Redesigning the Landscape for Women and Leadership: Insights Gained from the Covid-19 Pandemic. On Behalf of Women in Gastroenterology Network Asia Pacific (WIGNAP) and Women in Endoscopy (WIE)

Lubna Kamani,Nonthalee Pausawasdi,Jeanin E.Van Hooft,Amrita Sethi,Sharmila Sachithanandan 대한소화기내시경학회 2020 Clinical Endoscopy Vol.53 No.5

Ergonomic Injuries in Endoscopists and Their Risk Factors

Lubna Kamani,Hamid Kalwar 대한소화기내시경학회 2021 Clinical Endoscopy Vol.54 No.3

Background/Aims: Prolonged repetitive strain caused by the continuous performance of complex endoscopic procedures enhancesthe risk of ergonomic injuries among health-care providers (HCPs), specifically endoscopists. This study aimed to assess the riskfactors of ergonomic injuries among endoscopists and non-endoscopists. Methods: This cross-sectional study was conducted at the Gastroenterology Department of Liaquat National Hospital, Karachi,Pakistan. A total of 92 HCPs were enrolled, of whom 61 were involved in endoscopic procedures and 31 were non-endoscopists. Data were collected through a self-administered questionnaire during national gastroenterology conferences and analyzed usingSPSS version 22 (IBM Corp. Chicago, IL, USA). Results: Of the total study population, 95.08% of endoscopists were observed to have ergonomic injuries, whereas only 54.83% ofnon-endoscopists had ergonomic injuries (p<0.00). The most common injury associated with musculoskeletal (MSK) pain sites wasback (41%), leg (23%), and hand (19.7%) pain among endoscopists. Of 28 endoscopists performing ≥20 procedures/week, 26 hadMSK injury. However, 95.08% of endoscopists had developed MSK injury irrespective of working hours (>5 or <5 hr/wk). Conclusions: Endoscopists are at high risk of developing ergonomic injuries, representing the negative potential of the endoscopyassociatedworkload. To overcome these issues, an appropriate strategic framework needs to be designed to avoid occupationalcompromises.

Changing Trends in Biliary Stenting for Unresectable Malignant Perihilar Obstructions

Lubna Kamani,Muhammad Arshad 대한소화기내시경학회 2020 Clinical Endoscopy Vol.53 No.6

COMMENTARY

Novel stability indicating high-performance liquid chromatography method for the separation and simultaneous quantification of acalabrutinib and its impurities in pharmaceutical formulation

Venu Gopal Kamani,Sujatha M,Guna Bhushana Daddala 한국분석과학회 2023 분석과학 Vol.36 No.1

This study reports for the first time about a stability indicating RP-HPLC method for qualitative and quantitative determination of acalabrutinib in bulk and dosage form and in presence its impurities 1, 2 and 3. The chromatographic separation was carried on Zorbax XDB-C18 (250×4.6 mm; 5 μ id) as stationary phase, Phosphate buffer pH 6.4 and methanol 80:20 (v/v) as mobile phase at a flow rate of 1.0 mL/min, UV detection was carried at wavelength of 238 nm and the analysis was completed with a run time of 15 min. In these conditions the retention time of acalabrutinib and its impurities 1, 2 and 3 was observed to be 3.50, 4.83, 8.40 and 9.93 min respectively. The method was validated for system suitability, range of analysis, precision, specificity, stability and robustness. Spiked recovery at 50 %, 100 % and 150 % was carried for both standard and impurities and the acceptable % recovery of 98-102 was observed for acalabrutinib and both impurities studied and the % RSD in each spiked level was found to be less than 2. Stability tests were done through exposure of the analyte solution to five different stress conditions i.e expose to 1N hydrochloric acid, 1 N sodium hydroxide, 3 % peroxide, 80 oC temperature and UV radiation at 254 nm. In all the degradation condition, standard drug acalabrutinib was detected along with both the impurities studied and the degradation products were successfully separated. In the formulation analysis there is no other chromatographic detection of other impurities and formulation excipients. Hence the developed method was found to be suitable for the quantification of acalabrutinib and can separate and analyse impurities 1 and 2.

