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김방울,김경선,전홍열,강화정,김정상,홍석,김용진,Kim, Bang-Oul,Kim, Kyoung-Sun,Jeon, Hong-Yeol,Kang, Hwa-Jeong,Kim, Jeong-Sang,Hong, Seok,Kim, Yong-Jin 대한한방내과학회 2002 大韓韓方內科學會誌 Vol.23 No.2
Objectives : This study was designed to investigate the effects of Yukmijihwang-tang on contusion of the mice induced with medicine. Methods : I observed the effects of light and electron microscopes. and examined hematological changes and VEGF-immunohistochemistry. Results : Hematology: Leukocytes were increased significantly in a control group of mice compared with the experimental group. Light microscope : A few neurons were condensed in the 7-day experimental group, but condensed remarkedly in the 3-day control group. Most glial cells were observed in the 3-day experimental group. Edema and dilatation of vessels occurred significantly in the 3-day control group, and these results occurred weakly in the 7-day experimental group. VEGF-immunohistochemistry : VEGF-immunohistochemical reactivity for the glial cells was the highest in the 3-day experimental group, and immunoreactivity for the vessels and neurons highly increased in the 7-day experimental group. Electron microscope : In the 3-day control group, protoplasmic astrocytes concerned with angiogenesis contained weakly developed rough endoplasmic reticulum. and a few of glial filaments were observed. In the 7-day experimental group, the bundles of glial filaments were found in the cytoplasmic process of astrocytes. Conclusion : medication using Yukmijihwang-tang of mice contused by medical stress is highly effective in inflamatory response, curing cell damage and angiogenesis.
청조탕(淸燥湯)을 투여(投與)한 습열위증(濕熱威證) 환자(患者) 1례(例)에 대한 임상적(臨床的) 고찰(考察)
서철훈,김성진,이경환,김방울,최창원,이영수,김종석,김희철,유형천,Seo, Cheol-Hun,Kim, Seong-Jin,Lee, Kyung-Hwan,Kim, Bang-Oul,Choi, Chang-Won,Lee, Young-Soo,Kim, Jong-Seok,Kim, Hee-Chul,Ryu, Hyung-Cheon 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.3
This is a study of an admissional patient whose chief complaints were weakness and numbness in both legs, and lumbago. Diagnosis and treatment was based on overall analysis of symptoms from the point of view of muscular flaccidity due to damp-heat from an Oriental Medical point of view. 淸燥湯(Cheong Jo Tang) was administered against heat and dampness. Improvement was observed. For lack of objective criteria to evaluate improvement of these symptoms more case studies of this kind, done with screening tests and proper treatment through clinical application of the thinking of Oriental Medicine, will be needed.
단삼(丹蔘), 홍화(紅花)가 흰쥐의 뇌허혈에 미치는 영향
김방울,김정상,김경수,전상윤,홍석,Kim Bang-Oul,Kim Jeong-Sang,Kim Kyung-Soo,Jeon Sang-Yoon,Hong Seok 대한한의학방제학회 2003 大韓韓醫學方劑學會誌 Vol.11 No.2
Objectives: This study investigates the effects of Salviae miltiorrhizae Radix, Carthami Flos on Brain ischemia of the rats induced from the Occlusion of Lt. Common Carotid Artery. Methods: I observed effects using light microscopes and examined tissue of parietal lobe and hippocampus and VEGF-immunoreactive cells. Results: A small number of VEGF-immunoreactive cells are observed in the control group. VEGF-immunoreactive cells in Salviae miltiorrhizae Radix-administered group were slightly increased compared with control group. VEGF-immunoreactive cells in Carthami Flos-administered group were significantly increased compared with control group. Neurons of parietal lobe and pyramidal cells of hippocampus in the control group were greatly damaged.(neuronal densitity, form of dendrite and axon) On the other hand, neurons of parietal lobe and pyramidal cells of hippocampus in Salviae miltiorrhizae Radix-administered group were less damaged. Neurons of parietal lobe and pyramidal cells of hippocampus in Carthami Flos-administered group were significantly less damaged compared with control group. Conclusion : Salviae miltiorrhizae Radix, Carthami Flos can effect on stimulating angiogenesis and reducinging the damage of neurons in the rats induced from the Occlusion of Lt. Common Carotid Artery.
김행진,김성진,정수미,유형천,전상윤,홍석,김방울,Kim, Haeng-Jin,Kim, Seung-Jin,Jeung, Su-Mi,Ryu, Hyung-Cheon,Jeon, Sang-Yoon,Hong, Seok,Kim, Bang-Oul 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.2
Objective : This study was designed to evaluate the effects of oriental medicine therapy on a normal pressure hydrocephalus patient. Methods : The clinical data was analyzed on a patient with normal pressure hydrocephalus whose main symptoms were dementia, gait disturbance and urinary incontinence. The patient was admitted to the internal medicine department of Dong-shin University Oriental Hospital from December 7, 2002, and remaind until January 20, 2003. He was treated with herbal medicine(Yukmijiwhangtang), acupuncture and moxa therapy. Results : After treatment, improvement was seen in dementia, gait disturbance, and urinary incontinence. Conclusions : The study suggests that oriental medicine therapy is significantly effective on the treatment or normal pressure hydrocephalus.