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Comparative Genomic Hybridization 기법을 이용한 한국인 원발성 간세포암에서의 염색체 변화에 대한 연구
박훤겸,정풍만,이광수,조율희 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1
Comparative genomic hybridization(CGH) technique is one of the screening tests for DNA sequence copy number changes(losses, deletions, gains, amplifications) in tumor genomes. DNA changes in 23 hepatocellular carcinomas(HCC) associated with hepatitis B virus(HBV) were analyzed by CGH technique. Eighteen of the 23 cases showed genetic alterations. The remaining 5 cases showed no detectagble aberration. The losses of chromosome regions 17p(74%), 4q (57%), 16p (52%), 16q (48%), 8p (43%) and 13q (43%) were detected in the order of decreasing frequency. In cases of multiple losses of chromosomes, a combination of 17p,16p,16q,4q, and 8p losses was found in 5 cases (30%). On the other hand, chromosomal gains occurred on 1q (65%), 8q (52%), 20p (48%) and 20q (43%) in the order of decreasing frequency. And the simultaneous genomic gains of these 4 chromosomes were found in 9 cases (40%). Moreover, the combination of 5 genomic losses (17p, 16p, 16q, 4q, & 8p) and 4 genomic gains (1q, 8q, 20p, & 20q) was observed in 4 case s(23%). The pattern of chromosomal gains and losses in HCC with hepatitis B in Korean patients is very complex and involves virtually every site in the genome. This indicated a high genomic instability. This could possibly be explained either as the result of random chromosomal changes during early development of tumor, or as the highly variable and random pattern of integration of HBV in the HCC. The hepatocarcinogenesis may be the result of cumulative effocts rather than those orders of occurrence of those genomic changes. The sites of cellular DNA at which HBV integrates frequently undergo rearrangements, resulting in translocations, inverted duplications, deletions, and possibly recombinational events. But, CGH only detects changes of chromosomal copy number but could not identify translocations, inversions, and other aberrations of chromosome. The chromosomal analysis of HCC with HBV in Korean patients by CGH technique confirms the presence of complex and sporadic, but nonrandom genetic changes in the chromosome. In the future, more detailed oncogenic study could be carried out on the chromosomes which showed abnormal aberrations through this study.
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이보라,이정은,박경미,정진홍,유동열 대전대학교 한방병원 2001 惠和醫學 Vol.10 No.1
After treating a patient suffering from pelvic inflammatory disease, a significant result is gained as follows. This study was done from the patient who were at the oriental Medicine Hospital of Daejeon university during 15 days, from 12. 12 to 12. 26, 2001. A 27-year-old patient had complained an abdominal pain, chest discomfort, nausea, vomiting, urination difficulty and constipation. During the hospital periods, the kinds of therapy are acupuncture, moxibustion, herb-med and physical therapy. Given the treatment, she felt so satisfied about her symptom's improvement. But as a result of Ultrasonogram of pelvis, she had multiple follicles on the right ovary, so it had to be given a surgical operation. For the surgical operation, she was transferred to the Chungnam University Hospital
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지역냉방 시스템용 초고효율 판형 열교환기 개발에 관한 연구
박재홍(Jae-Hong Park),임혁(Hyug-Lim),조성열(Sung-Youl Cho),강인성(In-Sung Kang),김정규(Jung-Kyu Kim),허인은(In-Eun Hur),고성규(Seong-Kyu Ko),곽승식(Sung-Sik Kwak),김종재(Jong-Jae Kim) 한국마린엔지니어링학회 2010 한국마린엔지니어링학회 학술대회 논문집 Vol.2010 No.10
Plate heat exchanger consists of thin, rectangular, pressed sheet metal plates that are sandwiched between full peripheral gaskets and clamped together in a frame. The frame has a fixed end-cover plate, fitted with the connecting ports, which is bolted together with a movable cover plate to hold the embossed plates in between; the top and bottom carrying bars allow proper alignment of the plate stacks. When compared with the well-established shell and tube heat exchangers, the plate heat exchanger shows a lot of advantages like high NTU values, compactness, low cost, multi duties and reduced fouling etc. Plate heat exchangers are often used to transfer heating or cooling water which is produced in the energy production( district heating or district cooling) facilities to residential areas and industrial parks. The district cooling systems of Middle East are the biggest market of plate heat exchanger, but the technical specifications for cooling system are different from the domestic one. To achieve its specifications, the new plate heat exchanger was developed, and its thermal performance results are introduced in this paper.
