Inhibitory effects of acharan suIfate and its derivatives on embryonic angiogenesis

KH Shin,JY Shim,EJ Kim,SS Lim,SJ Wu,YS Kim 대한약학회 1999 大韓藥學會 總會 및 學術大會 Vol.48 No.-

완전 고환성 여성화증후군 1 례

최규홍,김경호,신성식,이미리,신훈범,유미정 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.11

Complete testicular feminization syndrome is characterized by female phenotype, in spite of the normal male karyotype 46,XY. There is a congenital insensitivity to androgens, transmitted by means of a maternal X-linked recessive gene responsible for the androgen intracellular receptor. Therefore, androgen induction of Wolffian duct developmetn does not occur. However, antimullerian hormone activity is present, and the individual does not have mullerian development.

Behcet씨 증후군 1예

김규현(KH Kim),김청수(CS Kim),강순범(SB Kang),신희철(HC Shin),신면우(MW Shin) 대한산부인과학회 1982 Obstetrics & Gynecology Science Vol.25 No.9

저자들은 비교적 희귀한 질환인 Behcet씨 증후군 1예를 경험하였기에 그의 문헌적 고찰과 함께 이어 보고하는 바이다. Behcets disease is a multisystemic disease charaterized by ulcers of the mouth, genitalia and inflammatory eye lesions forming the so-called triple syndrome. A case of ulcerative lesions in the oral mucous membrane and genitalia that recently experienced is presented with a brief review of the literatures.

대장암세포주에 대한 광역학치료의 효과

이한일,최동락,주대현,박기혁,박성환,유용운,박기호,신임희,신동건,김종기,조창호,김진천 대한대장항문학회 2003 Annals of Coloproctolgy Vol.19 No.4

人蔘의 放射線 感受性

KH. CHOI(崔光泰),M.W. KIM(金明苑),S.D. AHAN(安相得),H.S. SHIN(申熙錫) 한국육종학회 1981 한국육종학회지 Vol.13 No.1

In order to investigate radiosensitivity on ginseng (Panax qinsena C.A. Meyer), the dehiscent seeds with high water content, 55.1%, were irradiated with X-ray. The differences of biological injuries in ginseng seedlings due to the dose of X-ray were quite obvious in all of characters as well as germination rate. The lethal dose-50 per cent was about 2.5kR

전신성 흉반성 낭창이 합병된 임신의 경과 및 주산기 예후

신희철,윤보현,박교훈,이희선,노경록,김성훈 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.9

Objectives: The purpose of this study was to evaluate the course of systemic lupus erythematosus(SLE) during pregnancy and the outcome of pregnancy in patients with SLE. Methods: This retrospective study was done by the review of medical records of 73 pregnancies complicated with SLE in 24 patients between January, 1983 and April, 1996. Results: SLE was exacerbated in 28% during pregnancy. The most common clinical finding of the exacerbation was renal dysfunction such as increased proteinuria and/or increased level of blood urea nitrogen(BUN) and creatinine. Among 34 cases of viable pregnancies after diagnosis of SLE, there were 4 cases of spontaneous abortion(12%), 4 cases of stillbirth(12%), 7 cases of preterm birth(21%), 2 cases of neonatal death(6%), 4 cases of intrauterine growth retardation(12%), and 4 cases of pregnancy induced hypertension(PIH))12%). Among 25 neonates born by women with SLE, there was no case of neonatal lupus or congenital complete heart block. Therapeutic abortion, stillbirth, preterm birth, PIH occurred more frequently in women with renal involvement, but the difference was not statistically significant. And we compred the outcome of 26 pregnancies before the diagnosis of SLE with that of 43 pregnancies after the diagnosis of SLE. Preterm birth, PIH, low birth weight infant occurred more frequently after diagnosis of SLE, but the difference was not statistically significant. Con clusion: Our data suggest that 1) the risk of pregnancy induced exacerbation of SLE is not high enough to do serious harm to patients with SLE, 2) the incidence of stillbirth, preterm birth, intrauterine growth retardation, PIH, and neonatal death increases in patients with SLE, 3) the risk of neonatal lupus or congenital complete heart block is very low in neonates whose mothers have SLE, 4) there is no significant difference in the outcome of pregnancy whether the patients have lupus nephritis or not, 5) there is no significant difference in the outcome of pregnancies between after and before the diagnosis of SLE.

