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고삼규,지용철,문충배,최병연,조수호 대한신경외과학회 1986 Journal of Korean neurosurgical society Vol.15 No.2
Usually cases of brain stem hemorrhage reveal high mortality and poor prognosis in spite of meticulous medical or surgical treatment. Recently we experienced stereotaxic evacuation of brain stemhemorrhage with Brown-Robert-Wells(B.R.W.) system in four cases. If there were residual hemorrhage after initial aspiraion, those were evacuated with Urokinase irrigation via stereotaxically placed catheter in the hematoma. The entry point of our operation get on the crossing point of midpupillary line and 1㎝ behind coronal suture. Preliminary results: 1) Volume of removed hematoma :5㎖(average) 2) Dates of urokinase irrigation: 2 to 4 days after operation 3) No hydrocephalus, no surgical mortality 4) Average Glasgow coma scale was improved from 6 in preoperative state to 12 in postoperative state. 5) Operation was performed within 24 hours. 6) Advantages of our procedure: (1) Accurate, simple and safe. (2) Under local anesthesia. (3) Less traumatic procedure. (4) Could remove hematoma completely with Urokinase.
A Comparison of Standardization Methods in Near-infrared Analysis
Ko, Young-Hyun,Park, Kwang-Su,Lee, Hye-Seon,Jun, Chi-Hyuck,Ku, Min-Sik,Chung, Hoe-Il 한국근적외분광분석학회 2000 Near infrared analysis Vol.1 No.1
A variety of standardization methods between two near-infrared (NIR) spectrometers were investigated for the prediction of five constituents in trans-alkylation process. Spectra were collected by two different instruments (one is regarded as mater instrument, other on as slave instrument). Three well-known standardization methods of direct standardization (DS), piecewise direct standardization (PDS) and slope/bias correction of response variable were applied to trans-alkylation samples on the slave instrument. We have examined for a set of reliable standardization samples using smaller number of transfer samples in order to increase efficiency of standardization.
정을수,고삼규,김오룡,지용철,최병연,조수호 대한신경외과학회 1991 Journal of Korean neurosurgical society Vol.20 No.12
영남대학교 의과대학 신경외과학 교실에서는 향후 뇌동정맥 기형환자의 치료에 도움을 얻고자 최근 경험한 37례의 임상적, 방사선학적 소견 등을 후향성 조사 분석하여 아래와 같은 결과를 얻었다. 생산성이 높은 20-49세에 간질을 주소로 내원한 경우가 많았고, AVM의 크기가 작거나 유출정맥이 심부로 향할 때 출혈을, mixed type일때 간질을 주소로 내원한 경우가 않았다. 중간 크기일 경우 주로 eloquence 위치에 있고 유출정맥이 심부로 향했으며, 심부에 위치하거나 크기가 큰 경우 뇌동맥류의 동반이 많았으며, 수술후 치료 결과가 호전된 경우는 Grade가 낮은 경우가 많았고, 수술후 합병증은 low flow나 표재부에 위치한 경우에 간질이 많았고, 표재부에 있는 경우에 수술후 출혈이 많이 발생했다. Clinical and cerebral angiographic findings were reviewed retrospectively in thirty-seven patients with intracranial arterio-venous malformation(AVM). The results were as follow. Many patients who were in reproductive age had visited due to seizure(27%) and its angiographic findings were mixed Type(80%). Bleeding was predominant in the patients who had small sized nidus than medium or large one, and deep draining vein than superficial one. Medium sized AVM was located mainly in the anatomically deep portion(71%) and drained to deep portion also(71%). Associated aneurysm was more prevalent in deep seated or large sized AVM. Low grade AVM according to Spetzler's grading system showed good results of treatment. Postoperative hemorrhage or sizure were frequently found in patients who had superfically located AVM.
Overweight and its association with aortic pressure wave reflection after exercise.
Shim, Chi Young,Yang, Woo-In,Park, Sungha,Kang, Min-Kyung,Ko, Young-Guk,Choi, Donghoon,Jang, Yangsoo,Chung, Namsik,Ha, Jong-Won Elsevier ; Elsevier Science Pub. Co 2011 American journal of hypertension Vol.24 No.10
<P>Obesity is associated with arterial stiffening, left ventricular (LV) hypertrophy, and diastolic dysfunction. However, there is no data regarding dynamic changes in arterial hemodynamics with exercise in overweight subjects. We hypothesized that overweight women would show a different exercise response in wave reflection compared with lean women.</P>
( Ryoung-eun Ko ),( Chi Ryang Chung ),( Taewan Kim ),( Ire Heo ),( Areum Han ),( Chaiyoung Lee ),( Yunjoo Im ),( Gee Young Suh ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.0
Background Previous studies have shown that intensive care unit (ICU) survivors are affected by a wide range of physical, cognitive, and psychiatric issues. Among post intensive care syndrome, cognitive impairment and psychiatric problems worsen the quality of life of ICU survivors, and they have become important public health issues. Delirium is a frequent disorder in ICU and is associated with substantially increased morbidity and mortality after ICU care. This study conducted to evaluate the association between the presence of delirium during hospitalization involving ICU care and post-discharge cognitive impairment or psychiatric problems. Methods We conducted a retrospective cohort study using a database of nationwide insurance claims data. All patients aged 18 years or older who were admitted to an ICU between January 1, 2008, and May 31, 2015, and had no history of previous cognitive impairment or psychiatric problems were included. Results Of 306,011 patients, the proportion of those who experienced delirium during hospitalization was 55.0% (n = 168,190). The patients with delirium during hospitalization had significantly increased odds for cognitive impairment (adjusted HR 1.17; 95% CI, 1.05-1.29) and psychiatric problems (adjusted HR 1.78; 95% CI, 1.67-1.90) after discharge compared with patients without delirium. In patients who had delirium, the incidence of cognitive impairment was 210.8 per 1,000 person-years. In 19,496 patients who were diagnosed with cognitive impairment, depression (n = 3,233, 16.5%), sleep disorder (n = 1,791, 9.2%), and anxiety (n = 1,683, 8.6%) were commonly co-diagnosed. The most common psychiatric problem was sleep disorder (148.7 per 1,000 person-years), followed by depression (133.3 per 1,000 person-years). Conclusions Among patients received ICU care, those who experienced delirium during hospitalization had an increased risk of developing cognitive impairment or psychiatric problems post-discharge. Many patients showed multiple cognitive impairment and psychiatric problems during the follow-up period.
