만성 호중구성 백혈병 1예

박기령,조성민,우가은,이기현,손혜영,임정윤,최진혁,이순남,정화순 梨花女子大學校 醫科大學 醫科學硏究所 1997 EMJ (Ewha medical journal) Vol.20 No.2

Chronic neutrophilic leukemia(CNL) is a very rare myeloproliferative disease, characterized by sustained mature neutrophilic leukocytosis with granulocytic bone marrow infiltration, high NAP(neutrophilic alkaline phosphatase) score and absence of philadelphia chromosome, It is frequently accompanied by hepatosplenomegaly, elevated serum vitamin B_12 and uric acid level. For the diagnosis of CNL, the leukemoid reaction, especially secondary to neoplasia, infection and autoimmune diseases, should be excluded. Since Tuohy's first description in 1920, more than 50 cases fullfilling the above criteria have been reported worldwide, and 4 cases in Korea. Several authors have demonstrated the defect of intracellualr killing in the mature neutrophil and this finding correlates well with the very high incidence of fatal infection, The hemorrhagic diasthesis in CNL is caused by functional abnormality of the platelet. This disease has tendency to transform to blastic crisis and acute leukemia as in other myeloproliferative disease, but characteristically shows frequent coexistence with multiple myeloma. Until now , the therapeutic trials in CNL have been disappointing. Hydroxyrea and busulfan can control hyperleukocytosis. On the basis of functional defect in neutrophil, alpha-2b-interferon has been tried and several reports have demonstrated the clinical and functional effect of interferon on CNL. CNL is very rate hematologic disease and there are few report about general aspect of disorder. We report here a typical CNL case presenting with splenomegaly and leukocytosis with a review of the literature.

퍼지 이론을 이용한 이동 로보트의 주행에 대한 연구

이상배,박민용,가민호,김현덕,이창훈 연세대학교 산업기술연구소 1991 논문집 Vol.23 No.1

Autonomous action, which corresponds actively to the change of conditions in complicated circumstances, is a fundamental function equired to an intelligent mobile robot. To develop a control system for a mobile robot having such ability adaptable to the circumstances, it is necessary to establish the self-tracing technology which enabies the mobile robot to locate itself in its surrounding circumstances and manipulate its driving part with fiexibility. In this paper, to enable the mobile robot to find its location, the method of representing the route, necessary to make the route map which is used to move from the current position to the destination, is suggested. But the flexible navigation control is required for the mobile robot to navigate along the route map. So fuzzy control algorithm is suggested as navigation control algorithm. Such basic operations in navigation of the mobile robot as going straight, turning, avoiding obstacles are tested.

Electrical and physical properties of composite BaZr_0.85Y_0.15O_3−d-Nd_0.1Ce_0.9O_2−δ electrolytes for intermediate temperature-solid oxide fuel cells

Park, Ka-Young,Lee, Tae-Hee,Jo, Suyeon,Yang, Jayoon,Song, Sun-Ju,Lim, Hyung-Tae,Kim, Jung Hyun,Park, Jun-Young Elsevier 2016 Journal of Power Sources Vol.336 No.-

<P><B>Abstract</B></P> <P>Co-ionic (H<SUP>+</SUP>/O<SUP>2−</SUP>) electrolytes are fabricated by compositing both proton conductor (BaZr<SUB>0.85</SUB>Y<SUB>0.15</SUB>O<SUB>3-δ</SUB>, BZY) and oxygen-ion conductor (Nd<SUB>0.1</SUB>Ce<SUB>0.9</SUB>O<SUB>2−δ</SUB>, NDC) for intermediate temperature-solid oxide fuel cells (IT-SOFCs). This hybrid electrolyte decreases the electronic loss of NDC under reducing atmospheres and improves the poor sinterability of BZY. The electronic conduction caused by the NDC reduction is effectively blocked by the BZY in the composite electrolyte, thus offering both advantages of BZY with its high OCV and more rigid electro-chemo-mechanical property. In addition, the composite BZY-NDC electrolyte also exhibits great chemical stability against exposure to steam and CO<SUB>2</SUB>. Furthermore, the compositing of BZY and NDC improves the proton conductivity of the electrolytes, and the conductivity of composite electrolyte is higher than that of single BZY at temperatures >600 °C.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Co-ionic electrolyte is fabricated by compositing proton and oxygen-ion conductor. </LI> <LI> Hybrid electrolytes decrease electronic loss and improve poor sinterability. </LI> <LI> Conductivity of composite electrolyte is higher than that of single BZY at >600 °C. </LI> <LI> Composite electrolytes exhibits great chemical stability against steam and CO<SUB>2</SUB>. </LI> <LI> Mechanical stability of cells improves by preventing chemical expansion of ceria. </LI> </UL> </P>

Microscopic Investigation of the Macroscopic Soil Arch Phenomenon in Active Trapdoor Condition using Discrete Element Analysis

