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Rahul Kumar Sharma,Abhishek Purohit,Venkatesan Somasundaram,Pravas Chandra Mishra,Mrinalini Kotru,Ravi Ranjan,Sunil Kumar,Sudha Sazawal,Hara Prasad Pati,Seema Tyagi,Renu Saxena 대한혈액학회 2014 Blood Research Vol.49 No.4
Background Aberrant myeloid antigen (MA) co-expression and high expression of CD34 antigen on the blasts of acute lymphoblastic leukemia (ALL) patients are independently reported to have a role in pathogenesis and prognosis. This study was conducted to determine whether these two parameters are related. Methods A total of 204 cases of ALL were included in an analysis of blast immunophenotypic data. CD34 expression was categorized as low when less than 50% of blasts were CD34-positive (CD34low) and as high when 50% or more were CD34-positive (CD34high). Results Of 204 cases of ALL, 163 and 41 were of B-cell origin (B-ALL) and T-cell origin (T-ALL), respectively. Of all cases, 132 (64.7%) showed co-expression of MA and among these, 101 (76.51%) were CD34high, while the remaining 31 (23.48%) were CD34low. Of 72 cases without MA co-expression, 25 (34.72%) were CD34high and 47 (67.25%) were CD34low. Furthermore, of 163 cases of B-ALL, 111 showed co-expression of MA and 84 of these were CD34high. Of 52 cases of B-ALL without MA expression, 22 were CD34high. Among 41 cases of T-ALL, 21 co-expressed MA, 17 of which were CD34high. Moreover, all 20 cases of T-ALL without co-expression of MA were CD34low. These differences were statistically significant. Conclusion We observed a strong correlation between aberrant MA expression and CD34high expression on the blasts of ALL. We hypothesize that these different patient subsets may represent unique prognostic characteristics.
Vinod Kumar Srivastava,Rajeev Kumar Garg,Venkatesan Venkat Krishnan 한국화학공학회 2006 Korean Journal of Chemical Engineering Vol.23 No.4
this paper, a 2-dimensional model has been established for ethane cracking in a thermal cracker in laminar flow, using amolecular mechanistic model for ethane cracking. The model, consisting of 9-coupled partial diferential equations,is solved using the backward implicit numerical scheme. The resulting product distribution and temperature profilesare predicted throughout the reactor. The concentrations of acetylene and propylene show a maximum within the reac-tor. The efect of certain operational parameters - tube radius, wall temperature and mass flow rate - is also studiedon these profiles. The parameters are varied in the range of 0.005-0.0125 m for tube radius, 1.25 kg/hr-2.5 kg/hr foroC for tube wall temperature. It is observed that an increase in wall temperature and anincrease in tube radius or decrease in flow rate favours the conversion of ethane.
Design Framework for Context-Adaptive Control Methods Applied to Vehicle Power Management
Sudarsan Kumar Venkatesan,Rian Beck,Sorin Bengea,Joram Meskens,Bruno Depraetere 제어로봇시스템학회 2021 제어로봇시스템학회 국제학술대회 논문집 Vol.2021 No.10
The paper presents a combined data-driven and model-based design framework for context-adaptive algorithms applied to the power management of a hybrid electric vehicle. Focused on this application, a set of predefined driving contexts are derived from multiple standard driving cycles. The first contribution consists of computing optimal control parameters associated with power management for each driving context. The second contribution consists of customized supervised classification algorithms for estimating driving contexts. The context-adaptive tool chain integrates context-estimation and subsequent adaptation of control parameters. Simulation results illustrate energy-efficiency benefits of the context-adaptive control method in multiple scenarios.
Rahul Kumar Sharma,Abhishek Purohit,Venkatesan Somasundaram,Pravas Chandra Mishra,Mrinalini Kotru,Ravi Ranjan,Sunil Kumar,Sudha Sazawal,Hara Prasad Pati,Seema Tyagi,Renu Saxena 대한혈액학회 2014 Blood Research Vol.49 No.4
Background Aberrant myeloid antigen (MA) co-expression and high expression of CD34 antigen on the blasts of acute lymphoblastic leukemia (ALL) patients are independently reported to have a role in pathogenesis and prognosis. This study was conducted to determine whether these two parameters are related. Methods A total of 204 cases of ALL were included in an analysis of blast immunophenotypic data. CD34 expression was categorized as low when less than 50% of blasts were CD34-positive (CD34low) and as high when 50% or more were CD34-positive (CD34high). Results Of 204 cases of ALL, 163 and 41 were of B-cell origin (B-ALL) and T-cell origin (T-ALL), respectively. Of all cases, 132 (64.7%) showed co-expression of MA and among these, 101 (76.51%) were CD34high, while the remaining 31 (23.48%) were CD34low. Of 72 cases without MA co-expression, 25 (34.72%) were CD34high and 47 (67.25%) were CD34low. Furthermore, of 163 cases of B-ALL, 111 showed co-expression of MA and 84 of these were CD34high. Of 52 cases of B-ALL without MA expression, 22 were CD34high. Among 41 cases of T-ALL, 21 co-expressed MA, 17 of which were CD34high. Moreover, all 20 cases of T-ALL without co-expression of MA were CD34low. These differences were statistically significant. Conclusion We observed a strong correlation between aberrant MA expression and CD34high expression on the blasts of ALL. We hypothesize that these different patient subsets may represent unique prognostic characteristics.
