환경친화적 물류활동이 물류관리 성과에 미치는 영향

홍상태,강경식,김현수 韓國海運物流學會 2006 해운물류연구 Vol.48 No.-

교액성 폐쇄공탈장 1예

조태웅,민영돈,김경종,정권율,강성인,류소연,임성철 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.1

Obturator hernia is a rare pelvic hernia, occuring most frequently in elderly, extra-thin or debilitated women. Because of the anatomic character of the obturator foramen and the nonspecific symptoms in the presence of the hernia, the risk of strangulation of the herniated bowel is high, which leads to high morbidity and mortality rate. The authors experienced an unusual case of left obturator hernia with strangulation of the small bowel in an 80-year old female. The hernia was diagnosed by abdomino-pelvic computed tomography (CT) scan. Through the lower midline transperitoneal approach, resecting the strangulated small bowel, the hernia sac was ligated and the obturator foramen was repaired using adjacent broad ligament. We report these findings with a brief review of the literature.

大學「캠퍼스」屋外空間의 利用行態 調査硏究 : 東國大學校 서울「캠퍼스」를 中心으로 A Special of Dongguk University Campus in Seoul

金炅濟,姜泰昊 동국대학교 1987 論文集 Vol.26 No.-

The outdoor space of university campus is different from the other buildings. It is the place where students stay long time and take various activities. Therefore, it has to be made objectively on an educational level, because its main users are students. However, it is our real state of things that we cannot prepare for outdoor space of university campus rationally and sufficiently. Because the preparation of its environment has been made extemporaneously and we have taken measures suited to the increase in quantity of university students. The objective of this study is to analyze the real state of using the outdoor space of university campus and to draw out problems, and then to take the 1st step for the establishment of landscape plan and design. The object place of this case study is the campus of Dongguk University in Seoul. The writers made the behavior map according to the observation of the actual place. And then they investigated using styles of students and analyzed students' way of thinking by posing some questions. As the result of this study, the object place of this case study has narrow outdoor space. And the degree of confusion at outdoor space is increasing, because various activities of students are done at a same time. Also, it is the real state of things that the outdoor resting place is insufficient quantatively and qualitively and shading trees are insufficient, too. Another important point to recognize is that the readjustment of pedestrian way and space is urgent, because the section between vechicle road and walk way is difficult. Therefore, at a more general level, these problems should be reflected in the establishment of the plan and design which will be in progress, so that the comfortable space of campus can be established.

성인 급성 신부전의 원인 및 예후인자 분석

구영선,장윤경,양종오,강민규,황평주,김종학,나기량,이강욱,신영태 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.2

Acute renal failure is a frequent complication in hospitalized patients and is strongly related to the mortality. The Clinical outcome and prognostic factors of acute renal failure(ARF) have been analyzed by many authors. The present study describes the etiologic and clinical aspects, as well as other factors related to mortality. All the patients suffering from acute renal failure admitted during the period of January 1993 - August 1998 were included in the study. The average age of the patients was 52±17 years and mortality rate was 24%. The causes of acute renal failure were hemorrhagic fever with renal syndrome(HFRS), sepsis, renal hypoperfusion, urinary tract obstruction, acute tubular necrosis, etc. The etiology of ARF was a significant prognostic factor on mortality in ARF. Other significant prognostic factors were oliguria, organ failure, use of vasoconstrictors, hypotension, serum bicarbonate, premorbid conditions, sepsis, neurologic complications, gastrointestinal bleeding. On the other hands, operation, sex, anemia, thrombocytopenia, hypoalbuminemia, BUN, serum creatinine, and hyperkalemia were not significant factors for the mortality. We conclude that major prognostic factors of acute renal failure arc premorbid conditions, sepsis and multiorgan failure, and they are responsible for persistent high mortality of acute renal failure despite of advances of medical care.

S$_H$2 Reaction on Silicon-Carbon Bond in the Photoreactions of 2, 3-Benzo-1, 1-diphenyl(or dimethyl)-1-sila-2-cyclobutene with Carbonyl Compounds

Kang, Kyung-Tai,Okazaki, Renji,Inamoto, Naoki Korean Chemical Society 1984 Bulletin of the Korean Chemical Society Vol.5 No.1

The photoreaction of 2, 3-benzo-1, 1-diphenyl (or dimethyl)-1-sila-2-cyclobutene (9 or 10) with an aldehyde or ketone results in 1:1 cycloadduct of [4 + 2] type. In the reactions of 2, 3-benzo-1, 1-dimethyl-1-sila-2-cyclobutene (10) with acetone and butanone, another 1:1 adducts (13) were also formed, respectively. The following facts indicate that the formation of adduct involves an attack of a triplet carbonyl compound on the silicon of the benzosilacyclobutene, an $S_H2$ process. (1) Even when the reaction of 9 with acetophenone was carried out under conditions such that more than 99% of incident light was absorbed only by acetophenone using the filter solution of aq. cupric sulfate, the same adduct was still formed. (2) When the reaction of 9 with acetone was carried out under oxygen atmosphere, only trace amount of adduct was formed.

