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RISS 인기검색어
- 검색키워드
- 저자 : Kyoung-Seok Rha (검색결과 5 건)
- 무료
- 기관 내 무료
- 유료
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CMOS Transistors with a 70-nm Gate Length for 0.13-μm-Node High-Performance Applications
Kyoung-Seok Rha,Dong-Hun Lee,Eun-Seung Jung,Hae-Kyung Kong,Hyae-Ryoung Lee,Jeong-Ho Lyu,Jeong-Hwan Yang,Jin-Suk Jung,Jung-A Choi,Kwang-Pyuk Suh,Young-Wug Kim 한국물리학회 2004 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.44 No.1
Conventional CMOS transistors for high performance with a 70-nm physical gate length were fabricated to evaluate the 130-nm-technology node. In this work, we enhanced the performance of transistors by using high-dose P+ implantation, a plasma-nitridation gas oxide, a hydrogen prebake (HPB), and a mechanical stress layer. We also reduced the overlap capacitances by using an oset spacer. The NMOS and PMOS have drive currents equal to 880 A/m and 420 A/m, respectively, with Ioff = 10 nA/m at Vdd = 1.2 V. The unit delay of the ring oscillator (1 fan-out) was 11.5 ps.
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Lee, Sang-Hak,Cho, Kyoung-Im,Kim, Jang-Young,Ahn, Young Keun,Rha, Seung-Woon,Kim, Yong-Jin,Choi, Yun-Seok,Choi, Si Wan,Jeon, Dong Woon,Min, Pil-Ki,Choi, Dong-Ju,Baek, Sang Hong,Kim, Kwon Sam,Byun, You Elsevier 2012 Atherosclerosis Vol.221 No.1
<P><B>Highlights</B></P><P>► Rosuvastatin–fenofibrate combination and rosuvastatin monotherapy were compared. ► We randomized 180 Asians with mixed hyperlipidemia with 24-week drug treatment. ► Incidences of muscle or liver enzyme elevation were similar between the two groups. ► The combination changed homocysteine, renal and hematologic parameters more.</P> <P><B>Abstract</B></P><P><B>Objective</B></P><P>The aim of this study is to compare the non-lipid effects of rosuvastatin–fenofibrate combination therapy with rosuvastatin monotherapy in high-risk Asian patients with mixed hyperlipidemia.</P><P><B>Methods</B></P><P>A total of 236 patients were initially screened. After six weeks of diet and life style changes, 180 of these patients were randomly assigned to receive one of two regimens: rosuvastatin 10mg plus fenofibrate 160mg or rosuvastatin 10mg. The primary outcome variables were the incidences of muscle or liver enzyme elevation. The patients were followed for 24 weeks during drug treatment and for an additional four weeks after drug discontinuation.</P><P><B>Results</B></P><P>The rates of the primary outcome variables were similar between the two groups (2.8% and 3.9% in the combination and the rosuvastatin groups, respectively, <I>p</I>=1.00). The combination group had more, but not significantly, common treatment-related adverse events (AEs) (13.3% and 5.6%, respectively) and drug discontinuation due to AEs (10.0% and 3.3%, respectively) than the rosouvastatin group. Combination therapy was associated with higher elevations in homocysteine, blood urea nitrogen, and serum creatinine, whereas elevation in alanine aminotransferase was greater in the rosuvastatin group. Leukocyte count and hemoglobin level decreased to a greater extent in the combination group. The combination group showed greater reductions in TG and elevation in HDL-cholesterol.</P><P><B>Conclusion</B></P><P>In our study population, the rosuvastatin–fenofibrate combination resulted in comparable incidences of myo- or hepatotoxicity as rosuvastatin monotherapy. However, this combination may need to be used with caution in individuals with underlying pathologies such as renal dysfunction (NCT01414803).</P>
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( Hyun Kyu Kim ),( Hui Kyoung Chang ),( Seok Yun Baek ),( Jin Oh Chung ),( Chan Su Rha ),( So Young Kim ),( Beom Joon Kim ),( Myeung Nam Kim ) 한국균학회 2012 Mycobiology Vol.40 No.2
