Urinary tissue inhibitor of metalloproteinase-2 and insulin-like growth factor-binding protein 7 as biomarkers of patients with established acute kidney injury

( Won Yong Cho ),( Sung Yoon Lim ),( Ji Hyun Yang ),( Se Won Oh ),( Myung-gyu Kim ),( Sang-kyung Jo ) 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.3

Background/Aims: Urinary tissue inhibitor of metalloproteinase-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) have been recently discovered and validated as sensitive biomarkers that can predict stage 2 or 3 acute kidney injury (AKI) development in high-risk patients. We aimed to assess whether these biomarkers could predict adverse outcomes and renal recovery in established AKI patients. Methods: This was a single-center study prospectively enrolling 124 patients diagnosed with AKI. TIMP-2, IGFBP7, neutrophil gelatinase-associated lipocalin (NGAL), and kidney injury molecule 1 (KIM-1) levels were measured at the time of diagnosis and the predictive performance of short-term outcomes and renal recovery was assessed. Results: Patients were divided into 4 quartiles according to the initial urinary TIMP-2/IGFBP7 levels. Stage 3 AKI (odds ratio [OR], 17.86), classified by the Kidney Disease Improving Global Outcomes (KDIGO), as well as the third and fourth quartiles of TIMP-2/IGFBP7 (OR, 5.75 and 44.98, respectively), were found to be independent predictors of renal replacement therapy at the time of AKI diagnosis. In addition, KDIGO stage 3 AKI (OR, 2.468) or the third of fourth quartiles of urinary TIMP-2/IGFBP7 (OR, 1.896 and 3.622, respectively) were also found to be useful in predicting nonrecovery of renal function. In a separate analysis of patients with renal recovery at discharge, initial urinary TIMP-2/IGFBP7 or urinary IGFBP7 at discharge could also predict new-onset or progressive chronic kidney disease (CKD). Conclusions: In AKI patients, urine TIMP-2/IGFBP7 could serve as a biomarker for predicting adverse outcomes, renal recovery, or the development and progression of CKD.

Electrical, Thermal, and Thermoelectric Transport Properties of Se-doped Polycrystalline Re2Te5

Se Woong Lee,Okmin Park,Hyun-Sik Kim,Won-Seon Seo,Sang-il Kim 대한금속·재료학회 2022 대한금속·재료학회지 Vol.60 No.12

Re2Te5 is considered a potential thermoelectric material because of its intrinsically low thermalconductivity, due to its complex crystal structure. Herein, a series of Se-doped Re2Te5 (Re2Te5-xSex, x = 0, 0.2,1, and 2) samples were synthesized, and their electrical and thermal transport properties were investigated. Pure orthorhombic Re2Te5 phases were successfully synthesized without any impurities for all compositions,and the continuous decrease in the calculated lattice parameters confirmed the substitution of Se atoms atthe Te sites. A maximum power factor of 0.135 mW/mK2was achieved for the sample with x = 0.2 at 880 K,mainly due to the increase in carrier concentration and electrical conductivity. The lattice thermalconductivity significantly decreased for all doped samples, which was attributed to the point defect phononscattering caused by Se doping. The thermoelectric figure of merit, zT reached a maximum value of 0.20 at880 K for Re2Te4.8Se0.2 (x = 0.2) sample, which was approximately 22% higher than that of the pristine Re2Te5sample. The weighted mobility, quality factor, and expected zT were calculated to evaluate the optimizationof the power factor and zT.

Analysis of the Motion of a Harmonic Oscillator Coupled to Faraday's Law

KIM*, Se-Hun,KO, Tae-Eon,LEE, Se-Hyun,KIM, Kwang-Sun,OH, Seung-Won,KIM, Hyun-Seok Korean Physical Society 2018 새물리 Vol.68 No.1

Effect of Long -term Treatment with the Adventious Root Cultured Mountain Ginseng (CBN-3) on Functions of Central Nervous System in Healthy Human Volunteers

LEE SE0UL,YU KEE WON,KEUM KYUNG SOO,KIM NARI,PAEK KEE-YEUP,JUNG KYUY0NG,CHOI BONG KYU,OH GYUNG JAE4 대한약학회 2006 大韓藥學會 總會 및 學術大會 Vol.2006 No.1

