수지침요법이 중학생의 복통 완화에 미치는 효과

강현숙 ( Kyoul Ja Cho ),조결자 ( Hyun Sook Kang ) 경희대학교 동서간호학연구소 2007 동서간호학연구지 Vol.13 No.1

본 연구는 10-12세 사이에서 가장 빈도가 높은 복통(Oh, 1996)의 구급처치 방안으로 수지침이 효과적인지 확인하기 위해 시도하였다. 수지침요법은 손을 몸의 축소판으로 생각하여 수지 안에는 인체의 내장이 있고, 14경맥이 있으므로 이를 자극하여 치료 하는 자극요법으로 수지침요법은 상응점에 가는 침(needle)으로 1mm 깊이의 자극을 주어 치료하는 것을 말한다. 수지침과 같은 상응요법은 수지의 신체 해당부위(상응부)에서 과민 반응점(상응점)이 나타나는 부위에 자극을 주는 방법을 말하므로 수지 안에 있는 복통 상응점을 자극하면 통증이 감소된다(Yoo, 2001). 뿐만 아니라, 수지침은 약물 남용으로 인한 부작용과 내성등에 의한 위험 등 일체의 후유증이 없고 질병예방이 가능하며, 효과가 빠르고 시술이 간편하며 경제적이어서 원할 때 즉시 시술이 가능한 요법이다(Kim & Cho, 2001), 그러므로 학교보건실에서 복통완화를 위한 치료로서의 활용가능성을 검토하기 위하여 학교 보건실에 내방한 중학생을 대상으로 통증완화 효과를 검증하였다. 그 결과 수지침에 의해 주관적으로 느끼는 통증이 완화되었음을 보여주었고, 객관적인 통증척도 중 발한정도는 수지침 요법을 적용한 실험군에서 적용하지 않은 대조군 보다 유의하게 발한이 감소되었다. 또한 객관적인 통증척도인 안면표정과 음성변화에서는 비록 통계적으로는 유의한 차이를 보이지 않았지만 실험군이 대조군보다 통증완화점수의 감소폭이 컸었다. 이는 간헐성 복통 환아에 대한 수지침의 효과 검증결과 통증 강도가 감소하였음을 보고한 Hong(2005b)의 연구결과 와 유사하였다. 또한 두통완화를 위해 수지침을 시술한 결과 주관적 통증 점수와 객관적 통증 영역 중 음성변화 정도가 유의하게 감소하였다고 보고한 Cho와 Kang(2004)의 연구 결과와 복통, 요통 등의 증상을 보인 월경곤란증이 있는 대상자의 경우 수지침 요법이 뜸 요법보다 신속한 효과를 나타낸Kim과 Cho(2001)의 연구, 수지침이 여중생의 생리통 자각증상에 효과를 미치는 것으로 보고한 Moon(2003)의 연구결과에서도 수지침이 통증완화에 효과적이었으므로 본 연구 결과를 지지해주었다. 그러나 연구자마다 대상자들의 연령층이 각기 달랐고, 중학생을 대상으로 한 수지침요법의 효과에 관한 연구는 없었으며, 복통 환아를 대상으로 한 연구는 1편에 불과했기 때문에 본 연구와 정확히 비교하기는 어려웠다. 통증이란 경험하는 사람이 통증이라고 말하는 것은 무엇이나 통증이며 그가 통증이 있다고 말할 때는 언제나 존재 하는 것이다(McCaffery, 1977)고 하여 통증에 관하여 개인의 주관적인 느낌을 강조하고 있다. 객관적인 방법으로 통증을 측정한다고 하여도 수치상 큰 차이를 보이지 않으면 증명하기 어렵다. 그러므로 통증을 경험하고 있는 사람이 수지침 요법을 통해 통증이 완화되었다고 한다면 객관적인 면이 부족해도 본인의 느낌대로 통증이 감소하였다고 평가 할 수 있다. 더군다나 통증이 있을 때 객관적 통증반응 중 안면표정과 음성은 자신의 의지로 어느 정도 조절할 수 있지만 발한은 자신의 의지로 조절하기 어렵다. 따라서 통증의 객관적 반응인 발한정도가 감소되었다고 하는 본 연구의 결과는 비록 객관적 통증 반응인 안면표정이나 음성변화에 차이가 없었지만 이러한 맥락에서 수지침이 통증완화에 도움이 된다고 해석할 수 있다. 그러나 본 연구결과 안위 면에서는 수지침 요법의 효과를 나타내지 않았다. 통증이 완화되면 신체는 자연히 안락한 상태로 될 수 있을 것으로 보았으나 그렇지 못함을 보여주고 있다. 본 연구결과에서 객관적 통증반응이나 안위 면에서 통계적인 유의성이 검증되지 못한 것은 대상자 수가 적은 것과 대상자로부터 연구의 동의를 얻기는 했지만 침습적인 처치에 대한 두려움이 많은 연령층인 중학생이라는 점 등이라고 보아 앞으로는 대상자 수를 늘리며, 다른 연령층을 대상으로 하는 반복연구가 필요하다고 본다. 이상과 같이 본 연구결과 수지침은 복통환자의 주관적으로 느끼는 통증을 감소시키므로 수지침이 복통완화에 어느 정도 효과가 있음을 확인하였다. Purpose: The purpose of this study was to identify the effects of hand acupuncture on relieving of abdominal pain. Method: Fifty-five middle school students who complained abdominal pain were selected as subjects. There were 35 students in the experimental group while 20 students were in the control group. Convenience assignment was used. The experimental group received hand acupuncture treatment which was to puncture corresponding points (epigastric pain A8, A12, A16, K9, F4, E42; lower abdominal pain A1, A4, A6, A8, J1, H2) on both the palm and the back of a hand with disposable acupuncture needles, and then to remove them after a 20-30min. recess during the subjects was in supine position on a bed. Result: Degree of subjective pain decreased statistically in the experimental as compared to the control group. No statistical significant differences were found in objective pain and comfort between experimental and control group. Conclusion: These findings indicate that hand acupuncture is an effective method for reducing abdominal pain. Therefore, hand acupuncture could be considered as an independent nursing intervention for abdominal pain reduction.

