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Genomic Profiling Shows Increased Glucose Metabolism in Luminal B Breast Cancer
Shigeto Ueda,Hideki Takeuchi,Takashi Shigekawa,Kazuo Matsuura,Noriko Nakamiya,Hiroshi Sano,Hiroko Shimada,Eiko Hirokawa,Akihiko Osaki,Toshiaki Saeki 한국유방암학회 2013 Journal of breast cancer Vol.16 No.3
We had previously reported a close association between pathological response and the maximum tumor standardized uptake value (SUVmax) measured by 18F-fluorodeoxyglucose positron emission tomography prior to chemotherapy in estrogen receptor (ER)-positive breast cancer. We hypothesized that glucose hypermetabolism by luminal B tumors may result in chemotherapy responsiveness. Using a single-gene expression assay, TargetPrint® (Agendia) and a 70-gene expression classifier,MammaPrint® (Agendia), we divided 20 patients with ERpositive primary breast cancer into luminal A and luminal B subtypes and compared the tumor SUVmax value between the two groups. A significantly higher SUVmax was measured for luminal B tumors (n=10; mean±SD, 7.6±5.6) than for luminal A tumors (n=10; mean±SD, 2.6±1.2; p=0.01). Glucose hypermetabolism could help predict intrinsic subtyping and chemotherapy responsiveness as a supplement to ER, progesterone receptor, HER2,and Ki-67 histochemical scores.
Serum Bile Acid Composition in Fulminant Hepatitis; Comparative Study with Acute Hepatitis
Inaguma,Hideki,Tsukada,Katsuhiko,Takeuchi,Toshihiko,Masuko,Kazuo INSTITUTE OF TROPICAL MEDICINE YONSEI UNIVERSITY 1985 YONSEI REPORTS ON TROPICAL MEDICINE Vol.16 No.1
The serum bile acids of fulminant hepatitis 24 h after the onset of grade Ⅱ- encephalopathy were analyzed by high performance liquid chromatography in comparison with those of critical acute hepatitis. The total bile acid level tended to be lower in cases of fulminant hepatitis as compared to the cases of acute hepatitis. Regarding the bile acid composition, a decrease in the cholic acid and an increase in the chenodeoxycholic acid were observed in cases of fulminant hepatitis as compared to the cases of acute hepatitis. An increase in the glycine conjugated bile acids and a decrease in the taurine conjugated bile acids were observed in the cases of fulminant hepatitis. In two surviving cases of fulminant hepatitis, however, the taurine conjugated forms were kept relatively high and the level was close to that in acute hepatitis.