Trans-sphenoidal approach에 의한 pituitary microadenoma 수술 후의 임신 1례

여준규,이두룡,이미정,최종무,이원주,류효충,임만빈,최은주 啓明大學校 醫科大學 1993 계명의대학술지 Vol.12 No.3

We treated a patient with pituitary microadenoma having hyperprolactinemia and irregular menstruation infertility by transsphenoidal microsurgery. Her menstrual cycle become irregular after marriage but previous menstrual cycle was regular. When she visited our hospital due to infertility, initial serum prolactine level was slightly elevated 35.68ng/ml, During bromecriptine therapy, abrupt increase of serum prolactine level up to 126.52 ng/ml and headache and facial flush and galactorrhea developed. Pituitary microadenoma was confirmed by CT and MRI. The patient underwent transsphenoidal microsurgery. Patient was pregnant after surgery, and it was confirmed by USG and she is following up, OPD now.

NK/T 세포 림프종 환자에서 시행된 비골수제거성 조혈모세포이식

정준원,김진석,장준호,서형찬,이승태,김현옥,양우익,민유홍,한지숙,고윤웅 대한조혈모세포이식학회 2001 대한조혈모세포이식학회지 Vol.6 No.2

저자 등은 맹장, 충수돌기 및 흉막을 침범한 고위험군 NK/T 세포 림프종 환자에서 비골수제거 조혈모세포이식을 시행한 후 이식연관 합병증 없이 무병생존하였기에 보고하는 바이다. NK/T cell lymphoma is a rare type of non-Hodgkin"s lymphomas. It has the histological features of angiocentric lymphoma characterized by prominent angio-invasion by tumor cells, and commonly presents in nasal and paranasal structures. Non-nasal form of NK/T cell lymphoma involves skin, gastrointestinal tract, or liver. With conventional chemotherapy and/or radiotherapy, NK/T cell lymphoma shows poor response rate and seldom results in long term survival. Especially, non-nasal form has more aggressive clinical manifestations and grave outcome than nasal form. We report a case of NK/T cell lymphoma presenting with small bowel perforation and malignant pleural effusion due to lymphoma infiltration, transplanted with allogeneic peripheral blood stem cells from HLA identical sibling donor after fludarabine-based nonmyeloablative chemotherapy. After transplantation, the patient achieved an enduring tri-lineage hematological complete response without any evidence of relapse for 10 months.

大防風湯의 LPS誘發 關節炎 緩和效果에 관한 實驗的 硏究

田元準,辛吉祚,李源哲 동국대학교 한의학연구소 2000 東國韓醫學硏究所論文集 Vol.9 No.-

본 실험은 大防風湯이 혈관생성과 세포유착인자발현 억제를 통해 LPS(lipopolysaccharide)유발 관절염 완화에 미치는 영향을 조사하기 위해 LPS주사로 관절염이 유발된 생쥐에게 大防風湯 추출액을 음용 투여하였다. 실험동물은 20g된 female Balb/c계 생쥐암컷을 선별하여 아무런 처치를 하지 않은 대조군, 무릎관절에 LPS를 주사한 LPS군, LPS주사후 大防風湯 추출액을 투여한 DBP군으로 나누어, 다시 LPS와 DBP군을 LPS처리 후 시간의 경과에 따라 3, 7, 14일로 구분하였으며, 실험군 각각에는 실험동물을 10마리씩 배정하였다. 광학 현미경(BX50)으로 大防風湯 추출액 투여가 LPS주사 후 증가된 윤할 관절막내 혈관분포 증가에 미치는 영향과 아울러 윤활세포, 섬유화 및 섬유모세포, 비만세포와 염증관여세포, 세포유착인자 등의 윤활 관절막에서의 형태변화를 관찰하였다. DBP군에서는 자유면에서 윤활세포과형성의 억제와 침윤 림프구의 감소, 낮은 섬유화 양상과 침적 섬유모세포의 감소, 모세혈관 주변의 림프구 침적 감소와 비만세포 분포감소, 자유면과 섬유지지역분포 ICAM과 혈관주변분포VCAM 등과 같은 세포유착인자의 감소 등이 관찰되었다. 이상의 결과로 볼 때 大防風湯은 관절염 유발시 발생되는 혈관생성과 세포유착인자의 발현증가 등을 억제함으로써 이후 발생되는 윤활 관절막 손상을 완화하는 것으로 사료된다. Purpose : This study is to investigate the alleviation effects of Daebangpoongtang in LPS induced arthritis in mice knee joint. Methods : Daebangpoongtang was chosen to treat the arthritis caused by injecting 300 μg/kg LPS to mice knee joint. The control group had no treatment, while the LPS group was injected 300μg/kg LPS to mice knee joint and the DBP group was oral administrated of Daebangpoongtang. After injection of 300μg/kg LPS to mice knee joint, the alteration of synovial lining cell, vessel, fibrosis, distribution of collagen fiber, fibroblast, mast cell, infiltration of inflammation component cell and distribution of ICAM and VCAM was observed by light microscope(BX50). Results : In the DBP extract treatment group, the distribution of vessel, the enlargement of synovial lining cell layer, the synovial lining cells with filopodia, the fibrosis, the distribution of fibroblast in synovial membrane, the distribution of ICAM and VCAM on the knee joint was less than that of LPS group. Infiltrated lymphocyte into the apical surface had not observed in the DBP extract treatment group. The distribution of mast cell was as same as control group(no treatment group) and it showed granulated type. Conclusion : According to the above results, it might be considered that the administration of Daebangpoongtang has a curative effect on synovial membrane injury in arthritis by inhibiting increase of vessel, cell adhesion molecule(1CAM and VCAM) in LPS induced arthritis.

