생체분해성 망막압정을 이용한 망막고정에 대한 실험적 연구

김용백,민병무,김창식,박근성,김승영,길숙종,조항진,이성복,노승무,송규상,강대영,조준식,양준묵,정경수,최선웅,이진호,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Biodegradable retinal fixation devices obtain mechnical fixation of the retina with desirable chorioretinal scarring and with the potential for local, sustained release of antimetabolites and steroids to inhibit proliferative vitreoretinopathy. We manufactured a biodegradable retinal tack with barb that was designed in order to prevent intrusion from implantation of retinal tacks. This study was carried to evaluate the efficacy for retinal fixation and the capability for sustained release of drugs with a newly designed biodegradable retinal tack Biodegradable retinal tacks were made of polymers of glycolic acids and were designed with barbs in a shape to prevent the disinsertion. Biodegradale retinal tacks are divided into 3 parts, a conical portion that is inserted into the sclera, a cylinder portion that remains in the vitreous, and a neck portion between the pin and the cylinder. The tapered conical end was manufactured to allow easy insertion through the retina and choroid into the sclera. A cylinder portion was manufactured with a tapered angle that fixes firmly into the orifice of 19 gauge spinal needle. A neck portion, 0.4 mm in diameter, was designed to prevent disinsertion from following implantation of retinal tack. The applicator was a 19 gauge spinal needle and its orifice was prepared to 15°angle to accept the tapered cylinder portion of the retinal tack. The retinal tacks, secured in the needles, were passed through the formed vitreous and inserted into the retina, choroid, and sclera and were released by pushing the internal needle, usually within 2-3mm of the medullary ray of the posterior rabbit retina A retinal tack was placed in each of 8 pigmented rabbit eyes. Slit-lamp biomicroscopy, indirect ophthalmoscopy and fundus photography were performed periodically from 1 day to 8 weeks after surgery. Eight eyes were enucleated and studied by light microscopy at 8 weeks. Biomicroscopic evaluation of the animals revealed edemas adjacent to the retinal surfaces immediately after insertion of the biodegradable retinal tacks in all the animals. These edemas disappeared after 1 week. The first noticeable change in the size of retinal tacks was shown after 2weeks. The size of the retinal tacks gradually got smaller, decreasing to about one-half at 4 weeks and about one-third at 8 weeks. All retinal tacks remained in inserted places without any movement for an 8 week period. On light microscopy, epiretinal proliferations were seen to extend into the vitreous cavity. Cellular capsules that lined the inner aspect of the scleral defect caused by tack insertion were found. However the adjacent retina had a normal cytologic appearance and architecture in all specimens. We manufactured a biodegradable retinal tack that is designed to prevent intrusion from implantation of retinal tacks. All biodegradable retinal tacks reduce in size with time, but no retinal tacks extruded from the inserted place. The newly designed biodegradable retinal tack can be used for retinal fixation and may be used as a vehicle for the introduction of pharmacologic agents to prevent the cellular events that promote proliferative vitreoretinopathy.

생체분해성 고분자를 이용한 사시수술용 제형개발 및 효용성에 대한 연구

민병무,김용백,김승영,김창식,박근성,길숙종,조항진,이성복,노승무,송규상,강대영,조준식,양준묵,정경수,최선웅,이진호,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

A new device, muscle clamping system was developed to facilitate exact quatifying technique A strabismus surgery, and reduce the risk of complications. The device is composed of a lower fixing body with three jaws and an upper supporting body. They are used to clip an extraocular muscle and fix it to the sclera with a single bite. Superior rectus recession on 16 rabbit eyes were performed with this new device. Conjunctival injection, muscle adhesion strength, and light microscopic findings were examined at 1, 2, 4 and 8 weeks postoperatively. The Conjunctival injection were minimal, adhesion power ranged from 420 to 600 gram gravity, which is sufficient in withstand the normal pull of human extraocular muscle. In microscopic exam, some Inflammatory cells and fibrosis were found. The new device was technically easy, fast, and accurate, so it may be useful in stabismus surgery.

