좌측 대뇌 전두엽 실질내에 발생한 뇌실상의종(Ependymoma) 1치험례

문충배,변박장,이인수,강득용,지제근 대한신경외과학회 1977 Journal of Korean neurosurgical society Vol.6 No.1

A case of papillary ependymoma in the left frontal lobe was presented, because in Korea the cerebral ependymoma with no attachment to the ventricles was very rare. The patient was 40 years old female who had complained of severe headache and experienced occasional generalized tonic convulsions for 2 years prior to admission. We could treat the patient successfully by surgery. The tumor mass was attached to a part of the wall of a large cystic cavity which located within the brain substance of left frontal lobe. The tumor tissue was soft and papillary, and looked like a choroid plexus in the ventricles or a mural nodule in the wall of a large cyst which we may find occasionally in cerebellar hemangioblastomas. The cyst was filled with clear limpid yellow fluid of about 120 cc. The cyst-wall was not lined with any membrane, and was devoid of tumor tissue. The microscopic findings of tumor showed many papillary growths with the stroma having telangiectasias and irregular mixture of fibrous connective tissue and neuroglial cells.

Tannic acid의 혈압강하작용(血壓降下作用)

문충배,신홍기,김기순,Moon, Choong-Bai,Shin, Hong-Kee,Kim, Kee-Soon 대한생리학회 1979 대한생리학회지 Vol.13 No.1

The present study was undertaken to investigate depressor action of tannic acid and the mechanism underlies it in the rabbit. The changes in arterial blood pressure were studied after intravenous administration of tannic acid in normal rabbits and the animals pretreated with atropine, propranolol, dibenamine, and hexamethonium. The results obtained were as follows; 1) Following administration of 1.5 mg/kg, 3.0 mg/kg, and 5.0 mg/kg of tannic acid into rabbits the maximum depressor responses observed were $12.0{\pm}0.9\;mmHg$, $23.4{\pm}1.0\;mmHg$, and $34.0{\pm}1.8\;mmHg$ respectively and generally depressor responses increased in proportion to dosage of tannic acid. 2) Since there were no changes in depressor responses to tannic acid in animals pretreated. separately with atropine, propranolol, dibenamine, and hexamethonium, the depressor responses appeared to be resulting from direct vasodilator action of tannic acid on the vascular smooth muscle. Comparing tannic acid and acorn extract in their mechanisms of depressor responses, it is strongly indicated that in acorn there might exist another depressor substance. 3) After administration of large doses of tannic acid, in addition to respiratory changes, the mean arterial blood pressure decreased markedly and was never recovered throughout the experiment. comma Therefore it is also suggested that the lethal action of tannic acid resides in a drastic decline of arterial blood pressure and in respiratory changes as well.

제3흉추에 발생한 유골골종(Osteoid Osteoma) 1치험례

문충배,변박장,이인수 대한신경외과학회 1976 Journal of Korean neurosurgical society Vol.5 No.2

A case of osteoid osteoma of the third thoracic vertebra was presented because of its rarity in number in Korea. The patient was 27 years old male who had complained of severe attack-like referred pain in the right chest whenever he moved his neck. We could treat the patient successfully by surgical removal of it, which also showed the typical radiological and pathological findings of osteoid osteoma.

경 척수강에 발생한 경막외결핵성 육아종

조수호,최병연,문충배 영남대학교 의과대학 1984 Yeungnam University Journal of Medicine Vol.1 No.1

결핵성 척추압박골절등 결핵성 척추 골성변화나 결핵성 농양의 흔적이 전혀없이 척수강 배면에 발생한 아주 희귀한 단순성 단발성 경 척수강외 결핵성 육아종에 의해서 초래된 척수신경 압박증예를 치험하고 해부병리학적으로 확진한 후 문헌고찰과 함께 보고한다. A 44-year-old female with cervical cord compression signs had myelographic and computerized tomographic evidence of extradural spinal cord compression without any tuberculous bony lesion or cold abscess. At surgery, cervical spinal cord was compressed by extaosseous extradural granulomatous tissue which was histologically proved a very rare localized extradural tuberculous granuloma.

