Expression of Wnt Target Genes in Solid Pseudopapillary Tumor of the Pancreas: A Pilot Study

Kang, Chang Moo,Kim, Hyun Ki,Kim, Hoguen,Choi, Gi Hong,Kim, Kyung Sik,Choi, Jin Sub,Lee, Woo Jung Lippincott Williams Wilkins, Inc. 2009 PANCREAS Vol.38 No.2

OBJECTIVES:: Solid pseudopapillary tumor (SPT) of the pancreas is very rare. This study was performed to analyze the expression of Wnt signal target genes (matrix metalloproteinase-7 [MMP-7], cyclin-D1, and c-myc) and Ki-67 in resected SPTs to determine their clinicopathologic characteristics according to their expression. METHODS:: From January 1995 to December 2005, 23 patients underwent pancreatic resections for SPT of the pancreas. Among 23 formalin-fixed, paraffin-embedded tissues, 12 were evaluated as a pilot study. Immunohistochemistry was performed using various detection and antigen retrieval methods to detect MMP-7, cyclin-D1, c-myc, and Ki-67. The expression of Wnt target genes was correlated with clinicopathologic features of the patients. RESULTS:: Solid pseudopapillary tumors of the pancreas always showed cytoplasmic/nuclear accumulation of &bgr;-catenin, frequent expression of cyclin-D1, and low proliferation index. MMP-7, cyclin-D1, c-myc, and Ki-67 were not correlated with microscopic features suggesting malignant potential (P > 0.05). Tumor size was closely related to microscopic features of malignant potential and apparently has an inverse relationship with the expression of cyclin-D1 and Ki-67 (P < 0.05). CONCLUSIONS:: Low proliferative index and associated MMP-7 expression may cause an unpredictable clinical course in this tumor. Subtle changes in the intracellular environment, not pathologic (morphologic) changes, may elucidate the unpredictable clinical course of this tumor.

신이식에서 이식신의 생존분석

오선미,김종학,황평주,구영선,강민규,나기량,김종섭,김성숙,이강욱,신영태,설종구,배진선,손기섭 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.2

To investigate the prognostic factors for the survival of transplanted kidney in patients with end-stage renal failure, 59 cases of renal transplantation from September 1986 to Feburary 1997 in Chungnam National University Hospital were analyzed retrospectively. The results were as follows: 1)The mean age of recipients was 33.8 years and that of doners was 38.9 years. The male to female ratio of recipients was 2.5:1, and that of donors was 1.03:1 2) Living related donore(LRD) were 79.6% and living non-related donors were 20.3%. The HLA-identical donors(ID) in LRD were 18.7% and HLA-haploidentical donors(HID) were 61.0%. In living non-related donors(LNRD), mean matched HLA-AB antigens were 1.56 and mean matched HLA-DR antigens were 0.56. 3) The average 5-year patient survival fate was 94%, and average 5-year graft survival rate was 70%. The 5-year graft survival fate of HLA-ID was 100%, and those HLA-HID and LNR were 70% and 36% respectively. 4) Total 33 episodes of acute rejection were found in 45.8% of transplanted patients. The number of acute rejection episode did not show significant difference between LRD and LNRD(P > 0.05). There was no significant difference in MLC between two groups(p > 0.05). 5) In comparison between the 18 patients who lost their graft function in 5 years and 17 patients who are maintaining graft function for more than 5 years, MLC was significantly lower in patients with functioning graft than of patients with non-functioning graft (p < 0.05). The number of rejection episode was also lower in patients with functioning graft than that of the patients with non-functioning graft(p < 0.05). However, there were no significant difference in recepient and donor age and history of pre-transplantation donor specific transfusion between two groups. With the results above, we can speculate that adequate donor selection according to good matched HLA typing and low MLC is very important for graft survival in renal transplantation. Prevention and treatment of acute rejection in renal transplantation is also na important factor for graft survival.

