소화기계에 발생하는 동시성 다발성 원발성암

김선영,장은숙,장광주 啓明大學校 醫科大學 1986 계명의대학술지 Vol.5 No.2

During the years 1974-1986, the authors had undertaken a study of multiple primary malignant tumors in Keimyung University Dongsan Hospital, Taegu. A total 40 cases of multiple primary malignant tumors were identified. Eleven cases of simultaneous primary multiple cancers were in the alimentary tract (27.5%). Five cases out of eleven (45.4%), male to female ratio is 8 : 3, predominant inmale, mean age 54.7 year. It has been suggested that most human cancers occur both in a hereditary and non-hereditary form. In each case the tumors have been attributted to amultistage mutational process. However the answer is that multiple primary cancer are certainly a part of the overall oncology problem. We have found that multicentricity of cancer may give us clues to both cancer etiology and cancer predisposition. It is well known that adenomatous polyps are not only commonly associated with carcinoma and also are often the site of malignant transformation which is clearly proved in this study, furthermore recent reports demonstrate that in study of operative specimens of cancers of the colon one or more adenomas were present in about one-third of patient, and in 75% of these, adenomas coexisted with two or more carcinomas (Morson and Day 1981). Possible implication of these findings were discussed and related literatures were reviewed.

相間移動觸媒에 의한 鹽化 벤질과 알콜올類와의 反應

呂壽東,韓仁淑,沈光澤,張萬植 경북대학교 교육대학원 1985 논문집 Vol.17 No.-

Recently, Phase Transfer Catalyzed Organic Synthesis is studied intensely. The Reactions of benzyl chloride with various alcohols (Et, n-Pr, iso-Pr, n-Bu, iso-Bu, sec-Bu, tet-Bu, Ph, Bz-OH) were investigated under Phase Trasfer Catalysis in this research. Benzyltrietylammonium chloride(B.T.E.A.C), dodecyltrietylammonium bromide(L.T.E.A.B) and tetrabutylammonium chloride(T.B.A.C) were used as Phase Transfer Catalyst. The Optimum Conditions between benzyl chloride and varios alcohols were studied in the presence of T.B.A.C which proved to be most effective among catalysts tested. Optimized conditions were as following. The molar ratio between benzyl chloride and tertiary butanol was 1:3. The amount of catalyst was 1.08mmol. And the amount of 50% NaOH aqueous solution was 7g. Under optimized conditions, it has been observed that benzyltet-alkyl ether, benzylphenyl ether and dibenzyl ether can be obtained in good yield over 80%, benzyliso-alkyl ether in about 50%, benzyln-alkyl ether only in less than 20%. The tendency of yield in various alcohols was increased Et<Pr<Bu<Bz<Ph-OH. And the tendency of yield in isomeric alcohols was increased primary<secondary<tertiary alcohol.

Phytol과 들미나리추출물이 Sarcoma 180마우스의 T Subset에 미치는 효과

류태형,박건영,장명웅,이숙희,선우양일,김광혁 東亞大學校附設基礎科學硏究所 1993 基礎科學硏究論文集 Vol.10 No.1

본 연구는 녹황색채소류에서 추출되어 항암효과를 나타내는 활성물질로 보고 되어 있는 phytol과 들미나리추출물을 sarcoma 180마우스에 주사한 후 적출한 비장세포내 T 임프구와 T subset, 그리고 asialo ?? 세포를 정량하여 다음과 같은 결과를 얻었다. 1) 종양 마우스에 phytol을 투여하였을 때 비장세포내의 T cell과 T-subset은 종양세포이식에 의하여 상승된 치를 더욱 증가시켰다. 그러나 들미나리추출물의 경우는 대동소이하였다. 2) Asialo ?? 세포는 종양마우스에 phytol이나 들미나리추출물을 주사하였을 때 모두 상승하였으며 정상마우스에 phytol을 투여하였을 때도 대조군에 비하여 상승했지만 들미나리추출물을 작용시켰을 때는 저하되었다. 3) ??/?? 세포비는 종양마우스에 phytol을 주사하였을 때 감소를 보였지만 정상 마우스에 투여하였을 때는 더욱 크게 낮아졌다. 그러나 들미나리추출물을 정상마우스에 투여하였을때는 크게 감소하던 것이 종양마우스에 적요 시켰을때는 증가현상을 보였다. 이상의 결과로 미루어 볼 때 phytol이나 들미나리추출물은 종양마우스에서 작용자세포인 자연살해세포(natural killer cell)의 활성인자로서 작용할 가능성이 높을 것으로 사료된다. Several studies have shown that phytol isolated from perilla leaf and small water dropwort(Oenanthe javanica(BL)D.C, wild type)extract reveal antitumor activities. In the present study we investigated the effect of phytol and the small water dropwort extract on the T subset in the sarcoma 180-transplanted mice in order to elucidate the immunological mechanism of antitumor activity of these substances. The results obtained from the experiment were as follows : When phytol was injected into the sarcoma-180 transplanted mice(control), the levels of T cell and T subset by inoculation of the tumor cells were enhanced, but that of T cells in case of small water dropwort extract was similar to the control. Asialo ?? cells were increased when phytol or small water dropwort extract was injected into tumor-transplanted mice. In normal mice the number of asialo ?? cells increased with phytol injection and decreased with small water dropwort extract injection. ??/?? cell ratios were decreased when phytol was injected into tumor-transplanted mice, but increased in case of small water dropwort extract injection. In normal mice the ratios showed large decreases with phytol or small water dropwort extract injection. These results indicate that phytol or small water dropwort extract can activate the proliferation of natural killer cells that are effector cells in tumor-bearing mice.