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Park, Jung Youl,Chung, Jae-Ho,Lee, Hyung Chul,Lee, Byung-Il,Park, Seung-Ha,Yoon, Eul-Sik Korean Society of Plastic and Reconstructive Surge 2018 Archives of Plastic Surgery Vol.45 No.5
Background Adjuvant therapy after breast surgery, including tamoxifen or aromatase inhibitors, improves the postoperative outcomes and long-term survival of breast cancer patients. The aim of this study was to determine whether volume changes occurred in the contralateral breast during hormonal or other adjuvant therapies. Methods This study reviewed 90 patients who underwent unilateral breast reconstruction between September 2012 and April 2018 using tissue expanders and a permanent implant after the surgical removal of breast cancer. The volume of the contralateral breast was measured using a cast before the first (tissue expander insertion) and second (permanent implant change) stages of surgery. Changes in breast volume were evaluated to determine whether adjuvant therapy such as hormonal therapy, chemotherapy, and radiation therapy influenced the volume of the contralateral breast. Results The group receiving tamoxifen therapy demonstrated a significant decrease in volume compared with the group without tamoxifen (-7.8% vs. 1.0%; P=0.028). The aromatase inhibitor-treated group showed a significant increase in volume compared with those who did not receive therapy (-6.2% vs. 4.5%; P=0.023). There were no significant differences between groups treated with other hormonal therapy, chemotherapy, or radiation therapy. Conclusions Patients who received tamoxifen therapy showed a significant decrease in volume in the contralateral breast, while no significant change in weight or body mass index was found. Our findings suggest that we should choose smaller implants for premenopausal patients, who have a high likelihood of receiving tamoxifen therapy.
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Development of a Multiplex RT-PCR for the Simultaneous Detection of Three Viruses in Cherry Plants
Park, Chung Youl,Park, Jeongran,Lee, Geunsik,Yi, Seung-In,Kim, Byeong Hoon,Eom, Jung Sik,Lee, Som Gyeol,Kim, Hongsup The Korean Society of Plant Pathology 2018 식물병연구 Vol.24 No.3
A multiplex RT-PCR (mRT-PCR) assay was developed for the detection of the recently reported viruses, Cherry virus A (CVA), Little cherry virus 1 (LChV-1), and Little cherry virus 2 (LChV-2), in cherry plants in Korea. Eight sets of primers were designed for each virus and their specificity was tested by using various combinations of mixed primer sets. From the designed primer sets, one combination was selected and further evaluated to estimate the optimum temperature and detection limits of the mRT-PCR. A newly developed mRT-PCR assay was also tested using 20 cherry samples collected in the field. This mRT-PCR assay may be a useful tool for field surveys of diseases and the rapid detection of these three viruses in cherry plants.
