兒童行動目錄(CBCL)에 의한 國民學生의 行動問題 調査

홍강의,송혜양,김중술,홍경자,박성수 大韓神經精神醫學會 1988 신경정신의학 Vol.27 No.2

This is an epidemiological study of emotional/behavior problems in Korean elementary school children(total 2,399 : 1.236 boys, 1,163 girls) by empolying Children's Behavior Check List(CBCL) developed by Achenbach and Edelbrock(1983), to which 3 problem items were added for this study. A test-retest reliability of CBCL was was assessed by computing the Spearman-Browm correlation and the average correlation among items was. 72. The interparent agreeement was also assessed and the average correaltion between mother and father was. 62. The study subjects were drawm by stratified sampling from 5 schools in Korea ; 3 schools (A, B, C) from Seoul, one school(D) from a medium size city one school (E) from a rural town. School C is located in upper/middle-upper class residential area, School A and D in middle class, and School B and E in lower-middle/lower class. The present paper reports the prevalence of behavioral/emotional problems in relation to sex, grade, locality and socioeconomic variables. Some of the major findings were as follows ; 1) The mean total problem score excluding 3 additional items was 27.28 and did not differ significanthy according to sex and locality(Seoul vs non-Seoul), However, the mean total problem scores were significanthy different from school to school. The lowest score was observed in children of School C(22.15), higher scores for School B(30.89) and E(30.64) and in-between scores for the School A(27.58) and D(25.47). Father's education also had significant effect on the total problem scores : 31.46 for elementary of less 27.79 for middle and high school and 23.05 for college or more. As for to the grade, mean total score was lowest for the first graders(22.12), increasing up until 4th grade(29.83), then decreasing for 5th graders(26.81) and then relatively high score for the 6th graders(29.81). 2) Examination of each 122 problem items revealed that prevalence rate ranged from 2.1% to 61.7% : less than 5% for 13% items, 5-10% for 18 items, 10-20% for 31 items, 20-30% for 25 items, 30-40% for 15 items, 40-50% for 13 items, more than 50% for 7 items. Although sex did not make any difference in total problem scores, examination of the prevalence of each item revealed that 47 problem items were significanthy different between sexes : 26 items were more prevalent in boys and 21 items in girls. The items more prevalent for boys were externalizing problems such as hyperkinetic, aggressive and other behaviors and 21 items, more prevalent for girls were internalizing problems such as emotional and psychosomatic problems. School grade had significant effect in 47 items, only 3 of which showed lower prevalence in the younger children and the prevalence of 39 items were higher in older children. Significant differences were observed in 83 items, and 94 items, respectively according to school and father's education that could be considered to reflect socioeconomic status and it was reavealed that the lower the status, the higher the prevalence in most items. Items more common in upper class tend to be more anxiety-tension related(internalizing) and items more common in lower class tend to be more aggressive, hyperactive and other behavioval problems(externalizing). 3) Brief cross-cultural comparisons between the current study and other studies reported in the literature revealed major differences in several areas. The total problem score for Korean children was much higher than those of American and Dutch children, but lower than those of Canada and Chile. Although most of other studies reported higher total problem scores for boys, than for girls there was no sex difference in total problem score for Korean children. This was reflected in the finding of an almost equal numbers of items(26 for boys, 21 for girls) being more common than the other sex. Analyses by grade(age) also indicate major differences between Korean and American-Dutch children ; In contrast to the finding that total problem score was higher and larger number of items were more common for younger children in American and Dutch studies, they were higher for older children in Korean study. Socioeconomic variables seems to exert far more significant effect on the total score and the prevalence of each items in Korean study, when compared with American and Dutch studies. Further analyses of the data including a comparison with a clinic sample are deferred to another paper and so are the factor analysis results of 122 items into emotional/behavioral syndromes.

비유전독성 간발암물질인 Cloibrate 의 F344 랫드에 있어서 경구 아급성독성시험

정자영(Ja Young Jeong),이국영(Kook Kyung Lee),신동환(Dong Hwan Shin),한범석(Beom Seok Han),김대중(Dae Joong Kim),강태석(Tae Seok Kang),김기상(Ki Sang Kim),장동덕(Dong Deuk Jang),김창옥(Chang Ok Kim),김효정(Hyo Jung Kim),김지희(Jee He 한국응용약물학회 1995 Biomolecules & Therapeutics(구 응용약물학회지) Vol.3 No.1