동·서양 고전에 나타난 도덕적 통념에 관한 비판적 해석 -『논어』와 『에우티프론』에 나타난 아버지를 고발한 아들의 사례를 중심으로-

임명희 ( Lim Myung Hee ),김세원 ( Kim Se Won ) 동양철학연구회 2017 東洋哲學硏究 Vol.89 No.-

본 논문은 동서양의 고전 문헌에서 도덕적 통념에 관한 문제가 어떻게 다루어졌는지 고찰한 것이다. 이를 위해 『논어』에 나타난 `곧음(直)`에 관한 공자와 제자들의 대화, 『에우티프론』에 나타난 `경건함(?σιον)`에 관한 소크라테스와 에우티프론의 대화를 각각 분석하고, 그 철학적 함의를 검토하였다. 이를 통해 본 논문은, 공자와 소크라테스가 특정 도덕적 딜레마나 그것의 해결책 또는 특정 도덕관념에 대한 정의 자체에 관심이 있었다기보다, 독단적 자기 확신 또는 도덕적 통념에 관한 비판적 해석에 주안점을 두고 있었다는 것을 주장하였다. 결론적으로, 이들 철학자들은 아버지를 고발한 아들이라는 사례를 통해 우리의 삶에서 도덕적 믿음에 대한 반성적 태도가 중요함을 강조하며, 그 과정은 타자와의 대화를 수반한다는 점을 보여주고자 한 것이라 볼 수 있다. The aim of this study is to examine an issue of moral beliefs and moral conceptions in the Eastern and Western Classics. This paper focuses on the texts with one specific common material. That is the son who accused the father in the Analects(Lunyu) and the Plato`s Euthyphron. Confucius has a conversation with his follower about `Zhi(直)` and Socrates makes dialectical arguments with Euthyphron about a definition of `piety(to hosion)`. The philosophers critically examine opinions of the opposing parties to support the accusation. Other papers studied on aspects of moral dilemma(the private or the public, Physis and Nomos) or relation of religion and philosophy. But the important problem is relation between rightness(or justice) and honesty. In conclusion, this paper illuminates that the philosophers emphasize personal moral beliefs and their reflective attitudes toward one` own and lives, rather than the dilemma`s solution or the definition of moral ideas per se. Also, it is necessarily that the reflective courses involve a conversation with others.

조현병 환자의 언어성 환청과 정신병리의 PANSS 요인들 간의다차원적 관계

신샘이,김세현,이남영,윤탁,김용식,정인원,Shin, Sam Yi,Kim, Se Hyun,Lee, Nam Young,Youn, Tak,Kim, Yong Sik,Chung, In Won 대한생물정신의학회 2015 생물정신의학 Vol.22 No.4

Objectives This study was aimed to examine the multidimensional relationship between auditory verbal hallucinations (AVHs) and Positive and Negative Syndrome Scale (PANSS) factors of psychopathology in the patients with schizophrenia. And we explored the differences between assessments to hallucination by the clinicians and patients. Methods 82 patients with schizophrenia who were assessed by the Hamilton Program for Schizophrenia Voices Questionnaire (HPSVQ), Psychotic Symptom Rating Scale-Auditory Hallucination (PSYRATS-AHS), and the PANSS were recruited. Hwang's five-factor model of PANSS, items and total scores of hallucination scales, Kim's and Haddock's factor models of hallucination were applied to examine the correlations between psychopathology and AVHs. AVH-positive patients was 50 in PANSS-HPSVQ group and 24 in PANSS-PSYRATS-AHS. These two groups were separately analyzed. Results Among the five factors of the PANSS, negative and depression/anxiety factors were correlated with the total scores of HPSVQ and PSYRATS-AHS, and positive and autistic preoccupation factors were correlated only with the total score of PSYRATS-AHS. The activation factor was correlated with none of the total scores of HPSVQ/PSYRATS-AHS. These correlation patterns of a total score of HPSVQ/PSYRATS-AHS were same in the emotional factor of HPSVQ and physical factor of PSYRATS-AHS respectively. In the items which showed significant correlations, correlation coefficients of PANSS-PSYRATS-AHS group ranged between 0.406-0.755 and those of PANSS-HPSVQ ranged between 0.283-0.420. Conclusions This study suggested that the psychopathological domains of schizophrenia were differentially correlated with AVHs and the assessment of AVHs by clinicians and patients showed substantial differences which should be integrated into the therapeutic interventions.