대동맥 완전 폐쇄의 중재적 치료

심원흠,최동훈,이문형,이도연,장병철,권준 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.1

변이형 협심증 환자의 진단에 있어 Iodine-123Metaiodobenzylguanidine 심근 스캔의 유용성

하종원,이종두,장양수,정남식,권준,임세중,이영준,심원흠,조승연,김성순 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.2

Skew 다항식환에서의 Sharma 다항식

朴準元 慶一大學校 1997 論文集 Vol.14 No.2

For an ideal I in a skew polynomial ring S=R〔χ,α〕such that I∩R=(0), if Iη(χ) is a principal ideal and I= Iκ∩S, then there exists a Sharma polynomial of minimal degree in I. And for a principal ideal in S we can induce a principal ideal in R with some conditions.

합성 다이아몬드(diamond)의 열적열화(熱的劣化)현상에 대한 연구

현준원 단국대학교 1996 論文集 Vol.30 No.-

We have investigated thermal degradation behavior of thermally resistant, single crystalline synthetic diamond grains under high-strength. During heat-treatment at high temperature, cracks begin to occur at the interface between inclusion and diamond prior to melting of the inclusions. Cracks form initially at the site of inclusions and are kept to the high temperature. The crack propagates along the {111} plane. The cracks generated during heat-treatment decrease a loadability of grains.

단결정 합성 다이아몬드(diamond)의 함유물과 강도

현준원 단국대학교 신소재기술연구소 1995 신소재 Vol.5 No.-

Fe-Co-C계와 Mn-Ni-C 계의 촉매를 써서 합성한 단결정 합성 diamond의 함유물이 강도에 미치는 영향을 연구하였다. 금속촉매를 사용하여 합성한 diamond 결정들은 방향족 함유물과 위치 함유물을 포함하며, 이러한 함유물은 diamond 결정을 균열시켜 강도를 크게 감소 시키게 된다. 방향족 함유물을 지닌 Fe-Co-C계의 결정들이 위치 함유물로 특징 되어지는 Mn-Ni-C계의 diamond 결정보다 강도 면에서 우수함을 관찰하였다. 낮은 내열성 온도와 큰 열팽창이 합성 diamond의 강도를 감소시키며, 결정의 강도는 합성 온도에 의존한다. Inclusion of synthetic diamond monocrystals synthesized by Fe-Do-C and Mn-Ni-C systems were studied to examine the strength of diamonds. Diamond crystals synthesized by solving alloy contain the oriented and local inclusions. Because of these inclusions, diamond crystals easily crack and their strength decreases enormously. As for as concerned with the strength, crystals of Fe-Co-C system of the oriented inclusions were observed more excellent than diamond crystals of Mn-Ni-C. Due to the low-resistant temperature and large thermal-expansion coefficient, the strength of synthetic diamonds decreases and depends on the synthetic temperature.

경도 및 중등도 근시환자에서 PRK 후 교정법에 따른 인공수정체 도수 비교

신제원,김중곤,송병주 한양대학교 의과대학 2002 한양의대 학술지 Vol.22 No.1

To compare IOL powers which are calculated by post-op keratometric(K) values and refraction derived K values, and by refraction corrected method, respectively, in patients who have been treated with excimer laser photorefractive keratectomy(PRK) for mild to moderate myopia. A total of 38 consecutive eyes of 23 patients who were treated with PRK for mild to moderate myopia have been followed up for more than 6 months. IOL powers from SRK/T formula by post-op K values and refraction derived K values were compared with IOL powers by refraction corrected method. The mean values of IOL powers using post-op K values, refraction derived K values, and refraction corrected method were 20.69±0.93(18.21 to 22.93) diopter(D), 20.81±0.88 D(18.60 to 22.43), and 21.26±0.79 D(19.08 to 23.03) respectively. There was no significant statistical difference between the mean values of IOL powers using post-op K values and refration derived K values (p〉0.05). However, the mean value of IOL powers by refraction corrected method was statistically higher than other two values(p〈0.05). In patients with excimer laser PRK treatment for mild to moderate myopia, IOL power using refraction corrected method was statistically higher than IOL power using post-operative K values and refraction derived K values.

합성 다이아몬드의 자기적 특성에 관한 연구

현준원 단국대학교 신소재기술연구소 1997 신소재 Vol.7 No.-

고온·고압에서 Fe-Co, Fe-Ni 및 Mn-Ni 계로부터 합성된 다이아몬드의 자기적 특성에 대해 연구하였다. Mn-Ni 계는 Fe-Co와 Fe-Ni 계보다 용해온도가 낮기 때문에 금속함유물을 많이 포함하며, Fe-Co와 Fe-Ni 계의 다이아몬드 분말이 강자성을 띄는 반면 Mn-Ni계의 다이아몬드 분말들은 약상자성을 나타낸다. 따라서 합성 다이아몬드의 자기적 특성은 촉매금속과 온도에 크게 의존하게 된다. We have Investigated magnetic properties of diamond synthesized by Fe-Co, Fe-Ni and Mn-Ni sonvent alloys on high temperature, high pressure. Because melting point of Mn-Ni system is lower than Fe-Co and Fe-Ni system, it contains metal inclusions. The magnetic properties of synthetic diamonds depend on catalyst and synthetic temperature largely.