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김민경,이인환,신애숙,김나희,김혜미,심소라,나병조,조승연,박성욱,정우상,문상관,박정미,고창남,조기호,김영석,배형섭,Kim, Min-kyung,Lee, ln-whan,Shin, Ae-sook,Kim, Na-hee,Kim, Hye-mi,Shim, So-ra,Na, Byung-Jo,Cho, Seung-yeon,Park, Seong-uk,Jung, Woo Sang 대한중풍순환신경학회 2010 대한중풍.순환신경학회지 Vol.11 No.1
Object : This study was conducted as part of the national project to standardize stroke diagnosis in Korean medicine. In this study, we aimed to evaluate the characteristics of acute stroke between heat pattern group and cold pattern group. Methods : We recruited stroke patients from 5 universities(Kyung-Hee University oriental medical center, Kyung-Hee University East-West Neo medical center, Kyungwon university lncheon oriental medical center, Kyungwon university Songpa oriental medical center and DongGuk university llsan oriental medical center) from April, 2007 until February, 2010. We diagnosed them and selected 463 heat pattern patients and 182 cold pattern patients. Results : We find that the risk factor of smoking, alcohol, diet(prefer to meat) are more associated with the heat pattern group. On the other hand, inflammation history in recent 3 months and diet(prefer to sea food) are more associated with the cold pattern group. RBC, Hg, Hct, TG, CK and Cl are more related to the heat pattern group. CPT, total cholesterol and HDL are more related to the cold pattern group. Tae-eum type takes high distribution of the heat pattern group, and So-eum type takes high distribution of the cold pattern group. Conclusions : This study provides evidence that the heat pattern group have more risk factor than the cold pattern group.
( Sang Hyung Kim ),( Dong Hoon Yang ),( Jung Su Lee ),( Soyoung Park ),( Ho Su Lee ),( Hyojeong Lee ),( Sang Hyoung Park ),( Kyung Jo Kim ),( Byong Duk Ye ),( Jeong Sik Byeon ),( Seung Jae Myung ),( S 대한장연구학회 2015 Intestinal Research Vol.13 No.2
Lymph node metastasis is rare in small (i.e., <10 mm) rectal neuroendocrine tumors (NETs). In addition to tumor size, pathological features such as the mitotic or Ki-67 proliferation index are associated with lymph node metastasis in rectal NETs. We recently treated a patient who underwent endoscopic treatment of a small, grade 1 rectal NET that recurred in the form of perirectal lymph node metastasis 7 years later. A 7-mm-sized perirectal lymph node was noted at the time of the initial endoscopic treatment. The same lymph node was found to be slightly enlarged on follow-up and finally confirmed as a metastatic NET. Therefore, the perirectal lymph node metastasis might have been present at the time of the initial diagnosis. However, the growth rate of the lymph node was extremely low, and it took 7 years to increase in size from 7 to 10 mm. NETs with low Ki-67 proliferation index and without mitotic activity may grow extremely slowly even if they are metastatic. (Intest Res 2015;13:175-179)
Effect of Sub- and Super-critical Water Treatment on Physicochemical Properties of Porcine Skin
Jo, Yeon-Ji,Kim, Jae-Hyeong,Jung, Kyung-Hun,Min, Sang-Gi,Chun, Ji-Yeon Korean Society for Food Science of Animal Resource 2015 한국축산식품학회지 Vol.35 No.1
Super- and sub-critical water treatments have been of interest as novel methods for protein hydrolysis. In the present study, we studied the effect of sub-critical water (Sub-$H_2O$, $300^{\circ}C$, 80 bar) treatment as well as super-critical water (Super-$H_2O$, $400^{\circ}C$, 280 bar) treatment on the physicochemical properties of porcine skin (PS), which has abundant collagen. Porcine skin was subjected to pre-thermal treatment by immersion in water at $70^{\circ}C$, and then treated with sub- or super-critical water. Physicochemical properties of the hydrolysates, such as molecular weight distribution, free amino acid content, amino acid profile, pH, color, and water content were determined. For the molecular weight distribution analysis, 1 kDa hydrolyzed porcine skin (H-PS) was produced by Super-$H_2O$ or Sub-$H_2O$ treatment. The free amino acid content was 57.18 mM and 30.13 mM after Sub-$H_2O$ and Super-$H_2O$ treatment, respectively. Determination of amino acid profile revealed that the content of Glu (22.5%) and Pro (30%) was higher after Super-$H_2O$ treatment than after Sub-$H_2O$ treatment, whereas the content of Gly (28%) and Ala (13.1%) was higher after Sub-$H_2O$ treatment. Super-$H_2O$ or Sub-$H_2O$ treatment affected the pH of PS, which changed from 7.29 (Raw) to 9.22 (after Sub-$H_2O$ treatment) and 9.49 (after Super-$H_2O$ treatment). Taken together, these results showed that Sub-$H_2O$ treatment was slightly more effective for hydrolysis than Super-$H_2O$ was. However, both Sub-$H_2O$ and Super-$H_2O$ treatments were effective processing methods for hydrolysis of PS collagen in a short time and can be regarded as a green chemistry technology.