바이오매스 합성가스를 이용한 엔진 발전 시스템의 경제성 평가

문지홍(Ji Hong Moon),이정우(Jeung Woo Lee),방병열(Byung Ryeul Bang),김세원(Se Won Kim),이은도(Uen Do Lee) 한국열환경공학회 2010 한국열환경공학회 학술대회지 Vol.2010 No.추계

Biomass, a carbon neutral fuel, is one of the fastest growing renewable energy sources. In this study, economic feasibility of small scale power generation system using syngas from biomass has been investigated. Effects of important variables such as capital investment, cost of waste wood, renewable energy certificate(REC), system marginal price(SMP) on the benefit of business have been analyzed. Internal rate of return(IRR) was predicted as 16.90%, which implicates the business is promising based on the assumptions such as SMP of 137 Won/kWh, capital cost of 4.7 billion won, and waste wood price of 30 thousand won. Major factors affecting the benefit of business are as follows; system marginal price, operational rate, capital investment, expenditure of waste wood, certified emission reduction.

Thermoelectric Properties of Cu-added Polycrystalline Bi2O2Se Oxyselenide

Si-young Bae,Se Woong Lee,Hyun-Sik Kim,Okmin Park,Hyunjin Park,Won-Seon Seo,Sang-il Kim 대한금속·재료학회 2022 대한금속·재료학회지 Vol.60 No.12

Bi2O2Se oxyselenide has been actively studied as a potential n-type thermoelectric material becauseof its intrinsically low thermal conductivity and high Seebeck coefficient (S). However, Bi2O2Se has very lowelectrical conductivity (σ), resulting in relatively poor thermoelectric performance. Herein, we investigate theeffect of Cu addition on the electrical and thermal transport of n-type polycrystalline Bi2O2Se. A series ofCuxBi2O2Se (x = 0, 0.0025, 0.005, and 0.0075) polycrystalline samples were synthesized by a conventional solid state reaction. Tetragonal Bi2O2Se was successfully synthesized, and its lattice parameters graduallydecreased with the addition of Cu. Further, σ decreased and the magnitude of S increased with increasingCu content, according to the trade-off relationship between these parameters. Consequently, a maximumpower factor of 0.106 mW m-1 K-2 was achieved for the sample with x = 0.0025 at 300 K, owing to the increasein the magnitude of S. The Hall carrier concentration decreased exponentially with the addition of Cu, whichis mainly attributed to the possible enlargement of the band gap of the Cu-added samples. The lattice thermalconductivity decreased with increasing x, which was attributed to point-defect phonon scattering via Cuaddition. Therefore, a maximum zT of 0.222 was obtained at 790 K for the Cu0.0025Bi2O2Se (x = 0.0025) sample,which was approximately 8% higher than that of the pristine Bi2O2Se sample.

Use of Molecular Replacement to Determine the Phases of Crystal Structure of Taq DNA Polymerase

Kim, Young-Soo,Suh, Se-Won Korean Society for Biochemistry and Molecular Biol 1996 Journal of biochemistry and molecular biology Vol.29 No.1

Taq DNA polymerase from Thermus aquaticus has been shown to be very useful in the polymerase chain reaction method, which is being used for amplifying DNA. Not only does Taq DNA polymerase have high commercial value commercial value for the polymerase chain reaction application, but it is also important in studying DNA replication, because it is apparently an homologue to E. coli DNA polymerase I, which has long been used for DNA replication study (Lawyer et ai., 1993). The crystal structure determination of Taq DNA polymerase was initiated. An X-ray diffraction pattern breaks down a crystal structure into discrete sine waves in a Fourier series. The original shape of a crystal object in terms of electron density may be represented as the sum of those sine waves with varying amplitudes and phases in three dimensions. The molecular replacement method was initially employed to provide phase information for the structure of Taq DNA polymerase. The rotation search using the program MERLOT resulted in a solution peak with 5.4 r.m.s. PC-refinement of the X-PLOR program verified the result and also optimized the orientation angles. Next, the translation search using the X-PLOR program resulted in a unique solution peak with 7.35 r.m.s. In addition, the translation search indicated $P3_121$ to be the true space group out of two possible ones. The phase information from the molecular replacement was useful in the MIR phasing experiment.

Theoretical Analysis on the Hot Surface Ignition of a Rectangular-Shape Solid Fuel

Kim, Se-Won The Korean Society for Energy 1995 에너지공학 Vol.4 No.2

Ignition of a reactive solid in a shape of square corner by a hot surface is studied theoretically. Ignition time and the location of ignition point are determined as a function of dimensionless parameters, with the use of the homogeneous model of ignition. The effect of geometry on the ignition of solid fuel results in the local characteristics: the reaction is initiated in a hot point in depth of the substance. It is shown that ignition time is proportional to the dimensionless initial temperature, whereas for the ignition of the semiinfinite body this dependence was quadratic.