전 종격동 종양 환자의 마취시 발생한 환기장애

박기범,박상진,지대림,이보현 영남대학교 의과대학 2005 Yeungnam University Journal of Medicine Vol.22 No.1

Because of location, a mediastinal mass may cause complications such as a major airway obstruction, a superior vena caval obstruction, and cardiac compression during general anesthesia. The patient's condition need to be assessed by several methods to predict the risks associated with general anesthesia The authors took computed tomographs for a preoperative evaluation of two patients with an anterior mediastinal mass, and the risk of perioperative complications was predicted by measuring the tracheal area. The patients were managed according to the preoperative evaluation but severe ventilation impairments were encountered during anesthesia. In one patient, stable ventilation could not be maintained until spontaneous breathing appeared. The operation was cancelled and the patient was brought into the ICU. In the other patient, a tracheal tube was inserted deeper in an attempt to pass the narrowed tracheal portion due to mediastinal tumor compression resulting in improved ventilation

Bio-Inspired Nanomaterials and Nanotechnology to Control Stem Cell Fate

KiBum LEE 한국생물공학회 2017 한국생물공학회 학술대회 Vol.2017 No.4

The efficient architecture for H.264 intra frame encoder

Kibum Suh,Hee Tae Kim 대한전자공학회 2006 ICEIC:International Conference on Electronics, Inf Vol.2006 No.6

Values of Curriculum Cluster Program Sharing Physical Education Curriculum in Korea

Kibum Cho 한국체육학회 2019 International journal of human movement science Vol.13 No.2

The purpose of this study was to explore values of curriculum cluster program as a student-centered approach to complement an existing regular school curriculum. Focus group interviews (n=39) were conducted and participants were recruited from the four public high schools in Korea. This study revealed that first, the reason for students to participate in the curriculum cluster was that they were not satisfied with current offerings of the traditional physical education within their regular school curriculum. Second, the curriculum cluster promotes students’ learning motivation by cooperating with friends, resulting in building up trust between friends. Third, it is possible that the curriculum cluster could be expanded into the regular school curriculum as career exploration programs. Fourth, despite a variety of advantages, the pressure to move to another school site and the teachers’ indifference to the curriculum cluster may be indicative of the low participation rates. This study confirmed that the case of the curriculum cluster may be a good solution that addresses these and other practical challenges within school environments. Also, characteristics among instructors and cluster curriculum had a positive impact on occupational socialization that students cannot easily improve within the regular school curriculum.

Growth of 2D Layered Metal Chalcogenides and Oxides Using MOCVD

Kibum Kang(강기범) 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.2

The 2D layered materials are the potential components in next-generation semiconductor devices and quantum devices. For exploring possible applications of 2D layered materials, high-quality and large-scale materials grown by a gas-phase process are required. In this talk, I will introduce recent advances in gas-phase growth of 2D layered materials, including transition metal dichalcogenides, metal oxy-chalcogenides, and metal oxides.

LAMMER Kinase Modulates Cell Cycle by Phosphorylating the MBF Repressor, Yox1, in Schizosaccharomyces pombe

Kibum Park,Joo-Yeon Lim,Je-Hoon Kim,Jieun Lee,Songju Shin,Hee-Moon Park 한국균학회 2023 Mycobiology Vol.51 No.5

Lkh1, a LAMMER kinase homolog in the fission yeast Schizosaccharomyces pombe, acts as anegative regulator of filamentous growth and flocculation. It is also involved in the responseto oxidative stress. The lkh1-deletion mutant displays slower cell growth, shorter cell size,and abnormal DNA content compared to the wild type. These phenotypes suggest thatLkh1 controls cell size and cell cycle progression. When we performed microarray analysisusing the lkh1-deletion mutant, we found that only four of the up-regulated genes in thelkh1-deletion were associated with the cell cycle. Interestingly, all of these genes are regulatedby the Mlu1 cell cycle box binding factor (MBF), which is a transcription complexresponsible for regulating the expression of cell cycle genes during the G1/S phase. Transcription analyses of the MBF-dependent cell-cycle genes, including negative feedbackregulators, confirmed the up-regulation of these genes by the deletion of lkh1. Pull-downassay confirmed the interaction between Lkh1 and Yox1, which is a negative feedback regulatorof MBF. This result supports the involvement of LAMMER kinase in cell cycle regulationby modulating MBF activity. In vitro kinase assay and NetPhosK 2.0 analysis with theYox1T40,41A mutant allele revealed that T40 and T41 residues are the phosphorylation sitesmediated by Lkh1. These sites affect the G1/S cell cycle progression of fission yeast by modulatingthe activity of the MBF complex.