Nicotine 및 Ethanol이 가토 동방결절세포의 전기생리학적 특성에 미치는 효과

김기순,신홍기,고상돈,문충배 한양대학교 의과대학 1987 한양의대 학술지 Vol.7 No.2

The effects of nicotine and ethanol were studied on the electrophysiological characteristics of the isolated superfused sinoatrial node cells of the rabbit heart. Nicotine at concentrations between 0.025% and 0.05% increased APA (action potential amplitude) and prolonged APD??(time to 60% repolarizaton) of the isolated rabbit sinoatrial node cells, whereas RSF (rate of spontaneous firing) was significantly decreased by 0.05% nicotine. On the other hand, superfusion of the the isolated rabbit sinoatrial node cells with ethanol(0.8%, 2.4%) resulted in a decrease in RSF and a shortening of APD?? as well. APA of the sinus node cell decreased after superfusion with ethanol (0.8%~4.0%). Following composite superfusion with nicotine (0.05%) and ethanol (2.4%), RSF and APA of the sinus node cells decreased while APD?? was prolonged. Maximum changes in APA of the sinus node cells was observed in 7 min after superfusion with ethanol plus nicotine, and in 10 min after superfusion with nicotine alone. Thereafter these responses were restored almost to the original level in 20 min. When the sinus node was superfused in succession with nicotine and ethanol for 5 min with each drug, and initial increment in APA of the node cell followed by a subsequent decrease was observed. After superfusion with ethanol and successively with nicotine the time course of changes in APA of the sinus node cell was reversed. The results of present study indicate that effects on APA and APD of the sinus node cells nicotine and ethanol were counteracting, whereas that on RSF was additive.

송과체세포종

문충배,조수호,최병연 영남대학교 의과대학 1984 Yeungnam University Journal of Medicine Vol.1 No.1

본 교실에서는 송과체부위종양 중에서도 매우 드문 송과체세포종환자를,그 임상적 양상, 종양markers 및 방사선학적 조사 등을 종합분석하여 그 종양의 조직학적 성질을 미리 추정진단하므로서 최선의 치료방침을 세워 치험하고 이에 문헌고찰과 함께 보고하는 바이다. The management of pineal region tumors remains controversial. This paper reports a case of pineocytoma which was attempted to improve treatment planning by the use of clinical feature, computerized tomography, and markers for germ-cell tumors. A presumptive diagnosis could be made and this tumor less likely to respond to radiotherapy was subjected to primary surgery.

뇌 낭미충증에 관한 임상적 연구

문충배,최병연,조수호 영남대학교 의과대학 1984 Yeungnam University Journal of Medicine Vol.1 No.1

저자들이 지난 10년간 치험했던 25예의 중추신경계 낭미충증 환자를 임상분석한 결과 다음과 같은 결론을 얻었다. 1. 연령분포는 20-50세 사이가 약 70%로 대부분 이었고 남여별 빈도는 거의 비슷했다. 2. 임상증상의 기간은 대부분이 6개월 미만이었고 뇌실길형에서는 주로 간질발작, 국소신경이상소견, 뇌압항진소견등을 보인 반면 뇌실형에서는 뇌압항진소견과 소뇌이상소견을 주로 보였다. 3. Nieto 분류방법에 따라서 보면 뇌실형이 44%. 뇌실길형이 36%로 대부분을 차지했다. 4. 뇌신경마비는 제6 뇌신경마비, 제7뇌신경마비의 순으로 그 빈도가 나타났다. 5. 피하결절은 32%에서 촉지할 수 있었다. 6. 변검사상 충란은 20%에서 검출됐고, 호산구의 증가는 12%, 뇌척수액 담백질 증가는 80%, 혈침의 증가는 20%에서 볼 수 있었다. 7. 방사선학적 검사에서 이상소견은 단순촬영상17%, 뇌동맥조영술상 84%, 뇌실조영술상 94%에서 나타났고 콤퓨터 단층촬영상 이상소견은 시행했던 10예 모두 이상소견을 보였으며 이 방법이 뇌낭 충증 진단에 가장 정확한 진단방법이라고 판단된다. 8. 수술은 24예에서 25회 실시됐고 그 결과 약 72%에서는 호전이 됐고 24%는 변화가 없었으며 4%에서는 입원중 사망했다. 제4뇌실 낭미충증의 경우가 수술후 가장 좋은 예후를 보였고 후두와 개두술과 낭종의 흡인방법으로 비교적 쉽게 낭종의 제거가 가능했다. During last 10 years we experienced 25 cases of C.N.S. cysticercosis. Now clinical analysis and evaluation of our cases were made and the results are followings: 1. Prevalence in man and women are nearly same and about 70% of cases are distributed between 20-50 years old. 2. According to Nieto`s classification, mostly are ventricular(44%) and parenchymal type (36%). 3. Clinical manifestations were IICP (92%), focal neurological deficits (68%), seizure (48%), altered mental status (36%) and others listed on table 7. 4. In ventricular type, IICP and cerebellar dysfuction signs were predominated but seizure and focal neurological deficits were commonly seen in parenchymal type. 5. Subcutaneous cysticercus nodules were palpated in 32% of cases. 6. Positive stool ova was observed in 29% of cases. 7. Radiologic studies revealed as followings: 16% of cases showed abnormal findings on plain film, 84% on angiography, 94% on ventriculography and 100% on computed tomography and myelography. Computed tomography looks like most helpful diagnostic method for C.N.S. cysticercosis, they usually revealed lucent cystic lesion, hydrocephalic findings and contrast enhancement. 8. Suboccipital craniectomy, craniotomy with removal of parenchymal cyst or laminectomy were done according to location and types of lesion. 72% of operated cases revealed good reults and mortality was 4% of cases.

