The effect of CYP2C19 genotype on the time course of platelet aggregation inhibition after clopidogrel administration.

Kim, Ho-Sook,Cho, Doo-Yeoun,Park, Bo-Min,Bae, Soo-Kyoung,Yoon, Yune-Jung,Oh, Minkyung,Ghim, Jong-Lyul,Kim, Eun-Young,Kim, Dong-Hyun,Shin, Jae-Gook J.B. Lippincott Co. [etc.] 2014 The Journal of Clinical Pharmacology Vol.54 No.8

<P>We evaluated the effect of CYP2C19 genotype over time on the antiplatelet response of clopidogrel in healthy subjects. Seventy subjects enrolled for a pharmacodynamic study and 22 subjects for a pharmacokinetic and pharmacodynamic study took 300?mg clopidogrel on the first day and 75?mg once daily for six consecutive days. The subjects with CYP2C19 poor metabolizers (PM, N?=?22) and intermediate metabolizers (IM, N?=?37) had significantly delayed time to inhibition of platelet aggregation (IPA) compared with CYP2C19 extensive metabolizers (EM, N?=?33) (12 vs. 9 vs. 2?hours as median Tmax , P?<?.05) after a 300?mg of clopidogrel. During maintenance doses of clopidogrel, IPA values of only CYP2C19 PM subjects were gradually decreased from 30.0??21.9% on day 2 to 23.7??16.6% on day 8 (P?>?.05 for time effect; P?<?.05 for time and genotype interaction effect). CYP2C19 PM had decreased Cmax and AUC of thiol metabolite compared with CYP2C19 EM (0.42- and 0.37-fold on day 1, P?<?.01; 0.39- and 0.34-fold on day 7, P?<?.01, respectively). Delayed time to reach maximal IPA as well as decreased IPA may influence the increased risk of the acute cardiac events in CYP2C19 PM and IM.</P>

결핵성 복막염 102 예에 대한 임상적 고찰과 분석

김국륭 ( Koo Kyoung Kim ),김지운 ( Ji Woon Kim ),신우종 ( Woo Joung Shin ),박행렬 ( Haeng Lyul Park ) 대한내과학회 1980 대한내과학회지 Vol.23 No.8

후방 십자 인대의 재긴장술 및 보강술

김종원,태석기,한정우,정영복,양동렬,박철경 대한슬관절학회 2001 대한슬관절학회지 Vol.13 No.2

목적 : 남아있는 후방 십자 인대를 제거하지 않고 재긴장시킴 후 약해진 부분을 보강하는 술식으로 만성 후방 십자 인대 손상 환자를 치료한 결과를 분석하기 위함이다. 대상 및 방법 : 만성 후방 십자 인대 손상 환자에게 후방 십자 인대 재긴장술 및 보강술을 받은 환자 중 술후 추시관찰이 1년이상된 23명의 환자를 대상으로 하였고 평균 추시기간은 24.9개월 (16~43) 이었다. 관절경 검사상 연속성을 가진 인대를 경골부착부의 뼈와 함께 떼어낸 뒤 재긴장술을 시행하고, 자가 이식건 또는 동종이식건을 이용하여 보강술을 시행하였다. 결과 : 후방 불안정성 정도는 Telos^�기기를 이용한 방사선 사진 및 KT-1000 관절계측기를 이용한 최대 도수 전이 검사결과 건측과의 차이가 각각 수술전 평균 9.4mm(6~20) 및 7.0mm(5~10)에서 술후 평균 2.0mm*0~8) 및 1.7mm(0~5)로 감소되었다. 임상결과는 IKDC Knee Score경우 수술전 C군 11례, D군 12례에서 술 후 A군 4례, B군 14례, C군 5례이었고, OAK Knee Score는 수술전 양호 9례, 불량 14례에서 술후 최우수 8례, 우수 13례, 양호 2례이었고, 수술전 평균 66.3(42~79)에서 술후 87.3(79~97) 이었다. 결론 : 만성 후방 십자 인대 손상의 재건술시 연속성이 있는 후방 십자 인대를 제거하지 않고 재긴장술 및 보강술을 시행한 결과 후방 불안정성 및 임상결과에서 만족할 만한 결과를 얻었다. Purpose : To evaluate the outcome of the retensioning and augmentation of posterior cruciate ligament(PCL) in chronic PCL deficient patients. Materials and Methods : Twenty-three patients who underwent retensioning and augmentation of PCL were evaluated at average 24.9 months(16~43) after operation. Retensioning of remnant fiber of PCL by distally transferring of tibial bony attachment and augmentation with autogenous or allograft tendon were performed through a posterior approach in supine position. We assessed the posterior instability by stress radiographs with Telos^� stress device(Telos stress device; Austin & Associates, Inc.,G. Scheuda, HD) and maximal manual test with KT-1000 arthrometer(KT-1000(tm), MED metric, USA), and the clinical results by IKDC and OAK knee score before operation and after operation. Results : Average side to side difference in posterior stress radiograghs by Telos(r) stress device decreased from preoperatively 9.4mm(6~20) to postoperatively 2.0mm(0~8). Average side to side difference in maximal manual test with KT-1000 arthrometer also decreased from preoperatively 7.0mm(5~10) to postoperatively 1.7mm(0~5). Final IKDC score was A in four patients, B in fourteen and C in five, which was C in eleven and D in twelve preoperatively. Postoperative OAK score was excellent in eight patients, good in thirteen and fair in two, which was fair in nine and poor in fourteen preoperatively. Average OAK score improved from 66.3(42~79) to 87.3(79~97). Conclusion : The above results show favorable outcome after retensioning and augmentation of PCL without sacrificing the remaining fibers in reconstructive surgery for chronic PCL injury.

