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김선녀 ( Seon Nyo Kim ),이주영 ( Juyoung Lee ),신승한 ( Seung Han Shin ),최창원 ( Chang Won Choi ),김이경 ( Ee Kyung Kim ),김한석 ( Han Suk Kim ),김병일 ( Beyong Il Kim ),최중환 ( Jung Hwan Choi ) 대한주산의학회 2015 Perinatology Vol.26 No.3
Purpose: Capillary hemangiomas occur more frequently in preterm infants. We aimed to describe the clinical course of capillary hemangiomas in preterm infants. Methods: The records of preterm infants with a gestational age (GA) of <35 weeks who were admitted to two tertiary neonatal intensive care units from January 2004 to December 2013 and had capillary hemangiomas were reviewed retrospectively. Subgroup analysis of between infants of GA <30 weeks and GA 30-34+6 weeks were done and ad hoc analysis comparing study population and matched preterm infants without hemangioma for investigation of differences in clinical characteristics. Results: Of the 2,772 preterm infants, 112 (4%) infants developed capillary hemangiomas. The majority (91.9 %) of them had a solitary hemangiomas with the trunk was the most commonly involved site (43%). Three quarters of the patients were treated with topical corticosteroid, propranolol or laser treatment. When we divided this population as who were born before or after GA 30 weeks, there was no difference at postmenstrual age (PMA) of onset of capillary hemangiomas (median [IQR], 36+4 [30+5-40+5] vs. 36+2 [33+6-41+1] weeks, P= 0.275). The age at involution of capillary hemangiomas was also not differ between two groups (median [IQR], 7.75 [3.75-12.25] vs. 7.5 [4-13.75] months, P=0.425). There were no statistical differences between preterm infants with capillary hemangiomas and their age, weight and sex matched control preterm infants without hemangiomas in the neonatal and maternal factors. Conclusion: The development of capillary hemangiomas occurred at approximately 36 to 37weeks of PMA regardless of prematurity in preterm infants. Capillary hemangiomas of preterm infants resolved spontaneously and disappear completely by around 7 months of corrected age.
김상훈,김세계,정경화,윤성녀,김윤기,김민철,류삼곤,이해완,채영규,Kim, Sang Hoon,Kim, Se Kye,Jung, Kyoung Hwa,Yoon, Sung Nyo,Kim, Yun Ki,Kim, Min Cheol,Ryu, Sam Gon,Lee, Hae Wan,Chai, Young Gyu 한국군사과학기술학회 2015 한국군사과학기술학회지 Vol.18 No.4
Decontamination of biological agents utilizes hydrogen peroxide($H_2O_2$) for its effectiveness and safeness. Bacillus anthracis is a major target for $H_2O_2$ decontamination. To assess the effect of $H_2O_2$ on B. anthracis and identify biomarkers for decontamination, whole transcriptomic profiling of $H_2O_2$-treated B. anthracis was performed. Here we identified deregulation in stress response genes, transcription factors and cellular homeostasis genes. We also found that expression of antisense RNAs increased in B. anthracis during decontamination. We postulate that B. anthracis prioritizes survival and adaptation in response to $H_2O_2$ treatment by changing its gene expression pattern.
Late-Exponential Gene Expression in codY-Deficient Bacillus anthracis in a Host-Like Environment
Kim, Se Kye,Jung, Kyoung Hwa,Yoon, Sung Nyo,Kim, Yun Ki,Chai, Young Gyu Springer-Verlag 2016 Current microbiology Vol.73 No.5
<P>CodY is a pleiotropic regulator commonly found in Gram-positive bacteria and regulates various biological processes during the stringent response in a nutrient-limiting environment. CodY also participates in virulence factor expression in many low G+C Gram-positive pathogens, as observed in Bacillus anthracis. However, the mechanism by which B. anthracis CodY regulates metabolism and virulence factors in response to environmental changes is unclear. Here, we attempted to identify the link between CodY and B. anthracis regulation with codY-deficient and codY-overexpressing mutants using high-throughput transcriptional analysis. Growth pattern analyses of codY mutants in both rich and minimal media showed defects in early cell proliferation, with opposite patterns in the early stationary phase: CodY overexpression prolonged bacterial growth, whereas deletion inhibited growth. RNA sequencing of codY-deficient B. anthracis showed both positive and negative changes in the gene expression of proteases and virulence factors as well as genes related to stringent response-related metabolism and biosynthetic processing. We also found that changes in codY expression could alter virulence gene expression of B. anthracis, suggesting modes of regulation in its virulence in a CodY concentration-dependent manner. Collectively, we conclude from these results that CodY can both positively and negatively regulate its regulon via direct and/or indirect approaches, and that its mode of regulation may be concentration dependent.</P>
Requirements Study of a High-Resolution Satellite Image receiving, Processing and Archiving System
Hong, Min Nyo,Kim, Tae Jung,Gon , Tag 대한원격탐사학회 1999 International Symposium on Remote Sensing Vol.15 No.1
This paper addresses a new project being carried out at Satellite Technology Research Center. The purpose of the project is to implement a system which receives, processes and stores 1m resolution satellite image transmitted at over 300Mbps down link data rates. In order to develop such a system, a system operational concept design and a requirements study were being carried out. As a result of the operational concept design, system objectives, system context and system functions were defined. The system shall be operated according to the philosophy of maximum automation, rapid processing, reliability, integrity, cost effectiveness, and expandability. The system is divided into twelve independent processes and its behavior is modeled by operational scenario, which are combinations of independent processes. Process information and logs generated by the system shall be stored in databases and data received and generated be automatically archived and managed in a hierarchical storage device. The system shall have redundant components in order to be ready for recovering from sudden system failures. This paper will describe in detail the system operational concept design and the system requirements derived from the operational concept design.
Automated Image Reception, Processing and Distribution System for KOMPSAT-2
Park, Sung Og Park,Kim, Moon Gyu,Kim, Tae Jung,Kim, S. A. B.,Im, Yong Jo,Park, Seung Ran,Lee, Jong Ju,Shin, Dong Seok,Yoon, Tae Hun,Choi, Wook Hyun,Hong, Min Nyo,Kwak, Sung Hee 대한원격탐사학회 2001 International Symposium on Remote Sensing Vol.17 No.1
Korean Government is going to launch KOMPSAT 2 (KOrea Multi-Purpose SATellite-2) with MSC (Multi-Spectral Camera) payload in 2004. MSC is capable of 1 m panchromatic and 4m multi-spectral imaging. To fully utilize images taken by KOMPSAT 2, there have been great demands on Koreanization of ground segments. This paper addresses the development of the ground receiving system for KOMPSAT-2. The work scope is to develop a whole system for image receiving station except RF part for KOMPSAT-2. The work includes development of image receiving and archiving system, image processing system, and image distribution system. During last three years, we have developed most of subsystems and now we are integrating overall system. We conducted performance and functionality tests at the subsystem level, and achieved an image reception, processing and distribution system that can handle image data at the rate of up to 340Mbps. Considering image processing, due to the lack of available image data, we have tested up to 6.6m resolution images.