Clofibrate, a peroxisome proliferator, is hepatocarcinogenic in rats in a dose-dependent manner. A total of 70 male and female F344 rats, 5-week-old, were divided into three groups. Rats were fed clofibrate at 0, 0.25, or 0.5% in diet for 30 days. All rats were anesthetized with CO₂, blood samples were taken by cardiac puncture for hematology and clinical chemistry, and the rats were killed by exsanguination. Livers, kidenys, pancreas, adrenal glands, spleen, heart, lungs, thyroid gland, reproductive organs, and digestive organs were removed, weighed, later processed, and embedded with paraplast for histological examination. The relative liver and kidney weights with respect to final body weight in the clofibrate-treated group were significantly increased compared with those of control group at all dose levels (p<0.01). It has been suggested that clofibrate may influence on hepatotoxicity by increases in peroxisomal proliferation.

주암호 홍수조절용지내 침수 식물체의 영양염류 용출 특성

강세원(Se-Won Kang),서동철(Dong-Cheol Seo),한명자(Myung-Ja Han),한종학(Jong-Hak Han),임병진(Byung-Jin Lim),박종환(Jong-Hwan Park),김갑순(Kap-Soon Kim),이영재(Yeong-Jae Lee),최익원(Ik-Won Choi),이영한(Young-Han Lee),허종수(Jong-Soo He 한국토양비료학회 2011 한국토양비료학회지 Vol.44 No.2

상수원수의 수질개선과 효율적인 수질관리를 위한 저수구역내 초목류 관리방안을 제시하고자 주암호 홍수조절용지내에 서식하는 식물체들의 침수 시 일어나는 분해 특성 및 영양염류의 용출 특성을 조사하였다. 침수시기에 따른 식물체별 수질내 COD, T-N 및 T-P 용출 패턴은 식생에 관계없이 전반적으로 침수 4-6일 까지는 약간씩 감소하다가 침수 6-8일 이후부터 영양염류의 용출량이 서서히 증가하고 침수 20일 이후부터 급격히 증가하는 경향을 보였다. 침수지역간의 식물체별 영양염류 용출 특성은 큰 차이가 없었으며, 이삭사초의 COD 용출량은 7,893-7,917 mg m<SUP>-2</SUP> month<SUP>-1</SUP> 범위, T-N 용출량은 2,711-2,816 mg m<SUP>-2</SUP> month<SUP>-1</SUP>범위, T-P 용출량은 342-547 mg m<SUP>-2</SUP> month<SUP>-1</SUP> 범위이었다. 물억새의 COD 용출량은 6,487-6,507 mg m<SUP>-2</SUP> month<SUP>-1 </SUP>범위, T-N 용출량은 1,813-1,868 mg m<SUP>-2</SUP> month<SUP>-1 </SUP>범위이었으며, T-P 용출량은 226-405 mg m<SUP>-2</SUP> month<SUP>-1</SUP> 범위이었다. To improve the quality of water from water supply source and to establish the management plan of dead plants in flood control reservoir around Juam Lake, the effect of water quality by dead plant in column with passing time was investigated. In column test, the amounts of release by Carex dimorpholepis were 7,893-7,917 mg m<SUP>-2</SUP> month<SUP>-1</SUP> COD, 2,711-2,816 mg m<SUP>-2</SUP> month<SUP>-1</SUP> T-N and 342-547 mg m<SUP>-2</SUP> month<SUP>-1</SUP> T-P. The amounts of release by Miscanthus sacchariflorus were 6,487-6,507 mg m<SUP>-2</SUP> COD, 1,813-1,868 mg m<SUP>-2</SUP> T-N and 226-405 mg m<SUP>-2</SUP> month<SUP>-1</SUP> T-P in column. Therefore, the release of COD, T-N and T-P by Carex dimorpholepis were more than those by Miscanthus sacchariflorus Benth in column.

문제행동 양상에서의 성차이

오경자,이혜련,홍강의,Oh, Kyung-Ja,Lee, He-Len,Hong, Kang-E 대한소아청소년정신의학회 1991 소아청소년정신의학 Vol.2 No.1