Jo, Kyung-Wook,Hong, Sang-Bum,Kim, Dong Kwan,Jung, Sung Ho,Kim, Hyeong Ryul,Choi, Se Hoon,Lee, Geun Dong,Lee, Sang-Oh,Do, Kyung-Hyun,Chae, Eun Jin,Choi, In-Cheol,Choi, Dae-Kee,Kim, In Ok,Park, Seung-I The Korean Academy of Tuberculosis and Respiratory 2019 Tuberculosis and Respiratory Diseases Vol.82 No.4
Background: Recently, the number of lung transplants in South Korea has increased. However, the long-term outcome data is limited. In this study, we aimed to investigate the long-term outcomes of adult lung transplantation recipients. Methods: Among the patients that underwent lung transplantation at a tertiary referral center in South Korea between 2008 and 2017, adults patient who underwent deceased-donor lung transplantation with available follow-up data were enrolled. Their medical records were retrospectively reviewed. Results: Through eligibility screening, we identified 60 adult patients that underwent lung (n=51) or heart-lung transplantation (n=9) during the observation period. Idiopathic pulmonary fibrosis (46.7%, 28/60) was the most frequent cause of lung transplantation. For all the 60 patients, the median follow-up duration for post-transplantation was 2.6 years (range, 0.01-7.6). During the post-transplantation follow-up period, 19 patients (31.7%) died at a median duration of 194 days. The survival rates were 75.5%, 67.6%, and 61.8% at 1 year, 3 years, and 5 years, respectively. Out of the 60 patients, 8 (13.3%) were diagnosed with chronic lung allograft dysfunction (CLAD), after a mean duration of $3.3{\pm}2.8years$ post-transplantation. The CLAD development rate was 0%, 17.7%, and 25.8% at 1 year, 3 years, and 5 years, respectively. The most common newly developed post-transplantation comorbidity was the chronic kidney disease (CKD; 54.0%), followed by diabetes mellitus (25.9%). Conclusion: Among the adult lung transplantation recipients at a South Korea tertiary referral center, the long-term survival rates were favorable. The proportion of patients who developed CLAD was not substantial. CKD was the most common post-transplantation comorbidity.
High prevalence of Enterococcus spp. from dogs with otitis externa
Jo, Hyun-Jung,Chae, Hee-Sun,Kim, Hyun-Ju,Kim, Min-Ju,Park, Gyu-Nam,Kim, Sang-Hun,Chang, Kyung-Soo The Korean Society of Veterinary Service 2012 韓國家畜衛生學會誌 Vol.35 No.2
Otitis externa (OE) is a frequent disease in the ear canals of dogs. To identify the pathogens causing OE in dogs and to determine their antimicrobial resistances, specimens were collected from animal hospitals in Daejeon. The isolates were examined by morphological and biochemical tests, 16S rRNA analysis and antimicrobial susceptibility tests. We analyzed correlation between the isolated pathogens and external factors of dogs such as breed, age, gender, ear mite, hair in ears and experience with antibiotic therapy. Thirty three strains of bacteria were isolated from 26 of the 68 heads of dogs with OE. The most isolated bacteria were Enterococcus faecalis (E. faecalis) followed by Staphylococcus aureus (Sta. aureus), Sta. pseudointermedius, E. faecium, E. avium and Streptococcus canis (Strep. canis) in order of frequency of occurrence. Isolation frequency of Enterococcus spp. and Staphylococcus spp. were 51.5% and 45.5%, respectively. E. faecalis and E. faecium isolates showed VanB phenotype, which is resistant to vancomycin but sensitive to teicoplanin were 58% and 25%, respectively. Nine isolates among total twelve isolates of E. faecalis were isolated from the dogs treated with antibiotics. There was no methicillin-resistant Sta. aureus (MRSA), but were MR-Sta. pseudointermedius (MRSP) (57.1%) and vancomycin-resistant (VR)-Sta. pseudointermedius (14.3%) (VRSP) showing VanB phenotype. However, vanA, vanB and vanC genes were not detected in VR isolates from the dogs. Taken together, VR-Enterococcus spp. (VRE) is one of the major pathogens in domestic animals, as well as community-and hospital-acquired infection.
Differential Benefit of Statin 2ndary Prevention of AMI according to level of TG and HDL cholesterol
( Sang Woo Jeong ),( Wan Kim ),( Sun Ho Hwang ),( Won Yu Kang ),( Sang Cheol Cho ),( Kyung Hwan Kim ),( Gyu Ik Lee ),( Young Eun Jo ),( Myung Ho Jeong ),( Young Keum Ahn ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1
Background: The benefit of statin in acute myocardial infarction (MI) was well established. However, there were few studies about the differential efficacy of statin according to the baseline level of triglyceride and high-density lipoprotein (HDL)-cholesterol. Objective: To address the efficacy of statin in secondary prevention of MI according to the level of triglyceride and HDL-cholesterol on admission. Methods: The 36580 acute MI patients were enrolled from November 2005 to August 2012. Total patients were divided according to level of triglyceride and HDL cholesterol on admission and evaluated the efficacy of statin in patients with no lipid component of metabolic syndrome (Group A; n=15,461) (HDL cholesterol ≥40 mg/dL & triglyceride <150 mg/dL) and both components of metabolic syndrome (Group B; n=4,399)(HDL<0.001). However, the efficacy of statin was not prominent in Group B (HR=0.987; 95% CI; 0.708-1.376; p=0.939). After propensity matching, the survival analysis revealed that statin therapy reduced the risk of MACE in group A (HR=0.752, 95% CI; 0.609-0.929, p=0.008). This result was mainly due to reduction of cardiac death (HR=0.628, 95% CI; 0.420-0.938, p=0.023). Multivariate analysis revealed that use of statin contributed independently to improvement of clinical outcome in only Group A (HR=0.692, CI; 0.543-0.882, p=0.003). Conclusions: The long-term benefit ofstatin was not prominent in acute MI patients with lipid profiles of metabolic syndrome. Therefore, different lipid-lowering strategy is necessary in patients with low HDL and high triglyceride.