소아의 두뇌 손상후 속발된 공뇌증(Porencephaly) 2례

변박장,문충배,이인수 順川鄕病院 1976 順天鄕醫報 Vol.1 No.2

Case 1 is a boy of 5 7-ears, sustained craniocerebral injury and the emergency operation revealed subdural hematoma of ca 100 cc in the left frontal region with diffuse cerebral contusion, the hematoma was removed, and the craniectomy remained a skull defect of ca 7 cm in diameter on the left frontal region. The patient had been in a coma vigil state for two months there-after. When cranioplasty was made 7 months later, we found a large porencephaly in the left frontoparietal region which communicated broardly with the underlying left lateral ventricle. Case 2 is a boy of 3 months, sustained craniocerebral injury to make a linear fracture on the left parietal region and subdural hematoma of ca 60 co on the right frontoparietal region with diffuse cerebra1 contusion. The emergency operation was done to remove the hematoma, and left a skull defect of ca 4 cm in diameter on the right frontoparietal region. There-after the patient had remained in chronic coma like state and the skull had not grown any more. The head circumference had been in 41 cm till the age of 1 year and 5 months. Craniosrnostosis had occurred. At age of 11 months, in 8 months after the emergency operation we had performed the second operation to correct the craniosynostosis, while we found a large porencephaly in the right frontoparietal region which communicated broardly with the underlying right lateral ventricle. And also we ascertained that the development of the brain was ceased to make the secondary microcephaly with the craniosynos tosis. These two children gave rise to the large porencephaly in the frontoparietal area of one cerebral hemisphere as the later complication of the craniocerebral injury like a congenital porencephalic cyst.

소뇌에 발생한 결핵성 뇌농양 1례

변박장,문충배,이인수 대한신경외과학회 1978 Journal of Korean neurosurgical society Vol.7 No.2

The authors describe a case of tuberculous abscess of the cerebellum that originating , probably from pulmonary lesion. The development of such a lesion indicates a persistence of infection and an immunological breakdown which may partly have been due to unsatisfactory chemotherapy and protein malnutrition. Tuberculous brain abscess, an encapsulated collection of pus containing viable tubercle bacilli, is quite rare and it is different from tuberculoma in several points. Only five cases of tuberculous abscess have been fully documented and bacteriologically confirmed. The clinical, laboratory, and histopathological findings of those reported cases and the author's have been discussed.

조직화된 팽창성 자발성 뇌실질내 혈종

최병연,문충배,조수호 영남대학교 의과대학 1984 Yeungnam University Journal of Medicine Vol.1 No.1

저자들은 1½개월된 남아에서 vitamin K 의존인자 결핍으로 인한 뇌출혈 3주일후, 뇌혈관 기형에서 재차 출혈하여, 조직화한 팽창성 자발성 뇌실질내 혈종을 야기시킨 1예를 경험하고 문헌고찰과 함께 보고하는 바이다. The authors report a case of massive spontaneous intracerebral hematoma in a infant, caused by bleeding from cryptic vascular malformation associated with vitamin K dependant factor deficiency. The bleeding was initiated by vitamin K dependant factor deficiency, then 3 weeks later hematoma was expanded by rebleeding from malformed vessel after PT and PTT had been returned to normal values. The well circumscribed organized old hematoma with fresh bleeding component within a huge rusty colored cystic fluid cavity was recognized in operative field and pathological ground.