電子式 冷暖房器 試作에 關한 硏究(Ⅰ)

姜錤文,金元燮,柳喆魯 全北大學校 1971 論文集 Vol.13 No.-

1. The purpose of this research is trying to change the using motor-started air-conditioner and refrigerator, and to play a special part in coordination to progress our Electronic civilizations and to offer the reference data for the purpose of development of nationalization on Thermo-element. It is purpose of heat-control and improve the controlling apparatus of heat-control in the industrial part. 2. Have finished the Experiment on the Electronic thermo-elment to manufacture Air-conditioner and refrigerator, truly, have researched and investigated the designed construction of the Thermo-Box through basic experiment by the Electronic cooling and heating, air cooling and water cooling, and measurement of endothermic. The Thermo-Box is assemblized by the divised components, and have tested the characteristics of the thermo-Box. 3. By the results of the basic experiment, designed construction of Thermo-Box and the experiment of their characteristics we have got the merchandised problems considered faithfully economic class.

대장 및 직장암의 임상적 연구

孫基燮,姜珉圭 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.2

The colorectal cancer is the second most common cause of cancer deaths in the United States. The incidence of colorectal cancer is seemed to increase lately in our country as the dietary condition has been westernized. In addition that various diet, life style, hormonal, psychological variables and other unknown environmental factors may affect colorectal cancer. But earlier detection with numerous favorable means and appropriate surgical treatment for colorectal cancer used to improve survival and the quality of life of patients after surgical therapy. In this reguard authors reviewed 105 cases of colorectal cancers had been treated at the Department of General Surgery, College of Medicine, Chungnam National University from July 1984 to June 1988. The results are as follows; 1) The peak incidence reveales in the sixth decade and followed by seventh decade and those are 64.7%. The sex ratio is predominant in male as 1.1:1 2) The location of lesion is most frequent in the rectum(61.0%) and followed by sigmoid colon (16.2%). 3) The common symptoms and signs are bloody stool and melena, pencil like stool, constipation, abdominal pain and defication difficulty. 4) Major diagnostic methods and those accuracy are barium enema 96.2% sigmoidoscopy 92. 1 %, rectal. examination 54.3% and flexible fiberoptic colonoscopy 85.7%. 5) Pathologic diagnosis of patients were mostly adenocarcinoma 94.8%, which were moderately differentiated 66.7% and well differentiated 18.5%. 6) Dukes' classification shows. A: 16.7%, B: 19.8%, C:29.2%, D:34.4% and pathological staging shows. 1 :16.7%, Ⅱ:19.8%, Ⅲ:32.3%, Ⅳ:31.3%. 7) No correlation was found between the level of CEA and pathological grade and stage. 8) Major operative procedure were as follows; Miles' operation: 29.0%, sigmoid loop colostomy: 21.%, right hemicolectomy: 15.0%, anterior resection: 14.0%, lower anterior resection:9.0%. 9) Overall postoperative complication was 38.0% which include wound infection 34.7%, bladder dysfunction 24.5%, intestinal obstruction 18.4%, and leakage 10.2% and operative mortality is none. 10) Distant metastasis developed in the liver, 19.0% and in pelvic organ, 12.4%. 11) 4 years follow up shows as follows, 1 year survival rate is 83.0%, 2 years 61.5%, 3 years 30.4% and 4 years 29.6%.

Polydyn^�(Tissue Extract)의 각종 암환자에 대한 투여 효과

손기섭,강민규 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.2

Polydyn(tissue extract) was administrated intramusculary, 2 ampules (120mg) a day, on 21 cancer patients and effects on pain, would healing, granulation tissue proliferation, ascites and side effects were analyzed. The results were as follows: 1. Improvement of pain was noted on 83.3% after Polydyn administration and 83.3% belonged to Visick score I or II. 2. On wound healing, 6 patients (100%) were healed clearly. 3. 50% of Polydyn injection group showed prominent proliferation of granulation tissue on wound than non-injection group. 4. Effect on ascites was unclear. 5. No side effect was noted during Polydyn administration.