Ka-Hyun Park,Young-Hoon Jung,Seongmin Kim 한국철도학회 2018 International Journal of Railway Vol.11 No.2

Understanding the formation of soil arch in the ground subjected to active trapdoor condition is very important for predicting load redistribution in tunnels or piled embankments. Soil arching in the trapdoor problem was investigated via the discrete element simulation. In the simulation, mono-sized spheres were generated to build a hexagonal lattice structure. There exists the surface of sliding which rises from the edge of the trapdoor. The surface of separation is close to the failure surface in the Rankine’s passive zone with the lateral shortening described by Terzaghi. The results of the simulations showed that different frictional coefficients can affect the angle slope of the surface of sliding, especially for the portion approaching the top surface of the particle assembly.

New Class of Scorpionate: Tris(tetrazolyl)–Iron Complex and Its Different Coordination Modes for Alkali Metal Ions

Park, Ka Hyun,Lee, Kang Mun,Go, Min Jeong,Choi, Sung Ho,Park, Hyoung-Ryun,Kim, Youngjo,Lee, Junseong American Chemical Society 2014 Inorganic Chemistry Vol.53 No.16

<P>We report formation of a new metallascorpionate ligand, [Fe<I><B>L</B></I><SUB>3</SUB>]<SUP>3–</SUP> (IPtz), containing a Fe core and three 5-(2-hydroxyphenyl)-1<I>H</I>-tetrazole (<I><B>L</B></I>H<SUB>2</SUB>) ligands. It features two different binding sites, oxygen and nitrogen triangles, which consist of three oxygen or nitrogen donors from tetrazole. The binding affinities of the complex for three alkali metal ions were studied using UV spectrophotometry titrations. All three alkali metal ions show high affinities and binding constants (>3 × 10<SUP>6</SUP> M<SUP>–1</SUP>), based on the 1:1 binding isotherms to IPtz. The coordination modes of the alkali metals and IPtz in the solid were studied using X-ray crystallography; two different electron-donor sites show different coordination numbers for Li<SUP>+</SUP>, Na<SUP>+</SUP>, and K<SUP>+</SUP> ions. The oxygen triangles have the κ<SUP>2</SUP> coordination mode with Li<SUP>+</SUP> and κ<SUP>3</SUP> coordination mode with Na<SUP>+</SUP> and K<SUP>+</SUP> ions, whereas the nitrogen triangles show κ<SUP>3</SUP> coordination with K<SUP>+</SUP> only. The different binding affinities of IPtz in the solid were manipulated using multiple metal precursors. A Fe–K–Zn trimetallic complex was constructed by assembly of an IPtz ligand, K, and Zn precursors and characterized using X-ray crystallography. Oxygen donors are coordinated with the K ion via the κ<SUP>3</SUP> coordination mode, and nitrogen donors are coordinated with Zn metal by κ<SUP>3</SUP> coordination. The solid-state structure was confirmed to be a honeycomb coordination polymer with a one-dimensional infinite metallic array, i.e., −(K–K–Fe–Zn–Fe–K)<SUB><I>n</I></SUB>–.</P><P>A metallascorpionate complex featuring two different binding sites was prepared, and its different coordination modes with alkali metals in solution were studied. A honeycomb-coordinated structure with a one-dimensional infinite metallic array of −(K−K−Fe−Zn−Fe−K)<SUB><I>n</I></SUB>− was constructed by assembly of tetrazole and Fe, K, and Zn precursors.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/inocaj/2014/inocaj.2014.53.issue-16/ic5002336/production/images/medium/ic-2014-002336_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ic5002336'>ACS Electronic Supporting Info</A></P>

Operation Protocols To Improve Durability of Protonic Ceramic Fuel Cells

Park, Ka-Young,Kim, You-Dong,Lee, John-In,Saqib, Muhammad,Shin, Ji-Seop,Seo, Yongho,Kim, Jung Hyun,Lim, Hyung-Tae,Park, Jun-Young American Chemical Society 2019 ACS APPLIED MATERIALS & INTERFACES Vol.11 No.1