난소절제후 Estrogen을 투여한 흰쥐 대동맥에서 Protein Kinase C-α와 Fas 발현의 변화

이왕수,이상엽,안지현,송영빈,김학진,이광재,유재격,김상욱,김태호,김치정,류왕성 중앙대학교 의과대학 의과학연구소 2001 中央醫大誌 Vol.26 No.3

Estrogen is believed to decrease coronary artery disease. Protein kinase C-α(PKCα)appear to be important in signal conduction pathways. Estrogen treatment increases catalytic activity of PKCα,and activation of PKCαcan modulate estrogen receptor levels and responsiveness. And it was reported that activation of PKC can protect cells from apoptosis induced by Fas ligation. But the beneficial effect of estrogen on PKCαwas not clearly demonstrated. The objective of this study was to evaluate the role of PKCαafter ovariectomy and estrogen therapy in rat aorta. The results were summarized as below: 1. The significant pathological changes were not observed in the rat aorta irrelevant to ovariectomy and estrogen therapy. 2. The expression of Fas was decreased in the aorta of estrogen-treated rats than that of ovariectomized rats without estrogen therapy. 3. Increased expression of PKCαwas more marked in the aprta of estrogen-treated rats than that of ovariectomized rat without estrogen therapy. In conclusion,PKCαmay be important in signal conduation pathway on the effect of estrogen. Activation of PKCαby estrogen reduced Fas expression, suggesting that PKCαactivation may play a role in protection against atherasclerosis. Further studies are needed to elucidate the role of PKCαafter estrogen therapy.

긴 관동맥병변에서 긴 스텐트삽입에 대한 임상경과 및 재협착율

김영학,박성욱,정상식,박훈기,이상곤,이일수,이철환,김재중,홍명기,박승정 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.6

굵은 골재 종류에 따른 포장 콘크리트의 피로특성

김성권,김동호,윤병성,이봉학 江原大學校 産業技術硏究所 2004 産業技術硏究 Vol.24 No.A

It is the purpose of this study to identify comprehensive fatigue characteristics of pavement concretes considering coarse aggregate types. The types of coarse aggregates considered are limestone, sandstone and granite, which are the most representative stones in Korea. The static strength tests were carried out to check the compressive strength, flexural strength at 7 and 28 days, and split tension strength at 56 day in order to minimize the various effect of strength during the test. The results are follows. The comprehensive fatigue models of pavement concretes were developed considering coarse aggregate types. The developed model showed a good relationship between aggregate types. The fatigue models with coarse aggregate types were shown, respectively. The combined fatigue models was also shown.

Multiple myeloma 환자에서 Bortezomib치료 후 발생한 마비성 장폐색증 1례

김준영,이원식,손창학,박성길,진한영,박석주,조영완,정은욱,강명주,박정하,주영돈 인제대학교 2006 仁濟醫學 Vol.27 No.-

Bortezomib is the first clinically available proteasome inhibitor that is clinically effective in the treatment of multiple myeloma. A proteasome inhibitor acts through multiple mechanisms to arrest tumor growth, tumor spread, and angiogenesis. The main adverse effects of bortezomib are gastrointestinal symptoms, cytopenia, fatigue, and peripheral neuropathy. To date, severe paralytic ileus has not been reported as a toxic effect of bortezomib treatment in multiple myeloma. Bortezomib is a novel agent that has only been used clinically for 30 months, so a need exists to further evaluate its toxicity. We report a case of grade Ⅲ (NCI CTCAE v3.0) or grade Ⅳ(SWOG toxicity criteria) paralytic ileus in a 65-year-old man with relapsed multiple myeloma who underwent one cycle of single-agent bortezomib treatment scheduled in a 21-day cycle (1.3 mg/㎥ as a single i.v. bolus on days 1, 4, 8, and 11).

