate logistic regression model. RESULTS: In subjective data, DM prevalence was 12.4% (male, 14.7; female, 10.6) and obesity prevalence was 26.0% (male, 29.2; female, 23.4). Whereas, in objective data, DM prevalence was 15.0% (male, 17.8; fe-male, 12.9), and obese population was 32.4% (male, 34.4; female, 30.8). Based on the effect of obesity on DM prevalence from each data, using objective data increased the impact of obesity. Difference of relative risk of obesity between from subjective data and from objective was bigger in female than male and statistically significant. CONCLUSIONS: The differences of association pattern between subjective and objective data were found, due to higher obesity prevalence in objective data, and discrepancies of socio-economic status. These discrep-ancies could be inevitable Therefore we have to face them proactively, and understand the different aspect of various variables from different measurement.
Kyu-Seung Cho,Sun-Youl Ryu,Hong-Ran Choi 대한구강악안면외과학회 2007 대한구강악안면외과학회지 Vol.33 No.1
To verify the inhibitory or protective effects of light-emitting diode(LED) irradiation on apoptotic cell death induced by CoCl2, human SH-SY5Y cells were treated with CoCl2 and LED were used to irradiate the cells. In the cell viability assay, cells were died slowly from 50 μM to 250 μM and about 50% of cells died after 12 hours at 400 μM of CoCl2. The Diff-Quik staining revealed that cells showed condensation of DNA and blebbing of the cell membrane. The DNA fragmentation assay revealed the DNA fragmentation, which is another apoptosis marker, occurred in cells treated with 400 μM CoCl2 for 16 hours. In the western blot for HIF-1α, HIF-1αwas expressed after 3 hours from induction and peaked maximally at 16 hours. In the cell viability assay of the effects of LED irradiation (at 590 nm for 1 hour 20 minutes), the cells showed more proliferation (about 20%) than the control group. The RPA assay of various apoptosis-related molecules showed that pro-apoptosis molecules such as Bax, Bak, and Bid were upregulated in the CoCl2 treatment group. This means that the apoptotic cell population was increased. However there was some significant changes in LED irradiated cells. In the CoCl2-treated LED irradiation group, those molecules were down-regulated more than in the only CoCl2-treated group. These results have shown that CoCl2 may induce apoptotic cell death in human SH-SY5Y neuroblastoma cells. And LED irradiation has a positive effect on apoptotic cells by down-regulation of pro-apoptotic molecules.