Halon 1301과 Halon 대체 소화약제를 기포제로 이용한 포 소화약제에 대한 연구

정기창,임성묵,이창섭,강영구,김홍 (사단법인)韓國火災 ·消防學會 1996 한국화재소방학회논문지 Vol.10 No.3

포 소화약제는 물보다 비중이 가벼운 액체 가연물 또는 입체면이 많은 건물에서 포 수용액을 팽창 발포시켜 대상물을 덮어 씌우거나 봉쇄해서 질식소화 시킬 수 있다. 포 소화약제로 소화성능이 탁월한 수성막포(AFFF) 소화약제를 노즐에 의해 공기와의 혼합으로 포를 형성하는 기존의 방법과 다른 방법으로 본 연구에서는 Halon 1301 및 Halon 대체 소화약제를 기포제로 사용하여 소화성능과 팽창비를 향상시킨 소화약제를 개발하게 되었다. 개발한 Halon 1301과 Halon 대체 소화약제를 기포제로 사용한 수성막포 소화약제는 적은 양의 수성막포 수용액으로 많은 양의 포를 형성하므로 휴대용 포 소화기 또는 포 소화설비 등에 유용하게 사용할 수 있다. The AFFF(Aqueous Film Forming Foam : 3M Company's Light Water) agent are synthetic compounds that foams which are similar to those produced by protein based materials. The foam extinguishing agent was used in the extinguisher was the AFFF agent. We sought, however, to make other foams by using halon 1301(CF_3Br) and halon alternatives, such as HCFC Blend A(CHClF_2 82%, CF_3CHCl_2 4.75%, CF_3CHClF 9.5%, C_10H_16 3.75%), HFC-227ea (CF_3CHFCF_3). We selected these alternatives instead of air in order to raise the expansion ratio of the AFFF agent. By these means we discovered that it is possible to increase the expansion ratio of the AFFF agent up to 44 : 1 and up to 24 : 1 when HFC-227ea was used as a halon alternatives. Therefore our new foam extinguishing agents can be used in a portable extinguishers.

부분편향 시료에 대한 기약 Tensor해석

孫基洙,金榮柱,姜昞燮,李壬洙 慶北大學校 1989 論文集 Vol.48 No.-

Depending on structure and electronic resonances the second-order non-linear susceptibility Χ^(2) is usually measured by second-harmonic generation. The macroscopic non-linear optical susceptibility Χ^(2) for a system of partially oriented molecules is written as the ensemble average of molecular hyperpolarizability tensor β. The orientational distribution of these molecules is described by a probability function expanded in Wigner matrices. It confirmed that Χ^(2) has seven non-vanishing conponents for a rotationally invariant system. For a molecule with C_2υ we compared average orientation angle of sum-frequency generation with of SHG, determined elements β_zzz β_xzx of the dominant molecular tensor components and caculated average orientation angle.

乳房疾患의 臨床的 硏究

孫基燮,姜珉圭 충남대학교 의과대학 지역사회의학연구소 1987 충남의대잡지 Vol.14 No.2

The clinical study on 119 cases of breast diseases was carried out in the department of general surgery, college hospital of Chungnam National University for last 5 years. The results are as follows: 1) The most common lesion was breast cancer, in 47 cases, 39.5% and followed by fibrocystic disease in 36 cases, 30.3%, fibroadenoma in 19 cases, 15.9% in order. 2) The peak age incidence of breast cancer is fifth and sixth decades, 16 cases, 34% each, fibrocystic disease in third, fourth, and fifth decades, 30% each and fibroadenoma is third decade, 11 cases, 60%. 3) The most common chief complaint was palpable mass in 94%. The size of masses of cancer were larger than those of benign lesions. 4) The location of lesions, both cancer and benign diseases were more prominant in the right side and the rate is 5 : 4. 5) Both breast cancer and benign diseases were most commonly found in the upper outer quadrant and followed in the central portion. 6) The accuracy of preoperative diagnosis of breast cancer is 93.6%, fibroadenoma is 100%, and fibrocystic diseases is 72.2% respectively. 7) The most frequent region of metastasis was bone in 6 cases, 12.8% and followed by lung and pleura, and skin in 3 cases, 6. 4% respectively. 8) The surgical procedures were performed with modified radical mastectomy, which is the most common, in 34 cases, 72.4%, radical mastectomy in 10 cases, 21.3% simple mastectomy in 3 cases, 6.3% respectively for breast cancer. The excisional biopsy were performed for almost all cases of benign lesions in 64 cases, 95.5%.