스프렌딜 지속정(펠로디핀 5㎎)에 대한 스타핀 지속정의 생물학적동등성

조혜영,강현아,이석,백승희,박은자,최후균,문재동,이용복 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.4

Felodipine is a calcium antagonist that lowers blood pressure by reducing peripheral resistance by means of a direct, selective action on smooth muscle in arterial resistance vessels. Furthermore, it have been approved for the effective in angina pectoris and cardiac failure. The purpose of the present study was to evaluate the bioequivalence of two felodipine extended release (ER) tablets, Splendil (YuHan Corporation) and Stapin (Hana Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). THe felodipine release from the two felodipine formulations in vitro was tested using KP Ⅷ Apparatus Ⅱ method at pH 6.5 buffer solution. Twenty six healthy male subjects, 22.73±1.78 years in age and 66.66±7.28 ㎏ in body weight, were divided into two groups and a randomized 2×2 cross-over study was employed. After two tablets containing 5 ㎎ as felodipine were orally administered, blood sample was taken at predetermined time intervals and the concentrations of felodipine in serum were determined using column-switching HPLC method with UV detector. The dissolution profiles of two formulations were similar at pH 6.5 buffer solution. Besides, the pharmacokinetic parameters such as AUG_(t), C_(max) and T_(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC_(t) and C_(max) and untransformed T_(max). The results showed that the differences between two formulations based on the Splendil were 2.53%, 1.32% and 18.32% for AUC_(t), C_(max) and T_(mzx), respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25) (e.g., log(0.86)∼log(1.20) and long(0.89)∼long(1.23) for AUC_(t) and C_(max), respectively). Thus, the criteria of the KFDA guidelines for the bioequivalence was satisfied, indicating Stapin ER tablet and Splendil ER tablet are bioequivalent.