Diagnostic Value of Endoscopic Ultrasonography for Common Bile Duct Dilatation without Identifiable Etiology Detected from Cross- Sectional Imaging

Nonthalee Pausawasdi,Penprapai Hongsrisuwan,Lubna Kamani,Kotchakon Maipang,Phunchai Charatcharoenwitthaya 대한소화기내시경학회 2022 Clinical Endoscopy Vol.55 No.1

Background/Aims: Endoscopic ultrasonography (EUS) is warranted when cross-sectional imaging demonstrates common bile duct(CBD) dilatation without identifiable causes. This study aimed to assess the diagnostic performance of EUS in CBD dilatation ofunknown etiology. Methods: Retrospective review of patients with dilated CBD without definite causes undergoing EUS between 2012 and 2017. Results: A total of 131 patients were recruited. The mean age was 63.2±14.1 years. The most common manifestation was abnormalliver chemistry (85.5%). The mean CBD diameter was 12.2±4.1 mm. The area under the receiver operating characteristic curve(AUROC) of EUS-identified pathologies, including malignancy, choledocholithiasis, and benign biliary stricture (BBS), was 0.98(95% confidence interval [CI], 0.95-1.00). The AUROC of EUS for detecting malignancy, choledocholithiasis, and BBS was 0.91(95% CI, 0.85-0.97), 1.00 (95% CI, 1.00-1.00), and 0.93 (95% CI, 0.87-0.99), respectively. Male sex, alanine aminotransferase ≥3× theupper limit of normal (ULN), alkaline phosphatase ≥3× the ULN, and intrahepatic duct dilatation were predictors for pathologicalobstruction, with odds ratios of 5.46 (95%CI, 1.74-17.1), 5.02 (95% CI, 1.48-17.0), 4.63 (95% CI, 1.1-19.6), and 4.03 (95% CI, 1.37-11.8), respectively. Conclusions: EUS provides excellent diagnostic value in identifying the etiology of CBD dilatation detected by cross-sectionalimaging.

A Scientometric Analysis of 20 Years of Research on Breast Reconstruction Surgery: A Guide for Research Design and Journal Selection

Moghimi, Mehrdad,Fathi, Mehdi,Marashi, Ali,Kamani, Freshteh,Habibi, Gholamreza,Hirbod-Mobarakeh, Armin,Ghaemi, Marjan,Hosseinian-Sarajehlou, Mahdi Korean Society of Plastic and Reconstructive Surge 2013 Archives of Plastic Surgery Vol.40 No.2

Background Breast reconstruction refers to the rebuilding of a woman's breast using autologous tissue or prosthetic material to form a natural-looking breast. It is increasingly offered to women undergoing mastectomy for breast cancer. However, there is no systematic analysis available for the expanding area of research on breast reconstruction. Methods A bibliometric method was used to obtain a view of the scientific production about breast reconstruction by data extracted from the Institute for Scientific Information (ISI). Specific parameters were retrieved from the ISI. Articles about breast reconstruction were analyzed to obtain a view of the topic's structure, history, and document relationships using HistCite software. Trends in the most influential publications and authors were analyzed. Results The number of articles was constantly increasing. Most highly cited articles described the methods of flap construction in the surgery. Other highly cited articles discussed the psychological or emotional aspects of breast reconstruction, skin sparing mastectomy, and breast reconstruction in the irradiated breast. Conclusions This was the first breast reconstruction scientometric analysis, representing the characteristics of papers and the trends of scientific production. A constant increase in the number of breast reconstruction papers and also the increasing number of citations shows that there is an increasing interest in this area of medical science. It seems that most of the research in this field is focused on the technical aspects of surgery.

Antimicrobial and antidiarrhoeal activities of aqueous and methanolic extracts of Mangifera indica Linn stem bark (Anarcadiaceae) in Wistar rats

Tchoumba Tchoumi L. M.,Nchouwet M. L.,Poualeu Kamani S. L.,Yousseu Nana W.,Douho Djimeli R. C.,Kamanyi A.,Wansi Ngnokam S. L. 경희대학교 융합한의과학연구소 2021 Oriental Pharmacy and Experimental Medicine Vol.21 No.3

