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정상인에서 발생한 Mycobacterium Intracellulare에 의한 관절염 1예
강경훈 ( Gyung Hoon Kang ),김성훈 ( Sung Hoon Kim ),이홍열 ( Hong Yeul Lee ),서현웅 ( Hyun Woong Seo ),송은희 ( Eun Hee Song ),이기원 ( Ki Won Lee ),김성수 ( Sung Soo Kim ) 대한류마티스학회 2011 대한류마티스학회지 Vol.18 No.2
Nontuberculous mycobacteria (NTM) are widely distributed in nature and are usually of low pathogenic potential. NTM rarely has been recognized as a cause of musculoskeletal infections that involve joints, bone and soft tissue in immunocompetent patients. The risk factors of its infection are local traumas caused by surgery, injury, or injection. A fifty five-year-old immunocompetent patient visted to hospital due to right wrist mass and pain. Excisional biopsy was done. Histologically granulomatous inflammation was identified and Mycobacterium intracellulare was cultured. Although very rare, NTM should be suspected at least once as a causative pathogen of chronic arthritis when the cause is uncertain.
Kang, Gyung-Don,Lee, Ki-Hoon,Do, Sun-Gil,Kim, Chung-Sub,Suh, Jun-Gyo,Oh, Yang-Seok,Nahm, Joong-Hee Korean Society of Sericultural Science 2001 International Journal of Industrial Entomology Vol.2 No.1
Silk fibroin (SF) derided from the domestic silk worm, bombyx mori, is the natural protein and widely used as bio-functional materials as well as apparels. We studied the livers protective effect of SF from alcohol-induced hepatotoxicity in the alcohol preference mouse. To increase more absorption of SF in experimental animals, molecular weight of SF was lowered by 2N of HCI aqueous solution at 10$0^{\circ}C$ for 48 hrs. SF was added to liquid diet with alcohol and fed to the alcohol preference mice for 4 weeks. To assess the liver function, the concentration of alanine aminotransferase (AlT), aspartate aminotransferase (AST) and cholesterol present in either blood or liver tissue were measured. As compared with non-SF treated groups the SF-treated showed significantly low concentrations of ALT, AST, cholesterol and triacylglycerol values, respectively. Histopathological examination revealed that the extent of hepatocyte injury in the SF-treated group was reduced when it was compared with non SF-treated group. These results suggest that SF may have liver protective effects against alcohol-induced hepatotoxicity.
Crosslinking Reaction of Phenolic Side Chains in Silk Fibroin by Tyrosinase
Kang, Gyung-Don,Lee, Ki-Hoon,Ki, Chang-Seok,Park, Young-Hwan The Korean Fiber Society 2004 Fibers and polymers Vol.5 No.3
Tyrosinase oxidizes the tyrosyl residues in silk fibroin (SF) with oxygen, resulting in the production of ο-quinone residues. Subsequently, the inter-or intramolecular crosslinks are formed by reaction with amino groups in through nonenzymatic process. The measurement of oxygen consumption proved that the tyrosyl residues in SF were mostly oxidized to quinone residues by tyrosinase. The reaction mechanisms were proposed in this study and the crosslinking reaction of ο-quinone residues and the enzymatic oxidation of tyrosyl residues could be confirmed by the measurements of UV, $^1$H-NMR and GFC.
Kang Na Ri,Ahn Yo Han,박유진,Lee Keum Hwa,Baek Hee Sun,Kim Seong Heon,Cho Heeyeon,Cho Min Hyun,Shin Jae Il,Lee Joo Hoon,Cheong Hae Il,Kang Hee Gyung,Park Young Seo,Ha Il-Soo,Moon Duk-Soo,Han Kyoung Hee 대한의학회 2021 Journal of Korean medical science Vol.36 No.20
Background: Chronic kidney disease (CKD) has a negative impact on growth and development in children and is a risk factor for neurocognitive impairment; however, there is limited research on the cognitive function of children and adolescents with CKD. This study therefore aimed to investigate the mean intelligence and risk factors for low intelligence in children and adolescents with CKD. Methods: Eighty-one patients with CKD under 18 years old were included in the KoreaN cohort study for Outcomes in patients With Pediatric Chronic Kidney Disease (KNOW-Ped CKD). Participants completed either the Wechsler Intelligence Scale for Children (6–16 years), or Wechsler Adult Intelligence Scale (> 16 years). Results: The mean full-scale intelligence quotient (IQ) was 91 ± 19; 24.7% of participants scored a full-scale IQ below 80. Participants with a short stature (height Z scores < −1.88), failure to thrive (weight Z scores < −1.65), more severe CKD stage (≥ IIIb), longer duration of CKD (≥ 5 years), and those who were Medicare or Medicaid beneficiaries, had significantly lower mean full-scale IQs. Conclusion: On linear regression analysis, the association between the full-scale IQ, and longer duration of CKD and growth failure, remained significant after controlling for demographic and clinical variables. It is therefore necessary to investigate cognitive impairment in pediatric patients with CKD who exhibit growth failure or for a longer postmorbid period. It is believed that early interventions, such as kidney transplantation, will have a positive effect on IQ in children with CKD, as the disease negatively affects IQ due to poor glomerular filtration rate over time.
Silk Fibroin/Chitosan Conjugate Crosslinked by Tyrosinase
Kang, Gyung-Don,Lee, Ki-Hoon,Ki, Chang-Seok,Nahm, Joong-Hee,Park, Young-Hwan The Polymer Society of Korea 2004 Macromolecular Research Vol.12 No.5
Two biopolymers, silk fibroin (SF) and chitosan, were conjugated by tyrosinase (EC 1.14.18.1), a polyphenolic oxidase, to improve their physicochemical properties, such as their thermal properties and morphological stabilities in organic solvents. The crosslinking between SF and chitosan took place mainly through Michael addition reactions. A main reaction between the amino groups in chitosan and o-quinone, the oxidation product of the tyrosyl residue in SF, was confirmed by UV spectroscopy. Measurements of viscosity and light scattering indicated that the crosslinked SF/chitosan conjugate was compact: it had a smaller particle size because of tight bonding forces between the SF and chitosan molecular chains. Thermal decomposition of SF/chitosan conjugates crosslinked by tyrosinase occurred at higher temperatures. The adhesiveness of the SF/chitosan conjugates decreased steadily as the crosslinking reaction progressed. We propose that this new crosslinking method be used for the preparation of silk fibroin/chitosan conjugates using tyrosinase. We expect that SF/chitosan conjugates crosslinked by tyrosinase can be used preferentially in biomedical applications because of its unique properties and non-toxicity.