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강혁주,김성욱,최석진,이중현,장재식,서영범,윤병구,박건욱,김성자,김용섭,강승완,이구,양창헌,이창우,김욱년,이광헌,서정일 동국대학교 의학연구소 2000 東國醫學 Vol.7 No.-
과립상 세포종은 Schwann 세포 기원으로 생각되며 인체에 비교적 드물게 발생한다. 과립상 세포종은 전신 어느 곳에서나 발견될 수 있으나 주로 혀, 구강, 피부 혹은 유방 등에서 호발하며 드물게 위장관에서 발견된다. 위장관에서는 식도에서 가장 호발하며 다음으로 위, 대장 순이다. 과립상 세포종은 대부분, 특히 위장관에서는 양성이며 소수의 악성 병변이 보고되었다. 이러한 이유와 함께 수술 전의 진단이 어렵기 때문에 과립상 세포종에 대한 근본적인 치료는 현재까지 외과적 절제술이다. 최근에 시도되는 치료방법들로는 내시경적 레이저 치료, 용종절제술, 내시경적 점막 절제술 등이 있다. 저자들은 상부 소화관 내시경검사를 시행하여 식도 과립상 세포종을 진단하고 내시경적 점막 절제술을 시행하여 합병증 없이 퇴원하여 현재 재발없이 경과 관찰중인 1례를 경험하였기에 보고하는 바이다. Granular cell tumors, which occur infrequently, are probably of Schwann cell origin. They can occur almost anywhere in the body but usually affect the tongue, oral cavity, skin, or breasts and are rarely found in the gastrointestinal tracts. The esophagus is the most frequent gastrointestinal site, followed by the stomach and the colon. Granular cell tumors are generally benign, especially in the gastrointestinal tract, some malignant lesions have been reported. For this reason, and also because preoperative diagnosis is difficult, the standard treatment for granular cell tumor has until now been surgical excision. In recent years, other therapeutic methods is endoscopic laser therapy (ELT), polypectiomy, endoscopic mucosal resection (EMR). We report a case of esophageal granular cell tumor which was diagnosed by an endoscopy and managed using an endoscopic mucosal resection without complication.
이승호,정종철,김건중,정주성,유선열,박문성,김창룡 大韓顎顔面成形再建外科學會 1996 Maxillofacial Plastic Reconstructive Surgery Vol.18 No.4
Odontogenic infections are usually locally confined, self-limiting processes. However, under certain circumstances, they may break through the bony, muscular, and mucosal barriers and spread into contiguous fascial spaces or planes far from the initial site of involvement, resulting in severn life-threatening complications, such as retropharyngeal spread, suppurative mediastinal extension, airway obstruction, pleuropulmonary suppuration, and hematogenous dissemination to distant organs. The mortality arte for mediastinitis from odontogenic infection ranges from 40% to 60%. Therefore rapid evalution and treatment is essential with a combination of life support, antibiotic therapy, and surgical intervention. Recently, we experienced three cases of retropharyngeal and mediastinal abscesses secondary to odonogenic infections. In all patients, early diagnosis was possible by CT scanning and physical examination. The prognosis was good in all patients by using urgent aggressive surgical and antibiotic therapy.
초등학교 영어수업에서 멀티미디어 자료 적용범위에 따른 영어학습의 효관에 관한 연구
이동한,이건옥,제은주 부산교육대학교 교육대학원 1999 논문집 Vol.1 No.-
The purpose of this study is to investigate appropriate proportion of multimediarized environment for the elementary English classroom. For this study, 100% multimediarized English lesson was provided to 4th grade students at Nae-San elementary school and 50% multimediarized English lesson was given to 4th grade students at Min-An elementary school for 4 months from september to december in 1998. To Nae-San, whole class was progressed only by various multimedia materials without direct interaction between the teacher and students from the beginning to the end of lesson. For Min-An, the English lesson was performed with multimedia materials, activities with teacher: one half of the lesson was done by the use of multimedia materials and the other half was done by interaction between the teacher and students. The study result shows that there was no significant difference between Nae-San and Min-An elementary school students performed better than that of Nae-San elementary school students. The result of this study shows that students who have class with 50% multimedia is better than students who have studied with 100% multimedia environment in the point of speaking. In the conclusion, this paper suggests that the language teaching method with 50% multimedia including variable game activities and apposite materials is more effective than that of 100% multimedia.
한우에 감염된 Theileria sergenti merozoite의 순수분리와 genomic DNA probe에 관한 연구
채준석,이주묵,권오덕,채건상 全北大學校 基礎科學硏究所 1994 基礎科學 Vol.17 No.-
To make the genomic DNA probe of Theileria sergenti, the merozoites were purified from bovine crythrocytes. The infected erythrocytes were lysed by Aeromonas hydrophila(Ah-1) hemolysin, and the parasites were isolated by ultracentrifugation on a Percoll discontinuous density gradient. For construction of a T sergenti genomic DNA library, T sergenti DNA was digested with PstI and the fragments were ligated into the PstI site of pUC19 before transformation of Escherichia coli JM83. Out of thousands of transformants obtained by transformation of E coli JM83 with the genomic library, three plasmids were chosen. The sizes of the inserted DNAs were 2.9kb(2.4kb and 0.5kb) in pKTS1, 4.3kb in pKTS2 and 1.5kb in pKTS3, respectively. The DNA fragments used as probe KTS1(2.4kb), KTS2(4.3kb) and KTS3(1.5kb) were labeled digoxigenin-11-dUTP for the Southern hybridization. In Southern hybridization, all of the probes(KTS1, KTS2 and KTS3) reacted specifically to T sergenti DNA, but not to bovine leucocyte DNA. In order to find out the sensitivities of the digoxigenin-11-dUTP-labeled KTS1 and KTS3 as the probes, purified merozoite DNA and bovine DNA(control) were checked by dot blot hybridization with the probes. Both of the probes, KTS1 and KTS3, detected as minimum amount of 975pg of the T sergenti DNA, but not bovine DNA even to 500ng.