역설계 방법을 사용한 축류홴 설계

이경용(Kyoung-Yong Lee),최영석(Young-Seok Choi),김영률(Young-Lyul Kim),윤재호(Jae-Ho Yun) 한국유체기계학회 2006 유체기계 연구개발 발표회 논문집 Vol.- No.-

The axial fans for cooling condenser were designed by inverse design code TURBOdesign-1. The parameters of the inverse design were set by DOE(design of experiments). By changing the design parameters, such as the distribution of the blade loading, the spanwise circulation distribution and the stacking, 32 different fan designs were created. The overall performances and the local flow fields of these fans were computed by using a commercial CFD code. The results of the CFDcomputations were analyzed by DOE. The pressure rise and the efficiency were selected as the main responses and the main effects of the design parameters onthe responses were discussed. These procedures give a good way for the screening the parameters and the optimum design.

Isolation, Identification, and Probiotic Properties of Lactobacillus reuteri HY701 from Human Feces

Jun-Tae Kim,Hwang-Young Jung,Na-Kyoung Lee,Seong-Lyul Rhim,Hyun-Dong Paik 한국식품과학회 2006 Food Science and Biotechnology Vol.15 No.5

오송 생명과학단지 조경설계

김도경,김경렬,Kim Do-Kyong,Kim Kyoung-Lyul 한국조경학회 2005 韓國造景學會誌 Vol.33 No.1

This landscape design proposal was presented to a design competition for Osong Biohealth Technopolis Institute of Cheongwon Gun Chung Cheong Buk Do which was held by Ministry of Health and Welfare in March 2004. The site is located in. Osong Li, Kang Wei Myun, Cheonwon Gun, Chung Cheong Buk Do and has an area of $402,600m^2$. The judging criteria for landscape design set by the client could be articulated as follows: an environment friendly design respecting the surrounding environment, a functionally efficient site plan by clustering buildings with similar uses, a site plan having 'front yard' by locating buildings in rear areas toward existing 'groves'. The proposal set the main design concept of this project as 'clustering'. By doing that, existing grades and plants can be saved, buildings with similar uses can be clustered, huge 'front yard' as a symbolic image of this project can be achieved, and finally many small open spaces for everyday life can be designed accordingly.

발목자세가 정상성인의 정적균형에 미치는 효과

송창호,김경렬,이경진,신두철,이용우 대구대학교 특수교육재활과학연구소 2012 특수교육재활과학연구 Vol.51 No.3

본 연구는 정상성인을 대상으로 발목자세가 정적균형에 미치는 영향을 알아보고자 시행하였다. 서울시 소재의 대학에 재학 중인 건강한 학생 30명(남자 18명, 여자 12명)을 대상자로 선정하였다. 연구에 참여한 모든 대상자는 힘판 위에 맨 발로 서게 하였고 웨지를 사용하여 발에 각도변화 주고, 눈 뜬 상태와 감은 상태에서 정적균형을 측정하기 위해 힘판을 이용하여 자세동요를 측정하였다. 각각의 조건에 따른 자세동요의 좌우 자세동요 거리, 전후 자세동요 거리, 속도 모멘트를 분석하였다. 눈 뜬 상태와, 눈을 감은 상태에서 각각 운동면과 대칭이 자세동요에 유의한 영향을 미치는지 확인하였다. 좌우 자세동요 거리는 대칭일 때가 비대칭일 때보다 감소하며 시상면에서의 변화보다 전두면에서의 변화가 더 감소하는 것으로 나타났다. 전후 자세동요 거리는 대칭 유무에 따른 영향을 보이지 않았으나, 시상면에서의 변화보다 전두면에서의 변화가 감소하는 것으로 나타났다. 속도 모멘트는 시상면에서의 변화보다 전두면에서의 변화가 감소하며, 비대칭일 때보다 대칭일 때 더 감소하는 것으로 나타났다. 본 연구를 통하여 발목자세에 따라서 정적균형에 영향을 줄 수 있음을 확인하였으며, 발목의 시상면의 변화가 전두면의 변화보다 정적균형에 더 많은 영향을 준다는 것을 확인 하였다. The aim of the study was to investigate the effects of ankle position on static balance in healthy adult. For this study, 30 healthy adult (18 male, 12 female) were selected from university in Seoul. Each participant was asked to standing position with the under eye opened condition and eye closed condition in twelve different modes by wedges on force platform. The static balance parameters (ML sway length, AP sway length, velocity moment) were measured by the Good Balance system. Two-factor (motion plane, symmetry) repeated measures ANOVA was used to determine statistical significance of differences (p < .05) in all conditions. With the under eyes opened condition and eyes closed condition, there were significant differences of the ML sway Length in plane, symmetry, and plane ×symmetry (p < .05). With the under eyes opened condition and eyes closed condition, there were significant differences of the AP sway Length in plane. But, there was not significant differences of the AP sway Length in symmetry, and plane ×symmetry (p < .05). With the under eyes opened condition and eyes closed condition, there were significant differences of the velocity moment in plane, symmetry, and plane ×symmetry (p < .05). These results suggest that symmetry of ankle position affects postural sway and postural sway in sagittal plane is longer than in frontal plane.