The Results of Curative Radiotherapy for Carcinoma of Uterine cervix

강기문,유미령,장지영,서태석,윤세철,박용휘,신경섭,남궁성은,김승조,Kang Ki Mun,Ryu Mi Ryeong,Chang Gee Young,Suh Tae Suk,Yoon Sei Chul,Bahk Yong Whee,Shinn Kyung Sub,Namkoong Sung Eun,Kim Seung Jo The Korean Society for Radiation Oncology 1993 Radiation Oncology Journal Vol.11 No.1

가톨릭의과대학 강남성모병원 치료방사선과에서 1983년 3월부터 1989년 10월까지 79개월 동안에 자궁경부암으로 근치적 방사선치료를 받았던 135명의 환자들 중에서 추적이 가능하였던 120명의 환자들을 대상으로 치료결과및 예후에 영향을 미치는 인자에 대하여 후향적 분석을 하였다. 방사선 단독으로 치료한 환자는 78명이었고 유도 화학요법을 방사선 치료전에 시행한 환자는 42명이었다. 대상 환자들의 추적 조사기간은,2개월에서 106개월이었고 중간 추적조사 기간은 62개월이었다. 환자들의 나이는 32세부터 79세까지의 분포를 보였다(중앙값, 59세). FIGO 병기별 분류에 의하면, IB 기가 20명 ($16.7{\%}$), IIA 기가 19명 ($15.8{\%}$), IIB기가 49명 ($40.8{\%}$), IIIA 기가 5명 ($4.2{\%}$), IIIB기가 13명 ($10.8{\%}$), IVA 기가 14명 ($11.7{\%}$)이었다. 전체환자의 5년 생존율은 $50.8{\%}$였다. 병기별 5년 생존율은 IB 기가 $47.7{\%}$ IIA 기가 $70.2{\%}$, IIB 기가 $64.1{\%}$, IIIA 기가 $40.0{\%}$, IIIB 기가 $23.1{\%}$, IVA 기가 $14.3{\%}$였다. 치료방법에 따른 5년 생존율은 방사선 단독으로 치료한 환자가 $51.2{\%}$였고, 유도화학요법을 방사선 치료전에 시행한 환자는 $54.0{\%}$였다. 치료후 재발은 22명 ($18.3{\%}$,)에서 관찰되었고, 이중 14명 ($11.7{\%}$)에서 국소재발이, 7명 ($5.8{\%}$)에서 원격전이가, 1명 ($0.8{\%}$)에서 국소재발과 원격전이가 함께 발생하였다. 그리고, 치료에 의한 합병증은 41명 ($34.2{\%}$)에서 관찰되었으며 9명 ($7.5{\%}$)에서 습낙설, 8명 ($7.5{\%}$)에서 설사, 7명 ($5.8{\%}$)에서 방사선 직장염의 순으로 발생하였다. 예후와 관련된 생존율에 영향을 주었던 인자로는 나이 (p<0.0291), 병기(p<0.0001), 전신상태(p<0.0041), 초기 혈색소 수치 (p<0.0001), 강내 조사(p<0.0004)였고, 조직학적 소견(p<0.29), 유도 화학요법과의 병행치료(p<0.87)는 통계학적으로 유의하지 않았다. This is a retrospective analysis of 135 patients with invasive carcinoma of the uterine cervix treated with curative radiotherapy from March 1983 through October 1989 at the Department of Therapeutic Radiology, Kang-Nam 51. Mary's Hospital. Among them, 78 patients received radiotherapy alone and 42 patients treated with neoadjuvant chemotherapy followed by radiotherapy and 15 patients were lost to follow up. All patients had follow up from 2 to 106 months (median; 62 months). Age of the patients ranged from 32 to 79 years at presentation (median; 59 years). According to FIGO classification, there were 20 ($16.7{\%}$) in stage IB, 19 ($15.8{\%}$) in stage IIA,49 ($40.8{\%}$) in stage IIB, 5 ($4.2{\%}$) in stage IIIA, 13 ($10.8{\%}$,) in stage IIIB,14 ($11.7{\%}$) in stage IVA. The pathological classification showed 96 ($80.0{\%}$) squamous cell carcinomas, 5 ($4.2{\%}$) adenocarcinomas and 19 ($15.8{\%}$) proven by cytology. The overall 5-year survival rates was $50.8{\%}$, and the 5-year survival rates by stage IB, IIA, IIB, IIIA, IIIB, IVA was $47.7{\%},\;70.2{\%},\;64.1{\%},\;40.0{\%},\;23.1{\%},\;14.3{\%}$, respectively. The 5-year survival rates was noted $51.2{\%}$ of radiotherapy alone and $50.4{\%}$of neoadjuvant chemotherapy followed by radiotherapy. The overall failure rate was $18.3{\%}$(22/120) including $11.7{\%}$ (14/120) locoregional failure, $5.8{\%}$ (7/120) distant metastasis and $0.8{\%}$(1/120) locoregional failure with distant metastasis. Treatment failure rates by the stages were $15{\%}$ (3/20) in stage IB. $10.5{\%}$ (2/19) in stage IIA, $10.2{\%}$, (5/49) in stage IIB, $20{\%}$ (1/5) in stage IIIA, $61.5{\%}$(8/13) in stage IIB, and $28.6{\%}$ (4/14) in stage IVA. The overall complication rate was $34.2{\%}$(41/120) including wet desquamation $7.5{\%}$, (9/120), diarrhea $6.7{\%}(8/120), radiation proctitis $5.8{\%}$(7/120) in decreasing order. A multivariate analysis of factors influencing the survival showed patient age (p < 0.0291), FIGO stage (p<0.0001), Karnofsky performance status (p<0.0043), initial hemoglobin level (p<0.0001), and intracavitary radiation (p<0.0004), but, no significancy in histology (p<0.29) and treatment method (p < 0.87).