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Park, Hyung-Youl,Lim, Myung-Hoon,Jeon, Jeaho,Yoo, Gwangwe,Kang, Dong-Ho,Jang, Sung Kyu,Jeon, Min Hwan,Lee, Youngbin,Cho, Jeong Ho,Yeom, Geun Young,Jung, Woo-Shik,Lee, Jaeho,Park, Seongjun,Lee, Sungjoo American Chemical Society 2015 ACS NANO Vol.9 No.3
<P>Despite growing interest in doping two-dimensional (2D) transition metal dichalcogenides (TMDs) for future layered semiconductor devices, controllability is currently limited to only heavy doping (degenerate regime). This causes 2D materials to act as metallic layers, and an ion implantation technique with precise doping controllability is not available for these materials (<I>e</I>.<I>g</I>., MoS<SUB>2</SUB>, MoSe<SUB>2</SUB>, WS<SUB>2</SUB>, WSe<SUB>2</SUB>, graphene). Since adjustment of the electrical and optical properties of 2D materials is possible within a light (nondegenerate) doping regime, a wide-range doping capability including nondegenerate and degenerate regimes is a critical aspect of the design and fabrication of 2D TMD-based electronic and optoelectronic devices. Here, we demonstrate a wide-range controllable n-doping method on a 2D TMD material (exfoliated trilayer and bulk MoS<SUB>2</SUB>) with the assistance of a phosphorus silicate glass (PSG) insulating layer, which has the broadest doping range among the results reported to date (between 3.6 × 10<SUP>10</SUP> and 8.3 × 10<SUP>12</SUP> cm<SUP><B>-</B>2</SUP>) and is also applicable to other 2D semiconductors. This is achieved through (1) a three-step process consisting of, first, dopant out-diffusion between 700 and 900 °C, second, thermal activation at 500 °C, and, third, optical activation above 5 μW steps and (2) weight percentage adjustment of P atoms in PSG (2 and 5 wt %). We anticipate our widely controllable n-doping method to be a starting point for the successful integration of future layered semiconductor devices.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2015/ancac3.2015.9.issue-3/acsnano.5b00153/production/images/medium/nn-2015-00153b_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn5b00153'>ACS Electronic Supporting Info</A></P>
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Advanced Load Follow Operation Mode for Korean Standardized Nuclear Power Plants
Park, Jung-In,Oh, Soo-Youl,Song, In-Ho,Hah, Yung-Joon,Kuh, Jung-Eui,Lee, Un-Chul Korean Nuclear Society 1992 Nuclear Engineering and Technology Vol.24 No.2
An advanced load-follow operation mode, Mode K, is presented for the Korean Standardized Nuclear Power Plants. The Mode K utilizes a heavy worth bank dedicated to axial shape control independent of the existing regulating banks. In Mode K, the heavy bank provides a wide range of axial shape control and a monotonic relationship between its motion and the axial shape change, which makes it easy to automate axial shape control. The achievement of full automatic reactor power control both for the reactivity and power shape would reduce the burden due to load-follow operation on the operator. Also, it can accommodate the frequen-cy control, which requires the plant to respond to the unexpected demand. The Mode K design concepts were tested using simulation responses of Yonggwang Units 3&4, the reference plants for the Korean Standardized Nuclear Power Plants. The results illustrate that the Mode K is an adequate operation mode to provide practical load-follow capabilities for the Korean Standardized Nuclear Power Plants.
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Jung Youl Park,정재호,Hyung Chul Lee,Byung Il Lee,Seung-Ha Park,Eul-Sik Yoon 대한성형외과학회 2018 Archives of Plastic Surgery Vol.45 No.5
Background Adjuvant therapy after breast surgery, including tamoxifen or aromatase inhibitors, improves the postoperative outcomes and long-term survival of breast cancer patients. The aim of this study was to determine whether volume changes occurred in the contralateral breast during hormonal or other adjuvant therapies. Methods This study reviewed 90 patients who underwent unilateral breast reconstruction between September 2012 and April 2018 using tissue expanders and a permanent implant after the surgical removal of breast cancer. The volume of the contralateral breast was measured using a cast before the first (tissue expander insertion) and second (permanent implant change) stages of surgery. Changes in breast volume were evaluated to determine whether adjuvant therapy such as hormonal therapy, chemotherapy, and radiation therapy influenced the volume of the contralateral breast. Results The group receiving tamoxifen therapy demonstrated a significant decrease in volume compared with the group without tamoxifen (−7.8% vs. 1.0%; P=0.028). The aromatase inhibitor–treated group showed a significant increase in volume compared with those who did not receive therapy (−6.2% vs. 4.5%; P=0.023). There were no significant differences between groups treated with other hormonal therapy, chemotherapy, or radiation therapy. Conclusions Patients who received tamoxifen therapy showed a significant decrease in volume in the contralateral breast, while no significant change in weight or body mass index was found. Our findings suggest that we should choose smaller implants for premenopausal patients, who have a high likelihood of receiving tamoxifen therapy.
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