Current Trends in Viral Gene Therapy for Human Orthopaedic Regenerative Medicine
Jagadeesh Kumar Venkatesan,Ana Rey-Rico,Magali Cucchiarini 한국조직공학과 재생의학회 2019 조직공학과 재생의학 Vol.16 No.4
Background: Viral vector-based therapeutic gene therapy is a potent strategy to enhance the intrinsic reparative abilities of human orthopaedic tissues. However, clinical application of viral gene transfer remains hindered by detrimental responses in the host against such vectors (immunogenic responses, vector dissemination to nontarget locations). Combining viral gene therapy techniques with tissue engineering procedures may offer strong tools to improve the current systems for applications in vivo. Methods: The goal of this work is to provide an overview of the most recent systems exploiting biomaterial technologies and therapeutic viral gene transfer in human orthopaedic regenerative medicine. Results: Integration of tissue engineering platforms with viral gene vectors is an active area of research in orthopaedics as a means to overcome the obstacles precluding effective viral gene therapy. Conclusions: In light of promising preclinical data that may rapidly expand in a close future, biomaterial-guided viral gene therapy has a strong potential for translation in the field of human orthopaedic regenerative medicine.
Saravavana kumar Venkatesan,이명배,박장우,신창선,조영윤 조선대학교 IT연구소 2019 정보기술융합공학논문지 Vol.9 No.1
The purpose of this research is to develop a prediction method for strawberry growth. The main focus is to assess and compare the performance of the three beds using random forest and support vector machine method, in which the correlation of strawberry growth is identified by using water quantity, site selection, soil preparation and parameters. In addition, the suggested study uses three types of beds that are compared to find out the best bed production of strawberry fruits. The dataset includes collected from greenhouse strawberry product in South Korea and the four predicted variables consist of Strawberry production Maebang, Sulhyang Production, Water Type A, Maebang, Sulhyang Production, Water Type B and Maebang, Sulhyang Production, Water Type C. Through three Rooms Strawberry production test, this research suggests that the factors would closely influence the strawberry growth in fruit concentration directly with the variation of harvesting by every day.
Asymptomatic Giant Aneurysm of the Arteria Lusoria Treated by Debranching and Aneurysmal Resection
Aadithiyavikram Venkatesan,Akhilesh Gonuguntla,Anila Vasireddy,Guruprasad D Rai,Ganesh Sevagur Kamath,Arvind Kumar Bishnoi,Revanth Maramreddy 대한혈관외과학회 2022 Vascular Specialist International Vol.38 No.1
The aberrant right subclavian artery (ARSA, arteria lusoria) is the most common intrathoracic vascular anomaly, affecting up to 2% of the population. However, aneurysms of congenital anomalies are extremely unusual and often present with dysphagia, dysphonia, or dyspnea due to compression of the surrounding structures. We report a case of an asymptomatic 57-year-old male with chronic kidney disease who was incidentally found to have a large aneurysm of the ARSA on preoperative computed tomography for laparoscopic nephrectomy. Surgery is unequivocally warranted as these aneurysms are associated with a high risk of complications, including thrombosis, embolism, and rupture. We debranched the ARSA, followed by anastomosis to the right carotid artery through a right neck incision. Subsequently, aneurysmal resection was performed through left thoracotomy. The patient had an uneventful postoperative recovery and was asymptomatic during the follow-up.
Clinico-pathology of Lung Cancer in a Regional Cancer Center in Northeastern India
Mandal, Sanjeet Kumar,Singh, Thaudem Tomcha,Sharma, Takhenchangbam Dhaneshor,Amrithalingam, Venkatesan Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12
Background: Globally, there have been important changes in trends amongst gender, histology and smoking patterns of lung cancer cases. Materials and Methods: This retrospective study was conducted on 466 patients with lung cancer who were registered in Regional Cancer Center, Regional Institute of Medical Sciences, Manipur from January 2008 to December 2012. Results: Most were more than 60 years of age (67.8%) with a male: female ratio of 1.09:1. Some 78.8% of patients were chronic smokers with male smoker to female smoker ratio of 1.43:1. Consumption of alcohol was found in 29.4%, both smoking and alcohol in 27.5%, betel nut chewing in 37.9% and tobacco chewing in 25.3%. A history of tuberculosis was present in 16.3% of patients. The most frequent symptom was coughing (36.6%) and most common radiological presentation was a mass lesion (70%). Most of the patients had primary lung cancer in the right lung (60.3%). The most common histological subtype was squamous cell carcinoma (49.1%), also in the 40-60 year age group (45.9%), more than 60 year age group (51.6%), males (58.1%) and females (41.8%). As many as 91.9% of squamous cell carcinoma patients had a history of smoking. About 32.5% of patients had distant metastasis at presentation with brain (23.8%) and positive malignant cells in pleural effusions (23.1%) as common sites. The majority of patients were in stage III (34.4%), stage IV (32.5%) and stage II (30.2%). Conclusions: Our analysis suggests that the gender gap has been narrowed such that about half of the patients diagnosed with lung cancer are women in this part of India. This alarming rise in female incidence is mainly attributed to an increased smoking pattern. Squamous cell carcinoma still remains the commonest histological subtype. Most of the patients were elderly aged and presented at locally or distantly advanced stages.