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( Woo Yeon Hwang ),( Kidong Kim ),( Hye Yon Cho ),( Eun Joo Yang ),( Dong Hoon Suh ),( Jae Hong No ),( Jung Ryeol Lee ),( Jung Won Hwang ),( Sang Hwan Do ),( Yong Beom Kim ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-
Objective: Fatigue is a common symptom found after surgery. Several studies have reported that intravenous vitamin C treatment alleviates fatigue among cancer patients and even in healthy office workers. Similar to that our study aimed to assess the effect of intravenous ascorbic acid infusion on fatigue undergoing laparoscopic myomectomy. Methods: A total of 50 women undergoing laparoscopic myomectomy conducted in this randomized, double-blind parallel-group, placebo-controlled trial. The patients were randomly assigned in a 1:1 ratio to undergo laparoscopic myomectomy either with or without intravenous ascorbic acid. Starting 30 minutes before anesthesia, the study group received 2 grams of ascorbic acid with normal saline intravenously, while the placebo group were administered same volume of normal saline only for 2 hours intraoperatively. We measured fatigue score by using the Brief Fatigue Inventory-Korean version(BFI-K) consisting of 9 items. Results: Among the 50 randomized women, 2 and 3 in the study and control group, respectively, were excluded due to withdrawal of consent, cancellation of surgery or non-measurement of the endpoint. The baseline and operative characteristics were similar between each group. The fatigue scores were measured on postoperative day 2. Both the vitamin C group (n=23) and placebo group (n=22) had moderate level of global fatigue score (4.56±2.63, 5.21±2.02, P=0.351). Overall, in the vitamin C group, fatigue score tended to be lower for each item than placebo group, but there were no statistically significant differences. Conclusion: We anticipated that the intravenous ascorbic acid administration would reduce fatigue as in previous studies. The fatigue score measured by the BFI-K was lower in vitamin C group. However there were no statistically significant differences between trial and placebo groups in postoperative fatigue score.