관상동맥협착증에 있어서 관상동맥우회술의 치료효과

유영선,박진상,최세영,박창권,이광숙 啓明大學校 醫科大學 1994 계명의대학술지 Vol.13 No.4

Sixty-one patients with coronary artery stenosis underwent coronary artery bypass grafting from February 1986 to September 1993 at the department of Thoracic and Cardiovascular Surgery. There were 41 men and 20 women with a mean age of 54 years(range, 25 to 79 years). History of myocardial infarction was noted in 17 patients(28%). Twenty-eight patients(46%) had single-vessel disease, 24 patients(39%) had double-vessel disease and 9 patients(15%) had triple-vessel disease. The left main disease was in 4 patients(7%). Single aorta-coronary grafts were placed in 37 patients(60%), double or more grafts in 24 patients(40%). An average of 1.4 grafts were performed per patient. Saphenous vein grafts were employed in 49 patients(80%), and the internal mammary grafts, which were anastomosed to left anterior descending artery in 23 patients(38%). The mean bypass time was 135 minutes and cross-clamp time was 45 minutes. Early mortality was 16.4% (10 patients). Perioperative myocardial infarction was the most common complication, followed by atrial arrhythmia, wound infection, bleeding, pneumonia, pneumothorax. The 51 survivors were followed-up for 1 to 72 months, averaging 31 months. Ninety-five percent of the survivors were in New York Heart Association class I or Ⅱ postoperatively. There was one late death. Poor ejection fraction was significantly associated with hospital death(p<0.05).

불명열 환자에서 진단된 중증 만성 활동성 Epstein-Barr virus 감염증

전경만,김응호,손준성,장현하,정숙인,오원섭,백경란,송재훈,고광철,정철원,고영혜 대한감염학회 2003 감염과 화학요법 Vol.35 No.4

최근 장기적이고 심각한 임상 증상을 유발하는 만성 활동성 EBV 감염증의 개념이 정립되면서 그 증례들이 보고되고 있다. 만성 활동성 EBV 감염증은 소아나 젊은 성인들에게서 주로 발생되며, EBV-VCA IgG, EBV-EA IgG의 수치가 높게 관찰되고, 지속적인 발열, 전신쇠약감, 광범위한 임파선비대증, 간비장비대, 범혈구감소증, 다크론성감마병증을 나타낸다. 이 질환은 환자의 임상소견, 혈액학적 소견, EBV 항체 역가 및 침범 장기의 EBV genome 검출로 확진 되며 치료로 항 바이러스 체제, 항암 치료, 골수이식술 등이 시도되고 있으나 아직 검증되어 있지 않다. 저자들은 불명열을 주소로 내원하여 중증 만성 활동성 EBV 감염증으로 진단된 증례 4례를 경험하였다. 한 례에서는 항 바이러스 제제를 추여 후 임상적, 혈액학적 호전을 보였으나 치료 20일째 발생한 세균성 복막염과 패혈증으로 사망하였고, 두 례에서 총 6회의 CHOP 항암치료와 자가조혈모세포이식을 시행 받은 후 현재까지 증상 없이 추적관찰 중이다. 지속되는 발열을 주소로 내원한 불명열 환자들에게서 EBV에 대한 검사를 시행할 경우 불명열의 원인을 규명하는데 하나의 단서를 제공할 수 있을 것으로 사료된다. Epstein-Barr virus (EBV) is one of eight human herpesvirus. Primary infection with EBV in childhood is generally asymptomatic or mild, however, often causes overt diseases such as infectious mononucleosis (IM) and lymphoproliferative disorder (LPD), the latter occursing in immunologically compromised individuals. Historically, EBV has been considered to be etiologically linked to human malignancies such as EBV genome positive Burkitt's lymphoma and nasopharyngeal carcinoma. Recently, however, another category of EBV-related disease, "chronic active EBV infection", has been made to describe persons without a clearly defined underlying disease. We report 4 cases of patients, presented with episodic fever of unknown origin (FUO), who were diagnosed as severe chronic active EBV infection. A combined application of serology for EBV and in-situ hybridization established the diagnosis of the EBV infection.