Continuous Transforming Growth Factor β₁Secretion by Cell-Mediated Gene Therapy Maintains Chondrocyte Redifferentiation

Lee, Dug Keun,Choi, Kyoung Baek,Oh, In Suk,Song, Sun U.,Hwang, Sally,Lim, Chae-Lyul,Hyun, Jong-Pil,Lee, Hyeon-Youl,Chi, Guang Fan,Yi, Youngsuk,Yip, Vivian,Kim, Jeannie,Lee, Eun Byul,Noh, Moon Jong,Lee Mary Ann Liebert 2005 Tissue engineering Vol.11 No.1

<P>One of the most important factors in the production of cartilage is transforming growth factor beta1 (TGF-beta1). To obtain sustained release of TGF-beta1, a cell-mediated gene therapy technique was introduced. We infected chondrocytes with a retroviral vector carrying the TGF-beta1 gene. The single clone derivative showed sustained TGF-beta1 secretion. It also showed constitutive type II collagen expression. Whereas the TGF-beta1 protein itself is unable to induce formation of cartilage in vivo, human chondrocytes engineered to express a retroviral vector encoding TGF-beta1 showed cartilage formation in vivo when cells were injected into nude mice intradermally. These data suggest that cell-mediated gene therapy using TGF-beta1 as a transgene would be a promising treatment for osteoarthritis.</P>

Case Report : Development of Barrett`s Esophagus Soon after Total Gastrectomy

( Dong Hyun Sinn ),( Kyoung Mee Kim ),( Eun Ran Kim ),( Hee Jung Son ),( Jae J. Kim ),( Jong Chul Rhee ),( Poong Lyul Rhee ) The Editorial Office of Gut and Liver 2008 Gut and Liver Vol.2 No.1

The role of duodenal reflux and the time required for the development of Barrett`s esophagus has remained controversial. We report a case of Barrett`s esophagus that developed 6 months after total gastrectomy. A 76-year-old man diagnosed with gastric adenocarcinoma underwent a total gastrectomy and a Roux-en-Y esophagojejunostomy. The gastroesophageal junction in the resected specimen was both grossly and microscopically normal at the time of the operation. A routine follow-up endoscopic examination performed 6 months later revealed a tongue-like projection of red-colored columnar tissue. No reflux symptoms (heartburn or acid regurgitation) had been present during the intervening 6 months. A biopsy specimen from the esophagus showed intestinal-type metaplasia of the columnar epithelium. This case supports the development of Barrett`s esophagus solely from duodenal reflux and after a relatively short time in this clinical setting. (Gut and Liver 2008;2:51-53)

The Clinicopathological Features of Gastric Hyperplastic Polyps with Neoplastic Transformations: A Suggestion of Indication for Endoscopic Polypectomy

( A Reum Han ),( Chang Ohk Sung ),( Kyoung Mee Kim ),( Cheol Keun Park ),( Byung Hoon Min ),( Jun Haeng Lee ),( Jin Yong Kim ),( Dong Kyung Chang ),( Young Ho Kim ),( Poong Lyul Rhee ),( Jong Chul Rhe 대한소화기기능성질환·운동학회 2009 Gut and Liver Vol.3 No.4

Background/Aims: Although gastric hyperplastic polyps are usually considered as benign lesions, a low risk of carcinomatous conversion is currently recognized. We aimed to identify the characteristics of hyperplastic polyps undergoing neoplastic transformation. Methods: A total of 269 gastric hyperplastic polyps from 216 patients removed by endoscopic polypectomy (EP) or surgical resection were enrolled in this study, and their endoscopic pictures and pathology slides were reviewed. Results: Neoplastic transformation was detected on forceps biopsy specimen in 11 cases. However, the pathology findings from the EP or surgical specimen revealed neoplastic transformation in 14 cases (5.2%; 4 with dysplasia and 10 with adenocarcinoma). No significant difference was found between hyperplastic polyps with and without neoplastic transformation in age, sex, location, number of polyps or gross appearance. However, neoplastic transformations were more frequently found in gastric hyperplastic polyps >1 cm than in polyps ≤1 cm (12 of 143; 8.4% vs. 2 of 126; 1.6%) (p=0.013). Conclusions: Neoplastic transformations were more frequently found in gastric hyperplastic polyps >1 cm. Therefore, EP should be considered for gastric hyperplastic polyps >1 cm for the accurate diagnosis and definitive treatment. (Gut and Liver 2009;3:271-275)