유한세프라딘 캅셀(세프라딘 500mg)에 대한 브로드세프 캅셀의 생물학적 동등성

조혜영,이석,강현아,오인준,임동구,문재동,이용복 한국약제학회 2002 Journal of Pharmaceutical Investigation Vol.32 No.3

Cephradine is a first generation cephalosporin and has broad spectrum antibacterial activity against gram-positive and gram-negative microorganisms, through inhibition of bacterial cell wall synthesis. Cephradine is useful for treatment of infections of the urinary and respiratory tract, skin and soft tissues. The purpose of the present study was to evaluate the bioequivalence of two cephradine capsules, Cefradine Yuhan(YuHan Corporation) and Broadcef (Ilsung Pharmaceuticals Co. Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). The cephradine release from the two cephradine capsules in vitro was tested using KP Ⅶ Apparatus Ⅱ method with various different kinds of dissolution media (pH 1.2, 4.0, 6.8 buffer solution and water). Twenty normal male volunteers, 23.10±2.90 years in age and 67.69±8.04 ㎏ in body weight, were divided into two groups and a randomized 2×2 cross-over study was employed. After one capsule containing 500㎎ as cephradine was orally administered, blood was taken at predetermined time intervals and the concentrations of cephradine in serum were determined using HPLC method with UV detector. The dissolution profiles of two cephradine capsules were very similar at all dissolution media. Besides, the pharmacokinetic parameters such as AUC_t, C_max and T_max were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC_t and C_max and untransformed T_max. The results showed that the differences in AUC_t C_max and T_max between two capsules based on the Cefradine Yuhan were -2.87%, -0.96% and -4.85%, respectively. There were no sequence effects between two capsules in these parameter. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25) (e.g.,log(0.93)∼log(1.02) and log(0.88)∼log(1.13) for AUC_t and C)max, respectively). The 90% confidence interval using untransformed data was within ±20% (e.g., -17.54∼7.78 for T_max). All parameters met the criteria of KFDA guideline for bioequivalence, indicating that Broadcef capsule is bioequivalent to Cefradine Yuhan capsule.

탄수화물에서 광학활성 중간체 O-보호된 (S)-와 (R)-3-히드록시 알데히드의 합성

강석구,조현성,심형수 성균관대학교 기초과학연구소 1993 論文集 Vol.44 No.1

탄수화물로부터 유도된 불포화 퓨라노스 고리계를 입체 선택적인 수소화 반응에 의해 chiral synthon인 광학활성의 (S)-3-포르밀옥시 알데히드를 합성하였고, 탄수화물에서 유도된 3-히드록시 퓨라노스를 Barton-McCombie의 deoxygenation반응에 의해 (R)-3-포르밀옥시 알데히드를 합성하였다. (S)-e-Formyloxyaldehydes, chiral synthons for natural products, were synthesized via highly stereoselective hydrogenation of the unsaturated furanose ring system derived from D-glucose or D-xylose. Alternatively, (R)-3-formyloxyaldehydes were prepared via deoxygenation of 3-hydroxyfuranoses.

일 도시 고등학생의 음주동기와 음주문제

강혜영,신경은,장현지,나영화,조은희 韓國學校保健學會 2004 韓國學校保健學會誌 Vol.17 No.2

Purpose : The purpose of this study was to investigate drinking motives and the drinking-related problems of Korean high school students at a city in Jeonbuk province. Methods : There were 657 students from two academic and two vocational high schools at J city in Jeonbuk province. The sample was collected using a stratified sampling method and the data was collected from June 30th to July 16th 2003. The study instrument used to examine drinking motive was a 20.item summated scale (Cronbach's α = .95) and for drinking-related problems was an 18 item summated scale (Cronbach's α = .91). The data was analyzed using SPSS/PC+ by percentage, χ2.test, t-test and correlations. Results : 1. Drinking experience: Among the high school students, 74.3% of them had drinking episodes. Female students started drinking later (χ2 = 12.857, p = .002) and had more drinking friends (χ2 = 7.785, p = .020) than males. Vocational school students drank more frequently (χ2 = 32.138, p = .001), had more heavy drinking episodes (χ2 = 40.370, p = .001). 2. Drinking motives & Drinking-related problems: The mean score of drinking motives was 31.2 ± 11.12 out of 80 and that of drinking-related problems was 21.8 ± 5.85 out of 72 points. Neither score were stronger was significantly different according to gender and grade. On the other hand, both drinking motives (t = .4.077, p = .001) and drinking-related problems (t = .3.423, p = .001) were stronger in vocational school students than in academic school students. The correlation between drinking-related characteristics and problems were weak (from r = .286 to r = .520) but the correlation within the subcategories of drinking motives was high such as between enhancement and coping (r = .822) and enhancement and social motives (r = .822). Conclusion : The majority of Korean high school students start to drink during their junior high school days. Drinking motives and drinking-related problems were not serious but the drinking motives and the drinking-related problems are stronger among vocational school students. As a result, school-based health education and counseling programs should focus on solving drinking motives than on drinking-related problems.