A Stock Prediction System Based on News and Twitter

Kibum Kim,Seungmin Yang,Dongyoung Kim,Jeawon Park,Jaehyun Choi 보안공학연구지원센터 2016 International Journal of Software Engineering and Vol.10 No.6

As more concerns by the public about stock markets grow bigger, the more the people’s attention is drawn to a systematic method to predict stock prices that fluctuate. More importantly, as the modern stock markets react very sensitively to information for their stock prices, it is very important to predict the prices for investors. For that, this study shall utilize opinion mining and mechanical learning, which are widely used to analyze the meaning of information in systematic ways on analyzing data from news and Twitter to suggest a system that predicts stock prices. The stock price prediction system consists of a data collector, vocabulary analyzer, sentiment analyzer and stock price predictor. The stock price predicting steps consist of collecting contents of news and Twitter, extracting vocabularies by using morpheme analysis, executing sentiment analysis then predicting stock prices via mechanical learning. In order to evaluate the usefulness of the suggested method, we used the stock data for the last whole year on 7 companies in the bio industry that are most sensitive to information for the tests, and the accuracy of the results showed above 80%. The results of this study can be regarded as one of the methods to effectively predict stock prices of companies from various backgrounds in this modern information era that changes dramatically every moment.

Current Status of Erythrocyte Sedimentation Rate Test and Results According to Methods in Korea

Kibum Jeon,Young Min Kim,Young Kyung Lee 대한임상검사정도관리협회 2022 Journal of Laboratory Medicine And Quality Assuran Vol.44 No.3

Background: The erythrocyte sedimentation rate (ESR) test is one of the most frequently performed in clinical laboratories. In addition to traditional ESR methods such as the Westergren and Wintrobe methods, these methods have been diversified in recent years. We investigated the current status of ESR methods in Korea and the distribution of ESR results according to the methods based on the external quality assessment (EQA) data of the Korean Association of External Quality Assessment Service. Methods: Data from the ESR EQA, conducted twice a year from 2018 to 2021, were collected. We investigated the ESR methods, equipment usage status, and ESR results according to the methods. We also analyzed trends in proficiency test results by year. Results: The alternate method was the most frequently used ESR method in Korea (56.0%). The distribution of interlaboratory coefficients of variation (CVs) was 21.4%±14.3% (mean±standard deviation) for the Wintrobe method, 33.4%±12.8% for the Westergren method, and 22.8%±19.7% for the modified Westergren method, with no statistically significant difference between the three methods. The interlaboratory CVs of the alternate method were significantly lower than those of all other methods (6.2%±2.2%, P <0.001). The interlaboratory CVs showed a tendency to gradually decrease by year for all methods. Conclusions: Automated ESR methods are used in most laboratories in Korea. The interlaboratory CVs were lowest for the alternate method and tended to decrease as EQA was implemented. The ESR EQA is expected to improve the quality of the ESR.

Functional analysis of plant-derived HER2-positive breast cancer recombinant antibody anti-HER2 VHH-FcK

Kibum Kim,Se Ra Park,Yang Joo Kang,Hyun Joo Woo,Seung Ho Lee,Kisung Ko 한국당과학회 2022 한국당과학회 학술대회 Vol.2022 No.07

Overexpression of human epidermal growth factor receptor type 2 (HER2) protein is one of the prognostic factors to diagnose breast cancer, and HER2 is proto-oncogene located on chromosome 17, and overexpression of this oncogene plays an essential role in the growth and progression of certain violent types of breast cancer. This study demonstrated the expression of the anti-HER2 camelid single domain antibody VHH in tobacco plant. And we confirmed the function of recombinant VHH for the treatment of breast cancer. The anti-HER2 VHH was fused to human IgG Fc domain along with KDEL endoplasmic reticulum (ER) (VHH-FcK) in a gene expression cassette. The plant gene expression cassette was transferred to tobacco plants using Agrobacterium-mediated transformation. The transformants were screened by PCR and western blots. ELISA confirmed the binding activity of purified anti-HER2 VHH-FcK to HER2 positive breast cancer cell line BT-474. In conclusion, this study verified the possibility of anti-HER2 VHH-FcK as a therapeutic agent and suggests that the anti-breast cancer anti-HER2 VHH-FcK can be expressed, properly assembled and purified from plant expression system, which can be as an alternative system for antibody production.

Conceptual design of 240 mm 3 T no-insulation multi-width REBCO magnet

Kibum Choi,Jung Tae Lee,Jeseok Bang,Uijong Bong,Jeonghwan Park,Seungyong Hahn 한국초전도.저온공학회 2019 한국초전도저온공학회논문지 Vol.21 No.3

A rare-earth barium copper oxide (REBCO) superconducting magnet was designed using no-insulation (NI) and multi-width (MW) winding techniques. The proposed magnet is comprised of 58 REBCO-wound single pancake coils with a bore size of 240 mm. When the magnet is operated at 20 K, the center magnetic flux density is designed to reach 3 T with an operational current of 169.55 A, 70 % of its critical current. The critical current was evaluated using experimental data of a short REBCO conductor sample. The designed magnet was then simulated using FEM software with uniform current density model. Magnetic field and mechanical properties of the magnet are evaluated using the simulated data. This magnet was designed as one of the base designs for the project “Tesla-Level Magnets with Large Bore Sizes for Industrial Applications” which was initiated in 2019, and will be wound using REBCO wires with the defect-irrelevant-winding (DIW) technique incorporated to reduce the overall manufacturing cost.