아동기 심리장애의 표현양상에서의 성별차이를 알아보기 위하여 정신과 진료기관에 내원한 환자 834명을 부모설문형식의 CBCL을 통하여 평가한 후, 그 자료를 남녀별로 각각 요인분석하여 행동장애 증후군을 구성하였다. 그 결과 공격, 과잉활동, 비행, 사회적 위축, 정서불안정, 그리고 신체증상의 여섯 개 요인은 남녀 공통으로 얻어졌으나, 강박, 우울 등의 내면성 증후군과 정신병의 임상적 특징을 나타내는 요인은 남녀간에 상당히 다른 양상을 보였다. 공통적으로 얻어진 여섯 요인들의 경우에도, 그 핵심이 되는 문제행동들은 남녀가 공유하고 있었으나, 그 밖에 측면에서는 남아와 여아 집단은 서로 다른 특징을 보였다. 이같은 문제행동 증후군에서 성별차이는 행동양식에 대한 성역할 고정관념과 관련되어 논의 되었다. In an attempt to study sex differences in child behavior disorders, 834 clinic-refered children(582 boys and 252 girls) between the ages of 6 to 11 were assessed using CBCL parental form and the data were factor analysed to form empirically derived syndromes for each sex. The analyses yielded eight behavior disorder syndromes for boys and ten, for girls. Six syndromes(aggressive, hyperactive, delinquent, social withdrawal, emotional lability, physical complaints) were found in both sexes while obsessive, depressive and psychotic syndromes were organized differently in boys and girls. There were also considerable differences in item composition of the six syndromes common to box sexes, suggesting that clinical features of common behavior disorders such as aggression and hyperactiveity might be different for boys and girls despite their apparent similarity. The results were discussed in terms of culturally shared attitudes and beliefs concerning sex differences in behaviors.

내ㆍ외과계 임상간호사가 인지하는 간호역할행위의 중요도와 수행도 비교

임난영(Lim Nan-Young),강현숙(Kang Hyun-Sook),서문자(Suh Moon-Ja),이여진(Yi Yeo-Jin),권성복(Kwon Sung-Bok),김동옥(Kim Dong-Oak),김주현(Kim Joo-Hyun),박영숙(Park Young-Sook),손영희(Shon Young-Hee),손행미(Son Haeng-Mi),이은희(Lee Eun-He 기본간호학회 2004 기본간호학회지 Vol.11 No.2

IPA을 이용한 레저스포츠참가 선호도와 참여도 분석

김경식(Kim kyong-sik),구경자(Koo kyong-ja),진은희(Jin eun-he),송강영(Song kang-young) 한국콘텐츠학회 2009 한국콘텐츠학회 종합학술대회 논문집 Vol.7 No.1

본 연구는 IPA를 이용한 레저스포츠참가 선호도와 참여도를 규명하기 위하여 2009년 수도권의 만 19세 이상의 성인을 연구대상으로 설정한 다음, 유의표집법으로 250명을 표본추출 하였다. 수집된 자료는 SPSSWIN 16.0을 이용하여 신뢰도분석, 대응표본t검증, IPA 분석기법 등의 방법을 활용하였다. 결론은 다음과 같다. 첫째, 1사분면에서는 스킨스쿠버, 수상스키, 윈드서핑, 클레이사격으로 나타났으며 선호도, 참여도를 높이기 위한 개선 노력이 필요하다. 둘째, 2사분면에는 골프, 라켓볼, 스노우 보드, 스키, 낚시, 등산 등이며 선호도, 참여도가 모두 높기 때문에 현재의 수준과 같은 지속적 관심을 유지할 필요가 있는 영역이다. 셋째, 3사분면에 워터슬래드, 카트, 열기구, 스카이다이빙, 오리엔테어링, 행글라이딩, 모형비행기, 서바이벌게임 등이고 선호도, 참여도가 모두 낮으므로 이 종목들에 대해서는 가능한 현재 수준 이상의 과잉노력을 지향하는 것이 바람직하다. 넷째, 4사분면에는 트레킹, 산악자전거, 인라인스케이트, 래프팅, 사이클링 등이다. 선호도는 낮은 반면, 참여도는 높기 때문에 레저스포츠참가 정책의 현상유지가 필요하다. 종합해보면, 선호 하지만 현재의 레저스포츠참가가 어려운 종목들을 타개하기 위해서는 우선적으로 현재 참가하지 못하고 있는 중점개선부분의 종목들에 대한 사회적 인프라에 우선적으로 투자하고 지속적 관심이 필요하다. In this research, to identify the degree of preference and participation in leisure sports, over 19-year-old adults living in the capital region were collected as subjects, and among them, 250 persons were chosen by sampling. Using SPSSWIN 16.0, I analyzed the collected data by Reliability Analysis, Paired Sample T-Test, and IP A method. The conclusion is the following. First, the first quadrant showed skins-cuba, water-ski, wind surfing,, and clay-pigeon shooting, and as a result of this, it is necessary to improve the degree of participation in this field. Secondly, the second quadrant showed golf, snow board, ski, fishing, and climbing, and these field need to specific attention to maintain continuous attention, for they have a great deal of attendance. Thirdly, in the third quadrant, there are water sleigh, cart, balloon, sky-diving, orienteering, hang gliding, model plane, and survival game. As the degree of preference and participation in these sports is low, it is recommended that more effort should be made for these sports. Finally, in the forth quadrant, there are tracking, mountain bike, inline skates, rafting, and cycling. As it's the participation is high, while that of preference is low, it is important to maintain the policy of the participation in leisure sports. In conclusion, for the sports which is preferred that is difficult to join right now, most of all, it is necessary that we should pay attention to and invest the social infrastructure in which main items cannot be joined now.