들깻잎에서 동정한 Phytol의 항암 및 면역활성증강 효과

선우양일,류태형,박건영,이숙희,장명웅,김광혁 東亞大學校附設基礎科學硏究所 1993 基礎科學硏究論文集 Vol.10 No.1

Several studies have shown that extracts from yellow-green vegetables reveal antitumor activities. In the present study we investigated the effect of phytol in order to elucidate the immunological mechanism of antitumor activity of this substance. The results obtained from the experiment as follows : 1) Phytol showed cytotoxic effect on sarcoma 180 cells in vitro. 2) When phytol was injected into the peritoneal cavity of mice transplanted with sarcoma 180 cells, the average survival time(24.0 days) tended to increase as compared with the nontreated control(19.2 days). 3) When sarcoma 180 cells were injected subcutaneously into the right groin of mice and then phytol was injected into the peritoneal cavity the tumor inhibition ratio was 33%. 4) The natural killer(NK) cell activity was significantly augmented by phytol in vitro and in vivo. Similar augmentations of NK cell activity were obtained with culture supernatants of phytol exposed spleen cells and peripheral blood mononuclear cells. 5) Phytol on the macrophage from peritoneal cavity showed a higher effectiveness in vivo than in vitro. These results indicate that phytol shows the inhibitory effect for growth of sarcoma 180 cells in vitro, also it can augment macrophage and NK cell activities in vivo.

Effect of Hydroxybrazilin on Glutathione Depletion Induced by BrCCl₃ and Menadione in Cultured Rat Hepatocytes

Chang, Eun-Sook,Kim, Seong-Gon,Khil, Lee-Yong,So, Dhong-Su,Chang, Tong-Shin,Kim, Jin-Hyoung,Jeon, Sun-Duck,Park, Kwang-Sik,Moon, Chang-Kiu 한국환경독성학회 1996 환경독성보건학회지 Vol.11 No.2

In this study we investigated the effect of hydroxybrazilin on glutathione depletion induced by BrCCI₃ and menadione in cultured hepatocytes to understand the cellular mechanisms of hepatoprotective effect of hydroxybrazilin. Iydroxybrazilin alone had no effect on total glutathione level and the ratio of reduced glutathione/total glutathione (GSH/(GSSG+GSH)). BrCCI₃ dramatically decreased total glutathione level and hydroxybrazilin significantly prevented glutathion depletion by BrCCI₃. The ratio of GSH/(GSSG+ GSH) was also decreased by BrCCI₃ and recovered by hydroxybrazilin treatment. Menadione decreased total glutathione level and the ratio of GSH/(GSSG+GSH) but hydroxybrazilin showed no significant effects on menadione- induced glutathione depletion. These data suggest that hydroxybrazilin might prevent the hepatotoxicity induced by chemical-derived radicals but not the toxicity linked with oxidative stress.

Effects of Hydroxybrazilin on Glutathione Depletion Induced by $\textrm{BrCCl}_3$ and Menadione in Cultured Rat Hepatocytes

Chang, Eun-Sook,Kim, Seong-Gon,Khil, Lee-Yong,So, Dhong-Su,Chang, Tong-Shin,Kim, Jin-Hyoung,Jeon, Sun-Duck,Moon, Chang-Kiu,Park, Kwang-Sik The Korean Society of Environmental Toxicology 1996 환경독성보건학회지 Vol.11 No.3

In this study we investigated the effect of hydroxybrazilin on glutathione depletion induced by BrCCl$_3$ and menadione in cultured hepatocytes to understand the cellular mechanisms of hepatoprotective effect of hydroxybrazilin. Hydroxybrazilin alone had no effect on total glutathione level and the ratio of reduced glutathione/total glutathione (GSH/(GSSG+GSH)). BrCCl$_3$ dramatically decreased total glutathione level and hydroxybrazilin significantly prevented glutathion depletion by BrCCl$_3$. The ratio of GSH/(GSSG+ GSH) was also decreased by BrCCl$_3$ and recovered by hydroxybrazilin treatment. Menadione decreased total glutathione level and the ratio of GSH/(GSSG+GSH) but hydroxybrazilin showed no significant effects on menadione-induced glutathione depletion. These data suggest that hydroxybrazilin might prevent the hepatotoxicity induced by chemicalderived radicals but not the toxicity linked with oxidative stress.