리스페달 정(리스페리돈 2㎎)에 대한 리스펜 정의 생물학적 동등성

조혜영,박은자,강현아,백승희,이석,박찬호,문재동,이용복 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.2

The purpose of the present study was to evaluate the bioequivalence of two risperidone tablets, Risperdal (Janssen Korea Co., Ltd) and Rispen (Myung In Pharm. Co., Ltd), according to the guidelines of Korea Food and Drug Administration (KFDA). The risperione release from the two risperidone formulations in vitro was tested using KP Ⅷ Apparatus Ⅱ method with various of dissolution media (pH 1.2, 4.0, 6.8 butter solution and water). Twenty four healthy male subjects, 23.33±2.10 years in age and 69.24±8.05 kg in body weight, were divided into two groups and a randomized 2×2 crossover study was employed. After one tablet containing 2 ㎎ as risperidone was orally administered, blood was taken at predetermined time intervals and the concentration of risperidone in serum were determined using HPLC method with UV detector. The dissolution profiles of two formulations were similar at all dissolution media. Besides, the pharmacokinetic parameters such as AUC_(t), C_(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC_(t), C_(max) and untransformed T_(max). The results showed that the differences between two formulations based on the Risperdal were 0.20, -1.29 and -11.09% for AUC_(t), C_(max) and T_(max), respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25) (e.g., log(0.90)∼log(1.03) and log(0.84)∼log(1.09) for AUC_(t) and C_(max), respectively). Thus, the criteria of the KFDA guideline for the bioequivalence were satisfied, indicating Rispen tablet and Risperdal tablet were bioequivalent.

스쿠버다이빙을 통한 스포츠관광 활성화 연구

조동진,이강욱,박현서,박상규 朝鮮大學校 스포츠科學硏究所 2006 스포츠科學硏究 Vol.17 No.-

본 연구는 스쿠버관광의 현황을 파악하고 현안과제 및 개선방안을 통한 스포츠관광 활성화에 목적을 두고자 한다. 이를 위해 문헌조사와 포커스그룹인터뷰를 통해 전문가적인 방안을 제시하였다. 인터뷰 대상은 전국에서 활동중인 스쿠버강사를 대상으로 지역적 안배를 고려하였고 평균 나이41세, 강사경력 11년의 활동경력을 가진 전문가들이였으며 제주도에서 인터뷰가 실시되었다. 본 연구의 결과, 첫째, 관련업계 종사자들이 현안 문제를 해결하기 위해서는 적극적인 노력이 요구되며 둘째, 다양한 교육과 이벤트를 통한 수익창출과 장비 국산화를 통한 저가의 장비개발이 필요하며 셋째, 투자를 통한 시설의 확충으로 편리성을 제공하여야 하며 다양한 홍보를 통해 스쿠버의 안전성과 교육적 효과에 대해 대중에게 알려야 하는 것으로 분석되었다. The purpose of this study is to understand the situation of scuba tourism and revitalize sports tourism by examining pending tasks and methods for revitalization. In order to achieve this, literature review and focus group interview were used to present professional methods. An interview was conducted with practicing scuba instructors nationwide in Jeju-do in consideration of local arrangement. Subjects' mean age was 41, and mean career was 11 years. The following results were obtained. First, related-industry practitioners should make active efforts to solve pending problems. Second, it is needed to create profit through various education and events, and develop inexpensive equipment through the localization of equipment. Finally, it is needed to provide convenience with the expansion and improvement of facilities through investment, and introduce the safety and educational effect of scuba to the public using a variety of PR activity.