Chemical Transformation of Human Keratinocytes by 2,3,7,8-Tetrachlorodibenxo-$\rho$-dioxin

Kang, Mi-Kyung,Choi, Young-Sill,Ryeom, Tai-Kyung,Eom, Mi-Ok,Park, Mi-Sun,Jee, Seung-Won,Kim, Kang-Ryune,Kim, Ok-Hee,Kang, Ho-Il Korean Environmental Mutagen Society 2006 한국환경성돌연변이·발암원학회지 Vol.26 No.3

2,3,7,8-Tetrachlorodibenzo-$\rho$-dioxin(TCDD) is a ubiquitous, persistent environmental contaminant and the most powerful carcinogen categorized by IARC. Although the mechanism of carcinogenesis by TCDD is poorly understood, several studies have shown that the skin is one of target organs far TCDD. In this study, we investigated the neoplastic transformation of human keratinocyte-derived cell line, HaCaT, by chemical transformation method using N-methyl-N'-nitro-N-nitrorsoguanidine(MNNG) and TCDD. We found that subsequent exposure to TCDD for 3 weeks after initial exposure to MNNG markedly induced transformed cells. It was suggested that TCDD can act as a potent promoter in HaCaT cells. Furthermore, these transformed cells showed morphological alternations in soft agar and increased telomerase activity. Therefore, the TCDD treatment of HaCaT cells by initiated with MNNG could promote neoplastic transformation without stimulation by exogenous growth factors. As a result, TCDD had a strong potency as a promoter in nontumorigenic immortalized human epidermal keratinocytes.

내과하 부골증의 진단과 수술적 치료

이경태(Kyung-Tai Lee),양기원(Ki-Won Young),김재영(J-Young Kim),임태강(Tai-Kang Lim) 대한정형외과학회 2004 대한정형외과학회지 Vol.39 No.4

목적: 경골의 내과 하방에 발생하는 골편을, 방사선적 특징에 따른 원인에 상관없이, 내과하 부골증이라고 정의하고, 임상적 및 방사선적 특성과 수술적 치료에 대하여 알아보았다. 대상 및 방법: 1998년 11월 1일에서 2002년 6월 30일 사이 본원에서 내과하 부골증으로 진단 및 수술을 시행하고, 최소 1년 이상 추시가 가능하였던 28예 26명의 환자를 대상으로 임상적 특성과 수술 전과 수술 후의 주관적, 객관적, 방사선학적 치료결과에 대하여 비교 분석하였다. 수술의 성공여부를 판정하기 위하여 선수인 경우 수술 후 3개월 내에 시합에 복귀한 것을, 일반인인 경우 수술 후 1년 내에 일상 생활에 불편함이 없이 정상 생활이 가능한 것을 수술적 치료의 성공으로 판정하였다. 결과: 환자의 평균 연령은 18.3세였고, 전체환자 중 남자가 27예, 여자 1예이었고 양측에 수술적 치료를 시행한 경우는 2명이었으며 환자 중 축구선수가 20예, 농구선수가 2예였다. 동반질환으로는 만성 족관절 불안정증이 8예 전방 충돌증후군 1예와 족저건막염 1예가 있었으며 모든 환자에서 보행 또는 운동시 동통을 호소하였고 가장 흔한 이학적 증상은 족관절 내측부의 압통이었다. 방사선 검사상 골편의 존재여부를 확인하고 외상에 의한 급성골절의 경우는 연구에서 제외하였다. 내측부의 통증은 존재하지만, 국소 압통 부위가 모호한 경우나 족관절 통증의 다른 원인이나 동반 질환이 의심되는 환자에서는 골주사 검사(7예)나 MRI (3예)를 시행하여 골편과 증상과의 연관성을 확인하였다. 수술시 증상을 유발하는 골편을 제거하고 삼각 인대를 봉합 또는 재부착하는 술식을 시행하였고 동반질환으로 족관절 만성 불안정성이 있는 경우 변형 Brostrom 술식을 동시에 시행하였다. 수술 후 유발된 합병증은 없었으며, 수술 후 평균 2.2개월(l-6개월)에 내측부의 통증의 소실이 있었으며, 수술 후 1년 추시 결과 전례에서 큰 불편 없이 일상생활이 가능하였으며 축구선수의 경우 전례에서 수술 후 3개월 내 선수로의 복귀가 가능하였다. 결론: 내과하 부골증은 비교적 드문 질환이지만, 방사선 사진에서 경골의 내과 하방에 골편이 존재하는 모든 경우를 포함하여 정의할 수 있고, 보행시 통증이나 내과 부위의 국소 압통을 호소하는 임상 증상과 족관절의 단순 방사선 사진만으로 진단이 가능하다. 보존적인 치료 후에도 증상 호전이 없는 환자에서 수술적 치료를 고려할 경우, 골편의 완전 절제술과 삼각 인대의 정교한 봉합 또는 재부착술을 동시에 시행하는 방법이 효과적인 치료방법이 될 수 있다. Purpose: The objective of this study was to define the Os Submedialis Malleolare (OSM) as an any ossicles below medial malleolus of tibia and to determine the characteristics of clinical and radiological characteristics and to evaluate results of surgical treatment of OSM. Materials and Methods: Twenty-six patients with OSM were identified between November 1,1998 and June 30, 2002. Results: The mean age was 18.3 years. All patient except one were male and soccer players comprised 71% (20 cases). Associated disease were 8 cases (29%) of chronic ankle instabilities, one case (4%) of anterior impingement syndrome and one (4%) of plantar fascitis. The most common clinical symptom was pain during walking and sports activity and sign was tenderness around medial malleolus. Only simple radiograph could reveal presence of ossicle and differentiate with acute fracture. If symptom and sign obscured, Bone scan (7 cases) and MRI (3 cases) identify causes of pain and tenderness. As a surgical treatment, all bony fragment caused symptom and sign were eliminated and medial collateral ligament was reattached meticulously. Associated chronic ankle instability were present, modified Brostrom procedure was done simultaneously. On follow-up, The symptomatic pain were Wholly disappeared at average 2.2 months (1-6 months) after operation. On one year follow-up, all patients have been daily life without any complaints and all soccer players go back to the game within three months. Conclusion: Os Submedialis Malleolare have relatively rare incidence and most common clinical symptom and sign is tenderness on medial malleolar area of ankle, can be diagnosed both physical examination and plain X-ray film. As a treatment, Removal of ossicle and meticulous repair or reattachment of deltoid ligament could obtain excellent or good results.

