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간세포암환자에서 간동맥 화학 색전술 후 발생한 리피오돌에 의한 폐렴 1예
김소이,김유리,허현미,배서은,이명원,최윤정,김고흔,김태헌,유 권,문일환 이화여자대학교 의과대학 2009 EMJ (Ewha medical journal) Vol.32 No.2
Hepatocellular carcinoma(HCC)is one of common causes of cancer-related death in Korea where the majority of HCC patients were Hepaitc B virus(HBV)carriers and have cirrhosis. Transarterial chemoembolization(TACE)is commonly applied to the treatment of multinodular HCC in Korea and careful selection of candidate is important for the risk of various side effects. Besides common side effects as fever, nausea, abdominal pain and elevation of liver enzyme, TACE may predispose to hepatic failure, ischemic cholecystitis, pulmonary embolism, cerebral embolism and pneumonitis. In previous studies, some cases of pulmonary and cerebral embolism cases were reported but lipiodol pneumonitis after TACE was rarely reported. A 65-year-old woman with a multinodular HCC associated with HBV infection, was treated with TACE. Seven days after the procedure, nonspecific respiratory symptoms such as dyspnea and dry cough developed. Chest X-ray and chest computed tomography showed diffuse ground glass opacities in whole lung fields, suggestive of lipiodol pneumonitis. After several days of supportive care with steroid administration, radiologic abnormalities and subjective symptoms were much improved, considered that the disease was compatible with lipiodol pneumonitis.
문창종,김승준,위명복,김희석,정종태,박전홍,지영흔,Tanumab, Naoyuki,Matsumoto, Yoh,신태균 濟州大學校 農科大學 動物科學硏究所 2000 動物科學論叢 Vol.15 No.1
The expression of pro-apoptotic molecules, p53 and Bax, in the spinal cord of rats with experimental autoimmune encephalomyelitis (EAE) was examined. Apoptosis was confirmed by the terminal deoxynucleotidyl transferasemediated dUTP nick end-labeling (TUNEL) method. TUSEL (+) apoptotic cells were mainly either ED1 (+) macrophages or T-cells in the parenchyma of E N . Western blot analysis showed that both p53 and Bax expression significantly ( p < 0.01) increased in the spinal cords of EAE rats at the peak stage, and thereafter declined. An immunohistochemical study showed that inflammatory cells (notably T cells) in the parenchyma express p53 and Bax, while brain cells, includng neurons and glia, were devoid of these nuclear staining of these molecules. The nuclear expression of p53 largely matches apoptotic cells in the parenchyma of EAE. These finchngs suggest that pro-apoptotic molecules, p53 and Bax, may play an important role in eliminating T cells in the parenchyma in EAE.
대뇌피질 유발 저작 운동과 연수 망상체 신경세포 활성도에 관한 연구
우승표,안명석,김중수,이종훈 대한구강생물학회 1992 International Journal of Oral Biology Vol.16 No.2
This experiment was performed to clarify the role of brainstem for rhythm generation of mastication induced by stimulation of cerebral cortex. Rabbits were anesthetized with urethane and a pair of wire electrode was inserted into anterior digastric and masseter muscles, respectively. Experimental animal was placed to stereotaxic apparatus and occipital craniotomy and cervical laminectomy was performed to expose caudal brainstem. Cortically-induced mastication was evoked by electrical stimulation of cerebral masticatory area with concentric bipolar electrode and neural activity of brainstem and EMGs of masseter and anterior digastric muscle were recorded. The results obtained were as follows: 1. The neural activity of bulbar reticular formation was recorded at rostral 2-4㎜, lateral 0.5-1.5㎜ to obex and 1.5-2.5㎜ below the bulbar surfafce. 2. The site that neural activity corresponding with EMGs of masticatory muscles was recorded was medial bulbar reticular formation(MBRF) 3. The neural activity of medial bulbar reticular formation(MBRF) was corresponded with anterior digastric or masseteric EMG, respectively. 4. The neural activity of medial bulbar reticular formation(MBRF) and anterior digastric EMG was simultaneously recorded by twin pulse stimulation of contralateral cerebral masticatory area, and stimulation of ipsilateral medial bulbar reticular formation(MBRF) evoked anterior digastric EMG.
아드레날린 동작성 약물이 구강점막의 리도케인 Clearance에 미치는 영향
명재원,안명석,김중수,이종훈 대한구강생물학회 1992 International Journal of Oral Biology Vol.16 No.2
Some adrenergic drugs have been used as vasoconstrictors in local anesthetics for prolongation of acting duration and minimization of side effects. But, the exact role of vasoconstrictors on the clearance of local anesthetics in oral mucosa was not investgated. This experiment was carried out to clarify the influences of some adrenergic drugs on the clearance of lidocaine in oral mucosa. Sprague-Dawley rats were devided into control(no vasoconstrictor) group, epinephrine(1:100,000)-contained group, norepinephrine(1:30,000)-contained group and phenylephrine(1:2,500)-contained group. In urethane(1.2g/㎏) anesthetized rats, 300μl of 2% lidocaine with or without vasoconstrictor injected in the palatal mucosa. According to time schedule, they were sacrificed by exsanguination immediately, 30 and 60 minutes later after injection, respectively. The palatal mucosa was removed and homogenized by mechanical force and ultrasonicated in 0.1N HCl(500μl). The samples were centrifuged after akalization. Aliquat of the supernatant was injected into HPLC. Also, systemic effects of vasoconstrictors were evaluated with recording arterial blood pressures in common carotid artery. In control animals, lidocaine clearances reached 85.4% and 89.3% at 30 and 60 minutes after injection, respectively. At 30 minutes after injection, lidocaine clearances of vasoconstrictor contained group were different from control group significantly(p<0.01), and lidocaine clearance of phenylephrine contained group appeared higher than those of the other vasoconstrictor contained groups(p<0.05). But, at 60 minutes after injection, only epinephrine contained group had lower lidocaine clearance than control group(p<0.01). Intraperitoneal injection of the same dosage of palatal mucosa injecton of these vasoconstrictors did not elicit the change of blood pressure and heart rate.