아마릴 정(글리메피리드 2㎎)에 대한 글리메드 정의 생물학적 동등성

조혜영,박은자,강현아,백승희,이석,김세미,문재동,이용복 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.2

The purpose of the present study was to evaluate the bioequivalence of two glimepiride tables, Amaryl^(?)(Handok/Aventis Pharm. Co., Ltd.) and Glimed (Kuhn Ⅱ Pharm. Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). The glimepiride release from the two glimepiride formulations in vitro was tested using KP Ⅷ Apparatus Ⅱ method with a variety of dissolution media (pH 1.2, 4.0, 6.8 buffer solution, water and blend of PSB 80 into each dissolution medium). Twenty six healthy male subjects, 22.65±2.19 years in age and 66.55±8.85 kg in body weight, were divided into two groups and randomized 2×2 cross-over study was employed. After one tablet containing 2 ㎎ as glimepiride was orally administered, blood was taken at predetermined time intervals and the concentrations of glimepiride in serum were determined using HPLC method with UV detctor. The dissolution profiles of two formulations were similar at all dissolution media. Besides, the pharmacokinetic parameters such as AUC_(t), C_(max) and untransformed T_(max). The results showed that the differences between two formulations based on the Amaryl were -3.70, -8.28 and 0.61% for AUC_(t), C_(max) and T_(max), respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25)(e.g., log(0.84)∼log(1.04) and log(0.82)∼log(1.03) for AUC_(t) and C_(max), respectively). Thus, the criteria of the KFDA guideline for the bioequivalence were satisfied, indicating Glimed tablet and Amaryl tablet were bioequivalent.

뇌졸중 후 대상자의 동서재활자조관리 프로그램 개발 및 운영 효과 : A Preliminary Study

강현숙,김원옥,김정화,왕명자,조종희 성인간호학회 2004 성인간호학회지 Vol.16 No.1

Purpose: The purpose of this preliminary study was to develop and evaluate the effects of East-West Self-help program for Rehabilitation of post-stroke clients. Method: This program is developed through literature review, survey and seminar. The program is consisted of six sessions twice a week for 6 weeks. This program is composed of health education on stroke, exercise, oriental nursing interventions, and therapeutic recreation. The outcomes have been evaluated on the basis of perceived health status, self-efficacy. U/E function, ADLs and subjective response. Result: 1) After the 6 week program, the perceived health status had improved and the score of rehabilitation self-efficacy increased significantly. 2) After the 6 week program, the score of BADL increased significantly, but, the score of IADL was not statistically significant. 3) After the 6 week program, the amount of use and quality of movement of the affected U/E were increased significantly. 4) All of the participants showed satisfaction with this program. Conclusion: Considering these research results, the program is effective in improving functional abilities and self-management ability. Therefore this program could be continuously developed and implemented as a community based self-helf group program for post-stroke clients.

엘도스 캡슐(에르도스테인 300mg)에 대한 엘브론 캡슐의 생물학적 동등성

조혜영,이석,강현아,문재동,이용복 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.3

Erdosteine, the thiol derivatives chemically related to cysteine, is a mucolytic and mucoregulator agent which modulated mucus production and viscosity and increases mucoiliary transport. The purpose of the present study was to evaluate the bioequivalence of two erdosteine capsules, Erdos (Dae Woong Pharmaceutical Co., Korea) and Erblon (Kuhn Ⅱ Pharmaceutical Co., Korea), according to the guidelines of Korea Food and Drug Administration (KFDA). The erdosteine release from the two erodisteine capsules in vitro was tested using KP Ⅷ Apparatus Ⅱ method with various different kinds of dissolution media (pH 1.2, 4.0, 6.8 buffer solution and water). Twenty four healthy male subject, 23.33±2.06 years in age and 66.18±8.19 ㎏ in body weight, were divided into two groups and a randomized 2×2 cross-over study was employed. After three capsules containing 300 ㎎ as erdostein were orally administered, blood was taken at predetermined time intervals and the concentrations of erdostein in serum were determined using HPLC method with UV detector. The dissolution profiles of two formulations were similar at all dissolution media. Besides, the pharmacokinetic parameters such as AUC_(t), C_(max) and T_(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using log-arithmically transformed AUC_(t) and C_(max) and untransformed T_(max). The results showed that the differences between two formulations based on the Erdos were 0.20%, 1.10% and -9.44% for AUC_(t), C_(max) and T_(max), respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of long(0.8) to log(1.25)(e.g., long(0.94)∼long(1.22) and log(0.92)∼log(1.20) for AUC_(t) and C_(max), respectively. Thus, the criteria of the KFDA guidelines for the bioequivalence was satisfied, indicating Erblon capsule and Erdos capsule are bioequivalent.