임신중 고혈압성 질환의 임상적 고찰

신승권,김하봉,류형선,윤광혁,박명호 대한산부인과학회 1994 Obstetrics & Gynecology Science Vol.37 No.3

1988년 1월부터 1992년 12월까지 만 5년간 목포 성골롬반병원 산부인과에 입원 분만하였던 산모 총 17,755명중 502명의 임신중 고혈압성 질환 환자를 대상으로 임상통계학적으로 조사분석한 결과 다음과 같은 결론을 얻었다. 1. 총분만수에 대한 임신중 고혈압성 질환의 발생빈도는 2.83%였고, 매년 감소하는 경향을 보였다. 2. 분류에 의하면 경증 자간전증이 56.98%(286예), 중증 자간전증이 38.25%(192예), 자간증이 1.59%(8예), 만성 고혈압성 혈관질환이 3.18%(16예)였다. 3. 연령별 분포는 발생수는 25-29세군에서 가장 많았으나, 임신중 비고혈압성 질환군과 비교하였을때 35세이상에서는 높은 빈도를 보였다(p$lt;0.05). 4. 분만횟수별 발생수는 초산부에서 가장 많았고, 임신중 비고혈압성 질환군과 비교하였을때도 초산부에서 발생빈도가 가장 높았다(p$lt;0.05). 5. 계절별 분포는 동계에 가장 높은 분포를 보였으나 계절간의 의의있는 창를 보이지는 않았다. 6. 모체 혈액형에 따른 발생빈도는 A형에서 가장 높았다. 7. 태아 성별은 남아에서 53.7%로 빈도가 더 높았으나 큰 차이는 보이지 않았다. 8. 다태임신시 발생빈도는 18.75%로 단태임신에서의 임신중 고혈압성 질환의 발생빈도보다 월등히 높았다. 9. 임신기간과 신생아 체중은 임신중 고혈압성 질환군과 임신중 비고혈압성 질환군을 비교하였을때, 임신중 고혈압성 지롼군에서 조산과 저체중아의 발생빈도가 월등히 높았다(p$lt;0.05). 10. 산전관리 횟수는 전혀 산전관리를 받지 못한 경우가 32.1%였으며, 1회의 산전관리만을 받은 경우는 36.6%였다. 11. 분만방법은 질식자연분만이 30.9%, 질식유도분만이 21.9%, 질식흡입분만이 7.8%, 제왕절개술에 의한 분만이 39.4%였다. 12. 모성합병증은 빈혈 24.5%, 산후출혈, 4.6%, 태반조기박리 3.4%였고, 모성사망은 0.2%(1예)였다. 13. 태아 및 신생아 합병증은 자궁내 발육지연이 20.3%였고, 사산아는 0.8%, 신생아 사망은 3.6%였다. 14. 혈소판치가 10만/mm^3이하로 감소된 경우는 4.5%였다. This clinical study was undertaken for evaluation of 502 cases associated with hypertensive disorders in pregnancy, who were admitted to department of Obstetrics and Gynecology, St.Columban Hospital from January, 1988 to December, 1992. The results were as follows; 1. The incidence of hypertensive disorders in pregnancy (HDIP) was 2.83% of total deliveries. 2. Using the classification of American committee on Maternal Selfare, the incidence of hypertensive disorders in pregnancy was as follows; Preeclampsia, mild: 56.9% Preeclampsia, severe: 38.25% Eclampsia: 1.59% Chronic hypertensive vascular disorders: 3.18% 3.The highest number of HDIP was observed in the age group of 25-29, but the frequency of disease was higher in the age group above 35 years old. 4. According to parity, the higher frequency was noted innullipara. 5. Among four seasons, 29.5% of the patients were occurred in winter which was the most prevalent season, but a significant difference in seasonal distrubution was not noted. 6. Among four blood type, 44.8% of the patients were occurred in blood type A which was followed by B,O,AB,in orders. 7. There was slightly higher male predominance in fetuses of the hypertensive disorders in pregnancy, but a significantl difference was not seen. 8. The incidence of HDIP in twin pregnancy was 18.75%. 9. As to the gestational age and the birth weight, the preterm and the low birth weight were higher incidence in HDIP group than non-HDIP group. 10. The disease was more prevalent in women who did not take antenatal care. 11. 60.6% of the patients were delivered vaginally, 30.9% spontaneous, 21.9% induced, 7.8% with vacuum extraction and 39.4% of the patients were performed cesarean section. 12. As to maternal complication, anemia was found in 24.5$, postpartum hemorrhage in 4.6%, abruptio placentae in 3.4% and maternal death in 0.2%. 13. As to fetal complication, intrauterine growth retardation was found in 20.3%, stillbirth in 0.8% and neonatal death in 3.6%. 14. The mean level of platelet count was 226,800 /mm^3, and the group less than 100,000 was 4.5%