Multiple treatment modalities, including topical and systemic corticosteroid and phototherapy, have been used in treatment of patients with atopic dermatitis. However, long-term corticosteroid therapy may have various adverse effects. The purpose of this study was to investigate the therapeutic efficacy and safety of bath therapy using green tea extracts for treatment of patients with atopic dermatitis. A total of four patients with atopic dermatitis were enrolled in this study. A Malassezia multiplex detection kit was used in performance of multiplex PCR on clinical isolates, which confirmed Malassezia sympodialis. Subjects underwent treatment with bath therapy using green tea extracts three times per wk for a period of 4 wk. Assessment using the scoring atopic dermatitis (SCORAD) index, the visual analogue scale for pruritus, and transepidermal water loss was performed weekly. Laboratory tests were performed before and after treatment. All patients showed marked improvement on the mean SCORAD and visual analogue scale, and a significant decrease in the mean values of serum eosinophil counts was observed after treatment. Bath therapy with green tea extract is an effective, safe, and nonsteroidal therapy for treatment of patients with atopic dermatitis associated with Malassezia sympodialis.
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Human Skin Safety Test of Green Tea Cell Extracts in Condition of Allergic Contact Dermatitis
Hyun Kyu Kim,Sun Young Choi,Hui Kyoung Chang,Seok Yun Baek,Jin Oh Chung,Chan Su Rha,Beom Joon Kim,Myeung Nam Kim 한국독성학회 2012 Toxicological Research Vol.28 No.2
Various kinds of positive effects of green tea extracts had been studied for long time which included antiinflammation, anti-aging, and cardiometabolic effects. Although topical steroid and non-steroidal calcineurin inhibitors may control clinical symptoms of allergic contact dermatitis, some of patients also present allergic reaction to these topical agents. Therefore, we have tried green tea extracts for managing this skin disorder with expectation of anti-inflammatory effect without potential side effects including skin irritation and toxic responses. The toxicity test of green tea extract also did not show any sign of irritation in the skin throughout the test period. Moderate severity of allergic contact dermatitis presented satisfactory clinical outcome at second week follow-up which was final visit of outpatient. This result mean that green tea extract has a positive effect for managing allergic contact dermatitis but its potency and efficacy seem to be so not strong enough to control moderate severity allergy skin lesion. In this pilot study, we were able to conclude that green tea cell extracts might be applied for potential anti-inflammatory soaking without skin toxicity.
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Human Skin Safety Test of Green Tea Cell Extracts in Condition of Allergic Contact Dermatitis
Kim, Hyun-Kyu,Choi, Sun-Young,Chang, Hui-Kyoung,Baek, Seok-Yun,Chung, Jin-Oh,Rha, Chan-Su,Kim, Beom-Joon,Kim, Myeung-Nam Korean Society of ToxicologyKorea Environmental Mu 2012 Toxicological Research Vol.28 No.2
Various kinds of positive effects of green tea extracts had been studied for long time which included anti-inflammation, anti-aging, and cardiometabolic effects. Although topical steroid and non-steroidal calcineurin inhibitors may control clinical symptoms of allergic contact dermatitis, some of patients also present allergic reaction to these topical agents. Therefore, we have tried green tea extracts for managing this skin disorder with expectation of anti-inflammatory effect without potential side effects including skin irritation and toxic responses. The toxicity test of green tea extract also did not show any sign of irritation in the skin throughout the test period. Moderate severity of allergic contact dermatitis presented satisfactory clinical outcome at second week follow-up which was final visit of outpatient. This result mean that green tea extract has a positive effect for managing allergic contact dermatitis but its potency and efficacy seem to be so not strong enough to control moderate severity allergy skin lesion. In this pilot study, we were able to conclude that green tea cell extracts might be applied for potential anti-inflammatory soaking without skin toxicity.
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