Diarrhea is one of the leading causes of infant mortality in developing country. It has been reported that Mangifera indica is used as an antidiarrhoeal agent in traditional medicine. Thus, the aim of this study was to evaluate the antimicrobial and antidiarrhoeal activities of aqueous and methanolic extracts of Mangifera indica Linn stem bark. The extracts were tested in vitro on the growth of bacteria and fungi; and in vivo at doses of 300, 400 and 500 mg/kg on the effects of Escherichia coli, castor oil, misoprostol and charcoal meal in rats. In vitro, the methanolic extract was the most active with a minimum inhibitory concentration (MIC) of 256 µg/mL for all Gram negative and Gram postive bacteria tested; the value of MIC for all fungi tested was 32 µg/mL. In vivo, the aqueous extract at doses of 300 and 500 mg/kg and methanolic extract at dose of 500 mg/kg resulted in a significant decrease (p < 0.001) in the bacterial load in rats faeces. A significant reduction (p < 0.001) of diarrhoeal parameters was observed with both extracts after castor oil administration. The gut motility was significantly (p < 0.05) reduced with all doses of methanolic extract. Both extracts significantly (p < 0.001) reduced the increase of intestinal fluids volume induced by misoprostol. Histopathological analysis revealed few abnormalities in the structure and morphology of the ileum after treatment of rats with aqueous and methanolic extract. This study showed that Mangifera indica possesses antimicrobial and antidiarrheic properties and attest its usefulness in traditional treatment of gastrointestinal infection.

Optimization of fluoride adsorption onto natural and modified pumice using response surface methodology: Isotherm, kinetic and thermodynamic studies

Mohammad Hadi Dehghani,Maryam Faraji,Amir Mohammadi,Hossein Kamani 한국화학공학회 2017 Korean Journal of Chemical Engineering Vol.34 No.2

Natural pumice (NP), FeCl3·6H2O modified pumice (FEMP) and hexadecyl trimethyl ammonium bromide (HDTM.Br) modified pumice (HMP) were used for fluoride adsorption. The effect of pH (3-11), initial concentration (2-15mg/L), and adsorbent dosage (0.2-0.8 g/L) on the defluoridation was optimized by using central composite design (CCD) in the response surface methodology (RSM). Results showed optimum condition in the pH=3, initial concentration=2mg/L, and adsorbent dosage=0.71, 0.75, 0.70 g/L with the maximum removal efficiency of 9.39, 76.45, and 95.09% for NP, FEMP, and HMP, respectively. The adsorption equilibrium and kinetic data was in good agreement with Freundlich and pseudo-second order reaction. Thermodynamic parameters indicated a non-spontaneous nature for NP and spontaneous nature for FEMP and HMP. Positive enthalpy illustrated the endothermic nature of the process. On the basis of results, modification of pumice led to an increase in the fluoride removal efficiency.

Laser Diode – GaAlAs Acupuncture in the Treatment of Central Obesity: a Randomized Clinical Trial

Razzaghi Mohammadreza,Akbari Zahra,Mokmeli Soheila,Razzaghi Zahra,Rezaei-Tavirani Mostafa,Afzalimehr Maryam,Kamani Ehsan 사단법인약침학회 2023 Journal of Acupuncture & Meridian Studies Vol.16 No.6

Background: Obesity is a global health challenge. Traditional approaches, including increased physical activity, dietary interventions, and medical therapy, often yield limited success, propelling some patients toward costly and invasive procedures like bariatric surgery. Laser acupuncture has been suggested as a complementary therapeutic approach to overcome this challenge. The present study investigated the effectiveness of laser acupuncture treatment in weight loss and abdominal subcutaneous fat reduction. Methods: A randomized, blinded, sham-controlled clinical trial was conducted, with 30 subjects each in the intervention and control groups. Patients in the intervention group underwent 12 sessions of laser acupuncture treatment within a month (three sessions/ week), whereas those in the control group received sham laser treatment on identical acupoints. The patients were instructed not to alter their physical activity levels or dietary regimens. All parameters were evaluated before and after the treatment. Results: Significant reductions in weight, body mass index, and waist circumference were noted in both intervention and control groups. Further analysis revealed a more significant decrease in the laser acupuncture group. Abdominal sonography revealed a marked decrease in periumbilical fat thickness in the intervention group. Conversely, laboratory evaluations showed no significant difference between the two groups. Conclusion: Laser acupuncture is an effective method for weight loss in patients with periumbilical abdominal fat. The observed impact on subcutaneous fat suggests its potential as a non-invasive intervention for individuals seeking weight management alternatives. Further research is warranted to validate these findings and explore the underlying mechanisms of laser acupuncture in adipose tissue modulation.