제대혈천자술을 이용한 산전 세포유전학적 진단

신희철,문신용,윤보현,전종관,박교훈 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.2

Pure fetal blood was obtained by cordocentesis or cardiocentesis guided by USG in 160 fetuses at 15 to 37 weeks` gestation. Only 1 case failed to obtain cytogenetic result. Cytogenetic analysis of fetal lymphocytes yielded results within 5 days. Chromosomal abnormalities were found in 21 of 159 fetuses(13.2%). Abnormal karyotypes were found in 19 of 118 fetuses(16.1%) with structural malformations~8.6%(7/81) affected by isolated malformations vs. 32.4%(12/37) affected by multiple malformations. There were 12 cases of bradycardia which was the most common nonfatal complication (7.4%). One fetal death was recorded. Pregnancy outcome is as follows: 17 cases of stillbirth, 38 cases of termination of pregnancy, 15 cases of neonatal death, 5 cases of infantile death, 55 cases of living babies, and 29 cases lost to follow-up. It is concluded that rapid karyotyping by cordocentesis is advisable as effective method in fetuses at high risk of a chromosomal aberration, especially in advanced gestations.

태아의 제대기저부탈장이 동반된 임신의 임상적 양상과 예후

신희철,윤보현,박교훈,이희선,노경록,김성훈 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.11

Objective: To evaluate pregnancy course, and the perinatal outcomes of pregnancies with fetal omphalocele. Materials and Methods: The retrospective study was done by the review of medical records of 24 pregnancies with fetal omphalocele found between January, 1986 and June, 1996. Results: Fetal omphalocele was found one in 818 births during the study period: Two were terminated before 25 weeks of gestation. Associated anomalies were detected in 71%(17/ 24) of cases; cardiac(n=16), skeletal(n=5), chromosome(n=3), central nervous system(n=3), cleft lip and palate(n=2), etc. Five died in utero(23%, 5/22). Seven fetuses were growth-retarded(32 %, 7/22). Seventeen were liveborn. However, 41%(7/17) had low Apgar scores at 5 minutes ($lt;7). Cesarean section was performed in 12(71%). Five newborns died immediately after birth. Nine newborns received corrective operation, and seven survived; three had no associated anomalies and four had heart anomalies. Conclusions: Associated anomalies were found in 71%(17/24) of cases with omphalocele. Perinatal mortality was 55%(12/22): five died in utero, and seven during the neonatal period. However, 78%(7/9) of newborns who received corrective operation survived.

척추 결핵 치료에서의 금속 고정물의 안전성과 유용성

신병준,이재철,최성우,류시훈,조영일,윤태경,김경제,김연일 대한척추외과학회 2003 대한척추외과학회지 Vol.10 No.2