The Results of Curative Radiotherapy for Carcinoma of Uterine Cervix

Ryu, Ryeong,Chang, Gee Young,Namkong, Sung Eun,Bahk, Yong Whee,Shinn, Kyung Sub,Kim, Seung Jo,Suh, Tae Suk,Yoon, Sei Chul,Kang, Ki Mun CATHOLIC MEDICAL CENTER 1994 Bulletin of the Clinical Research Institute Vol.22 No.2

One-hundred five patients with invasive carcinoma of the uterine cervix treated with curative radiotherapy from March 1983 through October 1989 at the Department of Therapeutic Radiology, Kang-Nam St. Mary's Hospital. Among them, 78 patients received radiotherapy alone and 42 patients treated with neoadjuvant chemotherapy followed by radiotherapy and 15 patients were lost to follow up. All patients had follow up from 2 to 106 months (median; 62 months). Age of the patients ranged from 32 to 79 years at presentation (median; 59 years). The overall 5-year survival rates was 50.8%, and the 5-year survival rates by stage ⅠB, ⅡA, ⅡB, ⅢA, ⅢB, ⅣA was 47.7%, 70.2%, 64.1%, 40.0%, 23.1%, 14.3%, respectively. The 5-year survival rates was noted 51.2% of radiotherapy alone and 50.4% of neoadjuvant chemotherapy followed by radiotherapy. The overall failure rate was 18.3% (22/120) including 11.7% (14/120) locoregional failure, 5.8% (7/120) distant metastasis and 0.8% (1/120) locoregional failure with distant metastasis. Treatment failure rates by the stages were 15% (3/20) in stage ⅠB, 10.5% (2/19) in stage ⅡA, 10.2% (5/49) in stage ⅡB, 20% (1/5) for stage ⅢA, 61.5% (8/13) in stage ⅢB, and 28.6% (4/14) in stage ⅣA. The overall complication rate was 34.2% (41/120), including wet desquamation 7.5% (9/120), diarrhea 6.7% (8/120), radiation proctitis 5.8% (7/120) in decreasing order. A multivariate analysis of factors influencing the survival showed patient age (P=0.0291), FIGO stage (P=0.0001), Karnofsky performance status (P=0.0043), initial hemoglobin level (P=0.0001), and intracavitary radiation (P=0.0004), but, no significancy in histology (P=0.29) and teatment method (P=0.87).