( Young Guk Ko ),( Jong Youn Kim ),( Chi Young Shim ),( Sung Ha Park ),( Ki Chul Hwang ),( Dong Hoon Choi ),( Yang Soo Jang ),( Won Heum Shim ),( Nam Sik Chung ),( Seung Yun Cho ) 한국조직공학과 재생의학회 2006 조직공학과 재생의학 Vol.3 No.3
After coronary stenting, inflammatory mechanisms play a crucial role in the pathogenesis of neointimal proliferation and in-stent restenosis. Drug eluting stents(DES) have been shown to reduce in-stent restenosis in various studies. We investigated plasma C-reactive protein (CRP) levels after DES implantation and compared with those after bare metal stent(BMS) implantation. In a prospective single center study, we performed percutaneous coronary intervention with a single stent in 67 patients(n=21 in BMS group, n=46 in DES group) with clinically stable angina. Plasma CRP levels were determined before intervention and 48 hrs, 72 hrs and 2 weeks after coronary stenting. There were 54 men(80.6%) and the age of patients ranged from 37 to 75 years(mean, 59±9 years). There was no difference in clinical and angiographic baseline characteristics except that more diabetic patients were included in DES group(34.8% vs 9.5%, p=0.04) and that the stent diameter was larger in BMS group(3.4±0.5 mm vs 3.0±0.4 mm, p<0.01). The plasma CRP levels at 48(13.4±14.7 vs 5.9±4.9 mg/L, p<0.01) and 72 hrs(16.7±19.8 vs 5.4±3.9 mg/L, p<0.01) after stent implantation were significantly higher in BMS than DES group. DES showed significantly lower plasma CRP levels after coronary stent implantation compared to BMS. This may reflect potent effects of DES on acute inflammatory reactions induced by coronary intervention.
Safe and Feasibility of Continuous Ketamine Infusion for Analgosedation in Medical ICU Patients
( Ryoung-eun Ko ),( Chi Ryang Chung ),( Jihoon Jang ),( Sungmin Hong ),( Bo-guen Kim ),( Ju Yeun Song ),( Daegeun Lee ),( Gee Young Suh ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Background Some mechanical ventilated patients require deep sedation during acute respiratory distress syndrome management, and these patients frequently received opioids, benzodiazepine, and propofol. Recent meta-analysis has reported an increasing trend of ketamine use in mechanically ventilated patients and showed that ketamine may be play a role as a sedative-sparing agent. However, most previous continuous ketamine studies were conducted in patients with traumatic, post-operative, or cerebral ischemia with small sample sizes. This study conducted to assess the effect of continuous ketamine in patients who admitted medical or cardiac ICUs and received mechanical ventilator. Methods We conducted a retrospective cohort study between March 2012 and June 2020 at Samsung Medical Center. Adult patients who received mechanical ventilation support over 24 hours and received continuous ketamine infusion at least 8 hours were included. Results Of all 12,534 medical or cardiac ICU patients, 564 were eligible for analysis. Ketamine was used 33.3 (19.0-67.5) hours and median continuous infusion dose was 0.11 (0.06-0.23) mcg/kg/hr. Of all patients, 469 (83.2%) received continuous ketamine infusion concomitant with analgosedation. Blood pressure, and vasopressor inotropic score were not changed before and after continuous ketamine infusion. Heart rate was decreased significantly from 106.9 (91.4-120.9) in 8 hours prior- and to 99.8 (83.9-114.4) in 24 hours post-ketamine initiation. In addition, respiratory rate was decreased significantly from 21.7 (18.6-25.4) in 8 hours prior- and to 20.1 (17.0-23.0) in 24 hours post-ketamine initiation. Overall opioid usage was significantly reduced; 3.0 (0.0-6.0) mcg/kg/hr as fentanyl equivalent dose in 8 hours prior- and to 1.0 (0.0-4.1) mcg/kg/hr as fentanyl equivalent dose in 24 hours post-ketamine initiation. However, the use of sedatives and antipsychotic medication were not decreased. Conclusions Ketamine may be a safe and feasible analgesic for medical or cardiac ICU patients as an opioid sparing agent without adverse hemodynamic effects.