Caffeine이 지구성 운동 수행능력에 미치는 영향과 억제성 아미노산에 의하여 활성화되는 이온통로의 조절작용

김은경,김영표,천병옥,이계영,김연정,임백빈,조영욱,김창주,김성수 대한스포츠의학회 1999 대한스포츠의학회지 Vol.17 No.1

To investigate the effect and mechanism of caffeine on endurance exercise, two experiments were performed. First, to test caffeine effect on aerobic exercise, 200-300g Sprague-Dawley rats were used and three groups, control group, low caffeine injection group and high caffeine injection group, were divided. Blood smpling by heart puncture were done at rest, after 30 min treadmill exercise, and after maximal exercise. Blood glucose, free fatty acid concentration were detected and following results were obtained. Glucose concentration showed significant difference between groups(p=0.0305) and also significant changes were exhibited between time(p=0.0004). Free fatty acid concentration had no difference between groups. but had significance between times(p=0.00065). Exercise endurance performance time showed significant difference(p=0.02350 in high caffeine injection group compared to control group. In this experiments, endurance exercise capacity was increased by caffeine injection. Therefore, second experiment was performed to investigate the effect of caffeine on ion current induced inhibitory amino acid neurotransmitter. GABA and glycine. Single periaqueductal gray neuron was acutely dissociated and nystatin perforated patch clamp was performed under voltage clamping condition. Caffeine evoked outward current in PAG neuron dose dependent manner. 1mM of caffeine application had no response. but 3mM caffeine evoked about 32.5±8.539pA outward ion current and 10mM caffeine evoked about 215.46±19.4pA outward current. 10^-2mM GABA activated Cl￣current and recorded by inward current. Caffeine inhibited GABA activated Cl￣ current concentration dependent manner. 10^-2mM of caffeine had no effect on 1-^-2mM of GABA response. but 10^-1mM caffeine inhibited GABA activated Cl￣ current about 5.74±2.13%, 1mM caffeine inhibited about 17.25±2.70%, 10mM caffeine inhibited GABA response about 45.31±7.71%. 10^-1mM of glycine activated Cl￣ current and also recorded by inward current. Caffeine inhibited glycine activated Cl￣ current concentration dependent manner. 10^-2mM caffeine decreased glycine activated Cl￣ current about 4.61±1.650%, 10^-1mM caffeine decreased about 6.49±2.24%, 1mM caffeine decreased about 26.82±4.27%, and 10mM caffeine decreased glycine response about 94.47±1.39%. These results suggest that caffeine inhibite inhibitory amino acid, GABA and glycine, this response causes excitation of CNS and this seems to be the basic mechanism of increasing effect to aerobic exercise performance by caffeine.

결장직장암 환자의 임상적 고찰 : 조선대학교 부속병원의 10년 간의 결과

나은종,문성표,장정환,김권천,민영돈,김성환,조현진,김정용,김경종 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.2

Background and Objectives: The colorectal cancer rates 4th in the total cancer prevalence in Korea. The clinical patient demographics were considered with the incidence rate of the colon and rectal cancer. The clinicopathological factors were analyzed for the 5 year survival rate. Materials Methods: Of the 282 patients who were operated from Jan. 1, 1992 to Dec. 31, 2001 and diagnosed by pathological biopsy as colo-rectal cancer, 234 patients were followed up. The age, sex, location of the cancer, TNM stage, operation method, histopathological classification, metastatic region, complications after operation and the survival rate were investigated. Results: Of the 234 patients, male and female consisted of 120 cases (51.3%) and 114 cases (46.7%), with an average age of 61.6 years. The average follow up period was 52.3 months and the peri operative mortality was 5.6%. The site of the cancer was most frequent at the rectum with 127 cases (54.3%). The patients were classified according to the TNM stages with 38 cases of stage 1 (16.2%), 98 cases of II (41.9%), 72 cases of III (30.8%) and 26 cases of IV (11.1%). The 5 year survival rate in the age group older than 50 was 63.3 % and 73.5% in the group younger than 50. In regard to the operation type, the 5 year survival rate was 65.4% for elective operation and 65.8% for emergency operation. The 5 year survival rate for well differentiated, moderately differentiated, poorly differentiated cancer, and mucinous adenocarcinoma was 73.7%, 60.2%, 58.3%, and 92.6%, respectively. The 5 year survival rate of each of the TNM stage is 81.1%, 74.8%, 57.0%, and 11.5% for Classes I, II, III, and IV, respectively. Conclusion: The clinical factors were analyzed for the 5 year survival rate with no statistical significance for the age, sex, and location of the cancer. The TNM stage and histopathological differentiation were statistically significant. The colon cancer showed better prognosis compared to the rectal cancer.