석면 비산방지제의 성능평가 시험 연구

김창규(Chang-Kyu Kim),하광태(Kwang-Tae Ha),강미혜(Mi-Hyae Kang),정숙녀(Sook-Nye Chung),김지성(Ji-Sung Kim),김가연(Ga-Yeon Kim),정종흡(Jong-Heub Chung),어수미(Soo-Mi Eo),정권(Kweon-Jung) 대한환경공학회 2018 대한환경공학회지 Vol.40 No.7

본 연구의 목적은 석면 비산방지제의 성능을 평가하는 장치기술을 개발하여 현행 공정시험방법을 효율적으로 개선하고자 하였다. KS의 석면 비산방지제 시험방법(KS M 2757:2014)중 섬유비산 시험방법의 공기분사방식과 공기분사구의 압력조절방식을 개선하여 시험의 정확성을 증대시켰다. 공기분사방식을 1-way에서 2-way로 적용한 결과, 측정된 석면 평균농도는 0.051 f-PCM/㏄로서 기존의 1-way방식(0.012 f-PCM/㏄)보다 약 4배 높아 석면 검출능력이 향상되었다. 또한 공기분사구 압력조절방식 개선을 위해 표면압력측정부를 적용한 결과, 시험체 표면에 항상 일정한 풍속 약 10 ㎧를 유지하였다. 그러나 표면압력측정부가 없는 경우에는 구동모터의 이격거리 변화 때문에 풍속이 변화하여 각각 6.6, 4.8, 3.7 ㎧로 일정하지 못하였다. 그러므로 2-way공기분사방식을 통해 시험체에 충분한 유량을 사각지대 없이 공급하여 석면 검출능력을 높이고, 표면압력 측정기능을 통해 시험체에 일정한 풍속을 유지시킴으로써 시험방법의 정확성과 효율성을 개선하였다. The purpose of this study is to develop a device to evaluate the performance of asbestos stabilizers and improve the accuracy of the process test method. We increased the accuracy of the test method by applying the air injection method and pressure control method of the nozzle in the testing methods for performance evaluation of encapsulants in asbestos-containing building materials (KS M 2757:2014). As a result of applying the air injection method, the average concentration of asbestos obtained using the 2-way method was 0.051 f-PCM/㏄, which is approximately four times higher than that obtained using the 1-way method (0.012 f-PCM/㏄). In addition, as a result of applying the pressure control method, a constant air velocity of approximately 10 ㎧ was maintained at the air injection port to the specimen by using the surface pressure sensor. In the absence of the surface pressure measuring part, the air velocity was changed to 6.6, 4.8, and 3.7 ㎧ respectively, owing to the change of the travel distance of the turning motor. Therefore, the accuracy and efficiency of the test method were improved by supplying 2-way air injection to the specimen without blind spots and maintaining a constant air through the surface pressure sensing function.

Developement of the reinforced acrylic-based hybrid denture composite resin with vinyloligosilsesquioxane (POSS)

Nam, Kwang-Woo,Chang, Myung-Woo,Chang, Bok-Sook,Han, Dong-Hoo,Shim, June-Sung,Chang, Ik-Tae,Heo, Seong-Joo,An, Jung-Ho,Chung, Dong-June The Korean Academy of Prosthodonitics 2000 대한치과보철학회지 Vol.38 No.6

The mainly used polymeric material for the denture is PMMA because of its cost and easiness to handle. So it was widely used material among dentists for past decades. But the acrylic-based denture materials have several common weak points such as shrinkage after curing and lack of strength. In order to solve these problems, we adapted one of hybrid system using acrylic polymer and vinyloligosilsesquioxane(POSS). POSS, which is a well known expandable monomer during polymerization process, may eventually suppress volumetric shrinkage. And the hybrid system makes it possible for the polymer to be stable in various severe conditions. Eight different kinds of samples were designed and synthesized. Each samples were characterized with dynamic mechanical analyser(DMA) to confirm their thermodynamic properties, fractured to analyze the cross-sectional morphology of the samples. And elongation, flexural and impact tests were also executed to evaluate the mechanical properties of the samples. From the results, hybrid composites had well defined crosslinked network structure compared to the widely used denture materials, and the mechanical strength improved without changing any surface condition as increment with POSS ratio in hybrid system. Fractured morphology showed homogeneous surfaces in spite of mutli component system, therefore we can conclude that the adoption of the POSS brought the reinforcement of the denture resin.