Differential Gene Expression after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin in Hairless Mice Skin

Mi Kyung Kang,Ho Il Kang,Tai Kyung Ryeorn,Mi Ok Eom,Mi Sun Park,Seung Wan Jee,Ok Hee Kim 환경독성보건학회 2003 한국독성학회 심포지움 및 학술발표회 Vol.- No.-

마우스 피부암 발생과정에 있어서 2,3,7,8-Tetrachlorodibenzo-p-Dioxin(TCDD)처리에 의한 유전자발현 변화 연구

염태경(Tai Kyung Ryeom),김옥희(Ok Hee Kim),강미경(Mi Kyung Kang),박미선(Misun Park),지승완(Seung Wan Jee),엄미옥(Mi Ok Eom),강호일(Hoil Kang) 한국환경성돌연변이발암원학회 2005 한국환경성돌연변이·발암원학회지 Vol.25 No.1

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) displays high toxicity in animals and has been implicated in human carcinogenesis. Although the mechanism of carcinogenesis by TCDD is unclear, it is considered to be a non-genotoxic compound and tumor promoter. In our experiment, we investigated the effects of TCDD on gene expression in mouse skin carcinogenesis. We used cDNA microarray to detect the differential gene expression in tumors induced in hairless mouse skin by MNNG plus TCDD protocol. We found that erb-2, c-ets2 and p27^(kip1) were significantly up-regulated, but TNFR2, AKT-1, integrin β1, maspin, IGF-1, c-raf-1, Rb were significantly down-regulated, in tumor region, respectively. We also found that the expression of 53 genes involved in cell cycle, signal transduction, apoptosis, adhesion molecule, angiogenesis, and invasion, were changed two fold more, in tumor surrounding region, These data suggest that TCDD alters the expression of a large array of genes involved in apoptosis, cytokine production and angiogenesis in mouse skin carcinogenesis.

Chemical Transformation of Human Keratinocytes by 2,3,7,8-Tetrachlorodibenxo-ρ-dioxin

Mi-Kyung Kang,Young-Sill Choi,Tai-Kyung Ryeom,Mi-Ok Eom,Mi-Sun Park,Seung-Wan Jee,Kang-Ryune Kim,Ok-Hee Kim,Hoil Kang 한국환경성돌연변이발암원학회 2006 한국환경성돌연변이·발암원학회지 Vol.26 No.3

2,3,7,8-Tetrachlorodibenzo-ρ-dioxin (TCDD) is a ubiquitous, persistent environmental contaminant and the most powerful carcinogen categorized by IARC. Although the mechanism of carcinogenesis by TCDD is poorly understood, several studies have shown that the skin is one of target organs for TCDD. In this study, we investigated the neoplastic transformation of human keratinocyte-derived cell line, HaCaT, by chemical transformation method using N-methyl-N'-nitro-N-nitorsoguanidine (MNNG) and TCDD. We found that subsequent exposure to TCDD for 3 weeks after initial exposure to MNNG markedly induced transformed cells. It was suggested that TCDD can act as a potent promoter in HaCaT cells. Furthermore, these transformed cells showed morphological alternations in soft agar and increased telomerase activity. Therefore, the TCDD treatment of HaCaT cells by initiated with MNNG could promote neoplastic transformation without stimulation by exogenous growth factors. As a result, TCDD had a strong potency as a promoter in nontumorigenic immortalized human epidermal keratinocytes.