D.D.S.중독으로 인한 정신증

김학성 大韓神經精神醫學會 1977 신경정신의학 Vol.16 No.2

Several reports suggested that DDS could induce psychosis, whereas it seems that there are no clear descriptions about dosage, clinical course, symptomatology and prognosis. The author reported three cases of toxic psychosis in non-leprous persons following massive adminstration of DDS giving emphasis to clinical characteristics. The first case, a 30 year old male, presented definite psychotic symptoms with paranoid picture after daily administration of 300㎎ of DDS for 40 days. The second case, a 13 year old male, had mental symptoms similar to those of the first case 2 days after the administration of 1,200㎎ of DDS in 3 days. In both cases, such symptoms as slowly increasing irritability, anorexia and insomnia were presented prior to the development of definite psychosis. The last case, a 21 year old female, took more than 1,000㎎ of DDS at once. Several hours after ingestion, acute intoxication symptoms such as nausea, vomiting, cyanosis and loss of conscious-ness appeared. Ten days later, she improved in her mental state except fatigability and visual disturbance. But after 30 days of lucid period, psychotic symptoms with hysterical picture were manifested. In all case, there was no neurological abnormality except typical organic brain syndrome such as disorientation, distractability, disturbance of calculation and recent memory, and exacerbating tendency at night. Antipsychotics were used for the treatment of psychotic symptoms, which were gradually alleviated after at least 2 months of treatment. The following facts could be extracted from the clinical experiences with these patients. 1) Psychotic symptoms were presented by both single and repeated administration of DDS. 2) Acute brain syndrome was observed in all cases, whereas it's mental symptom clearly reflected premorbid personalily of the patients. 3) There was a lucid period before the onset of psychotic symptom in the case of acute intoxication by single dose. In this case, visual disturbance with retinal hemorrage and macular degeneration was noticed. 4) Methemoglobinemia was not found in all cases, suggesting that psychotic manifestation might not be related to cellular hypoxia due to the methemoglobinemia but to the serum concentration and toxicity of the sulfone per se. 5) Recovery seemed to be the rule but required prolonged treatment.

VES-LMC의 보수ㆍ보강 두께에 따른 RC보의 휨거동 특성

김성권,이봉학 강원대학교 산업기술연구소 2006 産業技術硏究 Vol.26 No.B

The purpose of this study was to investigate the flexural. interfacial behavior, crack propagation, nonlinear behavior, effect repaired and rehabilitated with VES-LMC using RC beam with 4-point-loading test. The results were following: The test result showed that repair and rehabilitation effect increased as its depth increased, which was verified by the increase of flexural stiffness. More than 40% of stiffness was improved when the depth of repair was up to steel position. However, there was a little difference between 8cm and 12cm repaired beam. This means the repair depth must be considered. The interfacial behavior data showed that the repaired or rehabilitated beams had a little relative displacement. This means that two materials behave comparatively acting together. This suggested that interface treatment were one of the most important jobs in composite beams.

성공적인 경피적 승모판 교련절개술 후 임상 경과와 재협착율

김영학,강덕현,송재관,최기준,이철환,홍명기,김재중,박성욱,박승정 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.2

Alphabet Type의 基本 Typeface 硏究

金學成 淑明女子大學校 1984 論文集 Vol.25 No.-

The purpose of this paper is to describe classification system of the basic typeface of alphabet type adapted for our actual circumstance. The export promotion and economic development of Korea have been expanded to make use alphabet from the various brandnames of goods exported in the world market to the media for an overseas information activity. There are demended an expert knowledge about alphabet typeface to our designers. Therefore, Our designers must have method of their own for recognizing and classifing alphabet type. It is thereby possible to bring some order into what must seem an extremely disorderly and disorganized branch of letter design. In such viewpoint, This paper is described process of transition of alphabet type and compared with various classifition methods of the basic typeface of alphabet type which is each country. According to the result of analysis above, It can be possible to present resonable classification system of the basic typeface considered process of transition of alphabet type and adapted for our actual circumstance; Gothic, Venetian, Old Face, Transitional, Modern Face, Egyptian, Sans Serif, Script, and Miscellaneous. It is a great pleasure to make use this paper for alphabet typeface design of our designers.