Plasma estradiol-17βand estrogen receptor increased during the artificial induce sexual maturation and it influence choriocapillary layer of eye in Japanese eel, Anguilla japonica

Ji-Yeon Hyeon,Sung-Pyo Hur,Jun-Hwan Byun,Eun-Su Kim3,Shin-Kwon Kim,Han-Jun Kim,Se-Jae Kim,Akihiro Takemura 한국수산해양기술학회(구 한국어업기술학회) 2018 한국수산해양기술학회 학술발표대회 Vol.2018 No.11

IEEE 802.11기반의 애드 혹 네트워크의 효율적인 동시적 전송

공현표,김은성,김두용 순천향대학교 산업기술연구소 2007 순천향 산업기술연구소논문집 Vol.13 No.1

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의사소통의 활성화가 수학적 추론 능력의 발달에 미치는 영향에 관한 사례연구

김익표,권은영,최정현 大邱大學校 師範大學 附設 敎育硏究所 2010 學校敎育硏究 Vol.5 No.2

NCTM(2000, p.60)은 수학적 추론 능력의 신장을 위한 의사소통의 활성화를 강조하고 있다. 그리고 추론을 포함한 수학적인 활동의 활성화를 위한 학생들 사이의 의사소통을 강조한 사례연구(Elbers, 2003; Goos, 2004)도 소개되었다. 이와 같이 많은 문헌들이 수학적 추론과 의사소통과의 관련성을 언급 하고 있지만 서로 어느 정도의 영향을 미치고 있는지에 대한 연구가 부족한 실정이다. 추론과 의사소통 을 포함한 수학적인 활동들이 별개의 것이 아닌 통합된 전체의 각 부분을 차지하면서 밀접하게 관련되어 있음을 인지하는 것은 학교 수학에서 중요한 부분이다. 따라서 수학교육의 목표를 향하여 가는 학생 들에게 관계망으로 연결된 수학적인 활동들은 효과적으로 목표에 도달할 수 있도록 도와주는 뼈대의 역할을 할 것이다. 본 연구의 목적은 학교 수학에서 의사소통의 활성화가 수학적 추론능력의 신장에 미치는 영향의 분석이다. 이를 위하여 학생들에게 단계적인 과제의 제시를 통하여 의사소통의 활성화를 유도하고 이것이 수학적 추론 능력의 신장에 미치는 영향을 탐색하고자 한다. The importance of mathematical communication and mathematical reasoning is currently standing out in mathematics education. As a matter of fact, lots of theses and documents are dealing with this subject, and are mentioning that these two factors develop together. However, there are few qualitative case studies in this fields. So, this study aimed at qualitative case study about the effects of active communication on mathematical reasoning devolopment throughout the experiments. This study recorded the process of improving mathematical reasoning through mathematical communication. For this, various problems which are from basic to advanced were presented by degrees. We hope this study has a lot of discussions about various methods in order that mathematical communication occurs actively in schools and that students become to recognize the importance of mathematical reasoning.

Calcium Carbonate와 fibrin adhesive의 병용이 성견 2급 치근분지부 치주조직 재생에 미치는 영향

서은표,정현주,김영준 전남대학교 치과대학 2000 전남치대논문집 Vol.12 No.1

The purpose of this study was to evaluate the effect of combined use of fibrin tissue adhesive and porous resorbable calcium carbonate on the periodontal regeneration of the class Ⅱ furcation defects in dogs. Class Ⅱ furcation defect was surgically created on the second, third, and fourth premolars bilaterally in the mandibles of six mongrel dogs. The experimental sites were divided into four groups according to the treatment modalities: Control-surgical debridement only; GroupⅠ-calcium carbonate grafting; Group Ⅱ-application of fibrin adhesive only; Group Ⅲ-application of fibrin adhesive after calcium carbonate grafting. The animals were sacrificed at 2, 4, and 12 weeks after periodontal surgery and the decalcified specimens were prepared for histologic and histometric examination. The results are as follows : Clinically, there were no inflammatory response in all groups after 2, 4, and 12 weeks. In the Control group, junctional epithelium migrated apically to the reference notch. In Group Ⅰ, graft materials exfoliated from the defect throughout the experimental periods and new bone was seen in the notch area at 4 and 12 weeks' specimens. At 2 weeks, fibrin adhesive was indistinguishable in Group Ⅱ. In Group Ⅲ, the graft material was maintained in the defect throughout the experimental periods and the amount of periodontal tissue regeneration was greater than other groups. These results suggest that the use of fibrin tissue adhesive in conjunction with porous resorbable calcium carbonate would improve the stability of graft material and inhibit the epithelial downgrowth and contribute to periodontal regeneration.

부산시 고령자의 통행행태에 관한 연구

오윤표,안영종,김은정 東亞大學校 建設技術硏究所 2005 硏究論文集 Vol.29 No.1

The purpose of this study os to analyze the elderly's travel behavior and to measure the factors affecting their travel mode choice. Questionnaire survey was conducted for this study. It is assumed that the elderly is over 65 years old for this study. The major results of this study are as follows:(1) Because driving alone is very expensive travel mode, bus is considered as main travel mode for the elderly over 65 years old. (2) The friendship, recreation, an medical treatment are significant travel purpose. It was showed that the elderly's travel pattern is irregular. (3) Going up and down of stairs are the most important restriction for the elderly's travel.

