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Mukherjee, Kakali,Saha, Bidyut Korean Chemical Society 2013 대한화학회지 Vol.57 No.4
Oxidation of glutamic acid is performed in aqueous acid media at $30^{\circ}C$ under the kinetic condition [glutamic acid]$_T{\gg}[Cr(VI)]_T$. Effect of combination of micellar catalyst (SDS, TX-100) and promoter (PA, bpy, phen) has been studied. Among the promoters phen accelerates the reaction most in aqueous media. But the rate acceleration is small in the case. Combination of promoter and catalyst produces much better result. Maximum rate enhancement occurs in presence of the combination of bpy and SDS.
Studies on the Anti-inflammatory Effects of Drymaria cordata Willd
Pulok K. Mukherjee,Kakali Mukherjee,S. Bhattacharya,M. Pal,B. p. Saha 한국생약학회 1998 Natural Product Sciences Vol.4 No.2
In folklore medicine Drymaria cordata Willd (Family-Caryophyllaceae) is reported to have laxative and anti-febrile properties along with anti-inflammatory activities. Sikkimis used this plant to treat all these ailments. The anti-inflammatory effect of the methanol extract of D. cordata was investigated against carrageenin, histamine, serotonin, dextran and PGE₁ induced rat hind paw oedema. It exhibited significant anti-inflammatory activity against all these phlogestic agents except PGE₁ in the order of carrageenin $gt; serotonin $gt; histamine. All these effects were compared with standard drug phenylbutazone in both the acute and chronic experimental models in albino rats.
Antiinflammatory Evaluation of Leucas lavandulaefolia Rees. Extract
Saha, Kakali,Mukherjee, Pulok K.,Das, J.,Mandal, Subhash C.,Saha, B.P.,Pal, M. The Korean Society of Pharmacognosy 1996 Natural Product Sciences Vol.2 No.2
The antiinflammatory activity of the methanol extract of Leucas lavandulaefolia Rees was evaluated on different experimental models of inflammation in rats. The extract has been found to possess significant, inhibitory activity against carrageenin, histamine, serotonin, and dextran induced hind paw oedema in rats. The effect produced by extract was comparable to that of phenylbutazone and a prototype, nonsteroidal antiinflammatory agent.
Wahile, Atul,Mukherjee, Kakali,Kumar, Venkatesan,Saha, Bishnu Pada,Mukherjee, Pulok K Kyung Hee Oriental Medicine Research Center 2007 Oriental pharmacy and experimental medicine Vol.7 No.1
Free radicals are known to play important role in pathophysiology of hepatic disorders and antioxidants are employed along with other chemotherapeutic agents in treatment of such diseases. In search of natural antioxidant, successive extracts of Hypericum (H.) hookerianum (Family: Hypericaceae) were evaluated by in vitro and in vivo methods. Extracts of aerial parts of H. hookerianum were subjected for 1,1-diphenyl 2-picryl hydrazyl radical scavenging activity (DPPH assay), nitric oxide radicals scavenging assay and thiobarbituric acid reactive substances (TBARS) assay. Methanolic extract was found to be more active than other extracts in DPPH and in vitro TBARS assay with $IC_{50}$ at 5.82 ${\pm}$ 1.33 ${\mu}g/ml$ and 49.78 ${\pm}$ 3.79 ${\mu}g/ml$ respectively. While petroleum ether extract showed more potentials in scavenging the nitric oxide radicals with $IC_{50}$ 220.97 ${\pm}$ 2.69 ${\mu}g/ml$. The administration of $CCl_{4}$ to the control animals caused decrease in the level of catalase and superoxide dismutase, together with significant increase in the level of TBARS in liver and kidney. Reversal of these changes towards normal group was observed by administration of H. hookerianum methanolic extract at 50 and 100 mg/kg body weight, while other extracts were found to be less active.
Atul Wahile,Kakali Mukherjee,Venkatesan Kumar,Bishnu Pada Saha,Pulok K Mukherjee 경희대학교 융합한의과학연구소 2007 Oriental Pharmacy and Experimental Medicine Vol.7 No.1
Free radicals are known to play important role in pathophysiology of hepatic disorders and antioxidants are employed along with other chemotherapeutic agents in treatment of such diseases. In search of natural antioxidant, successive extracts of Hypericum (H.) hookerianum (Family: Hypericaceae) were evaluated by in vitro and in vivo methods. Extracts of aerial parts of H. hookerianum were subjected for 1,1-diphenyl 2-picryl hydrazyl radical scavenging activity (DPPH assay), nitric oxide radicals scavenging assay and thiobarbituric acid reactive substances (TBARS) assay. Methanolic extract was found to be more active than other extracts in DPPH and in vitro TBARS assay with IC50 at 5.82 ± 1.33 μg/ml and 49.78 ± 3.79 μg/ml respectively. While petroleum ether extract showed more potentials in scavenging the nitric oxide radicals with IC50 220.97 ± 2.69 μg/ml. The administration of CCl4 to the control animals caused decrease in the level of catalase and superoxide dismutase, together with significant increase in the level of TBARS in liver and kidney. Reversal of these changes towards normal group was observed by administration of H. hookerianum methanolic extract at 50 and 100 mg/kg body weight, while other extracts were found to be less active.