Efficacy and Safety of Combination Antiplatelet Therapies in Patients With Symptomatic Intracranial Atherosclerotic Stenosis

Kwon, Sun U.,Hong, Keun-Sik,Kang, Dong-Wha,Park, Jong-Moo,Lee, Ju-Hun,Cho, Yong-Jin,Yu, Kyung-Ho,Koo, Ja-Seong,Wong, K.S. Lawrence,Lee, Seung-Hoon,Lee, Kyung Bok,Kim, Dong-Eog,Jeong, Sang-Wook,Bae, He Ovid Technologies Wolters Kluwer -American Heart A 2011 Stroke Vol.42 No.10

<P>An optimal strategy for management of symptomatic intracranial atherosclerotic stenosis (ICAS) has not yet been established. We compared the efficacy of 2 combinations of antiplatelets, aspirin plus cilostazol (cilostazol group) verus aspirin plus clopidogrel (clopidogrel group), on the progression of ICAS, which is known to be associated with clinical stroke recurrence.</P>

$GABA_A$-Benzodiazepine 수용체 이상과 불안장애

이상열,박민철,강희자,Lee Sang-Yeol,Park Min-Cheol,Kang He-Ja 대한불안의학회 2005 대한불안의학회지 Vol.1 No.1

In the 40 years since the first benzodiazepine was brought into clinical use there has been a substantial growth in understanding the molecular basis of action of these drugs and the role of their receptors in anxiety disorders. Benzodiazepine receptors are present throughout the brain with the highest concentration in cortex, and it potentiate and prolong the synaptic action of the inhibitory neurotransmitter GABA. Central benzodiazepine receptors and $GABA_A$ receptors are part of the same macromolecular complex. Abnormalities of these $GABA_A$-benzodiazepine receptors as a result of drug challenge tests and neuroimaging studies may underlie some anxiety disorders. The role of $GABA_A$-benzodiazepine receptors in the action of benzodiazepine and as a factor in anxiety disorder, in both animal and humans including knock-out and knock in technique, may lead to new anxiolytics that have potentially significant therapeutic gains without unwanted side effects.

성인에서 발병한 지역사회폐렴의 원인으로서 호흡기 바이러스의 역할

김지희,곽영호,나병국,이주연,신구철,정혜선,홍정연,오명돈,정희진,김민자,배현주,김양리,신완식,강재명,우준희,어수택,이환종 대한감염학회 2001 감염 Vol.33 No.1

Purposes : To investigate the viral etiology of community-acquired pneumonia in Korean adults, we have detected respiratory viruses (Respiatory syncytial virus, adenovirus, influenza virus and parainfluenza virus) in the way of prospective, multi-center study. Methods : From July 1997 to April 2000, nasal aspirates or sputum were obtained from adults patients with community pneumonia admitted to the participating hospitals and transferred immediately to the central laboratory at the Seoul National University Children's Hospital. The specimens were divided into three parts. One part was used for indirect immunofluorescent test for respiratory viruses, the other part for the culture of RSV and adenovirus in HEp-2 cell monolayer. The other part was used for the culture of influenza virus and parainfluenza virus in MDCK or LLC-MK2 cell monolayers. Results : Of 317 samples, 32 (10.1%) specimens were positive for viral agent by indirect IF staining or culture, including one dual-infected specimen (adenovirus and parainfluenza virus). Influenza virus was most commonly detected (16 specimens). Parainfluenza virus, adenovirus and RSV were detected in 10, 4 and 3 patients, respectively. All isolated influenza viruses were type A (H3N2 in 9 patients, HIN1 in 2 and unspecified in 5), and 8 out of 10 parainfluenza virus isolates were type 3. Conclusion : Similar to previous reports from other countries, a significant portion of community-acquired pneumonia in Korean adult is caused by respiratory viruses. (Korean J Infect Dis 33:8~14, 2001)