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Creation of Multi-Functional Foods
Yamada, Koji The Korean Society of Food Science and Nutrition 2004 식품산업과 영양 Vol.9 No.1
Foods contain various biologically functional components which contribute to our health. As shown in Table 1, bioregulatory function of food components are classified into five categories. In the enhancement of biodefense system, dietary fibers (DF), unsaturated fatty acids (UFA), antioxidants are effective. These components are also, effective in other categories. This means that food components are multifunctional. To maintain our health, effective use of multi-functional activity of food components is essential. (omitted)
Koji Kinoshita,Yuki Banno,Yuki Ono,Shohey Yamada,Mitsuru Handa 한국강구조학회 2019 International Journal of Steel Structures Vol.19 No.3
This study experimentally investigates eff ect of fatigue strength improvement of the Portable Pneumatic Needle-Peening treatment (PPP treatment) as a needle peening on out-of-plane gusset welded joints by using plate bending fatigue tests. This study also examined eff ect of the travel speed and the number of treatment passes of the PPP treatment with regards to its fatigue strength improvement. After the fatigue tests, the observation of the fracture surface with Scanning Electron Microscope was carried out in order to clarify the crack initiation. From those test results, it may be concluded that the eff ect of fatigue strength improvement might be governed by treatment passes with suffi cient travel speed. In addition, this study carried out additional fatigue tests that focus on fatigue crack closer by using the PPP treatment. As a result of additional fatigue tests for fatigue crack closure, it might be said that the eff ect of fatigue crack closure is eff ective when the distance between fatigue cracks and treatment area is less than 2.0 mm.
Fatigue Strength Improvement of Welded Joints of Existing Steel Bridges by Shot-Peening
Koji Kinoshita,Yuki Banno,Yuki Ono,Shohey Yamada,Mitsuru Handa 한국강구조학회 2019 International Journal of Steel Structures Vol.19 No.2
Shot-peening recently can be applied to existing steel bridges due to the development of new vacuuming techniques of shots after peening in the construction site. This study experimentally investigates eff ects of fatigue strength improvement of shot-peening on welded joints. Bending fatigue tests using out-of-plane gusset welded joints specimens were carried out and three type specimens were compared: as-welded, grit-blasted, and shot-peened. In addition, this paper examines diff erences of fatigue strength improvement eff ects in case of applying shot-peening to inside of scallop where shots might be diffi cult to hit perpendicularly to weld toe of welded joints because of narrow space, and the residual stress measurement in order to clarify introducing compressive residual stress were carried out. As a result, it may be concluded that shot-peening can improve fatigue strength of welded joints and its mechanism was identifi ed as extension of crack initiation life and delay crack propagation due to benefi cial compressive residual stress in the vicinity of surface layer.
Koji Akeda,Kohshi Ohishi,Koichi Masuda,Won C. Bae,Norihiko Takegami,Junichi Yamada,Tomoki Nakamura,Toshihiko Sakakibara,Yuichi Kasai,Akihiro Sudo 대한척추외과학회 2017 Asian Spine Journal Vol.11 No.3
Study Design: Preliminary clinical trial. Purpose: To determine the safety and initial efficacy of intradiscal injection of autologous platelet-rich plasma (PRP) releasate in patients with discogenic low back pain. Overview of Literature: PRP, which is comprised of autologous growth factors and cytokines, has been widely used in the clinical setting for tissue regeneration and repair. PRP has been shown in vitro and in vivo to potentially stimulate intervertebral disc matrix metabolism. Methods: Inclusion criteria for this study included chronic low back pain without leg pain for more than 3 months; one or more lumbar discs (L3/L4 to L5/S1) with evidence of degeneration, as indicated via magnetic resonance imaging (MRI); and at least one symptomatic disc, confirmed using standardized provocative discography. PRP releasate, isolated from clotted PRP, was injected into the center of the nucleus pulposus. Outcome measures included the use of a visual analog scale (VAS) and the Roland-Morris Disability Questionnaire (RDQ), as well as X-ray and MRI (T2-quantification). Results: Data were analyzed from 14 patients (8 men and 6 women; mean age, 33.8 years). The average follow-up period was 10 months. Following treatment, no patient experienced adverse events or significant narrowing of disc height. The mean pain scores before treatment (VAS, 7.5±1.3; RDQ, 12.6±4.1) were significantly decreased at one month, and this was generally sustained throughout the observation period (6 months after treatment: VAS, 3.2±2.4, RDQ; 3.6±4.5 and 12 months: VAS, 2.9±2.8; RDQ, 2.8±3.9; p <0.01, respectively). The mean T2 values did not significantly change after treatment. Conclusions: We demonstrated that intradiscal injection of autologous PRP releasate in patients with low back pain was safe, with no adverse events observed during follow-up. Future randomized controlled clinical studies should be performed to systematically evaluate the effects of this therapy.
Facial EMG pattern evoked by pleasant and unpleasant odor stimulus
( Hiroshi Yamada ),( Noriaki Kaneki ),( Koji Shimada ),( Hironori Okii ) 한국감성과학회 2002 춘계학술대회 Vol.2002 No.-
Activities of venter frontalis, corrugator, levator labii superioris and greater zygomatic muscles were measured for five male subjects while they made pleasant, unpleasant and neutral facial expressions, and while they were presented pleasant, disgusting, and neutral odors. Pleasant expression and odor activated zygomatic muscles while unpleasant expression and odor increased corrugator muscle activity.
Detoxification of Aflatoxin B1 Contaminated Maize Using Human CYP3A4
( Marie Yamada ),( Koji Hatsuta ),( Mayuko Niikawa ),( Hiromasa Imaishi ) 한국미생물 · 생명공학회 2020 Journal of microbiology and biotechnology Vol.30 No.8
Aflatoxin B1 (AFB1) is a mycotoxin produced by Aspergillus flavus (A. flavus). AFB1 is reported to have high thermal stability and is not decomposed by heat treatment during food processing. Therefore, in this study, knowing that AFB1 is metabolized by cytochrome P450 (CYP), our aim was to develop a method to detoxify A. flavus-contaminated maize, under normal temperature and pressure, using Escherichia coli expressing human CYP3A4. First, the metabolic activity of AFB1 by recombinant human CYP3A4 was evaluated. As a result, we confirmed that recombinant human CYP3A4 metabolizes 98% of AFB1. Next, we found that aflatoxin Q1, a metabolite of AFB1 was no longer mutagenic. Furthermore, we revealed that about 50% of the AFB1 metabolic activity can be maintained for 3 months when E. coli expressing human CYP3A4 is freeze-dried in the presence of trehalose. Finally, we found that 80% of AFB1 in A. flavus-contaminated maize was metabolized by E. coli expressing human CYP3A4 in the presence of surfactant triton X-405 at a final concentration of 10% (v/v). From these results, we conclude that AFB1 in A. flavus-contaminated maize can be detoxified under normal temperature and pressure by using E. coli expressing human CYP3A4.