Oriental medicine mangifera indica
Sujay Rai,Souvik Basak,Kakali Mukherjee,BP Saha,Pulok K Mukherjee 경희대학교 융합한의과학연구소 2007 Oriental Pharmacy and Experimental Medicine Vol.7 No.1
Mangifera indica Linn. (MI) (Family: Anacardiaceae) is commonly known worldwide as mango and ‘Aam’ in India. MI shares an important place in treatment of several diseases in various ancient system of medicine like Ayurveda and other Indian System of Medicine and some other Traditional Medicines world wide. Almost all the parts of MI have been used in oriental medicine, so in this review attempt has being made to review the history, traditional uses, phytoconstituents and therapeutic potentials of mango.
Hypoglycemic Activity of Ficus racemosa L. (Moraceae) Leaves in Streptozotocin-induced Diabetic Rats
Mandal, Subhash C.,Mukherjee, Pulok K.,Saha, Kakali,Das, J.,Pal, M.,Saha, B.P. The Korean Society of Pharmacognosy 1997 Natural Product Sciences Vol.3 No.1
The hypoglycemic effect of the extract of Ficus racemosa leaves was studied on streptozotocin-induced diabetic rats. Petroleum ether $(60-80^{\circ}C)$ extract of the plant obtained by soxhlet extraction from coarsely pulverised leaves was used. In the $LD_{50}$ determination of the extract no abnormalities were observed at the dose range of 3 g/kg (p.o.) of the extract. The extract (200 mg/kg and 400 mg/kg orally) caused a reduction of blood glucose levels in streptozotocin-induced diabetic rats by 28.9% (P<0.00l) and 34.6% (P<0.001) respectively at the end of 9 days. The results. of this study indicate that the petroleum ether $(60-80^{\circ}C)$ extract of the leaves possesses significant hypoglycemic activity in hyperglycemic animals compared with glybenclamide as standard drug.
Antidiarrheal Evaluation of Ficus racemosa Linn. Leaf Extract
Mandal, Subhash C.,Mukherjee, Pulok K.,Saha, Kakali,Pal, M.,Saha, B.P. The Korean Society of Pharmacognosy 1997 Natural Product Sciences Vol.3 No.2
A study was undertaken to evaluate the effect of petroleum ether extract of leaves of Ficus racemosa Linn. for its antidiarrheal potential against several experimental models of diarrhea in rats. Ficus racemosa leaves extract (FRLE) treated animals showed significant inhibitory activity against castor oil induced diarrhea and inhibited significantly $PGE_2$ induced enteropooling in rats. It also showed significant reduction in gastrointestinal motility following charcoal meal in rats. The results obtained establish the efficacy of FRLE as an antidiarrheal agent.
Studies on in vivo Wound Healing Activity of Cassia fistula Linn . Leaves (Leguminosae) in Rats
T. Bhakta,Pulok K. Mukherjee,Kakali Mukherjee,M. Pal,B. p. Saha 한국생약학회 1998 Natural Product Sciences Vol.4 No.2
Cassia fistula commonly known as Sundali was selected to evaluate its wound healing potentials based on traditional use and literature references. Methanol extract of C. fistula leaves were examined for its wound healing property in the form of an ointment in two types of wound models in rats : i) Excision wound model and ii) Incision wound model. The ointment of the leaf extract of two different concentrations (5% and 10% w/w ointment of leaves extract in simple ointment base) responded significantly in both models of wounds tested. The results were also comparable to that of standard drug, nitrofurazone in terms of wound contraction ability, epithelisation period, tensile strength and regeneration of tissue at wound area.
Oriental medicine mangifera indica
Rai, Sujay,Basak, Souvik,Mukherjee, Kakali,Saha, BP,Mukherjee, Pulok K Kyung Hee Oriental Medicine Research Center 2007 Oriental pharmacy and experimental medicine Vol.7 No.1
Mangifera indica Linn. (MI) (Family: Anacardiaceae) is commonly known worldwide as mango and ‘Aam’ in India. MI shares an important place in treatment of several diseases in various ancient system of medicine like Ayurveda and other Indian System of Medicine and some other Traditional Medicines world wide. Almost all the parts of MI have been used in oriental medicine, so in this review attempt has being made to review the history, traditional uses, phytoconstituents and therapeutic potentials of mango.