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The objective of this study was to determine whether the lipotropic effect of supplementary D,L-carnitine was dose dependent. Male Sprague-Dawley rats were fed a liquid diet in which 36% of the total calories were substituted by ethanol for 45 days. The ethanol diet, containing naturally 1.27㎍ of L-carnitine per 1 gram of diet, was fed as such or was further supplemented with 0.4%, 0.9%, 1.2%, and 1.6%(w/w, dry weight basis) D,L-carnitine. In both plasma and liver, result showed a definite inverse relationship between the levels of lipids and those of carnitines. The concentrations of total lipids and triglycerides was significantly reduced with increasing levels of supplementary carnitine while those of carnitine were significantly elevated. The changes in the plasma and hepatic concentrations of various classes of lipid and carnitine were inversely correlated ans were appeared to be progressive up to 0.8% D,L-carnitine supplementation. Therefore, it was concluded that the lipotropic effect of dietary carnitine is dose-dependent, and that the optimal supplementary level is 0.8% D,L-carnitine.
ICR mice were transplanted with sarcoma 180 ascites tumor cells. Linoleic acid from Allium sativum for. Pekinase MAKINO was injected into the tumor bearing mice. Antitumor effect of the compound was investigated by using morphological and in situ hybridization means, Linoleic acid was effective in delaying the tumorigenesis process. However, the effects were appeared not to be associated with changes in selected oncogene expression.
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To investigate the effect of ursolic acid on the expression of oncogenes in tumor cells of mice, sarcoma 180 ascites tumor cells were implanted into the left groin of ICR mice and the tumor bearing mice were treated with ursolic acid. The expression of oncogenes were measured by in situ hybridization method. Ursolic acid significantly reduced the expression of oncogenes in the tumor cells. Therefore, it can be said that the prestated anticarcinogenic effect of ursolic acid could be partly ascribed to the mechanism included in the oncogene''s transcription level.
본 연구는 녹황색채소류에서 추출되어 항암효과를 나타내는 활성물질로 보고 되어 있는 phytol과 들미나리추출물을 sarcoma 180마우스에 주사한 후 적출한 비장세포내 T 임프구와 T subset, 그리고 asialo ?? 세포를 정량하여 다음과 같은 결과를 얻었다. 1) 종양 마우스에 phytol을 투여하였을 때 비장세포내의 T cell과 T-subset은 종양세포이식에 의하여 상승된 치를 더욱 증가시켰다. 그러나 들미나리추출물의 경우는 대동소이하였다. 2) Asialo ?? 세포는 종양마우스에 phytol이나 들미나리추출물을 주사하였을 때 모두 상승하였으며 정상마우스에 phytol을 투여하였을 때도 대조군에 비하여 상승했지만 들미나리추출물을 작용시켰을 때는 저하되었다. 3) ??/?? 세포비는 종양마우스에 phytol을 주사하였을 때 감소를 보였지만 정상 마우스에 투여하였을 때는 더욱 크게 낮아졌다. 그러나 들미나리추출물을 정상마우스에 투여하였을때는 크게 감소하던 것이 종양마우스에 적요 시켰을때는 증가현상을 보였다. 이상의 결과로 미루어 볼 때 phytol이나 들미나리추출물은 종양마우스에서 작용자세포인 자연살해세포(natural killer cell)의 활성인자로서 작용할 가능성이 높을 것으로 사료된다. Several studies have shown that phytol isolated from perilla leaf and small water dropwort(Oenanthe javanica(BL)D.C, wild type)extract reveal antitumor activities. In the present study we investigated the effect of phytol and the small water dropwort extract on the T subset in the sarcoma 180-transplanted mice in order to elucidate the immunological mechanism of antitumor activity of these substances. The results obtained from the experiment were as follows : When phytol was injected into the sarcoma-180 transplanted mice(control), the levels of T cell and T subset by inoculation of the tumor cells were enhanced, but that of T cells in case of small water dropwort extract was similar to the control. Asialo ?? cells were increased when phytol or small water dropwort extract was injected into tumor-transplanted mice. In normal mice the number of asialo ?? cells increased with phytol injection and decreased with small water dropwort extract injection. ??/?? cell ratios were decreased when phytol was injected into tumor-transplanted mice, but increased in case of small water dropwort extract injection. In normal mice the ratios showed large decreases with phytol or small water dropwort extract injection. These results indicate that phytol or small water dropwort extract can activate the proliferation of natural killer cells that are effector cells in tumor-bearing mice.
There is a trend that the total number of cancer cases is steadily increasing as the population grows. It has been estimated that 85% of the cancer rate in the U. S. is attributed to environmental factors. Among the enviromental factors, diet and nutrition appear to be related to the largest number of human cancers.<br/> Diet and nutrition might be related to cancer by several mechanisms. Food may contain a direct carcinogen or precursors that become carcinogens by spontanous reactions, or by host metabolism, or through the actions of microbial flora. Chemicals that cause cancers generally have reactive electrophilic centers which can combine with electron-rich atoms in nucleic acids and cause cancers by changing the genetic activity of the cells. A variety of factors in foods might be involved in the etiology of carcinogenesis.<br/> Chemicals in food that cause cancers include carcinogens of plants and animal origin and also those in drinking water. Other then these, fungal metabolites alcohol, asbestos, heavy metals, pesticides, and food additives might be included as food carcinogenesis. The method of cooking foods also might contribute to carcinogenesis. Some chemicals in foods act as promoters in carcinogenesis.<br/> Prevention of cancers by dietary practises have received much interest. Consumption of certain vegetables or cellulose can reduce carcinogenic activity of several compounds. A variety of antioxidants or micronutrients may be effective anticarciongens.<br/> Glutathione in the soluble fraction of the cells, is a major defense against oxidative and alkylating carcinogens. Recently anticarcinogenic activity of chlorophyll was demonstrated. Daily consumption of milk appears to effectively reduce stomach cancer.
In many industries, the linear motor replaces the existing framework for linear transportation. Like existing motors, it is important to minimize the ripple of thrust and to maximize the thrust force of the linear motor. Because the two objectives are associated to each other, the multi-objective design process is necessary considering all objectives. This paper intends to optimize geometric parameters of the linear motor with two design objectives using design of experiments and the sequential response surface method
In many industries, the linear motor replaces the existing framework for linear transportation. Similar to other conventional motors, it is important to minimize the ripple of thrust and to maximize the thrust force of the linear motor. Because the two objectives are associated to each other, the multi-objective design process is necessary considering all objectives. This paper intends to optimize geometric parameters of the linear motor with two design objectives using design of experiments and sequential response surface method.