병원정보시스템의 경영전략적 활용방안에 관한 연구

이은효,신종연,윤병준,김영훈 서울보건대학 1999 서울보건대학 부설 병원경영연구소 논문집 Vol.4 No.2

This study includes an empirical analysis of utilization of strategic management with hospital information system and a policy implication on hospital management. The purposes of this study are to analyze the effects of strategic information and implementation on the major performance factors. For this study. the materials used are mailing survey data of 65 hospitals and related literature was reviewed. Crosstabulation and multiple response analysis were made to find the frequencies by groups. ANOVA and multiple regression analysis were adopted to examine the differences and the relationship between variables involved. The major findings are as follow: 1. Internal information needed for strategic management focuses on the patients' data and the ones of services being delivered. Using portion of financial indices also ranked 2nd by respondents. but financial analysis was not performed frequently. 2. The Effects of strategic information on the hospital management environment were the most in hospital planning and hospital administration and medical support tasks. Ane the effects of assessment of the external factors and rapidity and accuracy of decision making, however. were relatively low. 3. The more computer system group satisfy planning group on the material requested by planning group. the more effects of cost reduction and service promotion have favorable results. Besides. the more computer education and PR are performed. the more efficiencies of hospital management have favorable results. In result of more exploration, the relationship of between computer education and PR item and satisfaction level of planning group on requested material and cost reduction effects was statistically significant. Of the above results. there are favorable effects on the major performance factors. However. there are few results of being performed on systematic strategic planning, action and management. With regard to hospital management information system, there are many challenges in the future when applying strategic management methods. Hospital executives must begin to use information system strategically for survival and growth in the 2000s.

각종 변이원에 대한 쇠비름 추출물의 돌연변이 억제 효과

최근표,정성원,김은정,함승시 동아시아식생활학회 1997 동아시아식생활학회지 Vol.7 No.4

This study was performed to determine the effects of antimutagenicity of Porturaca oleracea L. in Korea. In Ames test, the ethanol extract of Poturaca oleracea L. inhibited mutagenic activity of N-methyl N'-nitro N-nitrosoguanidine(MNNG), 4-nitroquinoline-l-oxide (4NQO), benzo(α)pyrene(B(α) P) and 3 amino-1.4-dimethyl-5H-pyrido-(4,3-b)indole (Trp-P-1) in Salmonella typhimurium TA98 and TA100. But hot-water extract Porturaca oleracea L. only inhibited mutagenic activity of MNNG in Saltmonella typhimurium TA100. On 4NQO, the ethanol extract 100~1,600㎍ /plate of Porturaca oleracea L. showed a slight inhibitory effect of 13~48%, 4~47% in TA98 and TA100, respectively, but on MNNG, it showed higher inhibitory effect of 6~86% in TA100. And the treatment of 1,600㎍/plate of ethanol extract of Porturaca oleracea L. had strong antimutagenicity with 74-87% inhibition against TA98 and TA100 induced by B(a)P and with 85~93% inhibition against TA98 and TA100 induced by Trp-P-1. The ethanol extract was fractionated with ether, chloroform, ethylacetate, butanol and water. Among them, most of the fraction except water fraction showed strong antimutagenicity effects against mutation induced by 4-NQO, MNNG, B(a)P and Trp-P-1. Chloroform fraction had strong antimutagenicity with 91% inhibition against TA100 induced by MNNG, diethyl etherfraction had strong antimutagenicity with 92%, 98% inhibition against TA98 and TAI00 induced by 4NQO, Chloroform fraction had strong antimutagenicity with 97% inhibition against TA100 induced by B(a)P and diethyl etherfraction had strong antimutagenicity with 98% inhibition against both strain induced by Trp-P-1, respectively.

차동 기어의 진동 저감을 위한 동력 전달계 진동 해석

최은오,김희송,안병민,홍동표 한국공작기계학회 1997 한국생산제조학회지 Vol.6 No.3

Eigenvalue analysis of vibration mode and an analysis by frequency response among the methods of predicting gear noise are related with transmitting sound of vibration. In this study we intended to reduce the vibration noise of differential gear by reducing torque fluctuation of drive pinion shaft which causes vibration noise of differential gear in rear wheel drive vehicles. For this we developed multi-degree of freedom analysis model in which mass moment of inertia and torsional spring combined and we examined the influence of torsional vibration of driveline elements by performing forced vibration analysis of engine excitation torque. We studied the methods for reducing torsional vibration of driveline according to the design factor of propeller shaft and examined the effect reducing vibration in differential gear by flexible coupling.