Lee Keon-Joo,Shin Dong Woo,Park Hong-Kyun,Kim Beom Joon,박종무,Kang Kyusik,Park Tai Hwan,Lee Kyung Bok,Hong Keun-Sik,Cho Yong-Jin,Kim Dong-Eog,Ryu Wi-Sun,Lee Byung-Chul,Yu Kyung-Ho,오미선,Lee Soo Joo,Kim Ja 대한의학회 2022 Journal of Korean medical science Vol.37 No.33
This study aimed to present the prognosis after minor acute ischemic stroke (AIS) or transient ischemic attack (TIA), using a definition of subsequent stroke in accordance with recent clinical trials. In total, 9,506 patients with minor AIS (National Institutes of Health Stroke Scale ≤ 5) or high-risk TIA (acute lesions or ≥ 50% cerebral artery steno-occlusion) admitted between November 2010 and October 2013 were included. The primary outcome was the composite of stroke (progression of initial event or a subsequent event) and all-cause mortality. The cumulative incidence of stroke or death was 11.2% at 1 month, 13.3% at 3 months and 16.7% at 1 year. Incidence rate of stroke or death in the first month was 12.5 per 100 person-months: highest in patients with large artery atherosclerosis (17.0). The risk of subsequent events shortly after a minor AIS or high-risk TIA was substantial, particularly in patients with large artery atherosclerosis.
Roles of AKT1 and AKT2 in non-small cell lung cancer cell survival, growth, and migration.
Lee, Myoung W,Kim, Dae S,Lee, Joo H,Lee, Bum S,Lee, Soo H,Jung, Hye L,Sung, Ki W,Kim, Heung T,Yoo, Keon H,Koo, Hong H Japanese Cancer Association 2011 Cancer Science Vol.102 No.10
<P>Although AKT ? protein kinase B is constitutively active in nonsmall cell lung cancer (NSCLC) cells and is an attractive target for enhancing the cytotoxicity of therapeutic agents, the distinct roles of the AKT isoforms in NSCLC are largely unknown. In the present study, we investigated the roles of AKT1 and AKT2 in NSCLC cells using RNAi. The siRNA targeting of AKT1 or AKT2 effectively decreased protein levels of AKT1 and AKT2, respectively, in A549 and H460 cells. Cisplatin treatment of these cells increased apoptotic cell death compared with control. The siRNA-induced knockdown of AKT1 in H460 cells significantly decreased basal MEK? ERK1 ? 2 activity, resulting in nuclear factor-κB activation, whereas knockdown of AKT2 resulted in anti-apoptotic Bcl-2 family protein MCL-1 (MCL-1) cleavage, the collapse of mitochondrial membrane potential, cytochrome c release, and activation of the caspase cascade. Consequently, both siRNA treatments enhanced the chemosensitivity of H460 cells to cisplatin. However, neither AKT1 nor AKT2 siRNA treatment had any effect of p27 expression, and although both treatments tended to induced G2 ?M phase arrest, the effect was not statistically significant. Treatment with AKT1 siRNA markedly decreased colony formation growth and migration, but AKT2 siRNA had no significant effects on these parameters. These data suggest that AKT1 and AKT2 both contribute to cell survival, albeit via different mechanisms, and that the effects on cell growth and migration are predominantly regulated by AKT1. These findings may aid in refining targeted strategies for the inhibition of AKT isoforms towards the sensitization of NSCLC cells to therapeutic agents.</P>
Predictive Value of Pulse Pressure in Acute Ischemic Stroke for Future Major Vascular Events
Lee, Keon-Joo,Kim, Beom Joon,Han, Moon-Ku,Kim, Joon-Tae,Cho, Ki-Hyun,Shin, Dong-Ick,Yeo, Min-Ju,Cha, Jae-Kwan,Kim, Dae-Hyun,Nah, Hyun-Wook,Kim, Dong-Eog,Ryu, Wi-Sun,Park, Jong-Moo,Kang, Kyusik,Lee, So Ovid Technologies Wolters Kluwer -American Heart A 2018 Stroke Vol.49 No.1
<P>Conclusions-Our study shows that PP when measured in the acute period of ischemic stroke has nonlinear J-shaped relationships with major vascular events and stroke recurrence, and may have a stronger predictive power than other commonly used BP parameters.</P>
Nationwide Estimation of Eligibility for Endovascular Thrombectomy Based on the DAWN Trial
Keon-Joo Lee,Beom Joon Kim,김동억,Wi-Sun Ryu,Moon-Ku Han,Joon-Tae Kim,Kang-Ho Choi,Ki-Hyun Cho,Jae-Kwan Cha,Dae Hyun Kim,Hyun-Wook Nah,Jong-Moo Park,Kyusik Kang,Soo Joo Lee,Jae Guk Kim,오미선,Kyung-Ho Yu,By 대한뇌졸중학회 2018 Journal of stroke Vol.20 No.2