<P>To develop reliable and durable protonic ceramic fuel cells (PCFCs), the impacts of the operation protocols of PCFCs on the cell durability are investigated through analyses of the main degradation mechanisms. We herein propose three appropriately designed control protocols, including cathode air depletion, shunt current, and fuel cell/electrolysis cycling, to fully circumvent the operating-induced degradation of PCFCs. For this purpose, anode-supported cells, comprised of a NiO-BaCe<SUB>0.7</SUB>Zr<SUB>0.1</SUB>Y<SUB>0.1</SUB>Yb<SUB>0.1</SUB>O<SUB>3−δ</SUB> anode, BaCe<SUB>0.7</SUB>Zr<SUB>0.1</SUB>Y<SUB>0.1</SUB>Yb<SUB>0.1</SUB>O<SUB>3−δ</SUB> electrolyte, and NdBa<SUB>0.5</SUB>Sr<SUB>0.5</SUB>Co<SUB>1.5</SUB>Fe<SUB>0.5</SUB>O<SUB>5+δ</SUB>-Nd<SUB>0.1</SUB>Ce<SUB>0.9</SUB>O<SUB>2−δ</SUB> composite cathode, are prepared, and their long-term performances are evaluated under a galvanostatic condition of 0.5 A·cm<SUP>-2</SUP> at 650 °C. The cell voltages of the protected cells using the operation protocols to prevent performance degradation are stably maintained under the applied current density for more than 1200 h without any noticeable degradation, whereas the performance of the unprotected cell gradually decreased with time, and the decay ratio was 14.9% over 850 h. The significant performance decay of the unprotected cell is strongly associated with the cathode degradation phenomenon, which was caused by the water vapor continuously produced during the electrochemical reactions. Hence, the performance recovery of the PCFCs with the operation protocols is achieved by incrementally decreasing the cathode potential (close to a value of zero) to minimize the effect of high <I>P</I><SUB>H</SUB><SUB><SUB>2</SUB></SUB><SUB>O</SUB> and <I>P</I><SUB>O</SUB><SUB><SUB>2</SUB></SUB> during the PCFC operations.</P> [FIG OMISSION]</BR>

케일 중 Pyraclostrobin과 Fenvalerate 잔류 소실 특성

Hyun-Ji Park,Jung-Hun Sun,Sang-Jeong Park,Seung-Jun Ka,Joon-Kwan Moon 한국농약과학회 2022 한국농약과학회 학술발표대회 논문집 Vol.2022 No.4

State-Dependent Volume Change during Creep in Engineered Silty Sand

Park, Ka-Hyun,Chung, Choong-Ki,Jung, Young-Hoon American Society of Civil Engineers 2019 Journal of geotechnical and geoenvironmental engin Vol.145 No.6

Changes of Platycosides Components and Antimicrobial Activity on Bronchus Diseases Inducing Bacteria of Fermented Platycodon grandiflorum Root by Lactic Acid Bacteria

Ka Soon Lee(이가순),Bong Jae Seong(성봉재),Sun Ick Kim(김선익),Moo Geun Jee(지무근),Saet Byeol Park(박샛별),Myeong Hee Park(박명희),Shin Young Park(박신영),Hyun Ho Kim(김현호) 한국약용작물학회 2016 한국약용작물학회 학술대회논문집 Vol.2016 No.1

젖산발효 처리에 의한 도라지의 Platycosides 조성 및 호흡기 질환 유발세균에 대한 항균활성 변화

Ka Soon Lee,Bong Jae Seong,Sun Ick Kim,Moo Geun Jee,Saet Byeol Park,Myeong Hee Park,Shin Young Park,Hyun Ho Kim 한국약용작물학회 2016 한국약용작물학술대회 발표집 Vol.2016 No.05

Background : Platycodon grandiflorum root(PGR) was one of the primary herbs used in a phlegm-relieving herb from the past. Purified platycoside compounds from the roots of PGR may exhibit neuroprotective, antimicrobial, anti-inflammatory, anti-cancer, anti-allergy, improved insulin resistance, and cholesterol-lowering properties. To evaluate preference and functionality of PGR extracts, PGR was fermented by several lactic acid bacteria. Lactic acid bacteria used were Leuc. mesenteroides N12-4 and N58-5, L. plantarum N76-10 and 56-12, L. brevis N70-9 and E3-8. Methods and Results : This study was performed in order to investigate the changes of platycosides, as well as the antimicrobial activities on bronchus diseases inducing bacteria(C. diphtheriae, K. pnneumoniae, S. aureus, S. pyogenes) of Platycodon grandiflorum root(PGR) fermented by using lactic acid bacteria(Leuc. mesenteroides N12-4, Leuc. mesenteroides N58-5, L. plantarum N76-10, L. plantarum N56-12, L. brevis N70-9, L. brevis E3-8). Growth of L. plantarum on PGR was the most active during lactic acid fermentation by some different strains. Total platycoside, platycoside E, platycodin A, polygalacin D2, polygalacin D and diapioplatycoside E contents of PGR fermented for 96 hours at 37℃ by Leuc. mesenteroides and L. plantarum were increased, while platycodin D and platycodin D3 were decreased. The antimicribial activity on PGR fermented by L. plantarum N56-12 exhibited a strong microbial proliferation in all four kinds of bronchus diseases inducing bacteria and was higher than non-fermented PGR extract. Conclusion : Thus, this results showed antimicrobial activities on bronchus diseases inducing bacteria and platycosides content of PGR by L. plantarum N56-12 were higher than non-fermented PGR extract.